Page last updated: 2024-08-23

amikacin and Hearing Loss

amikacin has been researched along with Hearing Loss in 40 studies

Research

Studies (40)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (12.50)	18.7374
1990's	3 (7.50)	18.2507
2000's	3 (7.50)	29.6817
2010's	25 (62.50)	24.3611
2020's	4 (10.00)	2.80

Authors

Authors	Studies
Szymański, M; Zadrożniak, M; Łuszczki, JJ	1
Burt, RA; Lockhart, PJ; Ogier, JM	1
Budhathoki, C; Dooley, KE; Dowdy, DW; Farley, JE; Francis, HW; Han, HR; Hong, H	1
Brar, MS; Brode, SK; Sabur, NF; Wu, L	1
Choi, JE; Jeon, K; Jhun, BW; Kim, DH; Kim, SY; Ko, JY; Koh, WJ; Lee, H; Lee, SY; Moon, IJ; Park, HJ; Park, HY; Shin, SJ; Sohn, YM	1
Arnold, A; Chis Ster, I; Cooke, GS; Dedicoat, M; Harrison, TS; Kon, OM; Lipman, M; Loyse, A	1
Antonelli, PJ; Dirain, CO; Joseph, JK; Milne-Davies, B; Ng, MRAV	1
Hatano, M; Hattori, T; Hori, O; Ito, M; Noda, M; Shinozaki, T; Sugimoto, H; Takarada-Iemata, M; Yoshizaki, T	1
Brezun, JM; Cazals, Y; Edge, A; Lahlou, H; Lopez-Juarez, A; Ripoll, C; Wang, Q; Zine, A	1
Bach, A; Chen, KS; Shoup, A; Winick, NJ	1
Apostolidou, E; Kekes, G; Kouvelas, D; Maurer, J; Pavlidis, P	1
Bach, A; Chen, K; Shoup, A; Winick, N	1
Castagnola, E; Dallorso, S; Haupt, R	1
Capocci, S; Cropley, I; Garcia Medina, R; Hopkins, S; Katiri, S; Lipman, M; Melchionda, V; Solamalai, A; Wyatt, H	1
Aksoy, F; Dogan, R; Eren, SB; Hüseyinbas, Ö; Ozturan, O; Pektas, A; Veyseller, B	1
Kesenogile, B; Modongo, C; Ncube, R; Sirugo, G; Sobota, RS; Williams, SM; Zetola, NM	1
Aksoy, F; Dogan, R; Ozturan, O; Ozturk, B; Veyseller, B; Yenigun, A; Yildirim, YS	1
Eather, GW; Ellender, CM; Law, DB; Thomson, RM	1
Leufkens, HG; Mantel-Teeuwisse, AK; Mavhunga, F; Rennie, T; Ruswa, N; Sagwa, EL	1
Abdelmonem, S; Abdelsameea, AA; El-Anwar, MW; Galhoom, D; Nada, E	1
Avcı, D; Erkan, M; Güleç, Ş; Gündoğdu, R; Güneş, MS; Karabulut, D; Kökoğlu, K; Sönmez, MF	1
Alffenaar, JW; Borjas Howard, JF; Dijkstra, JA; Kosterink, JG; van Altena, R; van der Meer, ME; van der Werf, TS; van Soolingen, D	1
Carroll, K; Cohen, DM; Cross, CP; Feeney, MP; Garinis, AC; Gold, JA; Hunter, LL; Keefe, DH; Putterman, DB; Srikanth, P; Steyger, PS	1
Cediel, R; Contreras, J; Murillo-Cuesta, S; Varela-Nieto, I	1
Kocyigit, I; Oymak, O; Sipahioglu, MH; Somdas, MA; Tokgoz, B; Ucar, C; Unal, A; Utas, C	1
Saxena, RK; Singh Chauhan, R; Varshey, S	1
Hatano, M; Ito, M; Kelly, JB; Yoshizaki, T	1
Chen, ZT; Guo, WW; Li, DK; Li, L; Liu, HZ; Ren, LL; Sun, JH; Wu, N; Xing, GQ; Yang, SM; Zhao, LD	1
Campos, Mde S; Hyppolito, MA; Murashima, Ade A; Oliveira, AA; Oliveira, JA; Rossato, M	1
Campbell, KC; Hughes, LF; Klemens, JJ; Meech, RP; Somani, S	1
Erdem, T; Iraz, M; Miman, MC; Olmez, E; Ozturan, O	1
Campbell, KC; Dyrstad, SS; El-Azizi, M; Gerberi, MT; Hughes, LF; Klemens, JJ; Larsen, DL; Meech, RP; Mitchell, DL; Verhulst, SJ	1
Niemierko, J; Rutkowski, B	1
Lietman, PS; Moore, RD; Smith, CR	1
Britten, J; Caplan, E; deJongh, CA; Finley, RS; Fortner, CL; Newman, KA; Schimpff, SC; Wade, JC; Wiernik, PH	1
Deshpande, G; Faden, H; Grossi, M	1
Beaubien, AR; Karpinski, K; Ormsby, E	1
Fausti, SA; Frey, RH; Henry, JA; McDonald, WJ; Olson, DJ; Schaffer, HI	1
Tulkens, PM	1
Uziel, A	1

