aminocaproic acid has been researched along with Coagulation Disorders, Blood in 51 studies
Aminocaproic Acid: An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.
6-aminohexanoic acid : An epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator.
| Excerpt | Relevance | Reference |
|---|---|---|
| "ε-Aminocaproic acid treatment was initiated and was associated with rapid clinical improvement and diminished fibrinolysis based on a modified plasma-based thromboelastogram." | 1.43 | Thromboelastographic evidence of inhibition of fibrinolysis after ε-aminocaproic acid administration in a dog with suspected acute traumatic coagulopathy. ( Olver, CS; Sullivan, LA; Venn, E; Yoo, SH, 2016) |
| "The aim of the study was to create a trauma coagulopathy model (TCM) with a hyperfibrinolysis thrombelastography (TEG) pattern similar to injured patients and test the effects of different resuscitation fluids and antifibrinolytics on fibrinolysis." | 1.39 | Influence of resuscitation fluids, fresh frozen plasma and antifibrinolytics on fibrinolysis in a thrombelastography-based, in-vitro, whole-blood model. ( Cotton, BA; Holcomb, JB; Kostousov, V; Matijevic, N; Wade, CE; Wang, YW, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (80.39) | 18.7374 |
| 1990's | 6 (11.76) | 18.2507 |
| 2000's | 1 (1.96) | 29.6817 |
| 2010's | 3 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kostousov, V | 1 |
| Wang, YW | 1 |
| Cotton, BA | 1 |
| Wade, CE | 1 |
| Holcomb, JB | 1 |
| Matijevic, N | 1 |
| Yoo, SH | 1 |
| Venn, E | 1 |
| Sullivan, LA | 1 |
| Olver, CS | 1 |
| Sniecinski, RM | 1 |
| Levy, JH | 1 |
| LEGER, L | 2 |
| LANDE, M | 2 |
| FOURNET, R | 1 |
| GIBELLI, A | 1 |
| ROTH, F | 1 |
| ANDERSSON, L | 2 |
| BLOOM, AL | 1 |
| WEISS, M | 2 |
| YVER, J | 1 |
| SAMAMA, M | 2 |
| DUBOST, C | 2 |
| ZWEIBAUM, A | 1 |
| JOSSO, F | 1 |
| ROUSSELOT, LM | 1 |
| CAZES, B | 1 |
| GROSSI, CE | 1 |
| BERNARD, J | 1 |
| BOUSSER, J | 1 |
| DREYFUS, B | 1 |
| HAMBURGER, J | 1 |
| PEQUIGNOT, H | 1 |
| VAIREL, E | 1 |
| MARZETTI, L | 1 |
| MORINI, A | 1 |
| KAWAKITA, Y | 1 |
| KOLLER, F | 1 |
| FLUTE, PT | 1 |
| BRODSKY, I | 1 |
| ROSS, E | 1 |
| REID, WO | 1 |
| MARCHAL, G | 1 |
| BILSKI-PASQUIER, G | 1 |
| GUERY, J | 1 |
| UIHLEIN, A | 1 |
| OWEN, CA | 1 |
| COOPER, T | 1 |
| THOMPSON, JH | 1 |
| MCNICOL, GP | 3 |
| DOUGLAS, AS | 3 |
| SHARP, AA | 1 |
| DUBBER, AH | 1 |
| MELANDER, B | 1 |
| KOWALSKI, E | 1 |
| BUDZYNSKI, AZ | 1 |
| KOPEC, M | 1 |
| LATALLO, ZS | 1 |
| LIPINSKI, B | 1 |
| WEGRZYNOWICZ, Z | 1 |
| GANS, H | 1 |
| OPPELT, HG | 1 |
| BECK, L | 1 |
| SWEENEY, WM | 1 |
| Tobias, JD | 1 |
| Schmidt, B | 1 |
| Pringsheim, W | 1 |
| Künzer, W | 1 |
| Neidhart, JA | 1 |
| Roach, RW | 1 |
| Babu, SC | 1 |
| Bole, P | 1 |
| Sharma, P | 1 |
| Purdy, R | 1 |
| Clauss, RH | 1 |
| Kang, Y | 1 |
| Carr, ME | 1 |
| Carr, SL | 1 |
| McCardell, KA | 1 |
| Westaby, S | 1 |
| Cattaneo, M | 1 |
| Mannucci, PM | 1 |
| Forman, WB | 1 |
| Kraus, J | 1 |
| Kalishevskaia, TM | 1 |
| Pochukaeva, LS | 1 |
| Lewis, RT | 1 |
| Griffin, JD | 1 |
| Ellman, L | 1 |
| Koriakin, VA | 1 |
| Rzhavskov, IuV | 1 |
| Zeigler, ZR | 1 |
| Williams, EC | 2 |
| Sane, DC | 1 |
| Pizzo, SV | 1 |
| Greenberg, CS | 1 |
| Hasson, DM | 1 |
| Poole, AE | 1 |
