ambroxol has been researched along with Disease Models, Animal in 28 studies
Ambroxol: A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to investigate the protective effects of ambroxol in psoriasis-like skin inflammation both in vitro and in vivo and delineate the molecular mechanism of ambroxol." | 7.91 | Protective effects of ambroxol in psoriasis like skin inflammation: Exploration of possible mechanisms. ( Challa, VS; Godugu, C; Pooladanda, V; Sunkari, S; Thatikonda, S, 2019) |
| "In this study, the ability of pregabalin and ambroxol, used as single drugs or in combinations administered in a time-shifted manner to attenuate cold allodynia was assessed in the mouse cold plate test." | 7.88 | Time-shifted co-administration of sub-analgesic doses of ambroxol and pregabalin attenuates oxaliplatin-induced cold allodynia in mice. ( Fijałkowski, Ł; Furgała, A; Nowaczyk, A; Sałat, K; Sałat, R, 2018) |
| "8 contributes to capsaicin-induced and peripheral ischemia-induced MA and TH." | 7.78 | The differential effect of intrathecal Nav1.8 blockers on the induction and maintenance of capsaicin- and peripheral ischemia-induced mechanical allodynia and thermal hyperalgesia. ( Beitz, AJ; Kang, SY; Lee, JH; Moon, JY; Park, JH; Roh, DH; Song, S; Yoon, SY, 2012) |
| "To evaluate the possible therapeutic effect of ambroxol on pulmonary fibrosis induced by paraquat." | 7.77 | Protective effect of ambroxol against paraquat-induced pulmonary fibrosis in rats. ( Sun, HC; Yang, LT; Zhi, QM, 2011) |
| "To investigate the effects of ambroxol on rat models with nitrofen-induced congenital diaphragmatic hernia (CDH) and its potential mechanism." | 7.76 | [Effect of ambroxol on lung development of rat models with nitrofen-induced congenital diaphragmatic hernia]. ( Chen, G; Chen, L; Qiao, YL; Xiao, XM; Zheng, S, 2010) |
| "The purpose of this study was to investigate the protective effects of ambroxol in psoriasis-like skin inflammation both in vitro and in vivo and delineate the molecular mechanism of ambroxol." | 3.91 | Protective effects of ambroxol in psoriasis like skin inflammation: Exploration of possible mechanisms. ( Challa, VS; Godugu, C; Pooladanda, V; Sunkari, S; Thatikonda, S, 2019) |
| "In this study, the ability of pregabalin and ambroxol, used as single drugs or in combinations administered in a time-shifted manner to attenuate cold allodynia was assessed in the mouse cold plate test." | 3.88 | Time-shifted co-administration of sub-analgesic doses of ambroxol and pregabalin attenuates oxaliplatin-induced cold allodynia in mice. ( Fijałkowski, Ł; Furgała, A; Nowaczyk, A; Sałat, K; Sałat, R, 2018) |
| "Our work supports the proposition that ambroxol should be further investigated as a potential novel disease-modifying therapy for treatment of Parkinson disease and neuronopathic Gaucher disease to increase glucocerebrosidase activity and decrease α-synuclein and phosphorylated α-synuclein protein levels." | 3.83 | Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice. ( Bezard, E; Daly, L; Migdalska-Richards, A; Schapira, AH, 2016) |
| "8 contributes to capsaicin-induced and peripheral ischemia-induced MA and TH." | 3.78 | The differential effect of intrathecal Nav1.8 blockers on the induction and maintenance of capsaicin- and peripheral ischemia-induced mechanical allodynia and thermal hyperalgesia. ( Beitz, AJ; Kang, SY; Lee, JH; Moon, JY; Park, JH; Roh, DH; Song, S; Yoon, SY, 2012) |
| "To evaluate the possible therapeutic effect of ambroxol on pulmonary fibrosis induced by paraquat." | 3.77 | Protective effect of ambroxol against paraquat-induced pulmonary fibrosis in rats. ( Sun, HC; Yang, LT; Zhi, QM, 2011) |