Reviews

1 review(s) available for amikacin and Hearing Loss

Article	Year
Non-genetic factors affecting hearing development. Acta oto-laryngologica. Supplementum, 1985, Volume: 421 Topics: Adult; Age Factors; Amikacin; Aminoglycosides; Animals; Anti-Bacterial Agents; Cochlea; Deafness; Female; Guinea Pigs; Hearing Loss; Hearing Loss, Noise-Induced; Humans; Hyperbilirubinemia; Hypothyroidism; Infant; Infant, Newborn; Kanamycin; Maternal-Fetal Exchange; Pregnancy; Rats	1985

Trials

3 trial(s) available for amikacin and Hearing Loss

Article	Year
Risk factors for the development of auditory toxicity in patients receiving aminoglycosides. The Journal of infectious diseases, 1984, Volume: 149, Issue:1 Topics: Amikacin; Body Temperature; Female; Gentamicins; Hearing Loss; Humans; Kanamycin; Male; Probability; Risk; Sepsis; Statistics as Topic; Time Factors; Tobramycin	1984
Comparison of standard versus pharmacokinetically adjusted amikacin dosing in granulocytopenic cancer patients. Antimicrobial agents and chemotherapy, 1982, Volume: 22, Issue:2 Topics: Agranulocytosis; Amikacin; Bacterial Infections; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Fever; Hearing Loss; Humans; Kanamycin; Kidney; Kinetics; Moxalactam; Neoplasms; Piperacillin; Ticarcillin	1982
Pharmacokinetic and toxicological evaluation of a once-daily regimen versus conventional schedules of netilmicin and amikacin. The Journal of antimicrobial chemotherapy, 1991, Volume: 27 Suppl C Topics: Adult; Amikacin; Animals; Audiometry, Pure-Tone; Creatinine; Drug Administration Schedule; Drug Therapy, Combination; Female; Hearing Loss; Humans; Netilmicin; Pelvic Inflammatory Disease; Peptides; Phospholipids; Rats; Rats, Inbred Strains	1991

