amentoflavone and Neoplasms

amentoflavone has been researched along with Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for amentoflavone and Neoplasms

Article	Year
Inhibition of phospholipase cgamma1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla. Journal of natural products, 2000, Volume: 63, Issue:6 Investigation of the hooks of Uncaria rhynchophylla resulted in isolation of six phospholipase Cgamma1 (PLCgamma1) inhibitors (1-6). The structures of these compounds were elucidated as pentacyclic triterpene esters by spectroscopic and chemical analysis. Three of them, namely uncarinic acids C (1), D (2), and E (3), are newly reported as natural products. All the compounds showed dose-dependent inhibitory activities against PLCgamma1 in vitro with IC(50) values of 9.5-44.6 microM and inhibited the proliferation of human cancer cells with IC(50) values of 0.5-6.5 microg/mL. Topics: 3T3 Cells; Animals; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; Esters; Humans; Isoenzymes; Mice; Neoplasms; Phospholipase C gamma; Plants, Medicinal; Rubiaceae; Structure-Activity Relationship; Triterpenes; Tumor Cells, Cultured; Type C Phospholipases	2000

Article

Year

Inhibition of phospholipase cgamma1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla.

Journal of natural products, 2000, Volume: 63, Issue:6

Investigation of the hooks of Uncaria rhynchophylla resulted in isolation of six phospholipase Cgamma1 (PLCgamma1) inhibitors (1-6). The structures of these compounds were elucidated as pentacyclic triterpene esters by spectroscopic and chemical analysis. Three of them, namely uncarinic acids C (1), D (2), and E (3), are newly reported as natural products. All the compounds showed dose-dependent inhibitory activities against PLCgamma1 in vitro with IC(50) values of 9.5-44.6 microM and inhibited the proliferation of human cancer cells with IC(50) values of 0.5-6.5 microg/mL.

Topics: 3T3 Cells; Animals; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; Esters; Humans; Isoenzymes; Mice; Neoplasms; Phospholipase C gamma; Plants, Medicinal; Rubiaceae; Structure-Activity Relationship; Triterpenes; Tumor Cells, Cultured; Type C Phospholipases

2000