| "To investigate the effects of ambroxol on rat models with nitrofen-induced congenital diaphragmatic hernia (CDH) and its potential mechanism." | 3.76 | [Effect of ambroxol on lung development of rat models with nitrofen-induced congenital diaphragmatic hernia]. ( Chen, G; Chen, L; Qiao, YL; Xiao, XM; Zheng, S, 2010) |
| "To evaluate the protective effect of high dose ambroxol, a mucoactive drug, on acute lung injury caused by paraquat in rats." | 3.74 | [Effects of high dose ambroxol on lung injury induced by paraquat in rats]. ( Liu, JH; Lv, CH; Ma, YT; Shi, HW; Sun, ZP; Tian, YP, 2007) |
| "Ambroxol inhibited proinflammatory cytokines, reduced lung inflammation and accelerated recovery from LPS-induced ALI." | 3.72 | Inhibition of inflammatory responses by ambroxol, a mucolytic agent, in a murine model of acute lung injury induced by lipopolysaccharide. ( Bai, C; Song, Y; Su, X; Wang, L, 2004) |
| "Gaucher disease is an autosomal recessively inherited storage disorder caused by deficiency of the lysosomal hydrolase, acid β-glucosidase." | 1.39 | Transgenic mice expressing human glucocerebrosidase variants: utility for the study of Gaucher disease. ( Clarke, LA; Fuller, M; Hein, L; Hemmelgarn, H; Melrose, HL; Sanders, A, 2013) |
| " Thus a stimulation of the mucociliary transport rate by the other major pharmacodynamic mechanisms, secretagogue activity and stimulation of pulmonary surfactant, has to be considered." | 1.27 | Pharmacodynamic mechanism and therapeutic activity of ambroxol in animal experiments. ( Disse, BG; Ziegler, HW, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.14) | 18.7374 |
| 1990's | 1 (3.57) | 18.2507 |
| 2000's | 4 (14.29) | 29.6817 |
| 2010's | 17 (60.71) | 24.3611 |
| 2020's | 4 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Jiang, X | 1 |
| Zhang, J | 1 |
| Kou, B | 1 |
| Zhang, C | 1 |
| Zhong, J | 1 |
| Fang, X | 1 |
| Huang, X | 2 |
| Zhang, X | 1 |
| Xie, F | 1 |
| Hu, Q | 1 |
| Ge, H | 1 |
| Yu, A | 1 |
| Bouscary, A | 1 |
| Quessada, C | 1 |
| René, F | 1 |
| Spedding, M | 1 |
| Henriques, A | 1 |
| Ngo, S | 1 |
| Loeffler, JP | 1 |
| Khoury, T | 1 |
| Ishay, Y | 1 |
| Rotnemer-Golinkin, D | 1 |
| Zolotarovya, L | 1 |
| Arkadir, D | 1 |
| Zimran, A | 1 |
| Ilan, Y | 1 |
| Li, X | 2 |
| Zhao, Y | 1 |
| Yu, C | 1 |
| Yang, Y | 1 |
| Sun, S | 1 |
| Zhao, JM | 1 |
| Jin, ZZ | 1 |
| Zhao, QZ | 1 |
| Furgała, A | 1 |
| Fijałkowski, Ł | 1 |
| Nowaczyk, A | 1 |
| Sałat, R | 1 |
| Sałat, K | 1 |
| Sunkari, S | 1 |
| Thatikonda, S | 1 |
| Pooladanda, V | 1 |
| Challa, VS | 1 |
| Godugu, C | 1 |
| Cao, DW | 1 |
| Hou, MX | 1 |
| Zhang, XR | 1 |
| Sanders, A | 1 |
| Hemmelgarn, H | 1 |
| Melrose, HL | 1 |
| Hein, L | 1 |
| Fuller, M | 1 |
| Clarke, LA | 1 |
| Lu, Q | 2 |
| Yu, J | 2 |
| Bao, L | 1 |
| Ran, T | 2 |
| Zhong, H | 1 |
| Belkouch, M | 1 |
| Dansereau, MA | 1 |
| Tétreault, P | 1 |
| Biet, M | 1 |
| Beaudet, N | 1 |
| Dumaine, R | 1 |
| Chraibi, A | 1 |
| Mélik-Parsadaniantz, S | 1 |
| Sarret, P | 1 |
| Cheng, C | 1 |
| Du, L | 1 |
| He, Y | 1 |
| Su, X | 2 |
| Li, Z | 2 |
| Wang, M | 1 |
| Wang, Q | 1 |
| Lu, W | 1 |
| Zhou, Y | 1 |
| Xu, H | 1 |
| Ge, LT | 1 |
| Liu, YN | 1 |
| Lin, XX | 1 |
| Shen, HJ | 1 |
| Jia, YL | 1 |
| Dong, XW | 1 |
| Sun, Y | 1 |
| Xie, QM | 1 |
| Maor, G | 1 |
| Cabasso, O | 1 |
| Krivoruk, O | 1 |
| Rodriguez, J | 1 |
| Steller, H | 1 |
| Segal, D | 1 |
| Horowitz, M | 1 |
| Sanchez-Martinez, A | 1 |
| Beavan, M | 1 |
| Gegg, ME | 1 |
| Chau, KY | 1 |
| Whitworth, AJ | 1 |
