amifostine anhydrous has been researched along with Experimental Radiation Injuries in 142 studies
Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
amifostine : An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pantethine and the amino phosphorothioate, WR-77913, protected lenses against increased light scattering and opacification during cataract formation in five animal models: (1) radiation, (2) selenite, (3) galactose, (4) streptozotocin and (5) Royal College of Surgeons." | 3.69 | Delay or inhibition of rat lens opacification using pantethine and WR-77913. ( Clark, JI; Livesey, JC; Steele, JE, 1996) |
| "A phase separation inhibitor, WR77913 [S-3(amino-2-hydroxypropyl) phosphorothioate], was tested for its effects on lens opacification in the radiation (RAD), selenite (SEL), galactose (GAL), streptozotocin (STZ), and Royal College of Surgeons (RCS) models for cataract." | 3.68 | Phase separation inhibitors and lens transparency. ( Clark, JI; Livesey, JC; Steele, JE, 1993) |
| "Standard treatment of differentiated thyroid cancer includes total thyroidectomy and high-dose Radioactive Iodine Therapy (RIT) for ablation of remnant thyroid tissue." | 1.51 | Radioprotective Effects of Amifostine, L-Carnitine and Vitamin E in Preventing Early Salivary Gland Injury due to Radioactive Iodine Treatment. ( Altun, GD; Ergulen, A; Muratli, A; Serim, BD; Torun, N, 2019) |
| "Radiodermatitis and radioinduced oral mucositis are frequent and significant side effects among patients with breast and head and neck cancer, respectively." | 1.51 | Preventing Radiation-Induced Injury by Topical Application of an Amifostine Metabolite-Loaded Thermogel. ( Benel, L; Bloy, C; Bricout, D; Chargari, C; Clémenson, C; Deutsch, E; Haddad, R; Liu, W; Mondini, M; Soyez-Herkert, L; Wang-Zhang, X, 2019) |
| "Two groups of murine left hemimandibles were exposed to a human equivalent radiation dosage fractionated over 5 daily doses of 7 Gy." | 1.48 | Radioprotection With Amifostine Enhances Bone Strength and Regeneration and Bony Union in a Rat Model of Mandibular Distraction Osteogenesis. ( Buchman, SR; Dahle, SE; Deshpande, SS; Donneys, A; Goldstein, SA; Monson, LA; Nelson, NS; Sarhaddi, D; Tchanque-Fossuo, CN, 2018) |
| " Direct jejunal AMF administration incurred a systemic bioavailability of 61." | 1.48 | Novel Formulation Strategy to Improve the Feasibility of Amifostine Administration. ( Buchman, L; Buchman, SR; Donneys, A; Lipka, E; Lynn, J; Nelson, N; Ranganathan, K; Reyna, D; Rodriguez, J; Simon, E; Snider, A; Zhang, Y, 2018) |
| " Irradiated animals received a fractionated dosing schedule of 35 Gy, with amifostine-pretreated animals receiving amifostine before irradiation." | 1.40 | Prophylactic amifostine preserves the biomechanical properties of irradiated bone in the murine mandible. ( Ahsan, S; Buchman, SR; Deshpande, SS; Donneys, A; Felice, PA; Kozloff, KM; Nelson, NS; Perosky, JE, 2014) |
| "Metformin (250 mg/kg) was effective in protecting splenic cells from a 7 Gy dose in vivo (protection factor = 1." | 1.40 | Metformin exhibits radiation countermeasures efficacy when used alone or in combination with sulfhydryl containing drugs. ( Grdina, DJ; Miller, RC; Murley, JS, 2014) |
| "Pyridoxamine was more effective at protecting from radiation-induced apoptosis than amifostine, a synthetic thiol compound and the only FDA-approved radioprotector." | 1.35 | Pyridoxamine protects intestinal epithelium from ionizing radiation-induced apoptosis. ( Chetyrkin, S; Hallahan, D; Hudson, B; Thotala, D; Voziyan, P; Yazlovitskaya, E, 2009) |
| "Oral mucositis is a common side effect induced by radio/chemotherapy in patients with head and neck cancer." | 1.35 | Differential effect triggered by a heparan mimetic of the RGTA family preventing oral mucositis without tumor protection. ( Auperin, A; Barritault, D; Biti, G; Bourhis, J; Castaing, M; Deutsch, E; Frascogna, V; Mangoni, M; Morin, C; Opolon, P; Tao, Y; Violot, D; Vozenin-Brotons, MC; Yue, X, 2009) |
| "Pretreatment with lidocaine and amifostine-but not with pilocarpine-induced lower up-regulation of TN-C expression 72 h after radiation." | 1.34 | Pharmacological prevention of radiation-induced dry eye-an experimental study in a rabbit model. ( Beutel, J; Geerling, G; Hakim, SG; Kosmehl, H; Rades, D; Schroder, C; Sieg, P; von Hof, K; Wedel, T, 2007) |
| "The dose-response radioprotectant effects of amifostine on rat growth plate have not been studied." | 1.31 | Dose response of amifostine in protection of growth plate function from irradiation effects. ( Damron, LA; Damron, TA; Margulies, B; Spadaro, JA, 2000) |
| "After 24 h, chromosomal aberrations were studied in the bone marrow of the femur by routine metaphase preparation after colchicine treatment." | 1.30 | A comparative study of radioprotection by Ocimum flavonoids and synthetic aminothiol protectors in the mouse. ( Bisht, KS; Devi, PU; Vinitha, M, 1998) |
| " Therapeutic glucan treatment administered in combination with preirradiation WR-2721 or WR-3689 treatment synergistically increases both hematopoietic reconstitution and survival." | 1.28 | Radioprotection by polysaccharides alone and in combination with aminothiols. ( Brook, I; D'Alesandro, MM; MacVittie, TJ; Patchen, ML; Solberg, BD, 1992) |
