amd-070 and Warts

amd-070 has been researched along with Warts* in 2 studies

Trials

1 trial(s) available for amd-070 and Warts

ArticleYear
Results of a phase 2 trial of an oral CXCR4 antagonist, mavorixafor, for treatment of WHIM syndrome.
    Blood, 2020, 12-24, Volume: 136, Issue:26

    Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a rare primary immunodeficiency caused by gain-of-function mutations in the CXCR4 gene. We report the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of mavorixafor from a phase 2 open-label dose-escalation and extension study in 8 adult patients with genetically confirmed WHIM syndrome. Mavorixafor is an oral small molecule selective antagonist of the CXCR4 receptor that increases mobilization and trafficking of white blood cells from the bone marrow. Patients received escalating doses of mavorixafor, up to 400 mg once daily. Five patients continued on the extension study for up to 28.6 months. Mavorixafor was well tolerated with no treatment-related serious adverse events. At a median follow-up of 16.5 months, we observed dose-dependent increases in absolute neutrophil count (ANC) and absolute lymphocyte count (ALC). At doses ≥300 mg/d, ANC was maintained at >500 cells per microliter for a median of 12.6 hours, and ALC was maintained at >1000 cells per microliter for up to 16.9 hours. Continued follow-up on the extension study resulted in a yearly infection rate that decreased from 4.63 events (95% confidence interval, 3.3-6.3) in the 12 months prior to the trial to 2.27 events (95% confidence interval, 1.4-3.5) for patients on effective doses. We observed an average 75% reduction in the number of cutaneous warts. This study demonstrates that mavorixafor, 400 mg once daily, mobilizes neutrophil and lymphocytes in adult patients with WHIM syndrome and provides preliminary evidence of clinical benefit for patients on long-term therapy. The trial was registered at www.clinicaltrials.gov as #NCT03005327.

    Topics: Administration, Oral; Adolescent; Adult; Aminoquinolines; Benzimidazoles; Butylamines; Female; Humans; Leukocyte Count; Male; Middle Aged; Neutrophils; Primary Immunodeficiency Diseases; Prospective Studies; Receptors, CXCR4; Warts

2020

Other Studies

1 other study(ies) available for amd-070 and Warts

ArticleYear
Genotype-phenotype correlations in WHIM syndrome: a systematic characterization of CXCR4
    Genes and immunity, 2022, Volume: 23, Issue:6

    Warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome is a rare primary immunodeficiency predominantly caused by heterozygous gain-of-function mutations in CXCR4 C-terminus. We assessed genotype-phenotype correlations for known pathogenic CXCR4 variants and in vitro response of each variant to mavorixafor, an investigational CXCR4 antagonist. We used cell-based assays to analyze CXCL12-induced receptor trafficking and downstream signaling of 14 pathogenic CXCR4 variants previously identified in patients with WHIM syndrome. All CXCR4 variants displayed impaired receptor trafficking, hyperactive downstream signaling, and enhanced chemotaxis in response to CXCL12. Mavorixafor inhibited CXCL12-dependent signaling and hyperactivation in cells harboring CXCR4

    Topics: Agammaglobulinemia; Aminoquinolines; Benzimidazoles; Biomarkers; Butylamines; Genetic Association Studies; Humans; Immunoglobulin A; Immunologic Deficiency Syndromes; Neutropenia; Primary Immunodeficiency Diseases; Proto-Oncogene Proteins c-akt; Receptors, CXCR4; Warts

2022