ambroxol has been researched along with Pulmonary Fibrosis in 8 studies
Ambroxol: A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the possible therapeutic effect of ambroxol on pulmonary fibrosis induced by paraquat." | 7.77 | Protective effect of ambroxol against paraquat-induced pulmonary fibrosis in rats. ( Sun, HC; Yang, LT; Zhi, QM, 2011) |
| "To evaluate the possible therapeutic effect of ambroxol on pulmonary fibrosis induced by paraquat." | 3.77 | Protective effect of ambroxol against paraquat-induced pulmonary fibrosis in rats. ( Sun, HC; Yang, LT; Zhi, QM, 2011) |
| " The present study found that: (1) in healthy rats, the ambroxol-induced increase of alveolar antielastase activity did not appear due to reactivation of alpha 1-antitrypsin normally oxidized in the alveolar milieu; (2) in bleomycin-induced pulmonary fibrosis, ambroxol protection reduced total long collagen content at day 28, and (3) in paraquat-induced pulmonary fibrosis, alveolar phospholipids were markedly reduced throughout the 21 days of the experiment." | 3.67 | Relationship between changes in alveolar surfactant levels and lung defence mechanisms. ( Cetta, G; Coccia, P; Donnini, M; Luisetti, M; Pozzi, E; Rossi, A; Salmona, M; Spialtini, L, 1989) |
| " Patients in the treatment group took ambroxol orally at a dosage of 90 mg, three times per day for 3 months from the beginning of radiotherapy." | 2.75 | The protective effects of ambroxol on radiation lung injury and influence on production of transforming growth factor beta1 and tumor necrosis factor alpha. ( Dai, M; Mao, WD; Shen, WS; Shu, ZQ; Xi, L; Xia, DH; Xv, C; Yang, HZ, 2010) |
| "Pulmonary fibrosis is the end point of progressive functional disorder of respiratory mechanism and alveolo-capillary gas exchanges." | 2.66 | Nitrosourea derivatives-induced pulmonary toxicity in patients treated for malignant brain tumors. Early subclinical detection and its prevention. ( Butti, G; Gaetani, P; Knerich, R; Rossi, A; Silvani, V; Spanu, G, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xia, DH | 1 |
| Xi, L | 1 |
| Xv, C | 1 |
| Mao, WD | 1 |
| Shen, WS | 1 |
| Shu, ZQ | 1 |
| Yang, HZ | 1 |
| Dai, M | 1 |
| Zhi, QM | 1 |
| Yang, LT | 1 |
| Sun, HC | 1 |
| VANWORMER, DE | 1 |
| RANKIN, J | 1 |
| KOBAYASHI, M | 1 |
| BARBEE, RA | 1 |
| DICKIE, HA | 1 |
| Luisetti, M | 3 |
| Peona, V | 1 |
| Salmona, M | 3 |
| Pagnoni, AM | 1 |
| Villani, F | 1 |
| Knerich, R | 2 |
| Genghini, M | 2 |
| Abbà, L | 1 |
| Pozzi, E | 3 |
| Masturzo, P | 1 |
| Scelsi, M | 1 |
| Spialtini, L | 2 |
| Coccia, P | 1 |
| Rossi, A | 2 |
| Donnini, M | 1 |
| Cetta, G | 1 |
| Gaetani, P | 1 |
| Silvani, V | 1 |
| Butti, G | 1 |
| Spanu, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Ambroxol on the Inflammatory Markers and Clinical Outcome of Patients With Diabetic Peripheral Neuropathy[NCT05558878] | 80 participants (Anticipated) | Interventional | 2022-10-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for ambroxol and Pulmonary Fibrosis
| Article | Year |
|---|---|
The protective effects of ambroxol on radiation lung injury and influence on production of transforming growth factor beta1 and tumor necrosis factor alpha.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ambroxol; Carbon Monoxide; Female; Free Radical Scavengers; Hu | 2010 |
Nitrosourea derivatives-induced pulmonary toxicity in patients treated for malignant brain tumors. Early subclinical detection and its prevention.
Topics: Adult; Aged; Ambroxol; Brain Neoplasms; Bromhexine; Carmustine; Clinical Trials as Topic; Double-Bli | 1987 |
6 other studies available for ambroxol and Pulmonary Fibrosis
| Article | Year |
|---|---|
Protective effect of ambroxol against paraquat-induced pulmonary fibrosis in rats.
Topics: Ambroxol; Animals; Collagen; Cytokines; Disease Models, Animal; Expectorants; Lung; Male; Oxidative | 2011 |
FARMER'S LUNG.
Topics: Ambroxol; Biopsy; Farmer's Lung; Granuloma; Humans; Leukocyte Count; Pathology; Precipitin Tests; Pu | 1965 |
AGRICULTURAL DUSTS AND DIFFUSE PULMONARY FIBROSIS.
Topics: Agricultural Workers' Diseases; Allergy and Immunology; Ambroxol; Dust; Farmer's Lung; Fungi; Humans | 1965 |
Ambroxol and pulmonary toxicity induced by antineoplastic drugs.
Topics: Ambroxol; Animals; Antineoplastic Agents; Bleomycin; Bromhexine; Busulfan; Cyclophosphamide; Humans; | 1986 |
Role of alveolar phospholipids in bleomycin-induced pulmonary fibrosis in the rat.
Topics: Ambroxol; Animals; Bleomycin; Macrophages; Male; Membrane Fluidity; Phosphatidylcholines; Pulmonary | 1987 |
Relationship between changes in alveolar surfactant levels and lung defence mechanisms.
Topics: Ambroxol; Animals; Bleomycin; Bronchoalveolar Lavage Fluid; Collagen; Glutathione; Lung; Macrophage | 1989 |