aminocaproic acid has been researched along with Amyotonia Congenita in 3 studies
Aminocaproic Acid: An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.
6-aminohexanoic acid : An epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thompson, GH | 1 |
| Florentino-Pineda, I | 1 |
| Poe-Kochert, C | 1 |
| Armstrong, DG | 1 |
| Son-Hing, J | 1 |
| Van Renterghem, D | 1 |
| De Reuck, J | 1 |
| Schelstraete, K | 1 |
| Elinck, W | 1 |
| Van der Straeten, M | 1 |
| Vanneste, JA | 1 |
| van Wijngaarden, GK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Intravenous E-Aminocaproic Acid (EACA) on Blood Loss and Transfusion Requirements After Bilateral Varus Rotational Osteotomy (VRO)[NCT02257580] | Phase 4 | 28 participants (Actual) | Interventional | 2015-04-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Incidence of VTE (symptomatic of DVT or PE), infection (superficial, deep), hematoma, seroma, reoperation, and death, measured in person-years ( x cases per 100,000 person years) (NCT02257580)
Timeframe: an expected average of 1 week (post-surgery), Follow-up at 6 weeks
| Intervention | cases per 100,000 person years (Number) |
|---|---|
| E-Aminocaproic Acid (EACA) | 0 |
| Placebo | 0 |
Determined by estimated blood volume, calculated using difference in preoperative and postoperative hemoglobin and applied to the Nadler equation for estimating blood volume while adjusting for transfused hemoglobin to produce a single metric of calculated intraoperative blood loss. (NCT02257580)
Timeframe: Intraoperative (3-6 hours)
| Intervention | mL (Mean) |
|---|---|
| E-Aminocaproic Acid (EACA) | 535.7 |
| Placebo | 628.0 |
Number of participants requiring 1 unit of intraoperative cell saver transfusion. Patients either received or did not receive intraoperative cell saver transfusion. The maximum number of intraoperative units transfused in this study was 1 unit. The count of participants in the data table refers to the number of patients who received this transfusion. (NCT02257580)
Timeframe: Intraoperative, 1 day
| Intervention | Participants (Count of Participants) |
|---|---|
| E-Aminocaproic Acid (EACA) | 7 |
| Placebo | 7 |
postoperative day of discharge after surgery- day of intake. (NCT02257580)
Timeframe: Post-Surgery, an expected average of 1 week
| Intervention | days (Mean) |
|---|---|
| E-Aminocaproic Acid (EACA) | 5.5 |
| Placebo | 5.1 |
24 hour drain output (mL) (NCT02257580)
Timeframe: Post-Surgery, 24 hours
| Intervention | mL (Mean) |
|---|---|
| E-Aminocaproic Acid (EACA) | 72.5 |
| Placebo | 103.3 |
The number of participants that required 1 unit of blood transfused post-operatively. Patients received blood if necessary post operatively, and the maximum number of units a patient received was 1. The count of participants refers to the number of patients who received this transfusion unit. (NCT02257580)
Timeframe: Post-Surgery, an expected average of 1 week
| Intervention | Participants (Count of Participants) |
|---|---|
| E-Aminocaproic Acid (EACA) | 4 |
| Placebo | 3 |
3 other studies available for aminocaproic acid and Amyotonia Congenita
| Article | Year |
|---|---|
Role of Amicar in surgery for neuromuscular scoliosis.
Topics: Adolescent; Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Blood Transfusion; Cas | 2008 |
Epsilon amino caproic acid myopathy: additional features.
Topics: Alanine Transaminase; Aminocaproates; Aminocaproic Acid; Aspartate Aminotransferases; Carcinoma, Squ | 1984 |
Epsilon-aminocaproic acid myopathy. Report of a case and literature review.
Topics: Adult; Aminocaproates; Aminocaproic Acid; Biopsy; Electromyography; Humans; Male; Muscles; Myoglobin | 1982 |