amifostine anhydrous has been researched along with Leucocythaemia in 11 studies
Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
amifostine : An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human lymphocytes, p53 protein-deficient acute promyelocytic leukemia cell line HL-60, murine pro-B lymphoid cell line BaF3 and its TEL/ABL-transformed clone cells were exposed to idarubicin with and without pre-treatment with amifostine." | 3.71 | Amifostine differentially modulates DNA damage evoked by idarubicin in normal and leukemic cells. ( Błasiak, J; Drzewoski, J; Gloc, E; Młynarski, W; Skórski, T, 2002) |
| " The results of this study will show that amifostine protects normal late and early progenitor cells for the toxic effects of cyclophosphamide derivatives while preserving their antileukaemic effects." | 1.29 | Amifostine (WR-2721) protects normal haematopoietic stem cells against cyclophosphamide derivatives' toxicity without compromising their antileukaemic effects. ( Douay, L; Giarratana, MC; Gorin, NC; Hu, C, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (54.55) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pinto, JL | 1 |
| Fonseca, FL | 1 |
| Marsicano, SR | 1 |
| Delgado, PO | 1 |
| Sant'anna, AV | 1 |
| Coelho, PG | 1 |
| Maeda, P | 1 |
| Del Giglio, A | 1 |
| Gloc, E | 2 |
| Warszawski, M | 1 |
| Młynarski, W | 2 |
| Stolarska, M | 1 |
| Hoser, G | 1 |
| Skorski, T | 2 |
| Błasiak, J | 2 |
| Drzewoski, J | 1 |
| Facorro, G | 1 |
| Sarrasague, MM | 1 |
| Torti, H | 1 |
| Hager, A | 1 |
| Avalos, JS | 1 |
| Foncuberta, M | 1 |
| Kusminsky, G | 1 |
| Douay, L | 3 |
| Hu, C | 3 |
| Giarratana, MC | 3 |
| Gorin, NC | 4 |
| Bouchet, S | 1 |
| Conlon, J | 1 |
| Capizzi, RL | 2 |
| List, AF | 1 |
| Fauth, F | 1 |
| Martin, H | 1 |
| Sonnhoff, S | 1 |
| Bialleck, H | 1 |
| Wiesneth, M | 1 |
| Mihanovic, B | 1 |
| Hoelzer, D | 1 |
3 reviews available for amifostine anhydrous and Leucocythaemia
| Article | Year |
|---|---|
The potential role of amifostine (Ethyol) in haematological malignancies.
Topics: Acute Disease; Adult; Amifostine; Antineoplastic Agents; Bone Marrow Purging; Bone Marrow Transplant | 1996 |
Clinical status and optimal use of amifostine.
Topics: Amifostine; Animals; Antineoplastic Agents; Bone Marrow Cells; Clinical Trials, Phase III as Topic; | 1999 |
Use of amifostine in hematologic malignancies, myelodysplastic syndrome, and acute leukemia.
Topics: Acute Disease; Amifostine; Animals; Apoptosis; Cytoprotection; Hematologic Neoplasms; Hematopoietic | 1999 |
2 trials available for amifostine anhydrous and Leucocythaemia
| Article | Year |
|---|---|
Systemic chemotherapy-induced microsatellite instability in the mononuclear cell fraction of women with breast cancer can be reproduced in vitro and abrogated by amifostine.
Topics: Amifostine; Antimutagenic Agents; Antineoplastic Agents, Alkylating; Breast Neoplasms; Cell Line, Tu | 2010 |
Purging of G-CSF-mobilized peripheral autografts in acute leukemia with mafosfamide and amifostine to protect normal progenitor cells.
Topics: Acute Disease; Adjuvants, Immunologic; Adult; Amifostine; Bone Marrow; Bone Marrow Purging; Cyclopho | 2000 |
6 other studies available for amifostine anhydrous and Leucocythaemia
| Article | Year |
|---|---|
TEL/JAK2 tyrosine kinase inhibits DNA repair in the presence of amifostine.
Topics: Amifostine; Animals; Comet Assay; DNA Damage; DNA Repair; Kinetics; Leukemia; Mice; Oncogene Protein | 2002 |
Amifostine differentially modulates DNA damage evoked by idarubicin in normal and leukemic cells.
Topics: Amifostine; Animals; Cell Line, Transformed; Cell Survival; Comet Assay; DNA Damage; Dose-Response R | 2002 |
Oxidative study of patients with total body irradiation: effects of amifostine treatment.
Topics: Adolescent; Adult; Amifostine; Antioxidants; Bone Marrow Transplantation; Child; Erythrocytes; Femal | 2004 |
Amifostine (WR-2721) protects normal haematopoietic stem cells against cyclophosphamide derivatives' toxicity without compromising their antileukaemic effects.
Topics: Amifostine; Antineoplastic Agents; Bone Marrow Purging; Bone Marrow Transplantation; Cyclophosphamid | 1995 |
Amifostine improves the antileukemic therapeutic index of mafosfamide: implications for bone marrow purging.
Topics: Amifostine; Antineoplastic Agents; Bone Marrow; Bone Marrow Purging; Bone Marrow Transplantation; Ce | 1995 |
Comparative effects of amifostine (Ethyol) on normal hematopoietic stem cells versus human leukemic cells during ex vivo purging in autologous bone marrow transplants.
Topics: Amifostine; Bone Marrow Purging; Bone Marrow Transplantation; Cell Separation; Cell Survival; Cultur | 1994 |