amifampridine has been researched along with Muscle Contraction in 39 studies
Amifampridine: 4-Aminopyridine derivative that acts as a POTASSIUM CHANNEL blocker to increase release of ACETYLCHOLINE from nerve terminals. It is used in the treatment of CONGENITAL MYASTHENIC SYNDROMES.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The antagonisms to the d-tubocurarine-induced neuromuscular blockade by neostigmine and 3,4-diaminopyridine (DAP) were studied quantitatively in the isolated phrenic nerve-diaphragm preparation of mice in vitro and in lethality of mice in vivo by assaying concentrations of d-tubocurarine needed to produce 70% block of indirect muscle contraction and LD50, respectively." | 3.67 | Potentiation between neostigmine and 3,4-diaminopyridine in antagonizing the neuromuscular block induced by D-tubocurarine. ( Chang, CC; Hong, SJ; Lin, HL; Shieh, BH; Su, MJ, 1984) |
| "Nifedipine was also effective in these models, but propranolol was not." | 1.29 | Antianginal effects of YM-16151-4 in various experimental angina models. ( Asano, M; Shibasaki, K; Takenaka, T; Uchida, W, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (51.28) | 18.7374 |
| 1990's | 10 (25.64) | 18.2507 |
| 2000's | 7 (17.95) | 29.6817 |
| 2010's | 2 (5.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thyagarajan, B | 1 |
| Potian, JG | 1 |
| Garcia, CC | 1 |
| Hognason, K | 1 |
| Capková, K | 1 |
| Moe, ST | 1 |
| Jacobson, AR | 1 |
| Janda, KD | 1 |
| McArdle, JJ | 1 |
| Uchida, Y | 5 |
| Maezawa, Y | 2 |
| Nakamura, F | 1 |
| van Lunteren, E | 5 |
| Moyer, M | 5 |
| Armstrong, ML | 1 |
| Dua, AK | 1 |
| Murrant, CL | 1 |
| Morbiato, L | 1 |
| Carli, L | 1 |
| Johnson, EA | 1 |
| Montecucco, C | 1 |
| Molgó, J | 2 |
| Rossetto, O | 1 |
| Ionno, M | 1 |
| Pollarine, J | 1 |
| Chang, CC | 2 |
| Su, MJ | 1 |
| Shieh, BH | 1 |
| Lin, HL | 1 |
| Hong, SJ | 2 |
| Khan, RA | 1 |
| Lemeignan, M | 3 |
| Fukushima, K | 1 |
| Aoki, T | 1 |
| Ishikawa, J | 1 |
| Miledi, R | 1 |
| Parker, I | 1 |
| Zhu, PH | 1 |
| Blair, KL | 1 |
| Bennett, JL | 1 |
| Pax, RA | 1 |
| Uchida, W | 2 |
| Shibasaki, K | 2 |
| Asano, M | 2 |
| Takenaka, T | 2 |
| Braga, MF | 1 |
| Rowan, EG | 1 |
| Harvey, AL | 2 |
| Bowman, WC | 1 |
| Gilly, WF | 1 |
| Scheuer, T | 1 |
| Sadraei, H | 1 |
| Beech, DJ | 1 |
| Velasco, A | 1 |
| Maroto, M | 1 |
| Dueñas, A | 1 |
| Carvajal, A | 1 |
| Fernández de la Gándara, F | 1 |
| Nieto, A | 1 |
| Arai, Y | 1 |
| Okazaki, T | 1 |
| Maddison, P | 1 |
| Newsom-Davis, J | 1 |
| Mills, KR | 1 |
| Mistry, DK | 1 |
| Garland, CJ | 1 |
| Adler, M | 1 |
| Capacio, B | 1 |
| Deshpande, SS | 1 |
| Bauer, V | 1 |
| Sugimoto, T | 2 |
| Cook, NS | 1 |
| Marshall, DL | 1 |
| Khan, AR | 1 |
| Gibb, AJ | 1 |
| Marshall, IG | 1 |
| Kuromaru, O | 1 |
| Sakai, K | 1 |
| Uchiyama, T | 1 |
| Lechat, P | 1 |
| Roa, J | 1 |
| Montoya, GA | 1 |
| Fang, XM | 1 |
| Zhang, YP | 1 |
| Shi, YL | 1 |
| Wang, WP | 1 |
| Sonoki, H | 1 |
| Tomaru, T | 1 |
| Nakazawa, M | 1 |
| Mustafa, SJ | 1 |
| Delbono, O | 1 |
| Kotsias, BA | 1 |
| Oba, T | 1 |
| Hotta, K | 1 |
| Jou, MJ | 1 |
| Chiou, LC | 1 |
39 other studies available for amifampridine and Muscle Contraction
| Article | Year |
|---|---|
Effects of hydroxamate metalloendoprotease inhibitors on botulinum neurotoxin A poisoned mouse neuromuscular junctions.
