ameltolide has been researched along with Seizures in 9 studies
*Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beedle, EE; Krushinski, JH; Lawson, RR; Leander, JD; Parli, CJ; Potts, B; Robertson, DW | 1 |
| Beedle, EE; Clark, CR; Lawson, R; Leander, JD; Parli, CJ; Potts, BD; Robertson, DW | 1 |
| Clark, CR; Lin, CM; Sansom, RT | 1 |
| Clark, CR; Lin, CM; Norris, GN; Sansom, RT | 1 |
| Lambert, D; Masereel, B; Poupaert, JH; Stables, JP; Vamecq, J | 1 |
| Abdul-Karim, B; Barnhart, SD; Bin, T; Burnett, TJ; Engleking, DR; Freise, KJ; Newhall, K; Peters, SC; Rodewald, JM; Shannon, HE; Territo, PR | 1 |
| Pavana, RK; Raghavendran, JV; Sriram, D; Stables, J; Sudhan, K; Thirumurugan, R; Yogeeswari, P | 1 |
| Bourhim, M; Diouf, O; Lambert, DM; Poupaert, JH; Stables, JP; Vamecq, J | 1 |
| Albertson, TE; Stark, LG | 1 |
9 other study(ies) available for ameltolide and Seizures
| Article | Year |
|---|---|
Synthesis and pharmacological evaluation of a major metabolite of ameltolide, a potent anticonvulsant.
Topics: Animals; Anticonvulsants; Benzamides; Brain; Indicators and Reagents; Mice; Molecular Structure; Seizures; Structure-Activity Relationship | 1991 |
Discovery and anticonvulsant activity of the potent metabolic inhibitor 4-amino-N-(2,6-dimethylphenyl)-3,5-dimethylbenzamide.
Topics: Acetylation; Administration, Oral; Animals; Anticonvulsants; Benzamides; Dose-Response Relationship, Drug; Electroshock; Hexobarbital; Mice; Seizures; Sleep | 1987 |
Anticonvulsant activity of 2- and 3-aminobenzanilides.
Topics: Anilides; Aniline Compounds; Animals; Anticonvulsants; Electroshock; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures | 1986 |
Anticonvulsant activity of some 4-aminobenzanilides.
Topics: Anilides; Animals; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; Electroshock; Male; Mice; Pentylenetetrazole; Seizures; Structure-Activity Relationship | 1985 |
Anticonvulsant activity and interactions with neuronal voltage-dependent sodium channel of analogues of ameltolide.
Topics: Administration, Oral; Animals; Anticonvulsants; Batrachotoxins; Benzamides; Binding, Competitive; Brain; Electroshock; Injections, Intraperitoneal; Ion Channel Gating; Mice; Rats; Seizures; Sodium Channels; Structure-Activity Relationship; Synaptosomes | 1998 |
Nonlinear mixed effects pharmacokinetic/pharmacodynamic analysis of the anticonvulsant ameltolide (LY201116) in a canine seizure model.
Topics: Absorption; Animals; Anticonvulsants; Area Under Curve; Benzamides; Biological Availability; Dogs; Half-Life; Logistic Models; Male; Nonlinear Dynamics; Seizures; Tissue Distribution | 2008 |
Discovery of N-(2,6-dimethylphenyl)-substituted semicarbazones as anticonvulsants: hybrid pharmacophore-based design.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzamides; Chemical and Drug Induced Liver Injury; Drug Design; Female; gamma-Aminobutyric Acid; Male; Mice; Models, Molecular; Motor Activity; Rats; Seizures; Semicarbazones; Structure-Activity Relationship | 2005 |
Anticonvulsant and neurotoxicological properties of 4-amino-N-(2-ethylphenyl)benzamide, a potent ameltolide analogue.
Topics: Administration, Oral; Animals; Anticonvulsants; Benzamides; Convulsants; Dose-Response Relationship, Drug; Electroshock; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Nervous System; Pentylenetetrazole; Phenytoin; Rats; Rats, Sprague-Dawley; Seizures | 1997 |
The effects of LY-201116 [4-amino-N-(2,6-dimethylphenyl) benzamide] on the amygdala-kindled rat.
Topics: Amygdala; Analysis of Variance; Animals; Anticonvulsants; Benzamides; Dose-Response Relationship, Drug; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Reference Values; Seizures; Time Factors | 1990 |