| Schapira, AH | 2 |
| Migdalska-Richards, A | 1 |
| Daly, L | 1 |
| Bezard, E | 1 |
| Qiao, YL | 1 |
| Chen, G | 1 |
| Xiao, XM | 1 |
| Zheng, S | 1 |
| Chen, L | 1 |
| Zhi, QM | 1 |
| Yang, LT | 1 |
| Sun, HC | 1 |
| Moon, JY | 1 |
| Song, S | 1 |
| Yoon, SY | 1 |
| Roh, DH | 1 |
| Kang, SY | 1 |
| Park, JH | 1 |
| Beitz, AJ | 1 |
| Lee, JH | 1 |
| Wang, L | 1 |
| Song, Y | 1 |
| Bai, C | 1 |
| Zhao, SP | 1 |
| Guo, QL | 1 |
| Ai, YH | 1 |
| Wang, RK | 1 |
| Wang, E | 1 |
| He, M | 1 |
| Ma, YT | 1 |
| Tian, YP | 1 |
| Shi, HW | 1 |
| Lv, CH | 1 |
| Liu, JH | 1 |
| Sun, ZP | 1 |
| Dauberschmidt, R | 1 |
| Kuckelt, W | 1 |
| Bender, V | 1 |
| Hieronymi, U | 1 |
| Mrochen, H | 1 |
| Winsel, K | 1 |
| Zinsmeyer, J | 1 |
| Meyer, M | 1 |
| Hausen, B | 1 |
| Bahra, M | 1 |
| Mueller, P | 1 |
| Poets, CF | 1 |
| Hewitt, CW | 1 |
| Morris, RE | 1 |
| Ishibashi, Y | 1 |
| Okamura, T | 1 |
| Masumoto, Y | 1 |
| Tachiiri, T | 1 |
| Momo, K | 1 |
| Disse, BG | 1 |
| Ziegler, HW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Ambroxol on the Inflammatory Markers and Clinical Outcome of Patients With Diabetic Peripheral Neuropathy[NCT05558878] | 80 participants (Anticipated) | Interventional | 2022-10-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ambroxol and Disease Models, Animal
| Article | Year |
|---|---|
Drug repositioning in neurodegeneration: An overview of the use of ambroxol in neurodegenerative diseases.
Topics: Ambroxol; Amyotrophic Lateral Sclerosis; Animals; beta-Glucosidase; Disease Models, Animal; Disease | 2020 |
1 trial available for ambroxol and Disease Models, Animal
| Article | Year |
|---|---|
The protective effect of different airway humidification liquids to lung after tracheotomy in traumatic brain injury: The role of pulmonary surfactant protein-A (SP-A).
Topics: Adult; Ambroxol; Animals; Brain; Brain Chemistry; Brain Injuries; Budesonide; Disease Models, Animal | 2016 |
26 other studies available for ambroxol and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Ambroxol Improves Neuronal Survival and Reduces White Matter Damage through Suppressing Endoplasmic Reticulum Stress in Microglia after Intracerebral Hemorrhage.
Topics: Ambroxol; Animals; Cell Death; Cell Survival; Cerebral Hemorrhage; Disease Models, Animal; Endoplasm | 2020 |
A synergistic effect of Ambroxol and Beta-Glucosylceramide in alleviating immune-mediated hepatitis: A novel immunomodulatory non-immunosuppressive formulation for treatment of immune-mediated disorders.
Topics: Ambroxol; Animals; Anti-Inflammatory Agents; Concanavalin A; Cytokines; Disease Models, Animal; Drug | 2020 |
Ambroxol Hydrochloride Combined with Fluconazole Reverses the Resistance of
Topics: Ambroxol; Animals; Antifungal Agents; Biofilms; Candida albicans; Candidiasis; Disease Models, Anima | 2017 |
The preventive effect of ambroxol hydrochloride chitosan on postoperative intraperitoneal adhesion formation in a rat model.
Topics: Ambroxol; Animals; Chitosan; Disease Models, Animal; Expectorants; Hemostatics; Intestines; Peritone | 2017 |
Time-shifted co-administration of sub-analgesic doses of ambroxol and pregabalin attenuates oxaliplatin-induced cold allodynia in mice.
Topics: Ambroxol; Analgesics; Animals; Behavior, Animal; Binding Sites; Cold Temperature; Disease Models, An | 2018 |
Protective effects of ambroxol in psoriasis like skin inflammation: Exploration of possible mechanisms.
Topics: Ambroxol; Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Humans; Hyperplasia; | 2019 |
Ambroxol alleviates ventilator-induced lung injury by inhibiting c-Jun expression.
