amifostine anhydrous has been researched along with Metastase in 13 studies
Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
amifostine : An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mitomycin C (MMC)-vinblastine (VBL) is a regimen that has commonly been used as salvage therapy for advanced breast cancer for many years." | 9.08 | Mitomycin C and vinblastine in combination with amifostine in metastatic breast cancer. A feasibility study of the EORTC--Investigational Drug Branch for Breast Cancer (IDBBC). ( Awada, A; Geurs, F; Habboubi, N; Kerger, J; Kusenda, Z; Piccart, MJ; Van Vreckem, A, 1997) |
| "The effect of treatments with the hypoxic cell radiosensitizers misonidazole (MISO), SR-2508, RSU-1069, and with the radioprotector WR-2721 on spontaneously disseminated Lewis lung carcinoma (LLC) and B16 melanoma (B16M) was investigated." | 7.67 | Influence of misonidazole, SR-2508, RSU-1069 and WR-2721 on spontaneous metastases in C57BL mice. ( Chapman, JD; Kanclerz, A, 1988) |
| "Mitomycin C (MMC)-vinblastine (VBL) is a regimen that has commonly been used as salvage therapy for advanced breast cancer for many years." | 5.08 | Mitomycin C and vinblastine in combination with amifostine in metastatic breast cancer. A feasibility study of the EORTC--Investigational Drug Branch for Breast Cancer (IDBBC). ( Awada, A; Geurs, F; Habboubi, N; Kerger, J; Kusenda, Z; Piccart, MJ; Van Vreckem, A, 1997) |
| "The effect of treatments with the hypoxic cell radiosensitizers misonidazole (MISO), SR-2508, RSU-1069, and with the radioprotector WR-2721 on spontaneously disseminated Lewis lung carcinoma (LLC) and B16 melanoma (B16M) was investigated." | 3.67 | Influence of misonidazole, SR-2508, RSU-1069 and WR-2721 on spontaneous metastases in C57BL mice. ( Chapman, JD; Kanclerz, A, 1988) |
| " The lack of improved duration of response or impact on survival may be the result of the limited improvement of efficacy with the higher dosage of cisplatin in conjunction with WR-2721, or the limited number of patients accrued to this study." | 2.71 | Phase II randomized trial of cisplatin and WR-2721 versus cisplatin alone for metastatic melanoma: an Eastern Cooperative Oncology Group Study (E1686). ( Borden, E; Ewell, M; Glick, J; Glover, D; Ibrahim, J; Karp, D; Kirkwood, J; Stewart, J, 2003) |
| " Although a dose-response effect has been observed with cisplatin, the dose-limiting toxicities associated with cisplatin (e." | 2.70 | A Phase II trial of cisplatin plus WR-2721 (amifostine) for metastatic breast carcinoma: an Eastern Cooperative Oncology Group Study (E8188). ( Abeloff, MD; Glover, DJ; Gradishar, WJ; Moore, MR; Neuberg, DS; Piel, I; Stephenson, P; Windschitl, HE, 2001) |
| " Nontumor-bearing control animals were treated using the same dosing and surgery schedules." | 1.31 | Antimetastatic effectiveness of amifostine therapy following surgical removal of Sa-NH tumors in mice. ( Grdina, DJ; Hunter, N; Kataoka, Y; Lee, JY; Milas, L; Murley, JS; Swedberg, K; Weichselbaum, RR, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (38.46) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 6 (46.15) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grdina, DJ | 1 |
| Kataoka, Y | 1 |
| Murley, JS | 1 |
| Swedberg, K | 1 |
| Lee, JY | 1 |
| Hunter, N | 1 |
| Weichselbaum, RR | 1 |
| Milas, L | 2 |
| Glover, D | 1 |
| Ibrahim, J | 1 |
| Kirkwood, J | 1 |
| Glick, J | 1 |
| Karp, D | 1 |
| Stewart, J | 1 |
| Ewell, M | 1 |
| Borden, E | 1 |
| Boehme, S | 1 |
| Wilson, DB | 1 |
| Wakelee, H | 1 |
| Fisher, GA | 1 |
| Rude, JM | 1 |
| Mark, HL | 1 |
| Ramnath, N | 1 |
| LoRusso, P | 1 |
| Simon, M | 1 |