Other Studies

36 other study(ies) available for amikacin and Hearing Loss

Article	Year
N-Acetyl-L-cysteine Affects Ototoxicity Evoked by Amikacin and Furosemide Either Alone or in Combination in a Mouse Model of Hearing Threshold Decrease. International journal of molecular sciences, 2023, Apr-20, Volume: 24, Issue:8 Topics: Acetylcysteine; Amikacin; Aminoglycosides; Animals; Anti-Bacterial Agents; Auditory Threshold; Deafness; Furosemide; Hearing; Hearing Loss; Mice; Ototoxicity	2023
Intravenously delivered aminoglycoside antibiotics, tobramycin and amikacin, are not ototoxic in mice. Hearing research, 2020, Volume: 386 Topics: Amikacin; Animals; Anti-Bacterial Agents; Drug Administration Schedule; Hearing; Hearing Loss; Injections, Intravenous; Kidney; Kidney Diseases; Mice, Inbred C57BL; Ototoxicity; Species Specificity; Time Factors; Tobramycin	2020
Prevalence of Pre-Existing Hearing Loss Among Patients With Drug-Resistant Tuberculosis in South Africa. American journal of audiology, 2020, Jun-08, Volume: 29, Issue:2 Topics: Adolescent; Adult; Amikacin; Aminoglycosides; Anti-Bacterial Agents; Antitubercular Agents; Audiometry; Auditory Threshold; Cross-Sectional Studies; Female; Hearing Loss; HIV Infections; Humans; Hypoalbuminemia; Kanamycin; Male; Middle Aged; Ototoxicity; Prevalence; Renal Insufficiency; South Africa; Thinness; Tuberculosis, Multidrug-Resistant; Young Adult	2020
Low-dose amikacin in the treatment of Multidrug-resistant Tuberculosis (MDR-TB). BMC infectious diseases, 2021, Mar-10, Volume: 21, Issue:1 Topics: Adult; Amikacin; Antitubercular Agents; Cohort Studies; Drug Monitoring; Female; Hearing Loss; Humans; Male; Retrospective Studies; Tinnitus; Treatment Outcome; Tuberculosis, Multidrug-Resistant; World Health Organization	2021
Once-daily dosing of amikacin for treatment of The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2017, 07-01, Volume: 21, Issue:7 Topics: Aged; Amikacin; Anti-Bacterial Agents; Drug Administration Schedule; Drug Monitoring; Female; Hearing Loss; Humans; Kidney Diseases; Male; Middle Aged; Multivariate Analysis; Mycobacterium abscessus; Mycobacterium Infections, Nontuberculous; Republic of Korea; Retrospective Studies; Tinnitus	2017
Adverse Effects and Choice between the Injectable Agents Amikacin and Capreomycin in Multidrug-Resistant Tuberculosis. Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:9 Topics: Acute Kidney Injury; Adult; Amikacin; Antitubercular Agents; Capreomycin; Drug Therapy, Combination; Female; Hearing Loss; Humans; Hypokalemia; Male; Mycobacterium tuberculosis; Retrospective Studies; Tuberculosis, Multidrug-Resistant; Young Adult	2017
Evaluation of Mitoquinone for Protecting Against Amikacin-Induced Ototoxicity in Guinea Pigs. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2018, Volume: 39, Issue:1 Topics: Amikacin; Animals; Anti-Bacterial Agents; Antioxidants; Evoked Potentials, Auditory, Brain Stem; Guinea Pigs; Hair Cells, Auditory; Hearing; Hearing Loss; Organophosphorus Compounds; Otoacoustic Emissions, Spontaneous; Ubiquinone	2018
Microglial activation in the cochlear nucleus after early hearing loss in rats. Auris, nasus, larynx, 2019, Volume: 46, Issue:5 Topics: Amikacin; Animals; Animals, Newborn; Anti-Bacterial Agents; Calcium-Binding Proteins; Cochlear Nucleus; Evoked Potentials, Auditory, Brain Stem; Hearing Loss; Inflammation; Macrophage Activation; Microfilament Proteins; Microglia; Phagocytosis; Rats; Reverse Transcriptase Polymerase Chain Reaction	2019
