aminocaproic acid has been researched along with Complication, Intraoperative in 12 studies
Aminocaproic Acid: An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.
6-aminohexanoic acid : An epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixty patients were randomized in a double-blind fashion to receive epsilon-aminocaproic acid, aprotinin, or saline (placebo) in similar dosing regimens (loading dose, pump prime, and infusion)." | 2.71 | Antifibrinolytic therapy during cardiopulmonary bypass reduces proinflammatory cytokine levels: a randomized, double-blind, placebo-controlled study of epsilon-aminocaproic acid and aprotinin. ( Brouse, CF; Chi, L; Dimaio, JM; Greilich, PE; Jessen, ME; Whitten, CW, 2003) |
| " Further studies are needed to clarify optimal therapeutic dosing and to identify mechanisms of neuroprotection in rat SBI models." | 1.43 | Epsilon Aminocaproic Acid Pretreatment Provides Neuroprotection Following Surgically Induced Brain Injury in a Rat Model. ( Applegate, RL; Khatibi, N; Komanapalli, ES; Martin, RD; Rolland, W; Sherchan, P; Tang, J; Zhang, JH, 2016) |
| "Recently we came across a severe anaphylactoid reaction, possibly as a result of administration of plaslloid in a patient who was undergoing elective surgery for cervical carcinoma." | 1.28 | Suspected anaphylactoid shock to aminocaproic acid (plaslloid) during operation. ( Chan, KH; Hseu, SS; Lee, TY; Yien, HW, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (25.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Komanapalli, ES | 1 |
| Sherchan, P | 1 |
| Rolland, W | 1 |
| Khatibi, N | 1 |
| Martin, RD | 1 |
| Applegate, RL | 1 |
| Tang, J | 1 |
| Zhang, JH | 1 |
| Harvey, R | 1 |
| Salehi, A | 1 |
| Pustavoitau, A | 1 |
| Faraday, N | 1 |
| Greilich, PE | 1 |
| Brouse, CF | 1 |
| Whitten, CW | 1 |
| Chi, L | 1 |
| Dimaio, JM | 1 |
| Jessen, ME | 1 |
| Pedraz, J | 1 |
| Daudén, E | 1 |
| García-Diez, A | 1 |
| Maslow, AD | 1 |
| Chaudrey, A | 1 |
| Bert, A | 1 |
| Schwartz, C | 1 |
| Singh, A | 1 |
| Dorman, BH | 1 |
| Stroud, RE | 1 |
| Wyckoff, MM | 1 |
| Zellner, JL | 1 |
| Botta, D | 1 |
| Leonardi, AH | 1 |
| Ikonomidis, JS | 1 |
| Spinale, FG | 1 |
| Glick, R | 1 |
| Green, D | 1 |
| Ts'ao, C | 1 |
| Witt, WA | 1 |
| Yu, AT | 1 |
| Raimondi, AJ | 1 |
| Medina Pérez, A | 1 |
| De las Nieves, MA | 1 |
| Shukla, KK | 1 |
| Ambastha, SS | 1 |
| Dube, RK | 1 |
| Dube, B | 1 |
| Yien, HW | 1 |
| Hseu, SS | 1 |
| Chan, KH | 1 |
| Lee, TY | 1 |
| Artus, M | 1 |
| Hollocou, B | 1 |
| Bodin, JM | 1 |
| Noury, D | 1 |
| Roumeas, J | 1 |
| Malledant, Y | 1 |
| Launois, B | 1 |
| Saint Marc, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Influence of Elevated Baseline Serum Creatinine and Body Composition on Acute Kidney Injury in Cardiac Surgery - The InCreAS Trial[NCT02598271] | 200 participants (Actual) | Observational | 2016-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for aminocaproic acid and Complication, Intraoperative
| Article | Year |
|---|---|
Con: Antifibrinolytics Should Not Be Used Routinely in Low-Risk Cardiac Surgery.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Cardiac Surgical Procedures; Humans; Intraoperative Comp | 2016 |
Pro: Antifibrinolytics Should Be Used in Routine Cardiac Cases Using Cardiopulmonary Bypass (Unless Contraindicated).
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Cardiopulmonary Bypass; Humans; Intraoperative Complicat | 2016 |
[Practical management of C1 inhibitor deficiency].
Topics: Adolescent; Adult; Aminocaproic Acid; Angioedema; Bradykinin; Child; Child, Preschool; Complement C1 | 2007 |
2 trials available for aminocaproic acid and Complication, Intraoperative
| Article | Year |
|---|---|
Antifibrinolytic therapy during cardiopulmonary bypass reduces proinflammatory cytokine levels: a randomized, double-blind, placebo-controlled study of epsilon-aminocaproic acid and aprotinin.
Topics: Aged; Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Cardiopulmonary Bypass; Coronary Artery | 2003 |
Differential effects of epsilon-aminocaproic acid and aprotinin on matrix metalloproteinase release in patients following cardiopulmonary bypass.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical; Cardiopulmonary Bypass; | 2008 |
7 other studies available for aminocaproic acid and Complication, Intraoperative
| Article | Year |
|---|---|
Epsilon Aminocaproic Acid Pretreatment Provides Neuroprotection Following Surgically Induced Brain Injury in a Rat Model.
Topics: Aminocaproic Acid; Animals; Antifibrinolytic Agents; Behavior, Animal; Brain; Brain Edema; Brain Inj | 2016 |
Perioperative renal outcome in cardiac surgical patients with preoperative renal dysfunction: aprotinin versus epsilon aminocaproic acid.
Topics: Aged; Aged, 80 and over; Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Cardiac Surgical Pro | 2008 |
High does epsilon-aminocaproic acid prolongs the bleeding time and increases rebleeding and intraoperative hemorrhage in patients with subarachnoid hemorrhage.
Topics: Adult; Aged; Aminocaproates; Aminocaproic Acid; Bleeding Time; Blood Coagulation; Female; Humans; In | 1981 |
[Antifibrinolytics as a treatment for severe factor XI deficiency in laryngeal surgery].
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Hemophilia B; Humans; Intraoperative Complications; Lary | 1999 |
Use of antifibrinolytic therapy in prostate surgery.
Topics: 4-Aminobenzoic Acid; Aged; Aminobenzoates; Aminocaproic Acid; Antifibrinolytic Agents; Hemorrhage; H | 1979 |
Suspected anaphylactoid shock to aminocaproic acid (plaslloid) during operation.
Topics: Aminocaproic Acid; Anaphylaxis; Female; Humans; Hysterectomy; Intraoperative Complications; Middle A | 1992 |
[Anaphylactic shock during surgical treatment of hepatic hydatidosis].
Topics: Adult; Aminocaproic Acid; Anaphylaxis; Drug Therapy, Combination; Echinococcosis, Hepatic; Female; H | 1985 |