amifostine anhydrous has been researched along with Cancer, Embryonal in 4 studies
Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
amifostine : An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.
| Excerpt | Relevance | Reference |
|---|---|---|
| "High-dose cisplatin combined with etoposide and bleomycin (HDPEB) improves event-free survival (EFS) in advanced pediatric germ-cell tumors (PGCT), but has significant ototoxicity." | 1.33 | Amifostine does not protect against the ototoxicity of high-dose cisplatin combined with etoposide and bleomycin in pediatric germ-cell tumors: a Children's Oncology Group study. ( Billmire, DF; Chang, KW; Davis, MM; Frazier, AL; Giller, R; Lauer, SJ; London, WB; Malogolowkin, M; Marina, N; Olson, TA; Perlman, EJ; Rescorla, F; Womer, RB, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rick, O | 3 |
| Beyer, J | 3 |
| Schwella, N | 3 |
| Siegert, W | 3 |
| Marina, N | 1 |
| Chang, KW | 1 |
| Malogolowkin, M | 1 |
| London, WB | 1 |
| Frazier, AL | 1 |
| Womer, RB | 1 |
| Rescorla, F | 1 |
| Billmire, DF | 1 |
| Davis, MM | 1 |
| Perlman, EJ | 1 |
| Giller, R | 1 |
| Lauer, SJ | 1 |
| Olson, TA | 1 |
| Dubiel, M | 1 |
| Krusch, A | 1 |
| Hildebrandt, M | 1 |
| Schleicher, J | 2 |
| Serke, S | 1 |
| Schubart, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| High-Dose Cisplatin, Etoposide and Bleomycin (HD-PEB) Combined With Amifostine in Children With High-Risk Malignant Germ Cell Tumors - A POG Pilot Study[NCT00003811] | Phase 2 | 27 participants (Actual) | Interventional | 2000-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for amifostine anhydrous and Cancer, Embryonal
| Article | Year |
|---|---|
Influence of amifostine on reconstitution of lymphocyte subpopulations after conventional- and high-dose chemotherapy in patients with germ cell tumor.
Topics: Adult; Amifostine; Antineoplastic Combined Chemotherapy Protocols; CD4-CD8 Ratio; CD4-Positive T-Lym | 2002 |
PBPC mobilization with paclitaxel, ifosfamide, and G-CSF with or without amifostine: results of a prospective randomized trial.
Topics: Adult; Amifostine; Antigens, CD34; Blood Specimen Collection; Dose-Response Relationship, Drug; Gran | 2001 |
Assessment of amifostine as protection from chemotherapy-induced toxicities after conventional-dose and high-dose chemotherapy in patients with germ cell tumor.
Topics: Adult; Amifostine; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Granulocyte Colony-Sti | 2001 |
1 other study available for amifostine anhydrous and Cancer, Embryonal
| Article | Year |
|---|---|
Amifostine does not protect against the ototoxicity of high-dose cisplatin combined with etoposide and bleomycin in pediatric germ-cell tumors: a Children's Oncology Group study.
Topics: Adolescent; Amifostine; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Child; Child, Pre | 2005 |