amifostine anhydrous has been researched along with Mucositis in 13 studies
Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
amifostine : An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.
Mucositis: An INFLAMMATION of the MUCOSA with burning or tingling sensation. It is characterized by atrophy of the squamous EPITHELIUM, vascular damage, inflammatory infiltration, and ulceration. It usually occurs at the mucous lining of the MOUTH, the GASTROINTESTINAL TRACT or the airway due to chemical irritations, CHEMOTHERAPY, or radiation therapy (RADIOTHERAPY).
Excerpt | Relevance | Reference |
---|---|---|
"Amifostine has been shown to be capable of minimizing radiotherapy-induced oral mucositis, but whether it protects small intestinal mucosae from high-dose methotrexate-induced damage is presently unknown." | 7.79 | Protective effect of amifostine on high-dose methotrexate-induced small intestinal mucositis in mice. ( Cao, X; Chen, C; Hao, L; Li, X; Liu, Q; Sun, Q; Tian, L; Zhang, M; Zhang, X, 2013) |
"With the eventual goal of reducing relapse and thus improving overall survival in selected lymphoma patients, a Phase I study was performed using the cytoprotectant amifostine to permit safe dose-augmentation of melphalan in the carmustine (BCNU), etoposide, cytarabine (arabinosylcytosine), and melphalan (BEAM) regimen before autologous hematopoietic stem cell transplantation." | 5.15 | A Phase I trial: dose escalation of melphalan in the "BEAM" regimen using amifostine cytoprotection. ( Abboud, CN; Becker, MW; Bernstein, SH; Constine, LS; Friedberg, JW; Ifthikharuddin, JJ; Liesveld, JL; Loughner, JE; Milner, LA; Phillips, GL; Vesole, DH, 2011) |
"Amifostine has been shown to be capable of minimizing radiotherapy-induced oral mucositis, but whether it protects small intestinal mucosae from high-dose methotrexate-induced damage is presently unknown." | 3.79 | Protective effect of amifostine on high-dose methotrexate-induced small intestinal mucositis in mice. ( Cao, X; Chen, C; Hao, L; Li, X; Liu, Q; Sun, Q; Tian, L; Zhang, M; Zhang, X, 2013) |
" There were no reports of Grade >/=3 amifostine-related adverse events." | 2.73 | Efficacy and safety of subcutaneous amifostine in minimizing radiation-induced toxicities in patients receiving combined-modality treatment for squamous cell carcinoma of the head and neck. ( Christie, D; Kennedy, T; Law, A; Pellitteri, P; Wood, C; Yumen, O, 2007) |
"Radiation-induced mucositis is a common toxicity, especially in patients with head and neck cancers." | 2.58 | Pharmacological modulation of radiation-induced oral mucosal complications. ( Annede, P; Blanchard, P; Bockel, S; Bourdis, M; Chargari, C; Deutsch, É; Drouet, M; François, S; Le Gallic, C; Lévy, A; Magné, N; Riccobono, D; Tao, Y; Vallard, A, 2018) |
"Mucositis is a highly significant, and sometimes dose-limiting, toxicity of cancer therapy." | 2.50 | MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. ( Barasch, A; Bowen, J; Elad, S; Elting, L; Epstein, J; Keefe, DM; Lalla, RV; McGuire, DB; Migliorati, C; Nicolatou-Galitis, O; Peterson, DE; Raber-Durlacher, JE; Sonis, ST, 2014) |
"Nearly two thirds of all patients with cancer receive radiation therapy during the course of treatment, frequently resulting in acute skin and mucosal toxicities." | 2.49 | Prevention and management of radiation-induced dermatitis, mucositis, and xerostomia. ( Pace, MB; Radvansky, LJ; Siddiqui, A, 2013) |
"Current standard treatments for cancer are associated with major dose-limiting toxic effects on healthy tissue." | 2.44 | Prevention and treatment of regimen-related mucosal toxicity. ( Bowen, JM, 2008) |
"The pathobiology of mucositis is complex, and agents that target mechanisms to prevent mucositis or accelerate healing are in high demand." | 2.44 | Emerging drugs for chemotherapy-induced mucositis. ( Bowen, JM; Keefe, DM; Sonis, ST, 2008) |
"Radiation for head and neck cancers is often curative, but high doses are used." | 2.43 | How to reduce radiation-related toxicity in patients with cancer of the head and neck. ( Chambers, MS; Garden, AS; Lewin, JS, 2006) |