Engraftment of Human Stem Cell-Derived Otic Progenitors in the Damaged Cochlea. Molecular therapy : the journal of the American Society of Gene Therapy, 2019, 06-05, Volume: 27, Issue:6 Topics: Amikacin; Animals; Auditory Threshold; Cell Differentiation; Cell Enlargement; Cell Movement; Cyclosporine; Disease Models, Animal; Fibroblast Growth Factor 10; Fibroblast Growth Factor 3; Guinea Pigs; Hair Cells, Auditory; Hearing Loss; Humans; Immunosuppressive Agents; Induced Pluripotent Stem Cells; Living Donors; Ototoxicity; Stem Cell Transplantation	2019
Hearing loss and vestibular dysfunction among children with cancer after receiving aminoglycosides. Pediatric blood & cancer, 2013, Volume: 60, Issue:11 Topics: Amikacin; Aminoglycosides; Antineoplastic Agents; Child; Child, Preschool; Female; Hearing Loss; Humans; Male; Neoplasms; Vestibular Diseases; Vestibular Evoked Myogenic Potentials	2013
Memantine's action against aminoglycoside-induced ototoxicity. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2014, Volume: 271, Issue:6 Topics: Amikacin; Aminoglycosides; Animals; Cochlea; Excitatory Amino Acid Antagonists; Female; Hearing; Hearing Loss; Memantine; Otoacoustic Emissions, Spontaneous; Rabbits	2014
Invited reply to amikacin ototoxicity in children with cancer: the problem is the administration schedule. Pediatric blood & cancer, 2014, Volume: 61, Issue:2 Topics: Amikacin; Aminoglycosides; Antineoplastic Agents; Female; Hearing Loss; Humans; Male; Neoplasms; Vestibular Diseases	2014
Administration schedule and ototoxicity of amikacin in children with cancer. Pediatric blood & cancer, 2014, Volume: 61, Issue:2 Topics: Amikacin; Aminoglycosides; Antineoplastic Agents; Female; Hearing Loss; Humans; Male; Neoplasms; Vestibular Diseases	2014
Amikacin treatment for multidrug resistant tuberculosis: how much monitoring is required? The European respiratory journal, 2013, Volume: 42, Issue:4 Topics: Adult; Amikacin; Antitubercular Agents; Audiology; Drug Monitoring; Female; Hearing Loss; Humans; Kidney; Male; Retrospective Studies; Tuberculosis, Multidrug-Resistant	2013
Protective effect of trimetazidine on amikacin-induced ototoxicity in rats. International journal of pediatric otorhinolaryngology, 2014, Volume: 78, Issue:4 Topics: Amikacin; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Ear, Middle; Evoked Potentials, Auditory, Brain Stem; Female; Hearing Loss; Male; Random Allocation; Rats; Rats, Wistar; Reference Values; Trimetazidine	2014
Successful MDR-TB treatment regimens including amikacin are associated with high rates of hearing loss. BMC infectious diseases, 2014, Oct-09, Volume: 14 Topics: Adolescent; Adult; Amikacin; Antitubercular Agents; Drug Administration Schedule; Female; Hearing Loss; Humans; Incidence; Male; Middle Aged; Retrospective Studies; Risk; Treatment Outcome; Tuberculosis, Multidrug-Resistant; Young Adult	2014
Betahistine exacerbates amikacin ototoxicity. The Annals of otology, rhinology, and laryngology, 2015, Volume: 124, Issue:4 Topics: Amikacin; Animals; Betahistine; Cochlea; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Female; Hearing Loss; Injections, Intramuscular; Otoacoustic Emissions, Spontaneous; Rats; Rats, Wistar; Regional Blood Flow; Treatment Outcome; Vasodilator Agents	2015
Safety of IV amikacin in the treatment of pulmonary non-tuberculous mycobacterial disease. Respirology (Carlton, Vic.), 2016, Volume: 21, Issue:2 Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Amikacin; Anti-Bacterial Agents; Female; Hearing Loss; Humans; Lung Diseases; Male; Middle Aged; Mycobacterium avium; Mycobacterium avium Complex; Mycobacterium avium-intracellulare Infection; Retrospective Studies; Treatment Outcome; Vestibular Diseases	2016