| " The effectiveness of two doses of WR-2721 (300 mg/kg and 150 mg/kg body weight) alone or in combination with an optimal dose (20 mg/kg body weight) of MPG, on the mouse bone marrow was studied by the exogenous spleen colony assay (CFU-s) after a single whole body exposure to 4." | 1.28 | Drug combination against single drug treatment in radiation protection of the bone marrow CFU. ( Bisht, KS; Jagetia, GC; Kamath, G; Uma Devi, P, 1990) |
| " Dose modification factors (DMFs) were calculated as ratios of LD50 values." | 1.27 | Radioprotection of normal tissues against gamma rays and cyclotron neutrons with WR-2721: LD50 studies and 35S-WR-2721 biodistribution. ( Anderson, K; Krohn, KA; Mahler, P; Menard, T; Nelson, NJ; Rasey, JS, 1984) |
| " However, at concentrations less than 200 mg/kg, the radioprotective effect decreased in a dose-response manner with a concentration of 150 mg/kg providing 50% of the maximum effect observed." | 1.27 | Radiation protection of rat parenchymal hepatocytes with S-2-(3-aminopropylamino)ethylphosphorothioic acid. ( Crocker, IR; Jirtle, RL; Pierce, LJ; Strom, SC, 1985) |
| " Skin reactions, four different kidney assays, regrowth delay and local control of tumours have been used to construct dose-response curves from which the degree of radioprotection can be quantified as a protection factor." | 1.27 | Fractionation studies with WR-2721: normal tissues and tumour. ( Denekamp, J; Rojas, A; Smith, KA; Soranson, JA; Stewart, FA, 1986) |
| "Radiation induced cataracts are models for studying mechanisms of lens opacification." | 1.27 | Inhibition of lens opacification in x-irradiated rats treated with WR-77913. ( Clark, JI; Krohn, KA; Menard, TW; Osgood, TB, 1986) |
| " The toxic LD50/30 was 3574 mg/kg." | 1.26 | Toxicity and radiation protective effect of WR-77913 in BALB/c mice. ( Connor, AM; Grigsby, P; Mendiondo, OA, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 61 (42.96) | 18.7374 |
| 1990's | 31 (21.83) | 18.2507 |
| 2000's | 23 (16.20) | 29.6817 |
| 2010's | 27 (19.01) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Khalifa, J | 1 |
| François, S | 1 |
| Rancoule, C | 1 |
| Riccobono, D | 1 |
| Magné, N | 1 |
| Drouet, M | 1 |
| Chargari, C | 2 |
| Torun, N | 1 |
| Muratli, A | 1 |
| Serim, BD | 1 |
| Ergulen, A | 2 |
| Altun, GD | 1 |
| Hofer, M | 1 |
| Hoferová, Z | 1 |
| Depeš, D | 1 |
| Falk, M | 1 |
| Tchanque-Fossuo, CN | 4 |
| Donneys, A | 7 |
| Deshpande, SS | 6 |
| Sarhaddi, D | 4 |
| Nelson, NS | 4 |
| Monson, LA | 2 |
| Dahle, SE | 1 |
| Goldstein, SA | 3 |
| Buchman, SR | 7 |
| Ranganathan, K | 1 |
| Simon, E | 1 |
| Lynn, J | 1 |
| Snider, A | 1 |
| Zhang, Y | 1 |
| Nelson, N | 2 |
| Rodriguez, J | 1 |
| Buchman, L | 1 |
| Reyna, D | 1 |
| Lipka, E | 1 |
| Varghese, JJ | 1 |
| Schmale, IL | 1 |
| Mickelsen, D | 1 |
| Hansen, ME | 1 |
| Newlands, SD | 1 |
| Benoit, DSW | 1 |
| Korshunov, VA | 1 |
| Ovitt, CE | 1 |
| Clémenson, C | 1 |
| Liu, W | 1 |
| Bricout, D | 1 |
| Soyez-Herkert, L | 1 |
| Mondini, M | 1 |
| Haddad, R | 1 |
| Wang-Zhang, X | 1 |
| Benel, L | 1 |
| Bloy, C | 1 |
| Deutsch, E | 2 |
| Poushanchi, B | 3 |
| Weiss, DM | 1 |
| Ormsby, RJ | 1 |
| Lawrence, MD | 1 |
| Blyth, BJ | 1 |
| Bexis, K | 1 |
| Bezak, E | 1 |
| Murley, JS | 2 |
| Grdina, DJ | 5 |
| Sykes, PJ | 1 |
| Wang, K | 1 |
| Liu, C | 1 |
| Di, CJ | 1 |
| Ma, C | 1 |
| Han, CG | 1 |
| Yuan, MR | 1 |
| Li, PF | 1 |
| Li, L | 1 |
| Liu, YX | 1 |
| Felice, PA | 2 |
| Ahsan, S | 1 |
| Perosky, JE | 1 |
| Kozloff, KM | 1 |
| Fearon, JA | 1 |
| Miller, RC | 1 |
| Mata, J | 1 |
| Sheng, K | 1 |
| Hagspiel, K | 1 |
| Ruppert, K | 1 |
| Sylvester, P | 1 |
| Mugler, J | 1 |
| Fernandes, C | 1 |
| Guan, S | 1 |
| Larner, J | 1 |
| Read, P | 1 |
| Huang, EY | 1 |
| Wang, FS | 1 |
| Chen, YM | 1 |
| Chen, YF | 1 |
| Wang, CC | 1 |
| Lin, IH | 1 |
| Huang, YJ | 1 |
| Yang, KD | 1 |
| Akkus Yildirim, B | 1 |
| Çetin, E | 1 |
| Topkan, E | 3 |
| Ozyigit, G | 1 |
| Cengiz, M | 1 |
| Surucu, S | 1 |
| Usubutun, A | 1 |
| Akyol, F | 1 |
| Kar, T | 1 |
| Aksoy, Y | 1 |
| Yildirim, BA | 1 |
| Polyatskaya, Y | 1 |
| Rodriguez, JJ | 1 |
| Zheutlin, AR | 1 |
| Tas, S | 1 |
| Ozkul, F | 1 |
| Arik, MK | 1 |
| Kiraz, A | 1 |
| Vural, A | 1 |
| Singh, VK | 1 |
| Fatanmi, OO | 1 |
| Wise, SY | 1 |
| Newman, VL | 1 |
| Romaine, PL | 1 |
| Seed, TM | 1 |
| Aktoz, T | 1 |
| Caloglu, M | 4 |
| Yurut-Caloglu, V | 3 |
| Yalcin, O | 1 |
| Aydogdu, N | 1 |
| Nurlu, D | 1 |
| Arda, E | 1 |
| Inci, O | 1 |
| Tufan, H | 1 |
| Yavuz, AA | 1 |
| Bacanli, D | 1 |
| Onal, C | 1 |
| Kosdak, S | 1 |
| Yavuz, MN | 1 |
| Kilciksiz, S | 1 |
| Demirel, C | 1 |
| Erdal, N | 1 |
| Gürgül, S | 1 |
| Tamer, L | 1 |
| Ayaz, L | 1 |
| Ors, Y | 1 |
| Thotala, D | 1 |
| Chetyrkin, S | 1 |
| Hudson, B | 1 |
| Hallahan, D | 1 |
| Voziyan, P | 1 |
| Yazlovitskaya, E | 1 |
| Mangoni, M | 1 |
| Yue, X | 1 |
| Morin, C | 1 |
| Violot, D | 1 |
| Frascogna, V | 1 |
| Tao, Y | 1 |
| Opolon, P | 1 |
| Castaing, M | 1 |
| Auperin, A | 1 |
| Biti, G | 1 |
| Barritault, D | 1 |
| Vozenin-Brotons, MC | 1 |
| Bourhis, J | 1 |
| Durmus-Altun, G | 3 |
| Oz-Puyan, F | 1 |
| Ustun, F | 1 |
| Cosar-Alas, R | 2 |
| Saynak, M | 2 |
| Parlar, S | 1 |
| Turan, FN | 1 |
| Uzal, C | 4 |
| Usta, U | 1 |
| Kocak, Z | 2 |
| Soref, CM | 1 |
| Hacker, TA | 1 |
| Fahl, WE | 1 |
| Joseph, J | 1 |
| Panicker, SN | 1 |
| Janardhanan, KK | 1 |
| Boguslawski, MJ | 1 |
| Gallagher, KK | 1 |
| Razdolsky, ER | 1 |
| Farberg, AS | 1 |
| Sagowski, C | 2 |
| Wenzel, S | 2 |
| Jenicke, L | 1 |
