amifostine anhydrous has been researched along with Bone Cancer in 11 studies
Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
amifostine : An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Topotecan had limited activity in patients with Ewing sarcoma or PNET metastatic at diagnosis." | 5.12 | Intensive therapy with growth factor support for patients with Ewing tumor metastatic at diagnosis: Pediatric Oncology Group/Children's Cancer Group Phase II Study 9457--a report from the Children's Oncology Group. ( Bernstein, ML; Devidas, M; Dickman, PS; Dubowy, R; Gebhardt, M; Goorin, A; Grier, HE; Lafreniere, D; Link, MP; Meyers, PA; Nicholas, R; Perlman, EJ; Souid, AK; Stine, K; Wainer, IW, 2006) |
| "The primary objective was to assess the efficacy of any medical intervention to prevent hearing loss in children with cancer treated with platinum-based therapy (that is including cisplatin, carboplatin and/or oxaliplatin) when compared to placebo, no additional treatment or a different protective medical intervention." | 4.90 | Medical interventions for the prevention of platinum-induced hearing loss in children with cancer. ( van As, JW; van Dalen, EC; van den Berg, H, 2014) |
| "At the moment there is no evidence from individual studies in children with osteosarcoma and hepatoblastoma treated with different platinum analogues and dosage schedules which underscores the use of amifostine as an otoprotective intervention as compared to no additional treatment." | 2.48 | Medical interventions for the prevention of platinum-induced hearing loss in children with cancer. ( van As, JW; van Dalen, EC; van den Berg, H, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| van As, JW | 2 |
| van den Berg, H | 2 |
| van Dalen, EC | 2 |
| Liu, YN | 1 |
| Liu, M | 1 |
| Ren, PY | 1 |
| Bernstein, ML | 2 |
| Devidas, M | 1 |
| Lafreniere, D | 1 |
| Souid, AK | 2 |
| Meyers, PA | 1 |
| Gebhardt, M | 1 |
| Stine, K | 1 |
| Nicholas, R | 1 |
| Perlman, EJ | 1 |
| Dubowy, R | 1 |
| Wainer, IW | 1 |
| Dickman, PS | 1 |
| Link, MP | 1 |
| Goorin, A | 1 |
| Grier, HE | 1 |
| Gallegos-Castorena, S | 1 |
| Martínez-Avalos, A | 1 |
| Mohar-Betancourt, A | 1 |
| Guerrero-Avendaño, G | 1 |
| Zapata-Tarrés, M | 1 |
| Medina-Sansón, A | 1 |
| Ozkaynak, MF | 1 |
| Sahdev, I | 1 |
| Gross, TG | 1 |
| Levine, JE | 1 |
| Cheerva, AC | 1 |
| Richards, MK | 1 |
| Rozans, MK | 1 |
| Shaw, PJ | 1 |
| Kadota, RP | 1 |
| Margulies, BS | 1 |
| Damron, TA | 1 |
| Allen, MJ | 1 |
| Ramnath, N | 1 |
| LoRusso, P | 1 |
| Simon, M | 1 |
| Martino, S | 1 |
| Fahey, RC | 1 |
| Dubowy, RL | 1 |
| Newton, GL | 1 |
| Rubin, P | 1 |
| Salazar, O | 1 |
| Zagars, G | 1 |
| Constine, LS | 1 |
| Keys, H | 1 |
| Poulter, CA | 1 |
| Van Ess, JD | 1 |
| Warrell, RP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| INTENSIVE THERAPY WITH GROWTH FACTOR SUPPORT FOR PATIENTS WITH EWING'S TUMOR METASTATIC AT DIAGNOSIS: A PEDIATRIC ONCOLOGY GROUP PHASE II STUDY[NCT00002643] | Phase 2 | 130 participants (Actual) | Interventional | 1995-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for amifostine anhydrous and Bone Cancer
| Article | Year |
|---|---|
Medical interventions for the prevention of platinum-induced hearing loss in children with cancer.
Topics: Adolescent; Amifostine; Antineoplastic Agents; Bone Neoplasms; Carboplatin; Child; Child, Preschool; | 2014 |
Medical interventions for the prevention of platinum-induced hearing loss in children with cancer.
Topics: Adolescent; Amifostine; Antineoplastic Agents; Bone Neoplasms; Carboplatin; Child; Child, Preschool; | 2012 |
6 trials available for amifostine anhydrous and Bone Cancer
| Article | Year |
|---|---|
Intensive therapy with growth factor support for patients with Ewing tumor metastatic at diagnosis: Pediatric Oncology Group/Children's Cancer Group Phase II Study 9457--a report from the Children's Oncology Group.
Topics: Adolescent; Adult; Amifostine; Bone Neoplasms; Child; Child, Preschool; Cyclophosphamide; Female; Hu | 2006 |
Toxicity prevention with amifostine in pediatric osteosarcoma patients treated with cisplatin and doxorubicin.
Topics: Adolescent; Amifostine; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; | 2007 |
A pilot study of addition of amifostine to melphalan, carboplatin, etoposide, and cyclophosphamide with autologous hematopoietic stem cell transplantation in pediatric solid tumors-A pediatric blood and marrow transplant consortium study.
Topics: Adolescent; Adult; Amifostine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplan | 2008 |
Phase II evaluation of cisplatin and WR2721 for refractory metastatic breast cancer.
Topics: Adult; Aged; Amifostine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone | 1997 |
WR-2721 (amifostine) infusion in patients with Ewing's sarcoma receiving ifosfamide and cyclophosphamide with mesna: drug and thiol levels in plasma and blood cells, a Pediatric Oncology Group study.
Topics: Adolescent; Adult; Amifostine; Antineoplastic Combined Chemotherapy Protocols; Blood Cells; Bone Neo | 1999 |
Systemic hemibody irradiation for overt and occult metastases.
Topics: Amifostine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; C | 1985 |
3 other studies available for amifostine anhydrous and Bone Cancer
| Article | Year |
|---|---|
[Drug delivery of CPC/amifostine/cisplatin complex in vitro and its ability in repairing bone defect and eliminating tumor in vivo].
Topics: Amifostine; Animals; Bone Cements; Bone Neoplasms; Calcium Phosphates; Cisplatin; Drug Delivery Syst | 2010 |
The differential effects of the radioprotectant drugs amifostine and sodium selenite treatment in combination with radiation therapy on constituent bone cells, Ewing's sarcoma of bone tumor cells, and rhabdomyosarcoma tumor cells in vitro.
Topics: Amifostine; Animals; Bone Neoplasms; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitum | 2008 |
New inhibitors of osteolysis: implications for hypercalcemia and bone metastases.
Topics: Amifostine; Bone Neoplasms; Bone Resorption; Clodronic Acid; Diphosphonates; Humans; Hypercalcemia; | 1986 |