| de la Fuente, B | 1 |
| Hoyer, LW | 1 |
| LeVeen, HH | 1 |
| Ip, M | 1 |
| Ahmed, N | 1 |
| Hutto, RB | 1 |
| LeVeen, EG | 1 |
| Shah, PK | 1 |
| Chittora, MD | 1 |
| Vyas, MM | 1 |
| Tak, RS | 1 |
| Vyas, R | 1 |
| Schwartz, BS | 1 |
| Conlan, MG | 1 |
| Mosher, DF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective, Randomized, Single-blinded, Non-inferiority Study to Evaluate the Safety and Efficacy of the Saline-coupled Bipolar Sealer Compared to the Unipolar Electrocautery in Primary Unilateral Total Knee Arthroplasty[NCT03952546] | 211 participants (Actual) | Interventional | 2019-05-07 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Functional outcomes measured by the 2011 Knee Society Score. The Functional Activities section consists of 4 sub-sections with a total score ranging from 0-100 points. The higher the numerical value the better the outcome. The sub-sections consist of: (1)Walking and Standing 0-30 points (2)Standard Activities 0-30 points (3)Advanced Activities 0-25 points (4)Discretionary Knee Activities 0-15 points." (NCT03952546)
Timeframe: 8 weeks
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Arm | 56.45 |
| Control Arm | 61.79 |
Postoperative day 1 estimated blood loss as calculated by the Gross' Formula (NCT03952546)
Timeframe: Postoperative day 1
| Intervention | milliliters (Mean) |
|---|---|
| Treatment Arm | 924 |
| Control Arm | 1062 |
Participants were assessed for any wound infection within 90 days of surgery. (NCT03952546)
Timeframe: 90 days postoperatively
| Intervention | Number of events (Number) |
|---|---|
| Saline-Coupled Bipolar Sealer | 1 |
| Unipolar Electrocautery | 3 |
10 reviews available for aminocaproic acid and Coagulation Disorders, Blood
| Article | Year |
|---|---|
Bleeding and management of coagulopathy.
Topics: Algorithms; Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Coagulation Disorders; Bloo | 2011 |
EPSILON-AMINOCAPROIC ACID AND OTHER INHIBITORS OF FIBRINOLYSIS.
Topics: Aminocaproates; Aminocaproic Acid; Anaphylaxis; Biomedical Research; Blood Coagulation Disorders; Bl | 1964 |
PATHOLOGICAL FIBRINOLYSIS.
Topics: Aminocaproates; Aminocaproic Acid; Anticoagulants; Blood Coagulation Disorders; Blood Group Incompat | 1964 |
AMINOCAPROIC ACID, AN INHIBITOR OF FIBRINOLYSIS.
Topics: Aminocaproates; Aminocaproic Acid; Blood Coagulation Disorders; Blood Coagulation Tests; Chemical Ph | 1965 |
Strategies for minimizing blood loss in orthopedic surgery.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Coagulation Disorders; Blood Loss, Surg | 2004 |
Clinical use of synthetic antifibrinolytic agents during liver transplantation.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Coagulation Disorders; Blood Loss, Surgical; Clini | 1993 |
Coagulation disturbance in profound hypothermia: the influence of anti-fibrinolytic therapy.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aorta, Thoracic; Aortic Aneurysm; Aprotinin; Blood Coagu | 1997 |
Current status of non-transfusional haemostatic agents.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Blood Coagulation Disorders; Blood Loss, Surg | 1999 |
[Treatment of pulmonary hemorrhage in patients with tuberculosis of the respiratory organs (a lecture)].