| Bohuslavizki, KH | 1 |
| Kehrl, W | 2 |
| Zywietz, F | 2 |
| Roeser, K | 2 |
| Mazur, L | 1 |
| Augustynek, A | 1 |
| Halicka, HD | 1 |
| Deptała, A | 1 |
| Damron, TA | 4 |
| Margulies, BS | 2 |
| Strauss, JA | 2 |
| O'Hara, K | 1 |
| Spadaro, JA | 4 |
| Farnum, CE | 2 |
| Boerma, M | 1 |
| Kruse, JJ | 1 |
| van Loenen, M | 1 |
| Klein, HR | 1 |
| Bart, CI | 1 |
| Zurcher, C | 1 |
| Wondergem, J | 1 |
| Tokatli, F | 1 |
| Doganay, L | 1 |
| Kaya, M | 1 |
| Ture, M | 1 |
| Kurum, T | 1 |
| Alkaya, F | 1 |
| Karadag, H | 1 |
| Kutlu, K | 1 |
| Belkacémi, Y | 1 |
| Pasquier, D | 1 |
| Castelain, B | 1 |
| Warnet, JM | 1 |
| Lartigau, E | 1 |
| Kuna, P | 7 |
| Dostál, M | 1 |
| Neruda, O | 1 |
| Volenec, K | 1 |
| Vodicka, I | 1 |
| Navrátil, L | 1 |
| Petýrek, P | 2 |
| Svoboda, V | 1 |
| Simsa, J | 1 |
| Vávrová, J | 1 |
| Hermanská, J | 1 |
| Prouza, Z | 1 |
| Pitterman, P | 1 |
| Listík, E | 1 |
| Spurný, F | 1 |
| Knajfl, J | 1 |
| Podzimek, F | 1 |
| Spelda, S | 1 |
| Osterreicher, J | 1 |
| Konrád, F | 1 |
| Havránková, R | 1 |
| Horton, JA | 1 |
| Altaner, S | 1 |
| Yigitbasi, NO | 1 |
| McAleer, MF | 1 |
| Davidson, C | 1 |
| Davidson, WR | 1 |
| Yentzer, B | 1 |
| Farber, SA | 1 |
| Rodeck, U | 1 |
| Dicker, AP | 1 |
| Cassatt, DR | 1 |
| Fazenbaker, CA | 1 |
| Bachy, CM | 1 |
| Kifle, G | 1 |
| McCarthy, MP | 1 |
| Chen, Z | 1 |
| Wang, S | 2 |
| Cheng, Q | 1 |
| Lu, S | 1 |
| Beutel, J | 1 |
| Schroder, C | 1 |
| von Hof, K | 1 |
| Rades, D | 1 |
| Kosmehl, H | 1 |
| Wedel, T | 1 |
| Sieg, P | 1 |
| Geerling, G | 1 |
| Hakim, SG | 1 |
| Gevorgyan, A | 1 |
| La Scala, GC | 2 |
| Neligan, PC | 2 |
| Pang, CY | 2 |
| Forrest, CR | 2 |
| Gevorgyan, AM | 1 |
| Sukhu, B | 1 |
| Leung, IT | 1 |
| Ashrafpour, H | 1 |
| Yeung, I | 1 |
| Vygodskaia, AL | 1 |
| Iarmonenko, SP | 1 |
| Parkins, C | 1 |
| Fowler, JF | 3 |
| Denekamp, J | 3 |
| Rojas, A | 2 |
| Down, JD | 2 |
| Laurent, GJ | 1 |
| McAnulty, RJ | 1 |
| Steel, GG | 1 |
| Pratt, NE | 2 |
| Sodicoff, M | 3 |
| Liss, J | 1 |
| Davis, M | 1 |
| Sinesi, M | 1 |
| Yuhas, JM | 2 |
| Utley, JF | 1 |
| Quinn, CA | 1 |
| White, FC | 1 |
| Seaver, NA | 1 |
| Bloor, CM | 1 |
| Krajcovic, C | 1 |
| Grigsby, P | 2 |
| Maruyama, Y | 1 |
| Jensovský, V | 1 |
| Melek, J | 1 |
| Travis, EL | 4 |
| De Luca, AM | 2 |
| Padikal, TN | 1 |
| Mendiondo, OA | 1 |
| Connor, AM | 1 |
| Plotnikova, ED | 3 |
| Levitman, MKh | 1 |
| Shaposhnikova, VV | 3 |
| Eĭdus, LKh | 1 |
| Donaldson, SS | 1 |
| Moskowitz, PS | 1 |
| Evans, JW | 1 |
| Fajardo, LF | 1 |
| Parkins, CS | 1 |
| Holmes, SJ | 1 |
| Levitman, MK | 2 |
| Eidus, LK | 2 |
| Walden, TL | 2 |
| Draganac, PS | 1 |
| Farkas, WR | 1 |
| Rasey, JS | 4 |
| Nelson, NJ | 1 |
| Mahler, P | 1 |
| Anderson, K | 1 |
| Krohn, KA | 7 |
| Menard, T | 1 |
| Patchen, ML | 6 |
| MacVittie, TJ | 4 |
| Peters, GJ | 2 |
| van der Vijgh, WJ | 2 |
| Carroll, MP | 1 |
| Zera, RT | 1 |
| Roberts, JC | 1 |
| Schlafmann, SE | 1 |
| Feeney, DA | 1 |
| Johnston, GR | 1 |
| West, MA | 1 |
| Bubrick, MP | 1 |
| Macková, NO | 1 |
| Fedorocko, P | 1 |
| Wasserman, TH | 1 |
| Livesey, JC | 6 |
| Wiens, LW | 1 |
| Von Seggern, DJ | 1 |
| Barlow, WE | 1 |
| Arnold, AM | 1 |
| Perret, C | 1 |
| Foultier, MT | 1 |
| Vonarx-Coinsman, V | 1 |
| Quancard, O | 1 |
| Combre, A | 1 |
| Patrice, T | 1 |
| Clark, JI | 5 |
| Steele, JE | 4 |
| Prasanna, PG | 1 |
| Uma Devi, P | 3 |
| Besa, PC | 1 |
| Hunter, NR | 1 |
| Milas, L | 5 |
| Maisin, JR | 2 |
| Albert, C | 1 |
| Henry, A | 1 |
| Devi, PU | 2 |
| Bisht, KS | 3 |
| Vinitha, M | 1 |
| Tamurian, RM | 1 |
| Margulies, B | 1 |
| Damron, LA | 1 |
| Prabhu, S | 1 |
| Fatome, M | 2 |
| Laval, JD | 2 |
| Roman, V | 2 |
| Solberg, BD | 1 |
| D'Alesandro, MM | 2 |
| Brook, I | 1 |
| Garnes, BA | 1 |
| Nagy, B | 1 |
| Nishiguchi, I | 1 |
| Hunter, N | 2 |
| Murray, D | 4 |
| Fleck, R | 1 |
| Ito, H | 1 |
| Travis, E | 1 |
| Neumann, B | 1 |
| Ussmüller, J | 1 |
| Conger, AD | 2 |
| Trepper, P | 1 |
| Gralla, EJ | 1 |
| Sabo, JP | 1 |
| Hayden, DW | 1 |
| Yochmowitz, MG | 1 |
| Mattsson, JL | 1 |
| Panossian, D | 1 |
| Jung, TT | 1 |
| Weeks, D | 1 |
| Sandefur, J | 1 |
| Park, YM | 1 |
| Miller, SK | 1 |
| Srinivasan, V | 1 |
| Weiss, JF | 5 |
| Geng, L | 1 |
| Hanson, WR | 3 |
| Malkinson, FD | 1 |
| Souza, LM | 1 |
| Carnes, BA | 1 |
| Grahn, D | 1 |
| Sigdestad, CP | 1 |
| Magee, S | 1 |
| Chin, L | 1 |
| Naruka, K | 1 |
| Bhartiya, HC | 4 |
| Jagetia, GC | 1 |
| Kamath, G | 1 |
| Lockhart, SP | 1 |
| Buc-Calderon, P | 1 |
| Defresne, MP | 1 |
| Barvais, C | 1 |
| Roberfroid, M | 1 |
| Altschuler, EM | 1 |
| Reddy, VN | 1 |
| Ikebe, H | 1 |
| Giblin, FJ | 1 |
| Ando, K | 1 |
| Bhartiya, J | 1 |
| Meyn, RE | 2 |
| Kandasamy, SB | 1 |
| Kumar, KS | 1 |
| Hunt, WA | 1 |
| Steel, LK | 1 |
| Hughes, HN | 1 |
| Jackson, WE | 1 |
| Koshevoj, JV | 1 |
| Brown, DQ | 2 |
| Graham, WJ | 1 |
| MacKenzie, LJ | 1 |
| Pittock, JW | 1 |
| Shaw, LM | 2 |
| Brock, WA | 1 |
| Glover, D | 1 |
| Turrisi, A | 1 |
| Bonner, HS | 1 |
| Norfleet, AL | 1 |
| Weiler, C | 1 |
| Glick, JH | 1 |
| Kligerman, MM | 1 |
| Thomas, B | 1 |
| Chirigos, MA | 1 |
| Spence, AM | 3 |
| Badger, CC | 1 |
| Vera, DM | 1 |
| Houseman, KA | 1 |
| Collins, PW | 1 |
| Edmondson, SE | 1 |
| Bogo, V | 1 |
| Franz, CG | 1 |
| Jacobs, AJ | 1 |
| Young, RW | 1 |
| Donlon, M | 1 |
| Steel, L | 1 |
| Helgeson, EA | 1 |
| Wolfe, WW | 1 |
| Catravas, GN | 1 |
