Page last updated: 2024-10-17

aminocaproic acid and Acrocephaly

aminocaproic acid has been researched along with Acrocephaly in 6 studies

Aminocaproic Acid: An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.
6-aminohexanoic acid : An epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator.

Acrocephaly: Premature closing of the lambdoid and coronal sutures.

Research Excerpts

ExcerptRelevanceReference
"This multicenter international experience of pediatric craniofacial surgery reports no increase in seizures or thromboembolic events in those that received antifibrinolytics (tranexamic acid and epsilon-aminocaproic acid) versus those that did not."4.12Safety of antifibrinolytics in 6583 pediatric patients having craniosynostosis surgery: A decade of data reported from the multicenter Pediatric Craniofacial Collaborative Group. ( Benzon, HA; Goobie, SM; King, MR; Nelson, O; Pérez-Pradilla, C; Staffa, SJ; Stricker, PA, 2022)
" Current dosing recommendations are derived from adult extrapolations, and may or may not have clinical relevance."1.46Blood loss and transfusion requirements with epsilon-aminocaproic acid use during cranial vault reconstruction surgery. ( Demke, J; Nagy, L; Saadeh, C; Thompson, ME; Watkins, P, 2017)
"Aminocaproic acid (ACA) has been used at our institution during CVR for its antifibrinolytic effects."1.40Minimizing transfusions in primary cranial vault remodeling: the role of aminocaproic acid. ( Buchman, SR; Kapurch, J; Levi, B; Muraszko, KM; Oppenheimer, AJ; Ranganathan, K; Strahle, JM, 2014)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (50.00)24.3611
2020's3 (50.00)2.80

Authors

AuthorsStudies
King, MR1
Staffa, SJ1
Stricker, PA1
Pérez-Pradilla, C1
Nelson, O1
Benzon, HA1
Goobie, SM1
Pillutla, P1
Le, A1
Thompson, ME2
Watkins, P2
Nagy, L2
Demke, JC1
Borst, AJ1
Bonfield, CM1
Deenadayalan, PS1
Le, CH1
Xu, M1
Sobey, JH1
Reddy, SK1
Nguyen, TT1
Lam, HV1
Austin, TM1
Stricker, P1
Tunceroglu, H1
Schoenecker, J1
Oppenheimer, AJ1
Ranganathan, K1
Levi, B1
Strahle, JM1
Kapurch, J1
Muraszko, KM1
Buchman, SR1
Saadeh, C1
Demke, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy of ε-Aminocaproic Acid (EACA) in Children Undergoing Craniofacial Reconstruction Surgery[NCT02229968]Phase 222 participants (Actual)Interventional2014-10-31Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

6 other studies available for aminocaproic acid and Acrocephaly

ArticleYear
Safety of antifibrinolytics in 6583 pediatric patients having craniosynostosis surgery: A decade of data reported from the multicenter Pediatric Craniofacial Collaborative Group.
    Paediatric anaesthesia, 2022, Volume: 32, Issue:12

    Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Child; Craniosynostoses; Humans; I

2022
Dose Comparison of Epsilon-Aminocaproic Acid to Reduce Blood Loss in Infants Undergoing Cranial Vault Reconstruction Surgery: A Retrospective Pilot Study.
    Journal of clinical anesthesia, 2020, Volume: 66

    Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Craniosynostoses; Humans; Infant;

2020
ε-Aminocaproic acid versus tranexamic acid in children undergoing complex cranial vault reconstruction for repair of craniosynostosis.
    Pediatric blood & cancer, 2021, Volume: 68, Issue:8

    Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Child; Craniosynostoses; Humans; R

2021
Comparison of different dosage regimes of epsilon aminocaproic acid on blood loss in children undergoing craniosynostosis surgery.
    Paediatric anaesthesia, 2019, Volume: 29, Issue:8

    Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Craniosynostoses; Erythrocyte Tran

2019
Minimizing transfusions in primary cranial vault remodeling: the role of aminocaproic acid.
    The Journal of craniofacial surgery, 2014, Volume: 25, Issue:1

    Topics: Aminocaproic Acid; Antifibrinolytic Agents; Arterial Pressure; Blood Loss, Surgical; Blood Transfusi

2014
Blood loss and transfusion requirements with epsilon-aminocaproic acid use during cranial vault reconstruction surgery.
    Journal of clinical anesthesia, 2017, Volume: 36

    Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Blood Transfusion; Bone Transplant

2017