amifostine anhydrous has been researched along with Medulloblastoma in 8 studies
Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
amifostine : An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.
Medulloblastoma: A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We evaluated the pharmacokinetics of amifostine and WR1065 in pediatric patients with newly diagnosed medulloblastoma to assess the influence of patient covariates, including demographics, clinical characteristics, and genetic polymorphisms, on amifostine and WR1065 pharmacokinetic parameters." | 1.36 | Clinical pharmacokinetics of amifostine and WR1065 in pediatric patients with medulloblastoma. ( Bai, F; Fouladi, M; Gajjar, A; McKibbin, T; Okcu, MF; Panetta, JC; Stewart, CF, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gurney, JG | 1 |
| Bass, JK | 1 |
| Onar-Thomas, A | 1 |
| Huang, J | 1 |
| Chintagumpala, M | 3 |
| Bouffet, E | 1 |
| Hassall, T | 2 |
| Gururangan, S | 2 |
| Heath, JA | 1 |
| Kellie, S | 2 |
| Cohn, R | 1 |
| Fisher, MJ | 2 |
| Panandiker, AP | 1 |
| Merchant, TE | 2 |
| Srinivasan, A | 1 |
| Wetmore, C | 1 |
| Qaddoumi, I | 1 |
| Stewart, CF | 3 |
| Armstrong, GT | 1 |
| Broniscer, A | 2 |
| Gajjar, A | 3 |
| Fouladi, M | 2 |
| Ashley, D | 1 |
| Gronewold, L | 1 |
| Wallace, D | 1 |
| Hale, GA | 1 |
| Kasow, KA | 1 |
| Morris, B | 1 |
| Krasin, M | 1 |
| Kun, LE | 1 |
| Boyett, JM | 1 |
| Freyer, DR | 1 |
| Sung, L | 1 |
| Reaman, GH | 1 |
| McKibbin, T | 1 |
| Panetta, JC | 1 |
| Bai, F | 1 |
| Okcu, MF | 2 |
| Paulino, AC | 1 |
| Lobo, M | 1 |
| Teh, BS | 1 |
| South, M | 1 |
| Butler, EB | 1 |
| Su, J | 1 |
| Lange, BJ | 1 |
| Needle, MN | 1 |
| Janss, AJ | 1 |
| Shu, HK | 1 |
| Adamson, PC | 1 |
| Phillips, PC | 1 |
| Xiong, X | 1 |
| Tan, M | 1 |
| Boyett, J | 1 |
| Borsi, JD | 1 |
| Csaki, C | 1 |
| Ferencz, T | 1 |
| Oster, W | 1 |
3 trials available for amifostine anhydrous and Medulloblastoma
| Article | Year |
|---|---|
Evaluation of amifostine for protection against cisplatin-induced serious hearing loss in children treated for average-risk or high-risk medulloblastoma.
Topics: Adolescent; Amifostine; Antineoplastic Agents; Cerebellar Neoplasms; Child; Child, Preschool; Cispla | 2014 |
Amifostine protects against cisplatin-induced ototoxicity in children with average-risk medulloblastoma.
Topics: Adolescent; Adult; Amifostine; Antineoplastic Combined Chemotherapy Protocols; Cerebellar Neoplasms; | 2008 |
Amifostine for children with medulloblastoma treated with cisplatin-based chemotherapy.
Topics: Amifostine; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cisplatin; Drug | 2004 |
5 other studies available for amifostine anhydrous and Medulloblastoma
| Article | Year |
|---|---|
Prevention of hearing loss in children receiving cisplatin chemotherapy.
Topics: Amifostine; Child; Cisplatin; Hearing Loss; Humans; Medulloblastoma | 2009 |
Clinical pharmacokinetics of amifostine and WR1065 in pediatric patients with medulloblastoma.
Topics: Adolescent; Adult; Amifostine; Antineoplastic Combined Chemotherapy Protocols; Cerebellar Neoplasms; | 2010 |
Ototoxicity after intensity-modulated radiation therapy and cisplatin-based chemotherapy in children with medulloblastoma.
Topics: Adolescent; Amifostine; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Cerebe | 2010 |
A sequential procedure for monitoring clinical trials against historical controls.
Topics: Amifostine; Antineoplastic Agents; Brain Neoplasms; Child; Clinical Trials as Topic; Data Interpreta | 2007 |
Administration of Ethyol (amifostine) to a child with medulloblastoma to ameliorate hematological toxicity of high dose carboplatin.
Topics: Amifostine; Antineoplastic Agents; Carboplatin; Cerebellar Neoplasms; Child; Humans; Male; Medullobl | 1996 |