| Samel, A | 1 |
| Meistrich, ML | 1 |
| Finch-Neimeyer, MV | 1 |
| Watkins, TL | 1 |
| Kiss, I | 1 |
| Kumar, S | 1 |
| Begg, AC | 1 |
| Terry, NH | 1 |
| Jirtle, RL | 2 |
| Pierce, LJ | 1 |
| Crocker, IR | 1 |
| Strom, SC | 1 |
| Mönig, H | 1 |
| Sedlmeier, H | 1 |
| Messerschmidt, O | 1 |
| Stewart, FA | 1 |
| Soranson, JA | 1 |
| Smith, KA | 1 |
| France, HG | 1 |
| Mansbach, CM | 1 |
| Menard, TW | 2 |
| Osgood, TB | 2 |
| Miller, GG | 1 |
| Dawson, DT | 1 |
| Battista, JJ | 1 |
| Rozsíval, P | 1 |
| Obenberger, J | 1 |
| Zaydlar, K | 1 |
| Courteille, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Single Center, Open Label Clinical Investigation on the Treatment of Radiation Induced Dermatitis With Radiation Care® Gel[NCT04995328] | 23 participants (Actual) | Interventional | 2021-08-03 | Completed | |||
| Radiosensitization With a COX-2 Inhibitor (Celecoxib), With Chemoradiation for Cancer of the Head and Neck[NCT00581971] | Phase 1/Phase 2 | 30 participants (Actual) | Interventional | 2002-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Evaluate the response to concurrent celecoxib, carboplatin, paclitaxel, and radiotherapy in the treatment of locally advanced SSC of the head and neck. Response is determined by local control only, local and distant metastasis, distant metastasis only, second primary, and surgical salvage. (NCT00581971)
Timeframe: 2 years from end of treatment (Radiation therapy)
| Intervention | Participants (Number) | ||||
|---|---|---|---|---|---|
| Local Control Only | Local Control and Distant Metastasis | Distant Metastatsis Only | Secondary Primary - Site Unknown | Surgical Salvage | |
| Recurrence | 6 | 2 | 1 | 2 | 3 |
Particpants experiencing Acute Toxicities > Grade 3 (NCT00581971)
Timeframe: 2 years from radiation therapy
| Intervention | participants (Number) | ||
|---|---|---|---|
| Hematologic | Dermatitis | Mucositis/Dysphagia | |
| Acute Toxicity | 12 | 7 | 16 |
16 reviews available for amifostine anhydrous and Experimental Radiation Injuries
| Article | Year |
|---|---|
Gene therapy and cell therapy for the management of radiation damages to healthy tissues: Rationale and early results.
Topics: Amifostine; Animals; Antioxidants; Cell- and Tissue-Based Therapy; Clinical Trials as Topic; Dose Fr | 2019 |
Combining Pharmacological Countermeasures to Attenuate the Acute Radiation Syndrome-A Concise Review.
Topics: Acute Radiation Syndrome; Amifostine; Animals; Dinoprostone; Drug Administration Schedule; Drug Comb | 2017 |
[Radiation protectants of the crystalline lens].
Topics: Amifostine; Anethole Trithione; Animals; Apoptosis; Cataract; Cattle; Cell Cycle; Cells, Cultured; C | 2003 |
Radioprotection of craniofacial bone growth.
Topics: Amifostine; Animals; Bone and Bones; Cell Line; Facial Bones; Growth; Models, Animal; Radiation Inju | 2007 |
Protection of normal tissues from the cytotoxic effects of chemotherapy and radiation by amifostine (WR-2721): preclinical aspects.
Topics: Amifostine; Animals; Antineoplastic Agents; Hypothermia, Induced; Mutagenesis; Neoplasms, Radiation- | 1995 |
Protection of normal tissues from the cytotoxic effects of chemotherapy and radiation by amifostine (Ethyol): preclinical aspects.
Topics: Amifostine; Animals; Antineoplastic Agents; Bone Marrow; Cell Survival; DNA; Kidney; Prodrugs; Radia | 1994 |
Radiotherapeutic studies with amifostine (Ethyol).
Topics: Amifostine; Animals; Cell Survival; Clinical Trials as Topic; Colony-Forming Units Assay; Humans; Ne | 1994 |
Chemical protection against ionizing radiation.
Topics: Amifostine; Animals; Cysteine; Dose-Response Relationship, Drug; Glutathione; Immunologic Factors; M | 1989 |
Effect of radioprotective agents on X-ray cataracts.
Topics: Amifostine; Animals; Cataract; Cysteine; Galactose; Lens, Crystalline; Radiation Injuries, Experimen | 1989 |
Can WR-2721 be improved upon?
Topics: Amifostine; Animals; Body Temperature; Digestive System; Hematopoietic System; Neoplasms, Radiation- | 1988 |
Radioprotectors in tumor radiotherapy: factors and settings determining therapeutic ratio.
Topics: Amifostine; Animals; Cells, Cultured; Ditiocarb; Humans; Immune Tolerance; Neoplasm Metastasis; Neop | 1988 |
Pharmacokinetics of WR-2721.
Topics: Amifostine; Animals; Humans; Hydrolysis; Neoplasms; Neoplasms, Experimental; Organothiophosphorus Co | 1988 |
Radioprotection by biological response modifiers alone and in combination with WR-2721.
Topics: Amifostine; Animals; beta-Glucans; Biological Products; Drug Therapy, Combination; Glucans; Hematopo | 1988 |
Specific protection of different normal tissues.
Topics: Amifostine; Animals; Humans; Radiation Injuries; Radiation Injuries, Experimental; Radiation-Protect | 1988 |
Radiation protection in vivo by prostaglandins and related compounds of the arachidonic acid cascade.
Topics: Alprostadil; Amifostine; Animals; Arachidonic Acids; Misoprostol; Prostaglandins; Radiation Injuries | 1988 |
Studies on radioprotectors in mammals and their possible use in radiotherapy--a summary.
Topics: Amifostine; Amino Acids, Sulfur; Animals; Drug Combinations; Humans; Mice; Neoplasms; Organothiophos | 1985 |
126 other studies available for amifostine anhydrous and Experimental Radiation Injuries
| Article | Year |
|---|---|
Radioprotective Effects of Amifostine, L-Carnitine and Vitamin E in Preventing Early Salivary Gland Injury due to Radioactive Iodine Treatment.