Topics: Aminocaproic Acid; Aprotinin; Blood Coagulation Disorders; Dextrans; Hemoptysis; Humans; Tuberculosi | 1990 |
Elevated urokinase-type plasminogen activator level and bleeding in amyloidosis: case report and literature review.
Topics: Aminocaproic Acid; Amyloidosis; Blood Coagulation Disorders; Fibrinolysis; Fibrinolytic Agents; Hemo | 1989 |
41 other studies available for aminocaproic acid and Coagulation Disorders, Blood
| Article | Year |
|---|---|
Influence of resuscitation fluids, fresh frozen plasma and antifibrinolytics on fibrinolysis in a thrombelastography-based, in-vitro, whole-blood model.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Coagulation Disorders; Colloids; Crystalloid Solut | 2013 |
Thromboelastographic evidence of inhibition of fibrinolysis after ε-aminocaproic acid administration in a dog with suspected acute traumatic coagulopathy.
Topics: Aminocaproic Acid; Animals; Antifibrinolytic Agents; Blood Coagulation Disorders; Dog Diseases; Dogs | 2016 |
[Prevention and treatment by epsilon-aminocaproic acid of fibrinolytic syndromes in surgery].
Topics: Amino Acids; Aminocaproic Acid; Antifibrinolytic Agents; Biomedical Research; Blood Coagulation Diso | 1963 |
[Research on the antifibrinolytic action of 6-aminocaproic acid. II. The action of 6-aminocaproic acid in hyperfibrinolytic syndromes caused by transfusion incompatibility].
Topics: Amino Acids; Aminocaproic Acid; Antifibrinolytic Agents; Blood Coagulation Disorders; Blood Group In | 1962 |
[Orientation on the effect of 6-aminocaproic acid in obstetrics and gynecology].
Topics: Amino Acids; Aminocaproic Acid; Blood Coagulation Disorders; Caproates; Gynecology; Obstetrics; Preg | 1962 |
Studies on fibrinolysis in urinary tract disease and its treatment with epsilon-amino-caproic acid.
Topics: Amino Acids; Aminocaproic Acid; Antifibrinolytic Agents; Blood Coagulation Disorders; Caproates; Fib | 1962 |
FIBRINOLYTIC STATES IN PROSTATIC DISEASE AND THEIR TREATMENT WITH EPSILON-AMINO-CAPROIC ACID.
Topics: Aminocaproates; Aminocaproic Acid; Blood Coagulation Disorders; Caproates; Humans; Male; Prostatic D | 1963 |
ACTIVATION OF COAGULATION AND FIBRINOGEN LOSS AFTER USING AN EXTRACORPOREAL CIRCULATION.
Topics: Aminocaproates; Aminocaproic Acid; Ammonium Compounds; Animals; Blood Cell Count; Blood Coagulation; | 1963 |
[DISSOCIATED EFFECTS OF A NEW ANTIFIBRINOLYTIC AGENT (EPSILON-AMINOCAPROIC ACID) INJECTED "IN VIVO", ON "IN VITRO" FIBRINOLYSIS TESTS].
Topics: Aminocaproates; Aminocaproic Acid; Antifibrinolytic Agents; Blood Coagulation Disorders; Blood Coagu | 1963 |
[ANTIFIBRINOLYTIC AGENTS].
Topics: Aminocaproates; Aminocaproic Acid; Antifibrinolytic Agents; Blood Coagulation Disorders; Enzyme Inhi | 1963 |
[INACTIVATION BY THE LIVER OF FIBRINOLYTIC ENZYMES].
Topics: Aminocaproates; Aminocaproic Acid; Animals; Blood Coagulation Disorders; Carbon Tetrachloride Poison | 1963 |
[INDICATIONS AND HANDLING OF FIBRINOLYTIC ENZYME INHIBITORS].
