amifostine anhydrous has been researched along with Acute Radiation Syndrome in 4 studies
Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
amifostine : An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.
Acute Radiation Syndrome: A condition caused by a brief whole body exposure to more than one sievert dose equivalent of radiation. Acute radiation syndrome is initially characterized by ANOREXIA; NAUSEA; VOMITING; but can progress to hematological, gastrointestinal, neurological, pulmonary, and other major organ dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin (250 mg/kg) was effective in protecting splenic cells from a 7 Gy dose in vivo (protection factor = 1." | 1.40 | Metformin exhibits radiation countermeasures efficacy when used alone or in combination with sulfhydryl containing drugs. ( Grdina, DJ; Miller, RC; Murley, JS, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hofer, M | 1 |
| Hoferová, Z | 1 |
| Depeš, D | 1 |
| Falk, M | 1 |
| Miller, RC | 1 |
| Murley, JS | 1 |
| Grdina, DJ | 1 |
| Chen, CH | 1 |
| Kuo, ML | 1 |
| Wang, JL | 1 |
| Liao, WC | 1 |
| Chang, LC | 1 |
| Chan, LP | 1 |
| Lin, J | 1 |
| Lee, HJ | 1 |
| Kim, JS | 1 |
| Song, MS | 1 |
| Seo, HS | 1 |
| Yang, M | 1 |
| Kim, JC | 1 |
| Jo, SK | 1 |
| Shin, T | 1 |
| Moon, C | 1 |
| Kim, SH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I Study to Evaluate the Safety and Pharmacokinetics of RadProtect® in Healthy Volunteers[NCT02587442] | Phase 1 | 27 participants (Anticipated) | Interventional | 2015-10-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for amifostine anhydrous and Acute Radiation Syndrome
| Article | Year |
|---|---|
Combining Pharmacological Countermeasures to Attenuate the Acute Radiation Syndrome-A Concise Review.
Topics: Acute Radiation Syndrome; Amifostine; Animals; Dinoprostone; Drug Administration Schedule; Drug Comb | 2017 |
3 other studies available for amifostine anhydrous and Acute Radiation Syndrome
| Article | Year |
|---|---|
Metformin exhibits radiation countermeasures efficacy when used alone or in combination with sulfhydryl containing drugs.
Topics: Acetylcysteine; Acute Radiation Syndrome; Amifostine; Animals; Captopril; Cell Line, Transformed; Ce | 2014 |
CCM-AMI, a Polyethylene Glycol Micelle with Amifostine, as an Acute Radiation Syndrome Protectant in C57BL/6 Mice.
Topics: Acute Radiation Syndrome; Amifostine; Animals; Disease Models, Animal; Dose-Response Relationship, R | 2015 |
Amifostine ameliorates recognition memory defect in acute radiation syndrome caused by relatively low-dose of gamma radiation.
Topics: Acute Radiation Syndrome; Amifostine; Animals; Apoptosis; Doublecortin Protein; Gamma Rays; Hippocam | 2010 |