amifostine anhydrous has been researched along with Neuroblastoma in 8 studies
Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
amifostine : An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neuroblastoma is among the most common malignancies of childhood." | 2.38 | Neuroblastoma: a neurochemical approach. ( Schor, NF, 1991) |
| " Doxorubicin, vincristine, etoposide, cisplatin, 4-hydroperoxycyclophosphamide and 4-hydroperoxyifosfamide were equally cytotoxic with and without preincubation of WR-2721 (14 mM) or WR-1065 (40 microM) as shown by virtually identical dose-response curves and ID50 values." | 1.30 | Effects of WR-2721 (amifostine) and its metabolite WR-1065 on the antiproliferative activity of chemotherapeutic agents on neuroblastoma cells in vitro. ( Berthold, F; Fulda, S; Oster, W, 1997) |
| "Neuroblastoma is among the most common malignancies of childhood." | 1.28 | A neurologist's approach to neuroblastoma. ( Schor, NF, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 5 (62.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ozkaynak, MF | 1 |
| Sahdev, I | 1 |
| Gross, TG | 1 |
| Levine, JE | 1 |
| Cheerva, AC | 1 |
| Richards, MK | 1 |
| Rozans, MK | 1 |
| Shaw, PJ | 1 |
| Kadota, RP | 1 |
| Fichtner, I | 2 |
| Lemm, M | 1 |
| Becker, M | 1 |
| Berthold, F | 3 |
| Fulda, S | 2 |
| Oster, W | 1 |
| Renner, S | 1 |
| Klingebiel, T | 1 |
| Niethammer, D | 1 |
| Bruchelt, G | 1 |
| Meissner, T | 1 |
| Eisenbeiss, F | 1 |
| Hero, B | 1 |
| Schor, NF | 2 |
| Tabachnik Schor, NF | 1 |
1 review available for amifostine anhydrous and Neuroblastoma
| Article | Year |
|---|---|
Neuroblastoma: a neurochemical approach.
Topics: Amifostine; Animals; Dopamine; Drug Synergism; Hydroxydopamines; Mice; Nervous System Neoplasms; Neu | 1991 |
2 trials available for amifostine anhydrous and Neuroblastoma
| Article | Year |
|---|---|
A pilot study of addition of amifostine to melphalan, carboplatin, etoposide, and cyclophosphamide with autologous hematopoietic stem cell transplantation in pediatric solid tumors-A pediatric blood and marrow transplant consortium study.
Topics: Adolescent; Adult; Amifostine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplan | 2008 |
Preclinical and clinical aspects on the use of amifostine as chemoprotector in neuroblastoma patients.
Topics: Adolescent; Amifostine; Animals; Antineoplastic Agents; Bone Marrow Diseases; Carboplatin; Cell Divi | 2001 |
5 other studies available for amifostine anhydrous and Neuroblastoma
| Article | Year |
|---|---|
Effects of amifostine (WR-2721, ethyol) on tumor growth and pharmacology of cytotoxic drugs in human xenotransplanted neuroblastomas.
Topics: Amifostine; Animals; Antineoplastic Agents; Blood Platelets; Body Weight; Disease Models, Animal; Fe | 1997 |
Effects of WR-2721 (amifostine) and its metabolite WR-1065 on the antiproliferative activity of chemotherapeutic agents on neuroblastoma cells in vitro.
Topics: Amifostine; Antineoplastic Agents; Biomarkers, Tumor; Brain Neoplasms; Cell Division; Cell Line; DNA | 1997 |
Isotachophoretic determination of phosphate splitting from Amifostine and p-nitrophenyl phosphate in serum and neuroblastoma cells.
Topics: Amifostine; Carboplatin; Cell Division; Electrophoresis; Humans; Neuroblastoma; Nitrophenols; Organo | 1999 |
A neurologist's approach to neuroblastoma.
Topics: Adolescent; Amifostine; Animals; Antineoplastic Agents; Drug Synergism; Humans; Infant; Infant, Newb | 1992 |
Adjunctive use of ethiofos (WR-2721) with free radical-generating chemotherapeutic agents in mice: new caveats for therapy.
Topics: Amifostine; Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Free Radicals; | 1987 |