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ameltolide and Seizures

ameltolide has been researched along with Seizures in 9 studies

*Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder. [MeSH]

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19903 (33.33)18.7374
1990's4 (44.44)18.2507
2000's2 (22.22)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Beedle, EE; Krushinski, JH; Lawson, RR; Leander, JD; Parli, CJ; Potts, B; Robertson, DW1
Beedle, EE; Clark, CR; Lawson, R; Leander, JD; Parli, CJ; Potts, BD; Robertson, DW1
Clark, CR; Lin, CM; Sansom, RT1
Clark, CR; Lin, CM; Norris, GN; Sansom, RT1
Lambert, D; Masereel, B; Poupaert, JH; Stables, JP; Vamecq, J1
Abdul-Karim, B; Barnhart, SD; Bin, T; Burnett, TJ; Engleking, DR; Freise, KJ; Newhall, K; Peters, SC; Rodewald, JM; Shannon, HE; Territo, PR1
Pavana, RK; Raghavendran, JV; Sriram, D; Stables, J; Sudhan, K; Thirumurugan, R; Yogeeswari, P1
Bourhim, M; Diouf, O; Lambert, DM; Poupaert, JH; Stables, JP; Vamecq, J1
Albertson, TE; Stark, LG1

Other Studies

9 other study(ies) available for ameltolide and Seizures

ArticleYear
Synthesis and pharmacological evaluation of a major metabolite of ameltolide, a potent anticonvulsant.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:4

    Topics: Animals; Anticonvulsants; Benzamides; Brain; Indicators and Reagents; Mice; Molecular Structure; Seizures; Structure-Activity Relationship

1991
Discovery and anticonvulsant activity of the potent metabolic inhibitor 4-amino-N-(2,6-dimethylphenyl)-3,5-dimethylbenzamide.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:10

    Topics: Acetylation; Administration, Oral; Animals; Anticonvulsants; Benzamides; Dose-Response Relationship, Drug; Electroshock; Hexobarbital; Mice; Seizures; Sleep

1987
Anticonvulsant activity of 2- and 3-aminobenzanilides.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:8

    Topics: Anilides; Aniline Compounds; Animals; Anticonvulsants; Electroshock; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures

1986
Anticonvulsant activity of some 4-aminobenzanilides.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:9

    Topics: Anilides; Animals; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; Electroshock; Male; Mice; Pentylenetetrazole; Seizures; Structure-Activity Relationship

1985
Anticonvulsant activity and interactions with neuronal voltage-dependent sodium channel of analogues of ameltolide.
    Journal of medicinal chemistry, 1998, Aug-27, Volume: 41, Issue:18

    Topics: Administration, Oral; Animals; Anticonvulsants; Batrachotoxins; Benzamides; Binding, Competitive; Brain; Electroshock; Injections, Intraperitoneal; Ion Channel Gating; Mice; Rats; Seizures; Sodium Channels; Structure-Activity Relationship; Synaptosomes

1998
Nonlinear mixed effects pharmacokinetic/pharmacodynamic analysis of the anticonvulsant ameltolide (LY201116) in a canine seizure model.
    Journal of veterinary pharmacology and therapeutics, 2008, Volume: 31, Issue:6

    Topics: Absorption; Animals; Anticonvulsants; Area Under Curve; Benzamides; Biological Availability; Dogs; Half-Life; Logistic Models; Male; Nonlinear Dynamics; Seizures; Tissue Distribution

2008
Discovery of N-(2,6-dimethylphenyl)-substituted semicarbazones as anticonvulsants: hybrid pharmacophore-based design.
    Journal of medicinal chemistry, 2005, Oct-06, Volume: 48, Issue:20

    Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzamides; Chemical and Drug Induced Liver Injury; Drug Design; Female; gamma-Aminobutyric Acid; Male; Mice; Models, Molecular; Motor Activity; Rats; Seizures; Semicarbazones; Structure-Activity Relationship

2005
Anticonvulsant and neurotoxicological properties of 4-amino-N-(2-ethylphenyl)benzamide, a potent ameltolide analogue.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1997, Volume: 51, Issue:3

    Topics: Administration, Oral; Animals; Anticonvulsants; Benzamides; Convulsants; Dose-Response Relationship, Drug; Electroshock; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Nervous System; Pentylenetetrazole; Phenytoin; Rats; Rats, Sprague-Dawley; Seizures

1997
The effects of LY-201116 [4-amino-N-(2,6-dimethylphenyl) benzamide] on the amygdala-kindled rat.
    Neuropharmacology, 1990, Volume: 29, Issue:11

    Topics: Amygdala; Analysis of Variance; Animals; Anticonvulsants; Benzamides; Dose-Response Relationship, Drug; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Reference Values; Seizures; Time Factors

1990