Topics: Aminocaproates; Aminocaproic Acid; Blood Coagulation Disorders; Chymotrypsin; Enzyme Inhibitors; Fib | 1964 |
[EPSILON-AMINOCAPROIC ACID AND FIBRINOLYSIS].
Topics: Aminocaproates; Aminocaproic Acid; Blood Coagulation Disorders; Deoxyribonuclease I; Fibrinolysis; H | 1964 |
[OBSTETRICAL HEMORRHAGIC SYNDROMES. OBSERVATIONS AND CONSIDERATIONS OF A PHYSIOPATHOLOGICAL, CLINICAL AND THERAPEUTIC NATURE].
Topics: Aminocaproates; Aminocaproic Acid; Blood Coagulation Disorders; Blood Coagulation Tests; Cesarean Se | 1964 |
[MEDICAL EXAMINATION AND TREATMENT OF PURPURA].
Topics: Adrenochrome; Adrenocorticotropic Hormone; Aminocaproates; Aminocaproic Acid; Blood Coagulation Diso | 1964 |
INTRAVASCULAR CLOTTING AND SPONTANEOUS FIBRINOLYSIS.
Topics: Aminocaproates; Aminocaproic Acid; Aprotinin; Blood Coagulation; Blood Coagulation Disorders; Blood | 1964 |
HAEMORRHAGE AND FIBRINOLYSIS.
Topics: Aminocaproates; Aminocaproic Acid; Amniotic Fluid; Blood Coagulation Disorders; Blood Coagulation Te | 1964 |
THE USE OF THE SERIAL THROMBIN TIME IN EVALUATING THERAPY WITH EPSILON AMINOCAPROIC ACID IN MASSIVE THROMBOLYSIS AND PROTEOLYSIS.
Topics: Aminocaproates; Aminocaproic Acid; Blood Coagulation Disorders; Blood Coagulation Tests; Drug Therap | 1964 |
[FIBRINOLYSIS AND EPSILON-AMINOCAPROIC ACID].
Topics: Aminocaproates; Aminocaproic Acid; Blood Coagulation Disorders; Cardiac Surgical Procedures; Fibrino | 1964 |
[HEMORRHAGE, COAGULATION AND HEMOSTASIS IN "OPEN HEART" SURGERY PATIENTS. II. FAVORABLE INFLUENCE ON POSTOPERATIVE BLEEDING OF EPSILON-AMINOCAPROIC ACID INJECTION].
Topics: Aminocaproates; Aminocaproic Acid; Blood Coagulation Disorders; Cardiac Surgical Procedures; Heart, | 1964 |
BLEEDING TENDENCIES ASSOCIATED WITH PROFOUND-HYPOTHERMIA TECHNICS IN NEUROLOGIC SURGERY.
Topics: Aminocaproates; Aminocaproic Acid; Blood Coagulation Disorders; Fibrinogen; Heart, Artificial; Hemos | 1964 |
SOME PROPERTIES OF THE ANTIFIBRINOLYTICALLY ACTIVE ISOMER OF AMINO-METHYLCYCLOHEXANE CARBOXYLIC ACID.
Topics: Aminocaproates; Aminocaproic Acid; Blood Coagulation Disorders; Cyclohexanes; Deoxyribonuclease I; E | 1964 |
STUDIES ON THE MOLECULAR PATHOLOGY AND PATHOGENESIS OF BLEEDING IN SEVERE FIBRINOLYTIC STATES IN DOGS.
Topics: Aminocaproates; Aminocaproic Acid; Blood Coagulation Disorders; Blood Coagulation Tests; Deoxyribonu | 1964 |
[E-AMINOCAPROIC ACID IN OBSTETRICAL PRACTICE].
Topics: Aminocaproates; Aminocaproic Acid; Blood Coagulation Disorders; Female; Hemorrhage; Humans; Postpart | 1964 |
USE OF EPSILON AMINOCAPROIC ACID.
Topics: Aminocaproates; Aminocaproic Acid; Blood Coagulation Disorders; Drug Therapy; Fibrinolysis; Humans; | 1965 |
[BLOOD COAGULATION DISORDERS DURING LABOR WITH SPECIAL REFERENCE TO FIBRINOLYSIS].