Topics: Amifostine; Animals; Carcinoma, Papillary; Carnitine; Guinea Pigs; Injections, Intramuscular; Iodine | 2019 |
Radioprotection With Amifostine Enhances Bone Strength and Regeneration and Bony Union in a Rat Model of Mandibular Distraction Osteogenesis.
Topics: Amifostine; Animals; Biomechanical Phenomena; Bone Regeneration; Mandible; Osteogenesis, Distraction | 2018 |
Novel Formulation Strategy to Improve the Feasibility of Amifostine Administration.
Topics: Administration, Intravenous; Administration, Oral; Amifostine; Animals; Biological Availability; Cel | 2018 |
Localized Delivery of Amifostine Enhances Salivary Gland Radioprotection.
Topics: Acinar Cells; Amifostine; Animals; Female; Fluorescent Antibody Technique; Injections; Mercaptoethyl | 2018 |
Preventing Radiation-Induced Injury by Topical Application of an Amifostine Metabolite-Loaded Thermogel.
Topics: Amifostine; Animals; Blood Pressure; Breast Neoplasms; Disease Models, Animal; DNA Damage; Dogs; Dru | 2019 |
Amifostine protects vascularity and improves union in a model of irradiated mandibular fracture healing.
Topics: Amifostine; Animals; Disease Models, Animal; Fracture Healing; Humans; Mandible; Mandibular Fracture | 2013 |
Protection from radiation-induced apoptosis by the radioprotector amifostine (WR-2721) is radiation dose dependent.
Topics: Amifostine; Animals; Apoptosis; Bone Marrow; Dose-Response Relationship, Radiation; Female; Male; Mi | 2014 |
Kojic acid protects C57BL/6 mice from gamma-irradiation induced damage.
Topics: Amifostine; Animals; Antioxidants; Cell Proliferation; Cell Survival; CHO Cells; Cricetinae; Cricetu | 2014 |
Prophylactic amifostine preserves the biomechanical properties of irradiated bone in the murine mandible.
Topics: Amifostine; Animals; Biomechanical Phenomena; Bone Diseases; Chemoprevention; Dose Fractionation, Ra | 2014 |
Discussion: Prophylactic amifostine preserves the biomechanical properties of irradiated bone in the murine mandible.
Topics: Amifostine; Animals; Bone Diseases; Male; Mandible; Radiation Injuries, Experimental; Radiation-Prot | 2014 |
Metformin exhibits radiation countermeasures efficacy when used alone or in combination with sulfhydryl containing drugs.
Topics: Acetylcysteine; Acute Radiation Syndrome; Amifostine; Animals; Captopril; Cell Line, Transformed; Ce | 2014 |
Pulmonary toxicity in a rabbit model of stereotactic lung radiation therapy: efficacy of a radioprotector.
Topics: Amifostine; Animals; Female; Lung; Magnetic Resonance Imaging; Models, Animal; Rabbits; Radiation In | 2014 |
Amifostine alleviates radiation-induced lethal small bowel damage via promotion of 14-3-3σ-mediated nuclear p53 accumulation.
Topics: 14-3-3 Proteins; Amifostine; Animals; Cell Line, Tumor; Cell Nucleus; HCT116 Cells; HEK293 Cells; Hu | 2014 |
PREVENTION OF RADIATION-INDUCED RETINOPATHY WITH AMIFOSTINE IN WISTAR ALBINO RATS.
Topics: Amifostine; Animals; Apoptosis; Cobalt Radioisotopes; Female; Injections, Intraperitoneal; Radiation | 2015 |
Correspondence.
Topics: Amifostine; Animals; Female; Radiation Injuries, Experimental; Radiation-Protective Agents; Retina; | 2015 |
Reply: To PMID 25768249.
Topics: Amifostine; Animals; Female; Radiation Injuries, Experimental; Radiation-Protective Agents; Retina; | 2015 |
Prophylactic amifostine prevents a pathologic vascular response in a murine model of expander-based breast reconstruction.
Topics: Amifostine; Angiography; Animals; Breast Neoplasms; Disease Models, Animal; Dose-Response Relationsh | 2016 |
The effect of amifostine on bacterial translocation after radiation ınduced acute enteritis.
Topics: Amifostine; Animals; Bacterial Translocation; Cecum; Enteritis; Enterobacteriaceae; Female; Lymph; R | 2016 |
THE POTENTIATION OF THE RADIOPROTECTIVE EFFICACY OF TWO MEDICAL COUNTERMEASURES, GAMMA-TOCOTRIENOL AND AMIFOSTINE, BY A COMBINATION PROPHYLACTIC MODALITY.
Topics: Amifostine; Animals; Chromans; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiati | 2016 |
Histopathological and biochemical comparisons of the protective effects of amifostine and l-carnitine against radiation-induced acute testicular toxicity in rats.
Topics: Amifostine; Animals; Carnitine; Drug Evaluation, Preclinical; Male; Radiation Injuries, Experimental | 2017 |
Comparison of the protective effects of melatonin and amifostine on radiation-induced epiphyseal injury.
Topics: Amifostine; Animals; Bone Development; Dose Fractionation, Radiation; Extremities; Growth Plate; Mal | 2008 |
The effect of N-acetylcysteine on biomarkers for radiation-induced oxidative damage in a rat model.
Topics: Acetylcysteine; Amifostine; Animals; Biomarkers; Female; Free Radical Scavengers; Glutathione; Liver | 2008 |
Pyridoxamine protects intestinal epithelium from ionizing radiation-induced apoptosis.
Topics: Amifostine; Animals; Apoptosis; Cell Line; Cytoprotection; Free Radical Scavengers; Intestinal Mucos | 2009 |
Differential effect triggered by a heparan mimetic of the RGTA family preventing oral mucositis without tumor protection.
Topics: Amifostine; Animals; Cell Line, Tumor; Drug Administration Schedule; Drug Therapy, Combination; Fema | 2009 |
Histopathological and scintigraphic comparisons of the protective effects of L-carnitine and amifostine against radiation-induced late renal toxicity in rats.
Topics: Amifostine; Animals; Carnitine; Cytoprotection; Drug Evaluation, Preclinical; Female; Kidney; Kidney | 2009 |
Comparison of protective effects of L-carnitine and amifostine on radiation-induced toxicity to growing bone: histopathology and scintigraphy findings.
Topics: Amifostine; Animals; Bone Development; Carnitine; Cytoprotection; Drug Evaluation, Preclinical; Fema | 2010 |
A new orally active, aminothiol radioprotector-free of nausea and hypotension side effects at its highest radioprotective doses.
Topics: Administration, Oral; Amifostine; Animals; Diamines; Drug Evaluation, Preclinical; Female; Ferrets; | 2012 |
Protective effect of polysaccharide-protein complex from a polypore mushroom, Phellinus rimosus against radiation-induced oxidative stress.
Topics: Agaricales; Amifostine; Animals; Antioxidants; Brain; Catalase; Complex Mixtures; DNA Damage; Fungal | 2012 |
Amifostine remediates the degenerative effects of radiation on the mineralization capacity of the murine mandible.
Topics: Amifostine; Animals; Calcification, Physiologic; Male; Mandible; Microradiography; Radiation Dosage; | 2012 |
Quantitative histologic evidence of amifostine-induced cytoprotection in an irradiated murine model of mandibular distraction osteogenesis.
Topics: Amifostine; Animals; Drug Administration Schedule; External Fixators; Image Processing, Computer-Ass | 2012 |
[Reducing late toxicity with amifostine in fractionated irradiation of the rat salivary glands].
Topics: Amifostine; Animals; Cobalt Radioisotopes; Dose Fractionation, Radiation; Dose-Response Relationship | 2002 |
Induction of apoptosis in bone marrow cells after treatment of mice with WR-2721 and gamma-rays: relationship to the cell cycle.