Comparing amikacin and kanamycin-induced hearing loss in multidrug-resistant tuberculosis treatment under programmatic conditions in a Namibian retrospective cohort. BMC pharmacology & toxicology, 2015, Dec-10, Volume: 16 Topics: Adolescent; Adult; Amikacin; Anti-Bacterial Agents; Body Weight; Chi-Square Distribution; Child; Child, Preschool; Coinfection; Hearing Loss; Hearing Tests; HIV Infections; Humans; Incidence; Infant; Infant, Newborn; Kanamycin; Logistic Models; Middle Aged; Namibia; Retrospective Studies; Risk Assessment; Risk Factors; Sex Factors; Tuberculosis, Multidrug-Resistant	2015
Cilostazol Effect on Amikacin-Induced Ototoxicity: An Experimental Study. Audiology & neuro-otology, 2016, Volume: 21, Issue:4 Topics: Amikacin; Animals; Anti-Bacterial Agents; Cilostazol; Hearing Loss; Male; Neuroprotective Agents; Otoacoustic Emissions, Spontaneous; Rats; Tetrazoles	2016
A Prospective Experimental Study on the Protective Effect of Resveratrol against Amikacin-Induced Ototoxicity in Rats. The journal of international advanced otology, 2016, Volume: 12, Issue:3 Topics: Amikacin; Animals; Anti-Bacterial Agents; Antioxidants; Disease Models, Animal; Female; Hearing Loss; Otoacoustic Emissions, Spontaneous; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes	2016
Reduced Chance of Hearing Loss Associated with Therapeutic Drug Monitoring of Aminoglycosides in the Treatment of Multidrug-Resistant Tuberculosis. Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:3 Topics: Adult; Amikacin; Antitubercular Agents; Area Under Curve; Audiometry; Biological Availability; Drug Administration Schedule; Drug Dosage Calculations; Drug Monitoring; Extensively Drug-Resistant Tuberculosis; Female; Hearing Loss; Humans; Kanamycin; Male; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Retrospective Studies	2017
The cumulative effects of intravenous antibiotic treatments on hearing in patients with cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2017, Volume: 16, Issue:3 Topics: Adolescent; Adult; Age Factors; Amikacin; Anti-Bacterial Agents; Audiometry, Pure-Tone; Bacterial Infections; Cystic Fibrosis; Female; Hearing Loss; Humans; Male; Middle Aged; Patient Outcome Assessment; Sex Factors; Time; Tobramycin; United States; Vancomycin	2017
Comparison of different aminoglycoside antibiotic treatments to refine ototoxicity studies in adult mice. Laboratory animals, 2010, Volume: 44, Issue:2 Topics: Amikacin; Aminoglycosides; Animals; Anti-Bacterial Agents; Cochlea; Disease Models, Animal; Dose-Response Relationship, Drug; Evoked Potentials, Auditory, Brain Stem; Gentamicins; Hearing Loss; Kanamycin; Male; Mice; Mice, Inbred C57BL; Mortality; Neomycin	2010
Correlation between hearing loss and peritonitis frequency and administration of ototoxic intraperitoneal antibiotics in patients with CAPD. Renal failure, 2010, Volume: 32, Issue:2 Topics: Amikacin; Aminoglycosides; Anti-Bacterial Agents; Audiometry, Pure-Tone; Case-Control Studies; Cephalothin; Female; Hearing Loss; Humans; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Peritonitis; Regression Analysis; Risk Factors; Severity of Illness Index; Statistics, Nonparametric; Vancomycin	2010
The role of ultrahigh-frequency audiometry in the early detection of systemic drug-induced hearing loss. Ear, nose, & throat journal, 2011, Volume: 90, Issue:5 Topics: Adolescent; Adult; Aged; Amikacin; Anti-Bacterial Agents; Antineoplastic Agents; Audiometry; Cisplatin; Female; Gentamicins; Hearing Loss; Humans; Male; Middle Aged; Young Adult	2011
Changes in projections to the inferior colliculus following early hearing loss in rats. Hearing research, 2012, Volume: 287, Issue:1-2 Topics: Acoustic Stimulation; Age Factors; Amikacin; Animals; Animals, Newborn; Auditory Pathways; Auditory Threshold; Cochlear Nucleus; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Female; Fluorescent Dyes; Hearing Loss; Inferior Colliculi; Male; Neuroanatomical Tract-Tracing Techniques; Neuronal Tract-Tracers; Rats; Rats, Sprague-Dawley; Stilbamidines	2012
