aminocaproic acid has been researched along with Intracranial Aneurysm in 28 studies
Aminocaproic Acid: An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.
6-aminohexanoic acid : An epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator.
Intracranial Aneurysm: Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (
| Excerpt | Relevance | Reference |
|---|---|---|
| "A double-blind clinical trial of tranexamic acid was carried out on 39 patients with fresh subarachnoid hemorrhage from a ruptured aneurysm." | 9.04 | Treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm with tranexamic acid: a double-blind clinical trial. ( Chandra, B, 1978) |
| "5 g of epsilon-aminocaproic acid (EACA) per hour after subarachnoid hemorrhage (SAH) from an intracranial aneurysm." | 7.67 | Quantitative determination of plasma fibrinolytic activity in patients with ruptured intracranial aneurysms who are receiving epsilon-aminocaproic acid: relationship of possible complications of therapy to the degree of fibrinolytic inhibition. ( Bakay, RA; Burchiel, KJ; Hoffman, JM, 1984) |
| "A double-blind clinical trial of tranexamic acid was carried out on 39 patients with fresh subarachnoid hemorrhage from a ruptured aneurysm." | 5.04 | Treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm with tranexamic acid: a double-blind clinical trial. ( Chandra, B, 1978) |
| "5 g of epsilon-aminocaproic acid (EACA) per hour after subarachnoid hemorrhage (SAH) from an intracranial aneurysm." | 3.67 | Quantitative determination of plasma fibrinolytic activity in patients with ruptured intracranial aneurysms who are receiving epsilon-aminocaproic acid: relationship of possible complications of therapy to the degree of fibrinolytic inhibition. ( Bakay, RA; Burchiel, KJ; Hoffman, JM, 1984) |
| "We previously reported that epsilon-aminocaproic acid (EACA) prolonged the bleeding time in patients with intracranial aneurysms when given in doses of 36 to 48 gm/day." | 3.67 | Clinical and laboratory investigation of the effects of epsilon-aminocaproic acid on hemostasis. ( Atkinson, AJ; Cerullo, L; Cohen, I; Green, D; Ruo, TI; Ts'ao, CH, 1985) |
| "Patients suffering from a subarachnoid hemorrhage who were admitted to the Neurosurgical Unit of the Royal Perth Hospital during the period 1971 to 1979 were assessed with regard to the effectiveness of preoperative treatment with epsilon-aminocaproic acid, kanamycin, and reserpine." | 3.66 | Medical management of patients following a ruptured cerebral aneurysm, with epsilon-aminocaproic acid, kanamycin, and reserpine. ( Knuckey, NW; Stokes, BA, 1982) |
| "One hundred consecutive patients treated with epsilon aminocaproic acid 24 grams daily prior to surgery for ruptured intracranial aneurysms have been compared with the previous 100 patients managed similarly but without anti-fibrinolytic drugs." | 3.66 | Anti-fibrinolytic treatment in the pre-operative management of subarachnoid haemorrhage caused by ruptured intracranial aneurysm. ( Ameen, AA; Illingworth, R, 1981) |
| "A rapid fluorometric assay technique has been utilized to assess the degree of fibrinolytic inhibition in 20 patients with ruptured intracranial aneurysms treated with epsilon-aminocaproic acid (EACA)." | 3.66 | A method for monitoring antifibrinolytic therapy in patients with ruptured intracranial aneurysms. ( Burchiel, KJ; Schmer, G, 1981) |