Topics: Amifostine; Animals; Apoptosis; Bone Marrow Cells; Cell Count; Cell Cycle; Gamma Rays; Male; Mice; R | 2003 |
Sequential histomorphometric analysis of the growth plate following irradiation with and without radioprotection.
Topics: Age Factors; Amifostine; Animals; Anthropometry; Chondrocytes; Disease Models, Animal; Dose-Response | 2003 |
Increased deposition of von Willebrand factor in the rat heart after local ionizing irradiation.
Topics: Amifostine; Animals; Coronary Vessels; Dose-Response Relationship, Radiation; Endocardium; Endomyoca | 2004 |
The potential cardioprotective effects of amifostine in irradiated rats.
Topics: Amifostine; Animals; Biomarkers; Cardiomyopathies; Cobalt Radioisotopes; Drug Evaluation, Preclinica | 2004 |
Radioprotective effects of amifostine (WR-2721) or cystamine on radiation damage and its repair in rats whole body exposed to fission neutrons.
Topics: Amifostine; Animals; Cystamine; Drug Administration Schedule; Female; Gamma Rays; Male; Neutrons; Nu | 2004 |
Combinations of radioprotectants spare radiation-induced damage to the physis.
Topics: Amifostine; Animals; Body Weight; Bone Density; Bone Development; Drug Therapy, Combination; Femur; | 2004 |
The protective effect of amifostine on radiation-induced acute pulmonary toxicity: detection by (99m)Tc-DTPA transalveolar clearances.
Topics: Amifostine; Animals; Lung; Pulmonary Alveoli; Rabbits; Radiation Injuries, Experimental; Radiation-P | 2004 |
Novel use of zebrafish as a vertebrate model to screen radiation protectors and sensitizers.
Topics: Amifostine; Animals; Dose-Response Relationship, Radiation; Drug Evaluation, Preclinical; Embryo, No | 2005 |
Amifostine (ETHYOL) protects rats from mucositis resulting from fractionated or hyperfractionated radiation exposure.
Topics: Amifostine; Animals; Dose Fractionation, Radiation; Drug Evaluation, Preclinical; Female; Injections | 2005 |
[Morphological observation of amifostine's protective effect on radiation induced early middle ear injury].
Topics: Amifostine; Animals; Ear, Middle; Female; Guinea Pigs; Mucous Membrane; Radiation Injuries, Experime | 2005 |
Pharmacological prevention of radiation-induced dry eye-an experimental study in a rabbit model.
Topics: Actins; Amifostine; Animals; Dry Eye Syndromes; Female; Immunoenzyme Techniques; Lacrimal Apparatus; | 2007 |
Radiation-induced craniofacial bone growth inhibition: in vitro cytoprotection in the rabbit orbitozygomatic complex periosteum-derived cell culture.
Topics: Amifostine; Animals; Bone Development; Cells, Cultured; Cytoprotection; Male; Models, Animal; Orbit; | 2008 |
[The efficacy of gammaphos in whole-body irradiation during normal oxygenation and hypoxia].
Topics: Amifostine; Animals; Male; Mice; Organothiophosphorus Compounds; Oxygen; Radiation Dosage; Radiation | 1984 |
Lung radioprotection by WR-2721 at low X-ray doses per fraction.
Topics: Amifostine; Animals; Dose-Response Relationship, Radiation; Lung; Lung Diseases; Male; Mice; Mice, I | 1984 |
The influence of X ray dose levels on normal tissue radioprotection by WR-2721.
Topics: Amifostine; Animals; Mice; Organothiophosphorus Compounds; Oxygen; Radiation Dosage; Radiation Injur | 1984 |
Oxygen-dependent protection of radiation lung damage in mice by WR 2721.
Topics: Amifostine; Animals; Dose-Response Relationship, Radiation; Hair; Hydroxyproline; Lung; Male; Mice; | 1984 |
Radioprotection of the rat parotid gland by WR-2721: morphology at 60 days post-irradiation.
Topics: Amifostine; Animals; Blood Vessels; Female; Humans; Microscopy, Electron; Organothiophosphorus Compo | 1980 |
A more general role for WR-2721 in cancer therapy.
Topics: Amifostine; Animals; Cisplatin; Female; Mammary Neoplasms, Experimental; Neoplasms; Organothiophosph | 1980 |
Protection of normal tissue against late radiation injury by WR-2721.
Topics: Amifostine; Animals; Blood Vessels; Cobalt Radioisotopes; Dose-Response Relationship, Radiation; Hin | 1981 |
[Acute toxicity and radioprotective effectiveness of WR-2721 (Gammaphos) in rats (author's transl)].
Topics: Amifostine; Animals; Female; Male; Organothiophosphorus Compounds; Radiation Injuries, Experimental; | 1981 |
Modification of the oral radiation death syndrome with combined WR-2721 and misonidazole.
Topics: Amifostine; Animals; Dose-Response Relationship, Drug; Female; Lethal Dose 50; Mice; Mice, Inbred BA | 1981 |
Radioprotective effect of WR-2721 in rabbits: a comparison with cystamine.
Topics: Amifostine; Animals; Cystamine; Dose-Response Relationship, Radiation; Female; Male; Organothiophosp | 1981 |
The time course of radioprotection by WR 2721 in mouse skin.
Topics: Amifostine; Animals; Dose-Response Relationship, Radiation; Electrons; Male; Mice; Mice, Inbred BALB | 1982 |
[Appearance of radioprotective effect of Gammaphos (WR-2721) in mice].
Topics: Amifostine; Animals; Female; Gamma Rays; Male; Mice; Organothiophosphorus Compounds; Radiation Dosag | 1982 |
Toxicity and radiation protective effect of WR-77913 in BALB/c mice.
Topics: Amifostine; Animals; Bone Marrow; Dose-Response Relationship, Radiation; Female; Mice; Mice, Inbred | 1982 |
[Change in cerebral microcirculation at long-term periods following irradiation with protection by gammaphos].
Topics: Amifostine; Animals; Brain; Microcirculation; Organothiophosphorus Compounds; Radiation Injuries, Ex | 1983 |
Duration and degree of radioprotection of WR-2721 in mice following its intraperitoneal, intramuscular and subcutaneous administration.
Topics: Amifostine; Animals; Injections, Intramuscular; Injections, Intraperitoneal; Injections, Subcutaneou | 1983 |
Protection from radiation nephropathy by WR-2721.
Topics: Amifostine; Animals; Blood Urea Nitrogen; Body Weight; Dose-Response Relationship, Radiation; Female | 1984 |
WR-2721 protection of pneumonitis and fibrosis in mouse lung after single doses of x rays.
Topics: Amifostine; Animals; Dose-Response Relationship, Radiation; Male; Mice; Mice, Inbred CBA; Organothio | 1984 |
Protection of microcirculation in rat brain against late radiation injury by gammaphos.
Topics: Amifostine; Animals; Brain; Dose-Response Relationship, Radiation; Microcirculation; Organothiophosp | 1984 |
The elevation of blood levels of zinc protoporphyrin in mice following whole body irradiation.
Topics: Amifostine; Animals; Bilirubin; Dose-Response Relationship, Radiation; Erythrocyte Indices; Erythrop | 1984 |
Radioprotection of normal tissues against gamma rays and cyclotron neutrons with WR-2721: LD50 studies and 35S-WR-2721 biodistribution.
Topics: Amifostine; Animals; Cesium Radioisotopes; Dose-Response Relationship, Radiation; Female; Gamma Rays | 1984 |
Granulocyte colony-stimulating factor and amifostine (Ethyol) synergize to enhance hemopoietic reconstitution and increase survival in irradiated animals.
