amifostine anhydrous and Genome Instability studies

amifostine anhydrous and Genome Instability

Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
amifostine : An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.

Research Excerpts

Excerpt	Relevance	Reference
"Radiation-induced genomic instability has been detected after exposure to both low- and high-linear energy transfer (LET) radiations, but the mechanisms responsible for initiating or propagating genomic instability are not known."	1.36	Amifostine metabolite WR-1065 disrupts homologous recombination in mammalian cells. ( Baulch, JE; Dziegielewski, J; Goetz, W; Grdina, DJ; Morgan, WF; Murley, JS, 2010)

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (66.67)	29.6817
2010's	1 (33.33)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

0 (0.00)

18.2507

2000's

2 (66.67)

29.6817

2010's

1 (33.33)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Dziegielewski, J	2
Baulch, JE	2
Goetz, W	2
Coleman, MC	1
Spitz, DR	1
Murley, JS	2
Grdina, DJ	2
Morgan, WF	2
Komaki, R	1
Chang, JY	1
Wu, X	1
Allen, PK	1
Milas, L	1
Liao, Z	1
Fossella, FV	1
Travis, E	1
Spitz, MR	1

Studies

Dziegielewski, J

Baulch, JE

Goetz, W

Coleman, MC

Spitz, DR

Murley, JS

Grdina, DJ

Morgan, WF

Komaki, R

Chang, JY

Wu, X

Allen, PK

Milas, L

Liao, Z

Fossella, FV

Travis, E

Spitz, MR

Trials

1 trial available for amifostine anhydrous and Genome Instability

Article	Year
Mutagen sensitivity may predict lung protection by amifostine for patients with locally advanced non-small cell lung cancer treated by chemoradiotherapy. Seminars in oncology, 2005, Volume: 32, Issue:2 Suppl 3 Topics: Adult; Aged; Amifostine; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Non-S	2005

Article

Year

Mutagen sensitivity may predict lung protection by amifostine for patients with locally advanced non-small cell lung cancer treated by chemoradiotherapy.

Seminars in oncology, 2005, Volume: 32, Issue:2 Suppl 3

Topics: Adult; Aged; Amifostine; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Non-S

2005

Other Studies

2 other studies available for amifostine anhydrous and Genome Instability

Article	Year
WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability. Free radical biology & medicine, 2008, Dec-15, Volume: 45, Issue:12 Topics: Amifostine; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Dose-Response Relationship, Radia	2008
Amifostine metabolite WR-1065 disrupts homologous recombination in mammalian cells. Radiation research, 2010, Volume: 173, Issue:2 Topics: Amifostine; Animals; Camptothecin; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; DNA-Binding	2010

Article

Year

WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability.

Free radical biology & medicine, 2008, Dec-15, Volume: 45, Issue:12

Topics: Amifostine; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Dose-Response Relationship, Radia

2008

Amifostine metabolite WR-1065 disrupts homologous recombination in mammalian cells.

Radiation research, 2010, Volume: 173, Issue:2

Topics: Amifostine; Animals; Camptothecin; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; DNA-Binding

2010