| Martino, S | 1 |
| Kusenda, Z | 1 |
| Kerger, J | 1 |
| Awada, A | 1 |
| Geurs, F | 1 |
| Van Vreckem, A | 1 |
| Habboubi, N | 1 |
| Piccart, MJ | 1 |
| Awasthy, BS | 1 |
| Julka, PK | 1 |
| Agarwal, S | 1 |
| Nair, O | 1 |
| Bhamrah, R | 1 |
| Rath, GK | 1 |
| Gradishar, WJ | 1 |
| Stephenson, P | 1 |
| Glover, DJ | 1 |
| Neuberg, DS | 1 |
| Moore, MR | 1 |
| Windschitl, HE | 1 |
| Piel, I | 1 |
| Abeloff, MD | 1 |
| Constine, LS | 2 |
| Zagars, G | 2 |
| Rubin, P | 2 |
| Kligerman, M | 1 |
| Salazar, O | 1 |
| Keys, H | 1 |
| Poulter, CA | 1 |
| Van Ess, JD | 1 |
| Kanclerz, A | 1 |
| Chapman, JD | 1 |
| Murray, D | 1 |
| Brock, WA | 1 |
| Meyn, RE | 1 |
2 reviews available for amifostine anhydrous and Metastase
| Article | Year |
|---|---|
Amifostine-induced fever: case report and review of the literature.
Topics: Amifostine; Carcinoma, Squamous Cell; Combined Modality Therapy; Fever; Head and Neck Neoplasms; Hum | 2004 |
Radioprotectors in tumor radiotherapy: factors and settings determining therapeutic ratio.
Topics: Amifostine; Animals; Cells, Cultured; Ditiocarb; Humans; Immune Tolerance; Neoplasm Metastasis; Neop | 1988 |
7 trials available for amifostine anhydrous and Metastase
| Article | Year |
|---|---|
Phase II randomized trial of cisplatin and WR-2721 versus cisplatin alone for metastatic melanoma: an Eastern Cooperative Oncology Group Study (E1686).
Topics: Adult; Aged; Amifostine; Antineoplastic Combined Chemotherapy Protocols; Blood Pressure; Body Weight | 2003 |
A phase I trial of irinotecan (CPT-11) with amifostine in patients with metastatic colorectal cancer.
Topics: Adult; Amifostine; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasm | 2005 |
Phase II evaluation of cisplatin and WR2721 for refractory metastatic breast cancer.
Topics: Adult; Aged; Amifostine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone | 1997 |
Mitomycin C and vinblastine in combination with amifostine in metastatic breast cancer. A feasibility study of the EORTC--Investigational Drug Branch for Breast Cancer (IDBBC).
Topics: Adult; Aged; Amifostine; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplas | 1997 |
Effect of amifostine on toxicities associated with salvage combination chemotherapy.
Topics: Adult; Amifostine; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female | 2001 |
A Phase II trial of cisplatin plus WR-2721 (amifostine) for metastatic breast carcinoma: an Eastern Cooperative Oncology Group Study (E8188).
Topics: Adult; Aged; Amifostine; Antineoplastic Agents; Breast Neoplasms; Cisplatin; Disease Progression; Dr | 2001 |
Systemic hemibody irradiation for overt and occult metastases.
Topics: Amifostine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; C | 1985 |
4 other studies available for amifostine anhydrous and Metastase
| Article | Year |
|---|---|
Antimetastatic effectiveness of amifostine therapy following surgical removal of Sa-NH tumors in mice.
Topics: Amifostine; Angiostatins; Animals; Antineoplastic Agents; Cytoprotection; Mice; Mice, Inbred C3H; Ne | 2002 |
Sequential regional hyperthermia: a possible answer for the treatment of cancer.
Topics: Amifostine; Animals; Glucose; Hot Temperature; Humans; Neoplasm Metastasis; Neoplasms | 1982 |
Protection by WR-2721 of human bone marrow function following irradiation.
Topics: Amifostine; Bone Marrow; Humans; Neoplasm Metastasis; Organothiophosphorus Compounds; Palliative Car | 1986 |
Influence of misonidazole, SR-2508, RSU-1069 and WR-2721 on spontaneous metastases in C57BL mice.
Topics: Amifostine; Animals; Etanidazole; Lung Neoplasms; Male; Melanoma; Mice; Mice, Inbred C57BL; Misonida | 1988 |