| "10 patients suffering from intracranial aneurysm causing subarachnoid hemorrhage (SAH) have been treated during the acute pre-and postoperatory phase with omega-aminocaproic acid." | 3.66 | Fibrinolytic activity in blood and cerebrospinal fluid in subarachnoid hemorrhage from ruptured intracranial saccular aneurysm before and during EACA treatment. ( Collice, M; D'angelo, V; Donati, MB; Ferrara, M; Filizzolo, F; Porta, M, 1978) |
| "The incidence of hydrocephalus or symptomatic vasospasm was not unduly elevated in patients receiving preoperative EACA." | 1.30 | Reducing the risk of rebleeding before early aneurysm surgery: a possible role for antifibrinolytic therapy. ( Horner, TG; Leipzig, TJ; Redelman, K, 1997) |
| " The last 20 patients of the present series have been treated with very low doses of AMCA associated with parotid kallikrein inhibitor (Trasylol); this dosage has been effective in preventing recurrence and has appeared to be freer from severe side effects." | 1.26 | The use of antifibrinolytic drugs in aneurysmal subarachnoid hemorrhage. ( Schisano, G, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (85.71) | 18.7374 |
| 1990's | 1 (3.57) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (10.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baharoglu, MI | 1 |
| Germans, MR | 1 |
| Rinkel, GJ | 1 |
| Algra, A | 1 |
| Vermeulen, M | 1 |
| van Gijn, J | 1 |
| Roos, YB | 1 |
| Foreman, PM | 1 |
| Chua, M | 1 |
| Harrigan, MR | 1 |
| Fisher, WS | 1 |
| Tubbs, RS | 1 |
| Shoja, MM | 1 |
| Griessenauer, CJ | 1 |
| Malekpour, M | 1 |
| Kulwin, C | 1 |
| Bohnstedt, BN | 1 |
| Radmand, G | 1 |
| Sethia, R | 1 |
| Mendenhall, SK | 1 |
| Weyhenmeyer, J | 1 |
| Hendricks, BK | 1 |
| Leipzig, T | 1 |
| Payner, TD | 1 |
| Shah, MV | 1 |
| Scott, J | 1 |
| DeNardo, A | 1 |
| Sahlein, D | 1 |
| Cohen-Gadol, AA | 1 |
| UIHLEIN, A | 1 |
| OWEN, CA | 1 |
| COOPER, T | 1 |
| THOMPSON, JH | 1 |
| MULLAN, S | 2 |
| BECKMAN, F | 1 |
| VAILATI, G | 1 |
| KARASICK, J | 1 |
| DOBBEN, G | 1 |
| Spallone, A | 1 |
| Burchiel, KJ | 2 |
| Hoffman, JM | 1 |
| Bakay, RA | 1 |
| Yamaura, A | 1 |
| Nakamura, T | 1 |
| Makino, H | 1 |
| Hagihara, Y | 1 |
| Ramirez-Lassepas, M | 1 |
| Faria, MA | 1 |
| Fleischer, AS | 1 |
| Knuckey, NW | 1 |
| Stokes, BA | 1 |
| Brown, JA | 1 |
| Wollmann, RL | 1 |
| Ameen, AA | 1 |
| Illingworth, R | 1 |
| Alvarez Garijo, JA | 1 |
| Vilches, JJ | 1 |
| Aznar, JA | 1 |
| Shucart, WA | 1 |
| Hussain, SK | 1 |
| Cooper, PR | 1 |
| Schmer, G | 1 |
| Leipzig, TJ | 1 |
| Redelman, K | 1 |
| Horner, TG | 1 |
| Chowdhary, UM | 1 |
| Carey, PC | 1 |
| Hussein, MM | 1 |
| Chandra, B | 1 |
| Peerless, SJ | 1 |
| Filizzolo, F | 1 |
| D'angelo, V | 1 |
| Collice, M | 1 |
| Ferrara, M | 1 |
| Donati, MB | 1 |
| Porta, M | 1 |
| Schisano, G | 1 |
| Scott, RM | 1 |
| Garrido, E | 1 |
| Post, KD | 1 |
| Flamm, ES | 1 |
| Goodgold, A | 1 |
| Ransohoff, J | 1 |
| Langtitt, TW | 1 |
| Gulati, C | 1 |
| Green, D | 1 |
| Ts'ao, CH | 1 |
| Cerullo, L | 1 |
| Cohen, I | 1 |
| Ruo, TI | 1 |
| Atkinson, AJ | 1 |
| Biller, J | 1 |
| Godersky, JC | 1 |
| Adams, HP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Intra-arterial Vasospasm Trial(iVAST)- A Multi-center Randomized Study[NCT01996436] | Phase 4 | 330 participants (Anticipated) | Interventional | 2016-08-29 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for aminocaproic acid and Intracranial Aneurysm
| Article | Year |
|---|---|
Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage.
