amifostine anhydrous has been researched along with Cancer of Endometrium in 5 studies
Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
amifostine : An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Radiation colitis was assessed by clinical, endoscopic and histolopathological criteria." | 2.75 | Randomized phase II exploratory study of prophylactic amifostine in cancer patients who receive radical radiotherapy to the pelvis. ( Bai, M; Batistatou, A; Briasoulis, E; Capizzello, A; Christodoulou, D; Karavasilis, V; Katsanos, KH; Panelos, I; Tolis, C; Tsekeris, P; Tsianos, EV, 2010) |
| "Among the poor-outcome endometrial cancers, there is a high frequency of TP53 mutations." | 1.36 | Amifostine enhancement of the anti-cancer effects of paclitaxel in endometrial cancer is TP53-dependent. ( Beck, BB; Dai, D; Elmaoued, R; Fischer, E; Leslie, KK; Luo, W; Meng, X; Wu, F, 2010) |
| "Paclitaxel IC50 value was reduced from 14 to 2 nmol/L with pretreatment of a single dose of 178 micromol/L of amifostine for 72 hours." | 1.33 | A potential synergistic anticancer effect of paclitaxel and amifostine on endometrial cancer. ( Dai, D; Davies, S; Holmes, AM; Leslie, KK; Nguyen, T; Theele, DP; Verschraegen, C, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Katsanos, KH | 1 |
| Briasoulis, E | 1 |
| Tsekeris, P | 1 |
| Batistatou, A | 1 |
| Bai, M | 1 |
| Tolis, C | 1 |
| Capizzello, A | 1 |
| Panelos, I | 1 |
| Karavasilis, V | 1 |
| Christodoulou, D | 1 |
| Tsianos, EV | 1 |
| Luo, W | 1 |
| Wu, F | 1 |
| Elmaoued, R | 1 |
| Beck, BB | 1 |
| Fischer, E | 1 |
| Meng, X | 1 |
| Leslie, KK | 2 |
| Dai, D | 2 |
| Kouvaris, J | 1 |
| Kouloulias, V | 1 |
| Malas, E | 1 |
| Antypas, C | 1 |
| Kokakis, J | 1 |
| Michopoulos, S | 1 |
| Matsopoulos, G | 1 |
| Vlahos, L | 1 |
| Scudder, SA | 1 |
| Liu, PY | 1 |
| Wilczynski, SP | 1 |
| Smith, HO | 1 |
| Jiang, C | 1 |
| Hallum, AV | 1 |
| Smith, GB | 1 |
| Hannigan, EV | 1 |
| Markman, M | 1 |
| Alberts, DS | 1 |
| Holmes, AM | 1 |
| Nguyen, T | 1 |
| Davies, S | 1 |
| Theele, DP | 1 |
| Verschraegen, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Trial of Paclitaxel and Carboplatin With Amifostine in Advanced Recurrent or Refractory Endometrial Adenocarcinoma[NCT00003127] | Phase 2 | 57 participants (Actual) | Interventional | 1998-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for amifostine anhydrous and Cancer of Endometrium
| Article | Year |
|---|---|
Randomized phase II exploratory study of prophylactic amifostine in cancer patients who receive radical radiotherapy to the pelvis.
Topics: Adult; Aged; Amifostine; Colitis; Combined Modality Therapy; Endometrial Neoplasms; Female; Follow-U | 2010 |
Amifostine as radioprotective agent for the rectal mucosa during irradiation of pelvic tumors. A phase II randomized study using various toxicity scales and rectosigmoidoscopy.
Topics: Aged; Amifostine; Chi-Square Distribution; Data Interpretation, Statistical; Endometrial Neoplasms; | 2003 |
Paclitaxel and carboplatin with amifostine in advanced, recurrent, or refractory endometrial adenocarcinoma: a phase II study of the Southwest Oncology Group.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Amifostine; Antineoplastic Combined Chemotherapy Protocols; | 2005 |
2 other studies available for amifostine anhydrous and Cancer of Endometrium
| Article | Year |
|---|---|
Amifostine enhancement of the anti-cancer effects of paclitaxel in endometrial cancer is TP53-dependent.
Topics: Amifostine; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; C | 2010 |
A potential synergistic anticancer effect of paclitaxel and amifostine on endometrial cancer.
Topics: Amifostine; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Growth Processe | 2005 |