Page last updated: 2024-10-22

amfenac and Retinoblastoma

amfenac has been researched along with Retinoblastoma in 1 studies

amfenac: RN given refers to parent cpd; structure
amfenac : An oxo monocarboxylic acid that is benzophenone in which one of the phenyl groups is substituted by an amino group and a carboxymethyl group at position 2 and 3, respectively. The corresponding carboxamide, nepafenac, is a prodrug of amfenac and is used for the treatment of pain and inflammation following cataract surgery.

Retinoblastoma: A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)

Research Excerpts

ExcerptRelevanceReference
"When amfenac was added to both of the cell lines, a statistically significant reduction in proliferation was observed in both cell lines."1.33The effect of a selective cyclooxygenase-2 (COX-2) inhibitor on the proliferation rate of retinoblastoma cell lines. ( Anteka, E; Burnier, MN; Correa, ZM; Coutinho, AB; de Souza Filho, JP; Marshall, JC; Martins, MC, 2006)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
de Souza Filho, JP1
Correa, ZM1
Marshall, JC1
Anteka, E1
Coutinho, AB1
Martins, MC1
Burnier, MN1

Other Studies

1 other study available for amfenac and Retinoblastoma

ArticleYear
The effect of a selective cyclooxygenase-2 (COX-2) inhibitor on the proliferation rate of retinoblastoma cell lines.
    Eye (London, England), 2006, Volume: 20, Issue:5

    Topics: Blotting, Western; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Phenyl

2006
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