Topics: Administration, Oral; Aminocaproic Acid; Antifibrinolytic Agents; Brain Ischemia; Confidence Interva | 2013 |
Antifibrinolytic therapy in subarachnoid hemorrhage caused by ruptured intracranial aneurysm.
Topics: Aminocaproates; Aminocaproic Acid; Cyclohexanecarboxylic Acids; Humans; Intracranial Aneurysm; Ruptu | 1981 |
2 trials available for aminocaproic acid and Intracranial Aneurysm
| Article | Year |
|---|---|
Prevention of early recurrence of spontaneous subarachnoid haemorrhage by epsilon-aminocaproic acid.
Topics: Adolescent; Adult; Aged; Aminocaproates; Aminocaproic Acid; Arteriovenous Fistula; Basilar Artery; C | 1979 |
Treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm with tranexamic acid: a double-blind clinical trial.
Topics: Adult; Aged; Aminocaproic Acid; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Double-Blind | 1978 |
24 other studies available for aminocaproic acid and Intracranial Aneurysm
| Article | Year |
|---|---|
Antifibrinolytic therapy in aneurysmal subarachnoid hemorrhage increases the risk for deep venous thrombosis: A case-control study.
Topics: Adult; Aged; Aminocaproic Acid; Aneurysm, Ruptured; Angiography, Digital Subtraction; Antifibrinolyt | 2015 |
Effect of short-term ε-aminocaproic acid treatment on patients undergoing endovascular coil embolization following aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Aminocaproic Acid; Aneurysm, Ruptured; Antifibrinolytic Agents; Cohort Studies; Drug Ad | 2017 |
BLEEDING TENDENCIES ASSOCIATED WITH PROFOUND-HYPOTHERMIA TECHNICS IN NEUROLOGIC SURGERY.
Topics: Aminocaproates; Aminocaproic Acid; Blood Coagulation Disorders; Fibrinogen; Heart, Artificial; Hemos | 1964 |
AN EXPERIMENTAL APPROACH TO THE PROBLEM OF CEREBRAL ANEURYSM.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Cats; Dogs; Electric Stimulation; Femoral Artery; Humans | 1964 |
Antifibrinolytics in aneurysmal subarachnoid haemorrhage. A retrospective comparison of two different forms of antifibrinolytic therapy.
Topics: Adult; Aminocaproates; Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Drug Therapy, Combinat | 1982 |
Quantitative determination of plasma fibrinolytic activity in patients with ruptured intracranial aneurysms who are receiving epsilon-aminocaproic acid: relationship of possible complications of therapy to the degree of fibrinolytic inhibition.
Topics: Adolescent; Adult; Aged; Aminocaproates; Aminocaproic Acid; Cerebral Arteries; Depression, Chemical; | 1984 |
Cerebral complication of antifibrinolytic therapy in the treatment of ruptured intracranial aneurysm. Animal experiment and a review of literature.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Blood Pressure; Cerebral Cortex; Cisterna Magna; Cyclohe | 1980 |
Early and late surgery for ruptured aneurysm.
Topics: Aminocaproates; Aminocaproic Acid; Humans; Intracranial Aneurysm; Rupture, Spontaneous; Time Factors | 1982 |
Medical management of patients following a ruptured cerebral aneurysm, with epsilon-aminocaproic acid, kanamycin, and reserpine.
