amifostine anhydrous has been researched along with Cataract in 11 studies
Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
amifostine : An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.
Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, amifostine did not protect young rats against the late toxic effect of doxoubicin on linear growth, body weight, plasma leptin levels, and heart or testicular tissue." | 3.71 | Amifostine protects against early but not late toxic effects of doxorubicin in infant rats. ( Eksborg, S; Jahnukainen, K; Jahnukainen, T; Salmi, TT; Söder, O; Svechnikov, K, 2001) |
| "Pantethine and the amino phosphorothioate, WR-77913, protected lenses against increased light scattering and opacification during cataract formation in five animal models: (1) radiation, (2) selenite, (3) galactose, (4) streptozotocin and (5) Royal College of Surgeons." | 3.69 | Delay or inhibition of rat lens opacification using pantethine and WR-77913. ( Clark, JI; Livesey, JC; Steele, JE, 1996) |
| "A phase separation inhibitor, WR77913 [S-3(amino-2-hydroxypropyl) phosphorothioate], was tested for its effects on lens opacification in the radiation (RAD), selenite (SEL), galactose (GAL), streptozotocin (STZ), and Royal College of Surgeons (RCS) models for cataract." | 3.68 | Phase separation inhibitors and lens transparency. ( Clark, JI; Livesey, JC; Steele, JE, 1993) |
| "The variation of the phase-separation temperature (Tc) was studied in lenses during formation of cataracts induced by a subcutaneous injection of sodium selenite." | 3.68 | Phase-separation inhibitors and prevention of selenite cataract. ( Clark, JI; Steele, JE, 1992) |
| "Galactose, and the phosphorothioates, WR-77913 and WR-2721, which inhibit cataract produced by X-irradiation, were evaluated for their effects on the phase separation temperature, Tc, of calf lens homogenate." | 3.67 | Inhibition of phase separation by reagents that prevent X-irradiation cataract in vivo. ( Clark, JI; Osgood, TB; Trask, SJ, 1987) |
| "Radiation induced cataracts are models for studying mechanisms of lens opacification." | 1.27 | Inhibition of lens opacification in x-irradiated rats treated with WR-77913. ( Clark, JI; Krohn, KA; Menard, TW; Osgood, TB, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (36.36) | 18.7374 |
| 1990's | 5 (45.45) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Belkacémi, Y | 1 |
| Pasquier, D | 1 |
| Castelain, B | 1 |
| Warnet, JM | 1 |
| Lartigau, E | 1 |
| Vaezy, S | 1 |
| Clark, JI | 8 |
| Clark, JM | 1 |
| Livesey, JC | 5 |
| Wiens, LW | 1 |
| Von Seggern, DJ | 1 |
| Barlow, WE | 1 |
| Arnold, AM | 1 |
| Steele, JE | 4 |
| Jahnukainen, K | 1 |
| Jahnukainen, T | 1 |
| Salmi, TT | 1 |
| Svechnikov, K | 1 |
| Eksborg, S | 1 |
| Söder, O | 1 |
| Reddy, VN | 1 |
| Ikebe, H | 1 |
| Giblin, FJ | 1 |
| Osgood, TB | 3 |
| Trask, SJ | 1 |
| Menard, TW | 2 |
| Spence, AM | 1 |
| Krohn, KA | 2 |
2 reviews available for amifostine anhydrous and Cataract
| Article | Year |
|---|---|
[Radiation protectants of the crystalline lens].
Topics: Amifostine; Anethole Trithione; Animals; Apoptosis; Cataract; Cattle; Cell Cycle; Cells, Cultured; C | 2003 |
Effect of radioprotective agents on X-ray cataracts.
Topics: Amifostine; Animals; Cataract; Cysteine; Galactose; Lens, Crystalline; Radiation Injuries, Experimen | 1989 |
9 other studies available for amifostine anhydrous and Cataract
| Article | Year |
|---|---|
Quantitative analysis of the lens cell microstructure in selenite cataract using a two-dimensional Fourier analysis.
Topics: Amifostine; Animals; Cataract; Fourier Analysis; Image Processing, Computer-Assisted; Lens, Crystall | 1995 |
Inhibition of radiation cataractogenesis by WR-77913.
Topics: Amifostine; Animals; Cataract; Cesium Radioisotopes; Gamma Rays; Lens, Crystalline; Male; Radiation | 1995 |
Phase separation inhibitors and lens transparency.
Topics: Amifostine; Animals; Cataract; Disease Models, Animal; Female; Galactose; Lens, Crystalline; Male; R | 1993 |
Delay or inhibition of rat lens opacification using pantethine and WR-77913.
Topics: Amifostine; Animals; Cataract; Female; Galactose; Lens, Crystalline; Male; Pantetheine; Protein Dena | 1996 |
Amifostine protects against early but not late toxic effects of doxorubicin in infant rats.
Topics: Age Factors; Alopecia; Amifostine; Animals; Animals, Suckling; Antibiotics, Antineoplastic; Body Wei | 2001 |
Phase-separation inhibitors and prevention of selenite cataract.
Topics: Amifostine; Animals; Cataract; Chemical Phenomena; Chemistry, Physical; Lens, Crystalline; Rats; Rat | 1992 |
Inhibition of phase separation by reagents that prevent X-irradiation cataract in vivo.
Topics: Amifostine; Animals; Cataract; Cattle; Galactose; Lens, Crystalline; Organothiophosphorus Compounds; | 1987 |
Radioprotection against cataract formation by WR-77913 in gamma-irradiated rats.
Topics: Amifostine; Animals; Cataract; Cesium Radioisotopes; Gamma Rays; Organothiophosphorus Compounds; Rad | 1986 |
Inhibition of lens opacification in x-irradiated rats treated with WR-77913.
Topics: Amifostine; Animals; Body Water; Cataract; Crystallins; Lens, Crystalline; Male; Organothiophosphoru | 1986 |