amifostine anhydrous has been researched along with Cancer of Colon in 6 studies
Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
amifostine : An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A total of 92 patients with colorectal cancer or gastric cancer were enrolled, and randomly assigned to receive amifostine (500 mg/m2)(amifostine group, 46 patients) or glutamine (1500 mg/m2) (control group, 46 patients) just before oxaliplatin infusion." | 2.73 | [Prophylactic effect of amifostine on oxaliplatin-related neurotoxicity in patients with digestive tract tumors]. ( Fan, QX; Lu, P; Wang, LX; Wang, RL; Wang, X; Zong, H, 2008) |
| "By contrast, 60% of the tumors analyzed showed a loss of IAP expression in both epithelial cells and stroma, and only 10% to 15% of them demonstrated nuclear/cytoplasmic reactivity, which was confined to the epithelial cells." | 1.31 | Down-regulation of intestinal-type alkaline phosphatase in the tumor vasculature and stroma provides a strong basis for explaining amifostine selectivity. ( Giatromanolaki, A; Koukourakis, MI; Maltezos, E; Sivridis, E, 2002) |
| " injection of 200 mg/kg WR-2721 at 5 min prior to the administration of this combination enabled us to increase the CBDCA dose from a nontoxic level of 45 mg/kg to a normally toxic dose of 60 mg/kg in non-tumor-bearing BALB/c mice while maintaining the 5FU dose at 100 mg/kg." | 1.28 | Effect of WR-2721 on the toxicity and antitumor activity of the combination of carboplatin and 5-fluorouracil. ( Peters, GJ; Treskes, M; van der Vijgh, WJ; van der Wilt, CL; van Laar, JA, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lu, P | 1 |
| Fan, QX | 1 |
| Wang, LX | 1 |
| Wang, X | 1 |
| Zong, H | 1 |
| Wang, RL | 1 |
| Giatromanolaki, A | 1 |
| Sivridis, E | 1 |
| Maltezos, E | 1 |
| Koukourakis, MI | 1 |
| van der Wilt, CL | 2 |
| van Laar, JA | 2 |
| Gyergyay, F | 1 |
| Smid, K | 1 |
| Peters, GJ | 2 |
| Treskes, M | 1 |
| van der Vijgh, WJ | 1 |
| Rivoire, M | 1 |
| Bedwell, J | 1 |
| Chatlani, PT | 1 |
| MacRobert, AJ | 1 |
| Roberts, JE | 1 |
| Barr, H | 1 |
| Dillon, J | 1 |
| Bown, SG | 1 |
1 trial available for amifostine anhydrous and Cancer of Colon
| Article | Year |
|---|---|
[Prophylactic effect of amifostine on oxaliplatin-related neurotoxicity in patients with digestive tract tumors].
Topics: Amifostine; Antineoplastic Agents; Colonic Neoplasms; Female; Humans; Liver Neoplasms; Lung Neoplasm | 2008 |
5 other studies available for amifostine anhydrous and Cancer of Colon
| Article | Year |
|---|---|
Down-regulation of intestinal-type alkaline phosphatase in the tumor vasculature and stroma provides a strong basis for explaining amifostine selectivity.
Topics: Alkaline Phosphatase; Amifostine; Antigens, Neoplasm; Biomarkers, Tumor; Breast; Breast Neoplasms; C | 2002 |
Biochemical modification of the toxicity and the anti-tumour effect of 5-fluorouracil and cis-platinum by WR-2721 in mice.
Topics: Amifostine; Animals; Cisplatin; Colonic Neoplasms; Female; Fluorouracil; Leukopenia; Mice; Mice, Inb | 1992 |
Effect of WR-2721 on the toxicity and antitumor activity of the combination of carboplatin and 5-fluorouracil.
Topics: Amifostine; Anemia; Animals; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Colonic Ne | 1992 |
[Cancers of the colon and the rectum: news in 1992].
Topics: Amifostine; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Blood Transfusio | 1992 |
Enhanced tumour selectivity of photodynamic therapy in the rat colon using a radioprotective agent.
Topics: Aluminum; Amifostine; Animals; Colon; Colonic Neoplasms; Indoles; Laser Therapy; Light; Necrosis; Or | 1991 |