Topics: Ambroxol; Animals; Disease Models, Animal; Down-Regulation; Glutamate-Cysteine Ligase; Glutathione; | 2019 |
Transgenic mice expressing human glucocerebrosidase variants: utility for the study of Gaucher disease.
Topics: Ambroxol; Animals; Cerebellum; Cerebral Cortex; Disease Models, Animal; Enzyme Activation; Female; G | 2013 |
Effects of combined treatment with ambroxol and ciprofloxacin on catheter-associated Pseudomonas aeruginosa biofilms in a rat model.
Topics: Ambroxol; Animals; Anti-Bacterial Agents; Biofilms; Catheters; Ciprofloxacin; Disease Models, Animal | 2013 |
Functional up-regulation of Nav1.8 sodium channel in Aβ afferent fibers subjected to chronic peripheral inflammation.
Topics: Ambroxol; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Freund's Adjuvant; Ganglia, Spi | 2014 |
Ciprofloxacin plus erythromycin or ambroxol ameliorates endotracheal tube-associated Pseudomonas aeruginosa biofilms in a rat model.
Topics: Ambroxol; Animals; Anti-Bacterial Agents; Biofilms; Catheters, Indwelling; Ciprofloxacin; Disease Mo | 2015 |
Inhalation of ambroxol inhibits cigarette smoke-induced acute lung injury in a mouse model by inhibiting the Erk pathway.
Topics: Acute Lung Injury; Administration, Inhalation; Ambroxol; Animals; Cells, Cultured; Cytokines; Diseas | 2016 |
The contribution of mutant GBA to the development of Parkinson disease in Drosophila.
Topics: Ambroxol; Animals; Disease Models, Animal; Dopaminergic Neurons; Drosophila melanogaster; Endoplasmi | 2016 |
Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models.
Topics: Ambroxol; Animals; Disease Models, Animal; Dopaminergic Neurons; Drosophila melanogaster; Endoplasmi | 2016 |
Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice.
Topics: alpha-Synuclein; Ambroxol; Animals; Brain; Disease Models, Animal; Expectorants; Gaucher Disease; Gl | 2016 |
[Effect of ambroxol on lung development of rat models with nitrofen-induced congenital diaphragmatic hernia].
Topics: Ambroxol; Animals; Disease Models, Animal; Female; Hernia, Diaphragmatic; Hernias, Diaphragmatic, Co | 2010 |
Protective effect of ambroxol against paraquat-induced pulmonary fibrosis in rats.
Topics: Ambroxol; Animals; Collagen; Cytokines; Disease Models, Animal; Expectorants; Lung; Male; Oxidative | 2011 |
The differential effect of intrathecal Nav1.8 blockers on the induction and maintenance of capsaicin- and peripheral ischemia-induced mechanical allodynia and thermal hyperalgesia.
Topics: Ambroxol; Aniline Compounds; Animals; Capsaicin; Disease Models, Animal; Dose-Response Relationship, | 2012 |
Inhibition of inflammatory responses by ambroxol, a mucolytic agent, in a murine model of acute lung injury induced by lipopolysaccharide.
Topics: Ambroxol; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Dexamethasone; Disease Mo | 2004 |
[Prophylactic effect of ambroxol on acute hydrochloric acid aspiration - induced lung injury].
Topics: Acute Lung Injury; Ambroxol; Animals; Disease Models, Animal; Expectorants; Female; Hydrochloric Aci | 2005 |
[Effects of high dose ambroxol on lung injury induced by paraquat in rats].
Topics: Acute Lung Injury; Ambroxol; Animals; Disease Models, Animal; Lung; Male; Oxidative Stress; Paraquat | 2007 |
Effects of bromhexine metabolite VIII (NA 872) in an animal model of the respiratory distress syndrome.
Topics: Ambroxol; Animals; Blood Circulation; Bromhexine; Carbon Dioxide; Disease Models, Animal; Lactates; | 1980 |
Donor pretreatment with ambroxol or dexamethasone fails to ameliorate reperfusion injury in experimental lung transplantation.
Topics: Ambroxol; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Dexamethasone; Disease Mo | 1998 |
[Effects of carbocisteine on airway inflammation and related events in SO2-exposed rats].
Topics: Ambroxol; Animals; Carbocysteine; Cyclic AMP; Disease Models, Animal; Expectorants; Gases; Inflammat | 2001 |
Pharmacodynamic mechanism and therapeutic activity of ambroxol in animal experiments.
Topics: Albuterol; Ambroxol; Animals; Bromhexine; Cilia; Disease Models, Animal; Guinea Pigs; In Vitro Techn | 1987 |