amifampridine has been researched along with Palsy in 8 studies
Amifampridine: 4-Aminopyridine derivative that acts as a POTASSIUM CHANNEL blocker to increase release of ACETYLCHOLINE from nerve terminals. It is used in the treatment of CONGENITAL MYASTHENIC SYNDROMES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "4-Aminopyridine and 3,4-diaminopyridine were evaluated for their abilities to delay the onset of paralysis due to botulinum neurotoxin types A, B, and E." | 3.67 | A preclinical evaluation of aminopyridines as putative therapeutic agents in the treatment of botulism. ( Simpson, LL, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Vazquez-Cintron, E | 1 |
| Machamer, J | 1 |
| Ondeck, C | 1 |
| Pagarigan, K | 1 |
| Winner, B | 1 |
| Bodner, P | 1 |
| Kelly, K | 1 |
| Pennington, MR | 1 |
| McNutt, P | 1 |
| Beske, PH | 1 |
| Hoffman, KM | 1 |
| Machamer, JB | 1 |
| Eisen, MR | 1 |
| McNutt, PM | 1 |
| Adler, M | 3 |
| Deshpande, SS | 2 |
| Apland, JP | 1 |
| Murray, B | 1 |
| Borrell, A | 1 |
| Morbiato, L | 1 |
| Carli, L | 1 |
| Johnson, EA | 1 |
| Montecucco, C | 1 |
| Molgó, J | 1 |
| Rossetto, O | 1 |
| Blair, KL | 1 |
| Bennett, JL | 1 |
| Pax, RA | 1 |
| Macdonald, DA | 1 |
| Sellin, LC | 1 |
| Parker, GW | 1 |
| Capacio, B | 1 |
| Simpson, LL | 1 |
8 other studies available for amifampridine and Palsy
| Article | Year |
|---|---|
Symptomatic treatment of botulism with a clinically approved small molecule.
Topics: Amifampridine; Animals; Antitoxins; Botulinum Toxins; Botulinum Toxins, Type A; Botulism; Disease Mo | 2020 |
Use-dependent potentiation of voltage-gated calcium channels rescues neurotransmission in nerve terminals intoxicated by botulinum neurotoxin serotype A.
Topics: Amifampridine; Animals; Botulinum Toxins, Type A; Botulism; Calcium; Calcium Channels; Excitatory Po | 2017 |
Reversal of BoNT/A-mediated inhibition of muscle paralysis by 3,4-diaminopyridine and roscovitine in mouse phrenic nerve-hemidiaphragm preparations.
Topics: 4-Aminopyridine; Amifampridine; Animals; Botulinum Toxins, Type A; Diaphragm; Male; Mice; Paralysis; | 2012 |
Neuromuscular paralysis and recovery in mice injected with botulinum neurotoxins A and C.
Topics: 4-Aminopyridine; Amifampridine; Animals; Botulinum Toxins; Botulinum Toxins, Type A; Drug Resistance | 2007 |
Serotonin and acetylcholine: further analysis of praziquantel-induced contraction of magnesium-paralysed Schistosoma mansoni.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; Amifampridine; Animals; Arecoline; Carbachol; Colforsi | 1993 |
Effect of 3,4-diaminopyridine on rat extensor digitorum longus muscle paralyzed by local injection of botulinum neurotoxin.
Topics: 4-Aminopyridine; Amifampridine; Animals; Botulinum Toxins; Drug Interactions; Male; Muscle, Skeletal | 1996 |
Antagonism of botulinum toxin A-mediated muscle paralysis by 3, 4-diaminopyridine delivered via osmotic minipumps.
Topics: 4-Aminopyridine; Amifampridine; Animals; Botulinum Toxins, Type A; Drug Delivery Systems; Hindlimb; | 2000 |
A preclinical evaluation of aminopyridines as putative therapeutic agents in the treatment of botulism.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Botulinum Toxins; Botulism; Dose-Response R | 1986 |