Topics: 4-Aminopyridine; Acetylcholine; Amifampridine; Animals; Antidotes; Botulinum Toxins, Type A; Calcium | 2010 |
Role of calcium-activated potassium channels in the genesis of 3,4-diaminopyridine-induced periodic contractions in isolated canine coronary artery smooth muscles.
Topics: 4-Aminopyridine; Adrenergic beta-Agonists; Amifampridine; Animals; Calcium Channel Agonists; Calcium | 2011 |
Improvement of dy/dy dystrophic diaphragm by 3,4-diaminopyridine.
Topics: 4-Aminopyridine; Amifampridine; Animals; Diaphragm; Disease Models, Animal; Electric Stimulation; Ho | 2002 |
Wheel-running exercise alters rat diaphragm action potentials and their regulation by K+ channels.
Topics: 4-Aminopyridine; Action Potentials; Amifampridine; Animals; Diaphragm; Male; Motor Activity; Muscle | 2003 |
Sternohyoid muscle fatigue properties of dy/dy dystrophic mice, an animal model of merosin-deficient congenital muscular dystrophy.
Topics: 4-Aminopyridine; Amifampridine; Animals; Disease Models, Animal; Electric Stimulation; Humans; In Vi | 2003 |
Potassium initiates vasodilatation induced by a single skeletal muscle contraction in hamster cremaster muscle.
Topics: 4-Aminopyridine; Amifampridine; Animals; Arterioles; Barium Compounds; Chlorides; Cricetinae; Electr | 2007 |
Neuromuscular paralysis and recovery in mice injected with botulinum neurotoxins A and C.
Topics: 4-Aminopyridine; Amifampridine; Animals; Botulinum Toxins; Botulinum Toxins, Type A; Drug Resistance | 2007 |
Inotropic effects of the K+ channel blocker 3,4-diaminopyridine on fatigued diaphragm muscle.
Topics: 4-Aminopyridine; Action Potentials; Amifampridine; Animals; Diaphragm; Electric Stimulation; Electro | 2008 |
Potentiation between neostigmine and 3,4-diaminopyridine in antagonizing the neuromuscular block induced by D-tubocurarine.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Drug Synergism; Female; Male; Mice; Muscle | 1984 |
Effects of 3,4-diaminopyridine on mechanical and electrical responses of frog single muscle fibres.
Topics: 4-Aminopyridine; Action Potentials; Amifampridine; Aminopyridines; Animals; In Vitro Techniques; Ion | 1983 |
[Antagonistic effects of neostigmine, 4-aminopyridine and 3,4-diaminopyridine on muscle relaxing effects of d-tubocurarine].
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Muscle Contraction; Muscle Relaxation; Neos | 1983 |
Extracellular ions and excitation-contraction coupling in frog twitch muscle fibres.
Topics: 4-Aminopyridine; Action Potentials; Amifampridine; Aminopyridines; Animals; Arsenazo III; Calcium; C | 1984 |
Serotonin and acetylcholine: further analysis of praziquantel-induced contraction of magnesium-paralysed Schistosoma mansoni.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; Amifampridine; Animals; Arecoline; Carbachol; Colforsi | 1993 |
Antianginal effects of YM-16151-4 in various experimental angina models.
Topics: 4-Aminopyridine; Amifampridine; Angina Pectoris; Animals; Arginine Vasopressin; Atrioventricular Nod | 1993 |
Interactions between suxamethonium and non-depolarizing neuromuscular blocking drugs.
Topics: 4-Aminopyridine; Action Potentials; Amifampridine; Animals; Cats; Drug Interactions; Female; In Vitr | 1994 |
Voltage-dependent calcium and potassium conductances in striated muscle fibers from the scorpion, Centruroides sculpturatus.
Topics: 4-Aminopyridine; Amifampridine; Animals; Barium; Calcium; Calcium Channels; Cell Membrane; Electric | 1993 |
Ionic currents and inhibitory effects of glibenclamide in seminal vesicle smooth muscle cells.
Topics: 4-Aminopyridine; Amifampridine; Animals; Barium; Biological Transport, Active; Cadmium; Calcium; Cal | 1995 |
Effect of 4-aminopyridine and 3,4-diaminopyridine on guinea-pig isolated ileum.
Topics: 4-Aminopyridine; Acetylcholine; Amifampridine; Animals; Atropine; Calcium Channel Blockers; Diazoxid | 1997 |
Antianginal effects of YM430, a novel calcium entry-blocking and beta-adrenoceptor-blocking agent in several experimental angina models.
