amifostine anhydrous has been researched along with Heart Diseases in 7 studies
Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
amifostine : An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.
Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Instead, patients in the control arms of some of the trials have been exposed to more prolonged use or increased dosage of toxic chemotherapy that placed them at greater risk of the toxicity the protective agent was designed to prevent (eg, cardiotoxicity in trials of dexrazoxane, myelosuppression or thrombocytopenia in trials of growth factors)." | 4.80 | Design and interpretation of clinical trials that evaluate agents that may offer protection from the toxic effects of cancer chemotherapy. ( Phillips, KA; Tannock, IF, 1998) |
| "Compared to dexrazoxane, amifostine provided a comparable degree of protection against the nephrotoxicity of doxorubicin, but was less cardioprotective and did not prevent the mortality and loss of body weight produced by doxorubicin." | 3.70 | Comparison of the protective effects of amifostine and dexrazoxane against the toxicity of doxorubicin in spontaneously hypertensive rats. ( Chadwick, DP; Ferrans, VJ; Herman, EH; Zhang, J, 2000) |
| " Evaluation of these toxic effects, as well as of the cardioprotective efficacy of the administered drugs, was performed using (1) ECG-records before and during the infusion of the proarrhythmogenic compound, aconitine (8 microg/kg/min i." | 1.30 | The efficacy of selenium, WR-2721, and their combination in the prevention of adriamycin-induced cardiotoxicity in rats. ( Bokonjić, D; Dobrić, S; Dragojević-Simić, V; Jović, P; Marincić, D; Milovanović, S, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kanat, O | 1 |
| Evrensel, T | 1 |
| Baran, I | 1 |
| Coskun, H | 1 |
| Zarifoglu, M | 1 |
| Turan, OF | 1 |
| Kurt, E | 1 |
| Demiray, M | 1 |
| Gonullu, G | 1 |
| Manavoglu, O | 1 |
| Bolaman, Z | 1 |
| Cicek, C | 1 |
| Kadikoylu, G | 1 |
| Barutca, S | 1 |
| Serter, M | 1 |
| Yenisey, C | 1 |
| Alper, G | 1 |
| Gallegos-Castorena, S | 1 |
| Martínez-Avalos, A | 1 |
| Mohar-Betancourt, A | 1 |
| Guerrero-Avendaño, G | 1 |
| Zapata-Tarrés, M | 1 |
| Medina-Sansón, A | 1 |
| Dorr, RT | 1 |
| Dobrić, S | 1 |
| Dragojević-Simić, V | 1 |
| Bokonjić, D | 1 |
| Milovanović, S | 1 |
| Marincić, D | 1 |
| Jović, P | 1 |
| Phillips, KA | 1 |
| Tannock, IF | 1 |
| Herman, EH | 1 |
| Zhang, J | 1 |
| Chadwick, DP | 1 |
| Ferrans, VJ | 1 |
2 reviews available for amifostine anhydrous and Heart Diseases
| Article | Year |
|---|---|
Cytoprotective agents for anthracyclines.
Topics: Amifostine; Animals; Anthracyclines; Antioxidants; Doxorubicin; Heart; Heart Diseases; Mice; Rats | 1996 |
Design and interpretation of clinical trials that evaluate agents that may offer protection from the toxic effects of cancer chemotherapy.
Topics: Amifostine; Antineoplastic Agents; Cardiovascular Agents; Clinical Trials, Phase III as Topic; Heart | 1998 |
2 trials available for amifostine anhydrous and Heart Diseases
| Article | Year |
|---|---|
Protective effect of amifostine against toxicity of paclitaxel and carboplatin in non-small cell lung cancer: a single center randomized study.
Topics: Amifostine; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Non-Small-Cell L | 2003 |
Toxicity prevention with amifostine in pediatric osteosarcoma patients treated with cisplatin and doxorubicin.
Topics: Adolescent; Amifostine; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; | 2007 |
3 other studies available for amifostine anhydrous and Heart Diseases
| Article | Year |
|---|---|
The protective effects of amifostine on adriamycin-induced acute cardiotoxicity in rats.
Topics: Amifostine; Animals; Catalase; Doxorubicin; Glutathione; Heart Diseases; Male; Malondialdehyde; Orga | 2005 |
The efficacy of selenium, WR-2721, and their combination in the prevention of adriamycin-induced cardiotoxicity in rats.
Topics: Aconitine; Amifostine; Animals; Antibiotics, Antineoplastic; Arrhythmias, Cardiac; Aspartate Aminotr | 1998 |
Comparison of the protective effects of amifostine and dexrazoxane against the toxicity of doxorubicin in spontaneously hypertensive rats.
Topics: Amifostine; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Body Weight; Doxorubicin; H | 2000 |