amifostine anhydrous has been researched along with Neoplasms, Germ Cell and Embryonal in 4 studies
Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
amifostine : An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.
Neoplasms, Germ Cell and Embryonal: Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "High-dose cisplatin combined with etoposide and bleomycin (HDPEB) improves event-free survival (EFS) in advanced pediatric germ-cell tumors (PGCT), but has significant ototoxicity." | 1.33 | Amifostine does not protect against the ototoxicity of high-dose cisplatin combined with etoposide and bleomycin in pediatric germ-cell tumors: a Children's Oncology Group study. ( Billmire, DF; Chang, KW; Davis, MM; Frazier, AL; Giller, R; Lauer, SJ; London, WB; Malogolowkin, M; Marina, N; Olson, TA; Perlman, EJ; Rescorla, F; Womer, RB, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rick, O | 3 |
| Beyer, J | 3 |
| Schwella, N | 3 |
| Siegert, W | 3 |
| Marina, N | 1 |
| Chang, KW | 1 |
| Malogolowkin, M | 1 |
| London, WB | 1 |
| Frazier, AL | 1 |
| Womer, RB | 1 |
| Rescorla, F | 1 |
| Billmire, DF | 1 |
| Davis, MM | 1 |
| Perlman, EJ | 1 |
| Giller, R | 1 |
| Lauer, SJ | 1 |
| Olson, TA | 1 |
| Dubiel, M | 1 |
| Krusch, A | 1 |
| Hildebrandt, M | 1 |
| Schleicher, J | 2 |
| Serke, S | 1 |
| Schubart, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| High-Dose Cisplatin, Etoposide and Bleomycin (HD-PEB) Combined With Amifostine in Children With High-Risk Malignant Germ Cell Tumors - A POG Pilot Study[NCT00003811] | Phase 2 | 27 participants (Actual) | Interventional | 2000-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for amifostine anhydrous and Neoplasms, Germ Cell and Embryonal
| Article | Year |
|---|---|
Influence of amifostine on reconstitution of lymphocyte subpopulations after conventional- and high-dose chemotherapy in patients with germ cell tumor.
Topics: Adult; Amifostine; Antineoplastic Combined Chemotherapy Protocols; CD4-CD8 Ratio; CD4-Positive T-Lym | 2002 |
PBPC mobilization with paclitaxel, ifosfamide, and G-CSF with or without amifostine: results of a prospective randomized trial.
Topics: Adult; Amifostine; Antigens, CD34; Blood Specimen Collection; Dose-Response Relationship, Drug; Gran | 2001 |
Assessment of amifostine as protection from chemotherapy-induced toxicities after conventional-dose and high-dose chemotherapy in patients with germ cell tumor.
Topics: Adult; Amifostine; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Granulocyte Colony-Sti | 2001 |
1 other study available for amifostine anhydrous and Neoplasms, Germ Cell and Embryonal
| Article | Year |
|---|---|
Amifostine does not protect against the ototoxicity of high-dose cisplatin combined with etoposide and bleomycin in pediatric germ-cell tumors: a Children's Oncology Group study.
Topics: Adolescent; Amifostine; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Child; Child, Pre | 2005 |