amifostine anhydrous has been researched along with Acute Liver Injury, Drug-Induced in 10 studies
Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
amifostine : An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Administration of the radioprotective agent 2-(3-aminopropylamino) ethylphosphorothioic acid (WR2721) at 3 or 6 hr after carbon tetrachloride (CCl4) administration significantly prevented the liver necrosis produced by the hepatotoxin at 24 hr." | 7.69 | Radioprotectors as late preventive agents against carbon tetrachloride induced liver necrosis: protection by 2-(3-aminopropylamino) ethylphosphorothioic acid (WR2721). ( Castro, JA; de Castro, CR; Valles, EG, 1995) |
| "Administration of the radioprotective agent 2-(3-aminopropylamino) ethylphosphorothioic acid (WR2721) at 3 or 6 hr after carbon tetrachloride (CCl4) administration significantly prevented the liver necrosis produced by the hepatotoxin at 24 hr." | 3.69 | Radioprotectors as late preventive agents against carbon tetrachloride induced liver necrosis: protection by 2-(3-aminopropylamino) ethylphosphorothioic acid (WR2721). ( Castro, JA; de Castro, CR; Valles, EG, 1995) |
| " The aim of our study was to investigate amifostine effects on doxorubicin-induced toxic changes in rats." | 1.48 | The Efficacy of Amifostine against Multiple-Dose Doxorubicin-Induced Toxicity in Rats. ( Bokonjić, D; Dobrić, S; Dragojević-Simić, V; Jaćević, V; Kovačević, A; Kuča, K; Nepovimova, E; Tatomirović, Ž; Vališ, M, 2018) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| " 6 h after poisoning in three cumulative dosing groups: 250 mg/kg; 500 mg/kg; and 1600 mg/kg." | 1.33 | Use of amifostine, a novel cytoprotective, in alpha-amanitin poisoning. ( Haller, NA; Peter, D; White, LJ; Wills, BK, 2005) |
| " Although several approaches have been proposed to challenge the toxic action(s) of SM, no satisfactory treatment regimen has evolved." | 1.31 | Protective effects of amifostine and its analogues on sulfur mustard toxicity in vitro and in vivo. ( Bhattacharya, R; Kulkarni, A; Kumar, P; Pant, SC; Pathak, U; Rao, PV; Tulsawani, RK; Vijayaraghavan, R, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Jaćević, V | 1 |
| Dragojević-Simić, V | 1 |
| Tatomirović, Ž | 1 |
| Dobrić, S | 1 |
| Bokonjić, D | 1 |
| Kovačević, A | 1 |
| Nepovimova, E | 1 |
| Vališ, M | 1 |
| Kuča, K | 1 |
| Akbulut, S | 1 |
| Elbe, H | 1 |
| Eris, C | 1 |
| Dogan, Z | 1 |
| Toprak, G | 1 |
| Otan, E | 1 |
| Erdemli, E | 1 |
| Turkoz, Y | 1 |
| Anand, T | 1 |
| Vijayaraghavan, R | 2 |
| Rao, PV | 2 |
| Bansal, I | 1 |
| Bhattacharya, BK | 1 |
| Bleyer, A | 1 |
| Alberts, DS | 1 |
| Wills, BK | 1 |
| Haller, NA | 1 |
| Peter, D | 1 |
| White, LJ | 1 |
| Valles, EG | 1 |
| de Castro, CR | 1 |
| Castro, JA | 1 |
| Bhattacharya, R | 1 |
| Pant, SC | 1 |
| Kumar, P | 1 |
| Tulsawani, RK | 1 |
| Pathak, U | 1 |
| Kulkarni, A | 1 |
1 review available for amifostine anhydrous and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
9 other studies available for amifostine anhydrous and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
The Efficacy of Amifostine against Multiple-Dose Doxorubicin-Induced Toxicity in Rats.
Topics: Amifostine; Animals; Chemical and Drug Induced Liver Injury; Doxorubicin; Kidney Diseases; Male; Org | 2018 |
Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats.
Topics: Acetylcysteine; Amifostine; Animals; Antioxidants; Ascorbic Acid; Biomarkers; Chemical and Drug Indu | 2014 |
Attenuation of sulfur mustard toxicity by S-2(2-aminoethylamino)ethyl phenyl sulfide (DRDE-07) in mouse liver.
Topics: Amifostine; Animals; Chemical and Drug Induced Liver Injury; Chemical Warfare Agents; Female; Mice; | 2011 |
Re: Sodium thiosulfate in cisplatin overdose by Erdlenbruch B et al., Med Pediatr Oncol 2002;38:349-352.
Topics: Amifostine; Antineoplastic Agents; Chelating Agents; Chemical and Drug Induced Liver Injury; Cisplat | 2003 |
Use of amifostine, a novel cytoprotective, in alpha-amanitin poisoning.
Topics: Amanitins; Amifostine; Animals; Cell Death; Chemical and Drug Induced Liver Injury; Dose-Response Re | 2005 |
Radioprotectors as late preventive agents against carbon tetrachloride induced liver necrosis: protection by 2-(3-aminopropylamino) ethylphosphorothioic acid (WR2721).
Topics: Alkaline Phosphatase; Amifostine; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 1995 |
Protective effects of amifostine and its analogues on sulfur mustard toxicity in vitro and in vivo.
Topics: Amifostine; Animals; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Female; L-Lactate De | 2001 |