Topics: 4-Aminopyridine; Adrenergic beta-Antagonists; Amifampridine; Angina Pectoris; Animals; Calcium Chann | 1997 |
Effect of 3,4-diaminopyridine on the time course of decay of compound muscle action potential augmentation in the Lambert-Eaton myasthenic syndrome.
Topics: 4-Aminopyridine; Action Potentials; Adult; Aged; Amifampridine; Female; Fingers; Humans; Lambert-Eat | 1998 |
Electrophysiologic and inotropic effects of K+-channel blockade in aged diaphragm.
Topics: 4-Aminopyridine; Action Potentials; Adenosine Triphosphate; Aging; Amifampridine; Analysis of Varian | 1998 |
The influence of phenylephrine outward potassium currents in single smooth muscle cells from the rabbit mesenteric artery.
Topics: 4-Aminopyridine; Adrenergic alpha-Antagonists; Amifampridine; Animals; Caffeine; Calcium; Chelating | 1999 |
Antagonism of botulinum toxin A-mediated muscle paralysis by 3, 4-diaminopyridine delivered via osmotic minipumps.
Topics: 4-Aminopyridine; Amifampridine; Animals; Botulinum Toxins, Type A; Drug Delivery Systems; Hindlimb; | 2000 |
Effects of 3,4-diaminopyridine and tetraethylammonium on the pre- and post-junctional alpha-adrenoceptor mediated inhibitory actions of noradrenaline in the guinea-pig ileum.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Atropine; Electric Stimulation; Female; Gui | 1985 |
The effects of nicorandil on phasic contractions of isolated canine coronary artery.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Calmodulin; Coronary Vessels; Dogs; Ergonov | 1987 |
Effect of some potassium channel blockers on contractile responses of the rabbit aorta.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Aorta, Thoracic; Apamin; Calcium Channel Bl | 1989 |
Block of potassium channels and facilitation of acetylcholine release at the neuromuscular junction by the venom of the scorpion, Pandinus imperator.
Topics: 4-Aminopyridine; Acetylcholine; Action Potentials; Amifampridine; Aminopyridines; Animals; Chickens; | 1989 |
Effects of toxin II from the sea anemone Anemonia sulcata on contractile and electrical responses of frog skeletal muscle fibres.
Topics: 4-Aminopyridine; Action Potentials; Amifampridine; Aminopyridines; Animals; Cnidarian Venoms; Formam | 1986 |
Nicotinic antagonists produce differing amounts of tetanic fade in the isolated diaphragm of the rat.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Diaphragm; Electric Stimulation; Erabutoxin | 1986 |
Effects of nicorandil on the rhythmic contractile response of isolated miniature pig coronary artery to 3,4-diaminopyridine: comparison with nitroglycerin.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Coronary Vasospasm; Coronary Vessels; Femal | 1986 |
Equipotency of anti-curare activity of 4-aminopyridine and 3,4-diaminopyridine in anesthetized rats.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Anesthesia; Animals; In Vitro Techniques; Male; Musc | 1985 |
The effects of hemicholinium-3 (Hc-3) during tetanic (TP) and posttetanic potentiation (PTP) on sympathetic ganglion.
Topics: 4-Aminopyridine; Action Potentials; Amifampridine; Aminopyridines; Animals; Anura; Calcium; Electric | 1986 |
[Antagonism of the neuromuscular-blocking effect of polymyxin B by 3,4-diaminopyridine].
Topics: 4-Aminopyridine; Action Potentials; Amifampridine; Aminopyridines; Animals; Female; Male; Muscle Con | 1987 |
Decreasing potassium conductance--a possible mechanism of phasic coronary vasospasm.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Calcium; Coronary Vasospasm; Coronary Vesse | 1985 |
[Effects of 3,4-diaminopyridine on the contractions of guinea-pig tracheal smooth muscle induced by histamine and prostaglandin D2].
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Drug Synergism; Guinea Pigs; Histamine; In | 1988 |
Effects of adenosine and calcium entry blockers on 3,4-diaminopyridine-induced rhythmic contractions in dog coronary artery.
Topics: 4-Aminopyridine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Amifampridine; Aminopyridines; Animal | 1988 |
Relation between action potential duration and mechanical activity on rat diaphragm fibers. Effects of 3,4-diaminopyridine and tetraethylammonium.
Topics: 4-Aminopyridine; Action Potentials; Amifampridine; Aminopyridines; Animals; Caffeine; In Vitro Techn | 1987 |
Effects of extracellular calcium and calcium channel blocker on silver-induced contractures in frog skeletal muscle fibers.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Calcium; Calcium Channel Blockers; Diltiaze | 1987 |
Pre- and postsynaptic effects of nicotine on the mouse phrenic nerve-diaphragm preparation.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Calcium; Diaphragm; Electric Stimulation; F | 1987 |