Topics: Aminocaproates; Aminocaproic Acid; Blood Coagulation Disorders; Drug Therapy; Female; Fibrinogen; Fi | 1965 |
ACUTE FIBRINOLYTIC STATES IN SURGERY.
Topics: Aminocaproates; Aminocaproic Acid; Aprotinin; Blood Coagulation Disorders; Enzyme Inhibitors; Fibrin | 1965 |
[Epsylon-aminocaproic acid in the treatment of severe and dominating hyperfibrinolysis in a premature infant].
Topics: Aminocaproates; Aminocaproic Acid; Blood Coagulation Disorders; Blood Group Incompatibility; Exchang | 1980 |
Successful treatment of skeletal hemangioma and Kasabach-Merritt syndrome with aminocaproic acid. Is fibrinolysis "defensive"?
Topics: Adult; Aminocaproates; Aminocaproic Acid; Blood Coagulation Disorders; Bone Neoplasms; Fibrinolysis; | 1982 |
Pathological fibrinolysis secondary to pseudoaneurysms.
Topics: Aminocaproic Acid; Aneurysm; Aorta, Abdominal; Aortic Aneurysm; Blood Coagulation Disorders; Blood C | 1980 |
Use of TPA-induced clot lysis time (TCLOT) to diagnose abnormal clot structure and fibrinolysis in a patient with spontaneous bleeding into his leg.
Topics: Adult; Aminocaproic Acid; Antifibrinolytic Agents; Biomechanical Phenomena; Blood Coagulation; Blood | 1996 |
Transurethral resection in a patient with a dysfibrinogen: fibrinogen cleveland I.
Topics: Aged; Aminocaproic Acid; Blood Coagulation Disorders; Fibrinogen; Fibrinolysis; Humans; Male; Ohio; | 1977 |
[Use of protamine sulfate, epsilon-aminocaproic acid and serotonin in experimental hypofibrinogenemia and fibrinolysis caused by stimulation of the anticoagulant system].
Topics: Afibrinogenemia; Aminocaproates; Aminocaproic Acid; Animals; Atropine; Blood Coagulation Disorders; | 1976 |
Severe coagulopathy following insertion of the LeVeen shunt: a potentially fatal complication.
Topics: Adult; Aged; Aminocaproic Acid; Ascites; Blood Coagulation Disorders; Diagnosis, Differential; Femal | 1979 |
Epsilon-aminocaproic acid (EACA).
Topics: Aminocaproates; Aminocaproic Acid; Blood Coagulation Disorders; Female; Fibrinolysis; Hematuria; Hum | 1978 |
Effects of epsilon aminocaproic acid on primary hemostasis.
Topics: Administration, Oral; Aminocaproic Acid; Bleeding Time; Blood Coagulation Disorders; Hemostasis; Hum | 1991 |
Plasma alpha 2-antiplasmin activity. Role in the evaluation and management of fibrinolytic states and other bleeding disorders.
Topics: Adolescent; alpha-2-Antiplasmin; Aminocaproic Acid; Blood Coagulation Disorders; Child; Disseminated | 1989 |
The dental management of patients with spontaneous acquired factor VIII inhibitors.
Topics: Aminocaproic Acid; Blood Coagulation Disorders; Cyclophosphamide; Deamino Arginine Vasopressin; Dent | 1986 |
Coagulopathy post peritoneovenous shunt.
Topics: Aminocaproic Acid; Ascitic Fluid; Blood Coagulation Disorders; Blood Coagulation Factors; Humans; Pe | 1987 |
Primary pathological fibrinolysis in viper (Echis-Carinatus) bite treatment by epsilon aminocaproic acid.
Topics: Adult; Aminocaproates; Aminocaproic Acid; Blood Coagulation Disorders; Fibrinolysis; Humans; Male; S | 1987 |
Epsilon-aminocaproic acid in the treatment of patients with acute promyelocytic leukemia and acquired alpha-2-plasmin inhibitor deficiency.
Topics: alpha-2-Antiplasmin; Aminocaproates; Aminocaproic Acid; Blood Coagulation Disorders; Drug Therapy, C | 1986 |