Topics: Aminocaproates; Aminocaproic Acid; Drug Therapy, Combination; Female; Humans; Intracranial Aneurysm; | 1982 |
Myopathy induced by epsilon-aminocaproic acid. Case report.
Topics: Aged; Aminocaproates; Aminocaproic Acid; Biopsy; Female; Humans; Intracranial Aneurysm; Leg; Muscula | 1982 |
Anti-fibrinolytic treatment in the pre-operative management of subarachnoid haemorrhage caused by ruptured intracranial aneurysm.
Topics: Adolescent; Adult; Aged; Aminocaproates; Aminocaproic Acid; Antifibrinolytic Agents; Child; Female; | 1981 |
Preoperative treatment of ruptured intracranial aneurysms with tranexamic acid and monitoring of fibrinolytic activity.
Topics: Aminocaproic Acid; Cyclohexanecarboxylic Acids; Fibrin Fibrinogen Degradation Products; Humans; Intr | 1980 |
Epsilon-aminocaproic acid and recurrent subarachnoid hemorrhage: a clinical trial.
Topics: Aminocaproates; Aminocaproic Acid; Drug Evaluation; Humans; Intracranial Aneurysm; Recurrence; Subar | 1980 |
A method for monitoring antifibrinolytic therapy in patients with ruptured intracranial aneurysms.
Topics: Aminocaproates; Aminocaproic Acid; Humans; Injections, Intravenous; Intracranial Aneurysm; Plasminog | 1981 |
Reducing the risk of rebleeding before early aneurysm surgery: a possible role for antifibrinolytic therapy.
Topics: Adult; Aged; Aged, 80 and over; Aminocaproic Acid; Aneurysm, Ruptured; Antifibrinolytic Agents; Huma | 1997 |
Pre- and postoperative management of cerebral aneurysms.
Topics: Aminocaproic Acid; Brain Edema; Humans; Hydrocephalus; Hypertension; Intracranial Aneurysm; Ischemic | 1979 |
Fibrinolytic activity in blood and cerebrospinal fluid in subarachnoid hemorrhage from ruptured intracranial saccular aneurysm before and during EACA treatment.
Topics: Aminocaproates; Aminocaproic Acid; Fibrin Fibrinogen Degradation Products; Fibrinolysis; Humans; Int | 1978 |
The use of antifibrinolytic drugs in aneurysmal subarachnoid hemorrhage.
Topics: Adolescent; Adult; Aged; Aminocaproates; Aminocaproic Acid; Cyclohexanecarboxylic Acids; Humans; Int | 1978 |
Spontaneous thrombosis of an intracranial aneurysm during treatment with epsilon aminocaproic acid.
Topics: Adult; Aminocaproates; Aminocaproic Acid; Cerebral Hemorrhage; Female; Humans; Intracranial Aneurysm | 1977 |
Ruptured intracranial aneurysms. Case morbidity and mortality.
Topics: Adult; Aged; Aminocaproic Acid; Cerebral Hemorrhage; Humans; Hydrochlorothiazide; Hypertension; Intr | 1977 |
Conservative care of intracranial hemorrhage.
Topics: Aminocaproic Acid; Blood Pressure; Brain Edema; Cerebral Hemorrhage; Humans; Hydrocephalus; Hyperton | 1977 |
Anesthetic management of a patient with a giant intracranial aneurysm.
Topics: Adult; Aminocaproic Acid; Anesthesia, General; Electrocardiography; Humans; Intracranial Aneurysm; I | 1989 |
Clinical and laboratory investigation of the effects of epsilon-aminocaproic acid on hemostasis.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Aorta, Thoracic; Bleeding Time; Blood Platelets; Cattle; | 1985 |
Management of aneurysmal subarachnoid hemorrhage.
Topics: Aminocaproic Acid; Humans; Intracranial Aneurysm; Nervous System Diseases; Nicardipine; Nimodipine; | 1988 |