Migration and differentiation of mouse embryonic stem cells transplanted into mature cochlea of rats with aminoglycoside-induced hearing loss. Acta oto-laryngologica, 2013, Volume: 133, Issue:2 Topics: Amikacin; Animals; Cell Movement; Cell Survival; Cochlea; Deafness; Disease Models, Animal; Embryonic Stem Cells; Female; Fluorescent Dyes; Green Fluorescent Proteins; Hearing Loss; Immunohistochemistry; Male; Mice; Microscopy, Electron, Scanning; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley; Scala Tympani; Stem Cell Transplantation	2013
Persistence of the otoprotective effect: how long does otoprotection against amikacin lasts? Brazilian journal of otorhinolaryngology, 2012, Volume: 78, Issue:6 Topics: Amikacin; Animals; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Guinea Pigs; Hair Cells, Auditory, Outer; Hearing Loss; Microscopy, Electron, Scanning; Otoacoustic Emissions, Spontaneous; Time Factors	2012
Antioxidant enzyme levels inversely covary with hearing loss after amikacin treatment. Journal of the American Academy of Audiology, 2003, Volume: 14, Issue:3 Topics: Amikacin; Analysis of Variance; Animals; Anti-Bacterial Agents; Antioxidants; Case-Control Studies; Catalase; Cochlea; Evoked Potentials, Auditory, Brain Stem; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Guinea Pigs; Hearing Loss; Injections, Subcutaneous; Lipid Peroxidation; Malondialdehyde; Superoxide Dismutase	2003
Dose-dependent dual effect of melatonin on ototoxicity induced by amikacin in adult rats. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2005, Volume: 262, Issue:4 Topics: Amikacin; Animals; Anti-Bacterial Agents; Antioxidants; Dose-Response Relationship, Drug; Hearing Loss; Melatonin; Otoacoustic Emissions, Spontaneous; Rats; Rats, Sprague-Dawley; Treatment Outcome	2005
Prevention of noise- and drug-induced hearing loss with D-methionine. Hearing research, 2007, Volume: 226, Issue:1-2 Topics: Amikacin; Aminoglycosides; Animals; Carboplatin; Chinchilla; Cisplatin; Evoked Potentials, Auditory, Brain Stem; Guinea Pigs; Hearing Loss; Hearing Loss, Noise-Induced; In Vitro Techniques; Male; Methionine; Rats; Rats, Wistar; Safety; Species Specificity	2007
[Amikacin-induced hearing loss in patients treated with repeated hemodialysis]. Polski tygodnik lekarski (Warsaw, Poland : 1960), 1984, Nov-05, Volume: 39, Issue:45 Topics: Adult; Amikacin; Endocarditis, Bacterial; Female; Hearing Loss; Hearing Loss, Bilateral; Humans; Kanamycin; Kidney Failure, Chronic; Male; Middle Aged; Pneumonia; Renal Dialysis	1984
Renal and Auditory toxic effects of amikacin in children with cancer. American journal of diseases of children (1960), 1982, Volume: 136, Issue:3 Topics: Adolescent; Amikacin; Bacterial Infections; Child; Child, Preschool; Hearing Loss; Hearing Loss, High-Frequency; Humans; Infant; Kanamycin; Kidney Diseases; Neoplasms	1982
Toxicodynamics and toxicokinetics of amikacin in the guinea pig cochlea. Hearing research, 1995, Volume: 83, Issue:1-2 Topics: Amikacin; Animals; Auditory Threshold; Cluster Analysis; Cochlea; Guinea Pigs; Hair Cells, Auditory, Outer; Hearing Loss; Hearing Tests; Infusions, Intravenous; Male; Models, Biological	1995
High-frequency audiometric monitoring for early detection of aminoglycoside ototoxicity. The Journal of infectious diseases, 1992, Volume: 165, Issue:6 Topics: Amikacin; Anti-Bacterial Agents; Audiometry; Gentamicins; Hearing Loss; Hearing Loss, Bilateral; Hearing Loss, High-Frequency; Humans; Male; Middle Aged; Prospective Studies; Tobramycin	1992