"Mucositis is a significant complication of cancer therapy, with important clinical and economic implications." | 2.43 | Amifostine in the management of radiation-induced and chemo-induced mucositis. ( Bensadoun, RJ; Keefe, D; Lalla, RV; Schubert, MM, 2006) |
"Mucositis was scored by either the WHO, the National Cancer Institute-Common Toxicity Criteria (NCI-CTC) score, or the absence or presence of ulcerations, or the presence or absence of grades 3 and 4 mucositis." | 2.43 | Preventive intervention possibilities in radiotherapy- and chemotherapy-induced oral mucositis: results of meta-analyses. ( Boezen, HM; de Vries, EG; Roodenburg, JL; Schouten, JP; Spijkervet, FK; Stokman, MA, 2006) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 7 (53.85) | 29.6817 |
2010's | 6 (46.15) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Bockel, S | 1 |
Vallard, A | 1 |
Lévy, A | 1 |
François, S | 1 |
Bourdis, M | 1 |
Le Gallic, C | 1 |
Riccobono, D | 1 |
Annede, P | 1 |
Drouet, M | 1 |
Tao, Y | 1 |
Blanchard, P | 1 |
Deutsch, É | 1 |
Magné, N | 1 |
Chargari, C | 1 |
Radvansky, LJ | 1 |
Pace, MB | 1 |
Siddiqui, A | 1 |
Chen, C | 1 |
Tian, L | 1 |
Zhang, M | 1 |
Sun, Q | 1 |
Zhang, X | 1 |
Li, X | 2 |
Cao, X | 1 |
Liu, Q | 1 |
Hao, L | 1 |
Lalla, RV | 2 |
Bowen, J | 1 |
Barasch, A | 1 |
Elting, L | 1 |
Epstein, J | 1 |
Keefe, DM | 2 |
McGuire, DB | 1 |
Migliorati, C | 1 |
Nicolatou-Galitis, O | 1 |
Peterson, DE | 1 |
Raber-Durlacher, JE | 1 |
Sonis, ST | 2 |
Elad, S | 1 |
Bowen, JM | 2 |
Koukourakis, MI | 1 |
Tsoutsou, PG | 1 |
Karpouzis, A | 1 |
Tsiarkatsi, M | 1 |
Karapantzos, I | 1 |
Daniilidis, V | 1 |
Kouskoukis, C | 1 |
Phillips, GL | 1 |
Bernstein, SH | 1 |
Liesveld, JL | 1 |
Abboud, CN | 1 |
Becker, MW | 1 |
Constine, LS | 1 |
Ifthikharuddin, JJ | 1 |
Loughner, JE | 1 |
Milner, LA | 1 |
Vesole, DH | 1 |
Friedberg, JW | 1 |
Garden, AS | 1 |
Lewin, JS | 1 |
Chambers, MS | 1 |
Bensadoun, RJ | 1 |
Schubert, MM | 1 |
Keefe, D | 1 |
Stokman, MA | 1 |
Spijkervet, FK | 1 |
Boezen, HM | 1 |
Schouten, JP | 1 |
Roodenburg, JL | 1 |
de Vries, EG | 1 |
Kouvaris, JR | 1 |
Kouloulias, VE | 1 |
Vlahos, LJ | 1 |
Law, A | 1 |
Kennedy, T | 1 |
Pellitteri, P | 1 |
Wood, C | 1 |
Christie, D | 1 |
Yumen, O | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Randomized Study of a New Medical Device for Oral Mucositis (MDOM Trial)[NCT05104268] | Phase 1/Phase 2 | 100 participants (Anticipated) | Interventional | 2021-11-30 | Not yet recruiting | ||
Low Power Laser Therapy As Prevention Of Oral Mucositis And Oropharyngeal Pain In Patients Undergoing Allogenetic Hematopoietic Stem Cell Transplantation.[NCT06071637] | Phase 3 | 84 participants (Anticipated) | Interventional | 2023-08-01 | Recruiting | ||
Cryoprotection of Chemotherapy-induced Oral Mucositis After Autologous Stem Cell Transplantation, a Randomized Study[NCT03203733] | 182 participants (Actual) | Interventional | 2017-06-12 | Completed | |||
A Phase 1/Phase 2 Study for the Prevention of Oral Mucositis (SPOM)[NCT05338398] | Phase 1/Phase 2 | 100 participants (Anticipated) | Interventional | 2022-04-15 | Enrolling by invitation | ||
Opioid Therapy vs Multimodal Analgesia in Head and Neck Cancer: A Randomized Clinical Trial[NCT04221165] | Phase 2 | 62 participants (Anticipated) | Interventional | 2020-08-04 | Recruiting | ||
Phase I Study of Multiple Ascending Dose, to Investigate the Safety and Tolerability of the Use of Copaiba in Patients With Oral Cancer Submitted to Radiotherapy[NCT05308732] | Phase 1 | 36 participants (Anticipated) | Interventional | 2021-05-11 | Recruiting | ||
Impacts of Oral Supplement With L-Glutamine on the Radiation-induced Toxicity and Nutritional Status of Head and Neck Cancer Patients Under Radiotherapy[NCT03015077] | 59 participants (Actual) | Interventional | 2014-07-31 | Completed | |||
A Phase III Study of Magic Mouthwash Plus Sucralfate Versus Benzydamine HCl for Treatment of Radiation-induced Oral Mucositis in Head and Neck Cancer Patients.[NCT00814359] | Phase 3 | 67 participants (Actual) | Interventional | 2009-05-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
9 reviews available for amifostine anhydrous and Mucositis
Article | Year |
---|---|
Pharmacological modulation of radiation-induced oral mucosal complications.
