amfenac has been researched along with Inflammation in 3 studies
amfenac: RN given refers to parent cpd; structure
amfenac : An oxo monocarboxylic acid that is benzophenone in which one of the phenyl groups is substituted by an amino group and a carboxymethyl group at position 2 and 3, respectively. The corresponding carboxamide, nepafenac, is a prodrug of amfenac and is used for the treatment of pain and inflammation following cataract surgery.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diclofenac was selected as the reference compound." | 1.31 | Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy. ( Brady, MT; Gamache, DA; Graff, G; Spellman, JM; Yanni, JM, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bucolo, C | 1 |
| Marrazzo, G | 1 |
| Platania, CB | 1 |
| Romano, GL | 1 |
| Drago, F | 1 |
| Salomone, S | 1 |
| Gamache, DA | 1 |
| Graff, G | 2 |
| Brady, MT | 1 |
| Spellman, JM | 1 |
| Yanni, JM | 1 |
| Walsh, DA | 1 |
| Moran, HW | 1 |
| Shamblee, DA | 1 |
| Welstead, WJ | 1 |
| Nolan, JC | 1 |
| Sancilio, LF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Nepafenac Eye Drops on Intraocular Pressure - a Randomized Prospective Study[NCT01995890] | Phase 4 | 327 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for amfenac and Inflammation
| Article | Year |
|---|---|
Effects of topical indomethacin, bromfenac and nepafenac on lipopolysaccharide-induced ocular inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzeneacetamides; Benzophenones; Bromobenzenes; C | 2014 |
Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2000 |
Antiinflammatory agents. 4. Syntheses and biological evaluation of potential prodrugs of 2-amino-3-benzoylbenzeneacetic acid and 2-amino-3-(4-chlorobenzoyl)benzeneacetic acid.
Topics: Acetamides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzeneacetam | 1990 |