Topics: Amifostine; Animals; Cell Survival; Colony-Forming Units Assay; Drug Synergism; Female; Granulocyte | 1994 |
Amifostine plus granulocyte colony-stimulating factor therapy enhances recovery from supralethal radiation exposures: preclinical experience in animals models.
Topics: Amifostine; Animals; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cells; Lethal Dose 50 | 1995 |
Efficacy of radioprotective agents in preventing small and large bowel radiation injury.
Topics: Adenosine Triphosphate; Amifostine; Animals; Cysteine; Drug Therapy, Combination; Glutamine; Intesti | 1995 |
Combined radioprotective effect of Broncho-Vaxom and WR-2721 on hemopoiesis and circulating blood cells.
Topics: Adjuvants, Immunologic; Amifostine; Animals; Bacteria; Blood Cells; Cell Extracts; Drug Therapy, Com | 1995 |
Inhibition of radiation cataractogenesis by WR-77913.
Topics: Amifostine; Animals; Cataract; Cesium Radioisotopes; Gamma Rays; Lens, Crystalline; Male; Radiation | 1995 |
Malondialdehyde dosimetry in laser-irradiated tissues sensitized by hematoporphyrin derivative.
Topics: Amifostine; Animals; Hematoporphyrin Derivative; Lasers; Male; Malondialdehyde; Mice; Mice, Nude; Ra | 1994 |
Phase separation inhibitors and lens transparency.
Topics: Amifostine; Animals; Cataract; Disease Models, Animal; Female; Galactose; Lens, Crystalline; Male; R | 1993 |
Modification of WR-2721 radiation protection from gastrointestinal injury and death in mice by 2-mercaptopropionylglycine.
Topics: Amifostine; Animals; Drug Therapy, Combination; Gastrointestinal Diseases; Mice; Mice, Inbred Strain | 1993 |
Improvement in radiotherapy for a murine sarcoma by indomethacin plus WR-2721.
Topics: Amifostine; Animals; Contracture; Drug Therapy, Combination; Indomethacin; Male; Mice; Mice, Inbred | 1993 |
Reduction of short-term radiation lethality by biological response modifiers given alone or in association with other chemical protectors.
Topics: 16,16-Dimethylprostaglandin E2; Amifostine; Animals; Cysteine; Drug Therapy, Combination; Glucans; I | 1993 |
Delay or inhibition of rat lens opacification using pantethine and WR-77913.
Topics: Amifostine; Animals; Cataract; Female; Galactose; Lens, Crystalline; Male; Pantetheine; Protein Dena | 1996 |
A comparative study of radioprotection by Ocimum flavonoids and synthetic aminothiol protectors in the mouse.
Topics: Amifostine; Animals; Bone Marrow; Chromosome Aberrations; Flavonoids; Mice; Plant Extracts; Radiatio | 1998 |
Sparing radiation-induced damage to the physis by radioprotectant drugs: laboratory analysis in a rat model.
Topics: Amifostine; Animals; Bone Development; Disease Models, Animal; Femur; Growth Plate; Hindlimb; Pilot | 1999 |
Dose response of amifostine in protection of growth plate function from irradiation effects.
Topics: Amifostine; Animals; Dose-Response Relationship, Drug; Femur; Growth Disorders; Growth Plate; Male; | 2000 |
Modification of radiation induced damage in mouse intestine by WR-2721.
Topics: Amifostine; Animals; Apoptosis; Cell Death; Jejunum; Male; Mice; Mitosis; Radiation Injuries, Experi | 2000 |
Some recent data on chemical protection against ionizing radiation.
Topics: Administration, Oral; Amifostine; Animals; Biopharmaceutics; Cysteamine; Drug Carriers; Drug Compoun | 1992 |
Radioprotection by polysaccharides alone and in combination with aminothiols.
Topics: Amifostine; Animals; Cell Survival; Drug Therapy, Combination; Female; Gamma Rays; Glucans; Granuloc | 1992 |
Protection by WR-2721 and WR-151327 against late effects of gamma rays and neutrons.
Topics: Amifostine; Animals; Female; Gamma Rays; Male; Mice; Mice, Inbred Strains; Mutagenesis; Neoplasms, R | 1992 |
Radiation protection against early and late effects of ionizing irradiation by the prostaglandin inhibitor indomethacin.
Topics: Amifostine; Animals; Contracture; Digestive System; Drug Therapy, Combination; Gamma Rays; Hair Foll | 1992 |
[Radioprotective effectiveness of amifostine on the salivary glands of the rat during fractionated irradiation].
Topics: Amifostine; Animals; Cobalt Radioisotopes; Dose Fractionation, Radiation; Male; Neoplasm Transplanta | 2002 |
Systemic factors affecting the radioprotective effectiveness of phosphorothioates.
Topics: Amifostine; Animals; Mercaptoethylamines; Mice; Organothiophosphorus Compounds; Radiation Injuries, | 1977 |
Radioprotection by WR-2721 against long-term chronic damage to the rat parotid gland.
Topics: Amifostine; Amylases; Animals; Dose-Response Relationship, Radiation; Female; Organ Size; Organothio | 1978 |
The effect of selected drugs on first-stage radioemesis in beagle dogs.
Topics: Amifostine; Amphetamine; Animals; Antiemetics; Body Weight; Chlorpromazine; Dimenhydrinate; Diphenhy | 1979 |
Effect of the radioprotector WR2721 on irradiation-induced injury to ciliated cells of eustachian tube.
Topics: Amifostine; Animals; Chinchilla; Cilia; Eustachian Tube; Microscopy, Electron, Scanning; Mucociliary | 1992 |
Radioprotection by vitamin E: injectable vitamin E administered alone or with WR-3689 enhances survival of irradiated mice.
Topics: Amifostine; Animals; Injections, Subcutaneous; Male; Mice; Radiation Injuries, Experimental; Radiati | 1992 |
Topical or systemic 16, 16 dm prostaglandin E2 or WR-2721 (WR-1065) protects mice from alopecia after fractionated irradiation.
Topics: 16,16-Dimethylprostaglandin E2; Administration, Topical; Alopecia; Amifostine; Animals; Injections, | 1992 |
Postirradiation treatment with granulocyte colony-stimulating factor and preirradiation WR-2721 administration synergize to enhance hemopoietic reconstitution and increase survival.
Topics: Amifostine; Animals; Cell Survival; Drug Synergism; Female; Granulocyte Colony-Stimulating Factor; H | 1992 |
Protection against late effects of radiation by S-2-(3-aminopropylamino)-ethylphosphorothioic acid.
Topics: Amifostine; Animals; Cobalt Radioisotopes; Female; Gamma Rays; Mice; Mice, Inbred Strains; Neoplasms | 1991 |
Misoprostol, a PGE1 analog, protects mice from fission-neutron injury.
Topics: Amifostine; Animals; Drug Therapy, Combination; Male; Mice; Misoprostol; Neutrons; Radiation Injurie | 1991 |
Response of mouse tissues to neutron and gamma radiation: protection by WR-3689 and WR-77913.
Topics: Amifostine; Animals; Cell Survival; Dose-Response Relationship, Radiation; Intestines; Mice; Neutron | 1990 |
Combined modality radioprotection: the use of glucan and selenium with WR-2721.
Topics: Amifostine; Animals; Bone Marrow; Colony-Forming Units Assay; Drug Synergism; Female; Glucans; Hemat | 1990 |
Radioprotection of pronormoblasts and normoblasts by WR-2721.
Topics: Amifostine; Animals; Bone Marrow; Bone Marrow Cells; Cell Count; Cobalt Radioisotopes; DNA Damage; M | 1990 |
Drug combination against single drug treatment in radiation protection of the bone marrow CFU.