Topics: Amifostine; Analgesics; Anti-Inflammatory Agents; Benzydamine; Dietary Supplements; Fibroblast Growt | 2018 |
Prevention and management of radiation-induced dermatitis, mucositis, and xerostomia.
Topics: Administration, Topical; Amifostine; Analgesics; Antineoplastic Protocols; Combined Modality Therapy | 2013 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
Topics: Amifostine; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antineop | 2014 |
Prevention and treatment of regimen-related mucosal toxicity.
Topics: Amifostine; Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Cytoprotection; Humans; I | 2008 |
Emerging drugs for chemotherapy-induced mucositis.
Topics: Acetylcysteine; Amifostine; Antineoplastic Agents; Drugs, Investigational; Fibroblast Growth Factor | 2008 |
How to reduce radiation-related toxicity in patients with cancer of the head and neck.
Topics: Amifostine; Anti-Infective Agents; Deglutition Disorders; Fibrosis; Free Radical Scavengers; Growth | 2006 |
Amifostine in the management of radiation-induced and chemo-induced mucositis.
Topics: Amifostine; Antineoplastic Agents; Combined Modality Therapy; Esophagitis; Evidence-Based Medicine; | 2006 |
Preventive intervention possibilities in radiotherapy- and chemotherapy-induced oral mucositis: results of meta-analyses.
Topics: Amifostine; Anti-Bacterial Agents; Antineoplastic Agents; Colony-Stimulating Factors; Cranial Irradi | 2006 |
Preventive intervention possibilities in radiotherapy- and chemotherapy-induced oral mucositis: results of meta-analyses.
Topics: Amifostine; Anti-Bacterial Agents; Antineoplastic Agents; Colony-Stimulating Factors; Cranial Irradi | 2006 |
Preventive intervention possibilities in radiotherapy- and chemotherapy-induced oral mucositis: results of meta-analyses.
Topics: Amifostine; Anti-Bacterial Agents; Antineoplastic Agents; Colony-Stimulating Factors; Cranial Irradi | 2006 |
Preventive intervention possibilities in radiotherapy- and chemotherapy-induced oral mucositis: results of meta-analyses.
Topics: Amifostine; Anti-Bacterial Agents; Antineoplastic Agents; Colony-Stimulating Factors; Cranial Irradi | 2006 |
Amifostine: the first selective-target and broad-spectrum radioprotector.
Topics: Amifostine; Humans; Mucositis; Neoplasms; Radiation-Protective Agents; Radiotherapy; Treatment Outco | 2007 |
3 trials available for amifostine anhydrous and Mucositis
Article | Year |
---|---|
Radiochemotherapy with cetuximab, cisplatin, and amifostine for locally advanced head and neck cancer: a feasibility study.
Topics: Adult; Aged; Aged, 80 and over; Amifostine; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanize | 2010 |
A Phase I trial: dose escalation of melphalan in the "BEAM" regimen using amifostine cytoprotection.
Topics: Adult; Aged; Amifostine; Antineoplastic Combined Chemotherapy Protocols; Atrial Fibrillation; Carmus | 2011 |
Efficacy and safety of subcutaneous amifostine in minimizing radiation-induced toxicities in patients receiving combined-modality treatment for squamous cell carcinoma of the head and neck.
Topics: Adult; Aged; Amifostine; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squ | 2007 |
1 other study available for amifostine anhydrous and Mucositis
Article | Year |
---|---|
Protective effect of amifostine on high-dose methotrexate-induced small intestinal mucositis in mice.
Topics: Amifostine; Animals; Body Weight; Female; Immunosuppressive Agents; Intestine, Small; Leucovorin; Ma | 2013 |