amifostine anhydrous has been researched along with Benign Neoplasms, Brain in 6 studies
Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
amifostine : An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In Europe fotemustine (Muphoran) is widely used in the treatment of brain metastases in melanoma patients." | 9.08 | Combined treatment of stage IV melanoma patients with amifostine and fotemustine--a pilot study. ( Breitbart, E; Makki, A; Mohr, P; Schadendorf, D, 1998) |
| " In Europe fotemustine (Muphoran) is widely used in the treatment of brain metastases in melanoma patients." | 5.08 | Combined treatment of stage IV melanoma patients with amifostine and fotemustine--a pilot study. ( Breitbart, E; Makki, A; Mohr, P; Schadendorf, D, 1998) |
| " Doxorubicin, vincristine, etoposide, cisplatin, 4-hydroperoxycyclophosphamide and 4-hydroperoxyifosfamide were equally cytotoxic with and without preincubation of WR-2721 (14 mM) or WR-1065 (40 microM) as shown by virtually identical dose-response curves and ID50 values." | 1.30 | Effects of WR-2721 (amifostine) and its metabolite WR-1065 on the antiproliferative activity of chemotherapeutic agents on neuroblastoma cells in vitro. ( Berthold, F; Fulda, S; Oster, W, 1997) |
| " Toxicity assessments in the mouse yielded a LD50 of 297 mg/kg and in the rat 389 mg/kg." | 1.29 | Toxicity, biodistribution and radioprotective capacity of L-homocysteine thiolactone in CNS tissues and tumors in rodents: comparison with prior results with phosphorothioates. ( Ali-Osman, F; Chin, L; Dwyer-Hansen, L; Grunbaum, Z; Krohn, KA; Livesey, J; Nelson, N; Rasey, JS; Spence, AM; Stein, D, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Meyer, AK | 1 |
| Young, NM | 1 |
| Xiong, X | 1 |
| Tan, M | 1 |
| Boyett, J | 1 |
| Spence, AM | 1 |
| Rasey, JS | 1 |
| Dwyer-Hansen, L | 1 |
| Grunbaum, Z | 1 |
| Livesey, J | 1 |
| Chin, L | 1 |
| Nelson, N | 1 |
| Stein, D | 1 |
| Krohn, KA | 1 |
| Ali-Osman, F | 1 |
| Fulda, S | 1 |
| Oster, W | 1 |
| Berthold, F | 1 |
| Mohr, P | 1 |
| Makki, A | 1 |
| Breitbart, E | 1 |
| Schadendorf, D | 1 |
| Bergström, P | 1 |
| Johnsson, A | 1 |
| Bergenheim, T | 1 |
| Henriksson, R | 1 |
1 review available for amifostine anhydrous and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Auditory late effects of chemotherapy.
Topics: Adolescent; Adult; Age Factors; Amifostine; Animals; Antineoplastic Agents; Brain Neoplasms; Child; | 2009 |
1 trial available for amifostine anhydrous and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Combined treatment of stage IV melanoma patients with amifostine and fotemustine--a pilot study.
Topics: Amifostine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Brai | 1998 |
4 other studies available for amifostine anhydrous and Benign Neoplasms, Brain
| Article | Year |
|---|---|
A sequential procedure for monitoring clinical trials against historical controls.
Topics: Amifostine; Antineoplastic Agents; Brain Neoplasms; Child; Clinical Trials as Topic; Data Interpreta | 2007 |
Toxicity, biodistribution and radioprotective capacity of L-homocysteine thiolactone in CNS tissues and tumors in rodents: comparison with prior results with phosphorothioates.
Topics: Amifostine; Animals; Brain; Brain Neoplasms; Female; Homocysteine; Male; Mice; Mice, Inbred C3H; Rad | 1995 |
Effects of WR-2721 (amifostine) and its metabolite WR-1065 on the antiproliferative activity of chemotherapeutic agents on neuroblastoma cells in vitro.
Topics: Amifostine; Antineoplastic Agents; Biomarkers, Tumor; Brain Neoplasms; Cell Division; Cell Line; DNA | 1997 |
Effects of amifostine on cisplatin induced DNA adduct formation and toxicity in malignant glioma and normal tissues in rat.
Topics: Amifostine; Animals; Brain; Brain Neoplasms; Cell Division; Cell Line; Cisplatin; DNA Adducts; Gliom | 1999 |