Topics: Amifostine; Animals; Bone Marrow; Colony-Forming Units Assay; Drug Combinations; Mice; Organothiopho | 1990 |
Inhaled thiol and phosphorothiol radioprotectors fail to protect the mouse lung.
Topics: Acetylcysteine; Administration, Inhalation; Aerosols; Amifostine; Animals; Cysteamine; Lung; Male; M | 1990 |
N-acyl dehydroalanines protect from radiation toxicity and inhibit radiation carcinogenesis in mice.
Topics: Alanine; Amifostine; Animals; Female; Free Radicals; Hydroxides; Hydroxyl Radical; Lymphoma; Mice; M | 1989 |
Protection by WR-3689 against gamma-ray-induced intestinal damage: comparative effect on clonogenic cell survival, mouse survival, and DNA damage.
Topics: Amifostine; Animals; Cell Survival; DNA Damage; DNA, Neoplasm; Jejunum; Mice; Mice, Inbred C3H; Orga | 1989 |
[Chemical radioprotectors].
Topics: Amifostine; Animals; Female; Lethal Dose 50; Mice; Mice, Inbred C3H; Muscles; Neutrons; Radiation Do | 1987 |
Variations in sialic acid content of testis in irradiated mouse preinjected with a thiophosphate.
Topics: Amifostine; Animals; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; N-Acetylneuramin | 1987 |
Radioprotection of mouse jejunum by WR-2721 and WR-1065: effects on DNA strand-break induction and rejoining.
Topics: Amifostine; Animals; Cesium Radioisotopes; Cricetinae; DNA; DNA Repair; Gamma Rays; Jejunum; Mercapt | 1988 |
Opposite effects of WR-2721 and WR-1065 on radiation-induced hypothermia: possible correlation with oxygen uptake.
Topics: Amifostine; Animals; Brain; Cobalt Radioisotopes; Gamma Rays; Guinea Pigs; Hypothermia; Male; Mercap | 1988 |
Protection of mice against mixed fission neutron-gamma (n: gamma = 1:1) irradiation by WR-2721, 16,16-dimethyl PGE2, and the combination of both agents.
Topics: 16,16-Dimethylprostaglandin E2; Amifostine; Animals; Drug Therapy, Combination; Female; Mice; Mice, | 1988 |
Protection of microvasculature in rat brain against late radiation injury by gammaphos.
Topics: Amifostine; Animals; Brain; Microcirculation; Organothiophosphorus Compounds; Radiation Injuries, Ex | 1988 |
Mechanism of unusual cell enlargement in the testis of irradiated mouse following treatment with a radioprotective thiophosphate.
Topics: Amifostine; Animals; Male; Mice; Organothiophosphorus Compounds; Radiation Injuries, Experimental; R | 1988 |
Bone marrow cell protection and modification of drug toxicity by combination of protectors.
Topics: Amifostine; Animals; Bone Marrow; Chromosome Aberrations; Drug Therapy, Combination; Mice; Radiation | 1988 |
WR-2721, WR-77913 and WR-3689 radioprotection in the rat spinal cord.
Topics: Amifostine; Animals; Cesium Radioisotopes; Female; Injections, Intraventricular; Paralysis; Radiatio | 1988 |
Effects of ethiofos (WR-2721) and radiation on monkey visual discrimination performance.
Topics: Amifostine; Animals; Macaca mulatta; Male; Motor Activity; Organothiophosphorus Compounds; Radiation | 1988 |
Protection of mouse lung by WR-2721 after fractionated doses of irradiation.
Topics: Amifostine; Animals; Dose-Response Relationship, Radiation; Female; Lung; Mice; Organothiophosphorus | 1985 |
WR-2721 inhibition of radiation-induced prostaglandin excretion in rats.
Topics: Amifostine; Animals; Cobalt Radioisotopes; Dinoprost; Gamma Rays; Male; Organothiophosphorus Compoun | 1985 |
Comparison of cAMP with other radioprotectors against chronic damage to the rat parotid gland.
Topics: Amifostine; Animals; Cyclic AMP; Female; Isoproterenol; Parotid Gland; Radiation Injuries, Experimen | 1985 |
Late functional and biochemical changes in mouse lung after irradiation: differential effects of WR-2721.
Topics: Amifostine; Animals; Cesium Radioisotopes; DNA; Dose-Response Relationship, Radiation; Hydroxyprolin | 1985 |
Stromal radiosensitivity: influence of tumour type on the Tumour Bed Effect assay.
Topics: Adenocarcinoma; Amifostine; Animals; Dose-Response Relationship, Radiation; Mice; Mice, Inbred CBA; | 1985 |
Radiation protection of rat parenchymal hepatocytes with S-2-(3-aminopropylamino)ethylphosphorothioic acid.
Topics: Amifostine; Animals; Cell Survival; Cobalt Radioisotopes; Dose-Response Relationship, Drug; Dose-Res | 1985 |
The influence of the solvent on the toxicity and radioprotective effect of thiophosphate WR2721 in mice.
Topics: Amifostine; Animals; Hydrogen-Ion Concentration; Male; Mice; Organothiophosphorus Compounds; Radiati | 1986 |
Fractionation studies with WR-2721: normal tissues and tumour.
Topics: Amifostine; Animals; Carcinoma; Female; Kidney; Lethal Dose 50; Mammary Neoplasms, Experimental; Mic | 1986 |
Intracolonic WR 2721 protection of the rat colon from acute radiation injury.
Topics: Amifostine; Animals; Colon; Male; Organothiophosphorus Compounds; Radiation Injuries, Experimental; | 1986 |
Radioprotection against cataract formation by WR-77913 in gamma-irradiated rats.
Topics: Amifostine; Animals; Cataract; Cesium Radioisotopes; Gamma Rays; Organothiophosphorus Compounds; Rad | 1986 |
[Radioprotective action of cystamine and gammaphos in gamma ray exposure (Czechoslovak Socialist Republic)].
Topics: Amifostine; Animals; Cystamine; Czechoslovakia; Dogs; Drug Evaluation, Preclinical; Gamma Rays; Male | 1986 |
Computed tomographic assessment of radiation induced damage in the lung of normal and WR 2721 protected LAF1 mice.
Topics: Amifostine; Animals; Lung; Male; Mice; Organothiophosphorus Compounds; Radiation Injuries, Experimen | 1986 |
Effect of S-2(3-aminopropylamino) ethyl phosphorothioic acid on ATPase activity in the testis of irradiated mouse.
Topics: Adenosine Triphosphatases; Amifostine; Animals; Male; Mice; Organothiophosphorus Compounds; Radiatio | 1986 |
Inhibition of lens opacification in x-irradiated rats treated with WR-77913.
Topics: Amifostine; Animals; Body Water; Cataract; Crystallins; Lens, Crystalline; Male; Organothiophosphoru | 1986 |
[Protection of the lens against ionizing radiation injury using gammaphos].
Topics: Amifostine; Animals; Gamma Rays; Lens, Crystalline; Organothiophosphorus Compounds; Rabbits; Radiati | 1986 |
Radioprotective effect of WR-2721 (gammaphos) or cystamine in non-uniform lethal gamma irradiated mice.
Topics: Amifostine; Animals; Cystamine; Gamma Rays; Mice; Mice, Inbred Strains; Organothiophosphorus Compoun | 1986 |
Radioprotective activity of ethylcellulose microspheres containing WR 2721, after oral administration.
Topics: Administration, Oral; Adsorption; Amifostine; Animals; Biological Availability; Cellulose; Female; G | 1987 |