amifostine anhydrous has been researched along with Brain Neoplasms in 6 studies
Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
amifostine : An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In Europe fotemustine (Muphoran) is widely used in the treatment of brain metastases in melanoma patients." | 9.08 | Combined treatment of stage IV melanoma patients with amifostine and fotemustine--a pilot study. ( Breitbart, E; Makki, A; Mohr, P; Schadendorf, D, 1998) |
| " In Europe fotemustine (Muphoran) is widely used in the treatment of brain metastases in melanoma patients." | 5.08 | Combined treatment of stage IV melanoma patients with amifostine and fotemustine--a pilot study. ( Breitbart, E; Makki, A; Mohr, P; Schadendorf, D, 1998) |
| " Doxorubicin, vincristine, etoposide, cisplatin, 4-hydroperoxycyclophosphamide and 4-hydroperoxyifosfamide were equally cytotoxic with and without preincubation of WR-2721 (14 mM) or WR-1065 (40 microM) as shown by virtually identical dose-response curves and ID50 values." | 1.30 | Effects of WR-2721 (amifostine) and its metabolite WR-1065 on the antiproliferative activity of chemotherapeutic agents on neuroblastoma cells in vitro. ( Berthold, F; Fulda, S; Oster, W, 1997) |
| " Toxicity assessments in the mouse yielded a LD50 of 297 mg/kg and in the rat 389 mg/kg." | 1.29 | Toxicity, biodistribution and radioprotective capacity of L-homocysteine thiolactone in CNS tissues and tumors in rodents: comparison with prior results with phosphorothioates. ( Ali-Osman, F; Chin, L; Dwyer-Hansen, L; Grunbaum, Z; Krohn, KA; Livesey, J; Nelson, N; Rasey, JS; Spence, AM; Stein, D, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Meyer, AK | 1 |
| Young, NM | 1 |
| Xiong, X | 1 |
| Tan, M | 1 |
| Boyett, J | 1 |
| Spence, AM | 1 |
| Rasey, JS | 1 |
| Dwyer-Hansen, L | 1 |
| Grunbaum, Z | 1 |
| Livesey, J | 1 |
| Chin, L | 1 |
| Nelson, N | 1 |
| Stein, D | 1 |
| Krohn, KA | 1 |
| Ali-Osman, F | 1 |
| Fulda, S | 1 |
| Oster, W | 1 |
| Berthold, F | 1 |
| Mohr, P | 1 |
| Makki, A | 1 |
| Breitbart, E | 1 |
| Schadendorf, D | 1 |
| Bergström, P | 1 |
| Johnsson, A | 1 |
| Bergenheim, T | 1 |
| Henriksson, R | 1 |
1 review available for amifostine anhydrous and Brain Neoplasms
| Article | Year |
|---|---|
Auditory late effects of chemotherapy.
Topics: Adolescent; Adult; Age Factors; Amifostine; Animals; Antineoplastic Agents; Brain Neoplasms; Child; | 2009 |
1 trial available for amifostine anhydrous and Brain Neoplasms
| Article | Year |
|---|---|
Combined treatment of stage IV melanoma patients with amifostine and fotemustine--a pilot study.
Topics: Amifostine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Brai | 1998 |
4 other studies available for amifostine anhydrous and Brain Neoplasms
| Article | Year |
|---|---|
A sequential procedure for monitoring clinical trials against historical controls.
Topics: Amifostine; Antineoplastic Agents; Brain Neoplasms; Child; Clinical Trials as Topic; Data Interpreta | 2007 |
Toxicity, biodistribution and radioprotective capacity of L-homocysteine thiolactone in CNS tissues and tumors in rodents: comparison with prior results with phosphorothioates.
Topics: Amifostine; Animals; Brain; Brain Neoplasms; Female; Homocysteine; Male; Mice; Mice, Inbred C3H; Rad | 1995 |
Effects of WR-2721 (amifostine) and its metabolite WR-1065 on the antiproliferative activity of chemotherapeutic agents on neuroblastoma cells in vitro.
Topics: Amifostine; Antineoplastic Agents; Biomarkers, Tumor; Brain Neoplasms; Cell Division; Cell Line; DNA | 1997 |
Effects of amifostine on cisplatin induced DNA adduct formation and toxicity in malignant glioma and normal tissues in rat.
Topics: Amifostine; Animals; Brain; Brain Neoplasms; Cell Division; Cell Line; Cisplatin; DNA Adducts; Gliom | 1999 |