Page last updated: 2024-10-22

amfenac and Inflammation

amfenac has been researched along with Inflammation in 3 studies

amfenac: RN given refers to parent cpd; structure
amfenac : An oxo monocarboxylic acid that is benzophenone in which one of the phenyl groups is substituted by an amino group and a carboxymethyl group at position 2 and 3, respectively. The corresponding carboxamide, nepafenac, is a prodrug of amfenac and is used for the treatment of pain and inflammation following cataract surgery.

Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.

Research Excerpts

ExcerptRelevanceReference
"Diclofenac was selected as the reference compound."1.31Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy. ( Brady, MT; Gamache, DA; Graff, G; Spellman, JM; Yanni, JM, 2000)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bucolo, C1
Marrazzo, G1
Platania, CB1
Romano, GL1
Drago, F1
Salomone, S1
Gamache, DA1
Graff, G2
Brady, MT1
Spellman, JM1
Yanni, JM1
Walsh, DA1
Moran, HW1
Shamblee, DA1
Welstead, WJ1
Nolan, JC1
Sancilio, LF1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Nepafenac Eye Drops on Intraocular Pressure - a Randomized Prospective Study[NCT01995890]Phase 4327 participants (Actual)Interventional2012-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

3 other studies available for amfenac and Inflammation

ArticleYear
Effects of topical indomethacin, bromfenac and nepafenac on lipopolysaccharide-induced ocular inflammation.
    The Journal of pharmacy and pharmacology, 2014, Volume: 66, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzeneacetamides; Benzophenones; Bromobenzenes; C

2014
Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy.
    Inflammation, 2000, Volume: 24, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase

2000
Antiinflammatory agents. 4. Syntheses and biological evaluation of potential prodrugs of 2-amino-3-benzoylbenzeneacetic acid and 2-amino-3-(4-chlorobenzoyl)benzeneacetic acid.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:8

    Topics: Acetamides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzeneacetam

1990