ambroxol has been researched along with Cystic Fibrosis in 11 studies
Ambroxol: A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The therapeutic efficacy of oral N-acetylcysteine (NAC) and ambroxol as compared with the effect of placebos was studied in 36 cystic fibrosis (CF) patients with mild to moderate pulmonary disease." | 9.05 | A double-blind placebo controlled trial with oral ambroxol and N-acetylcysteine for mucolytic treatment in cystic fibrosis. ( Bender, SW; Hofmann, D; Posselt, HG; Ratjen, F; Stöver, B; Wönne, R, 1985) |
| "Ambroxol, a mucokinetic anti-inflammatory drug, has been used for treatment of cystic fibrosis (CF)." | 7.79 | The effect of ambroxol on chloride transport, CFTR and ENaC in cystic fibrosis airway epithelial cells. ( Hussain, R; Johannesson, M; Oliynyk, I; Roomans, GM; Strid, H; Varelogianni, G, 2013) |
| "The therapeutic efficacy of oral N-acetylcysteine (NAC) and ambroxol as compared with the effect of placebos was studied in 36 cystic fibrosis (CF) patients with mild to moderate pulmonary disease." | 5.05 | A double-blind placebo controlled trial with oral ambroxol and N-acetylcysteine for mucolytic treatment in cystic fibrosis. ( Bender, SW; Hofmann, D; Posselt, HG; Ratjen, F; Stöver, B; Wönne, R, 1985) |
| "Ambroxol, a mucokinetic anti-inflammatory drug, has been used for treatment of cystic fibrosis (CF)." | 3.79 | The effect of ambroxol on chloride transport, CFTR and ENaC in cystic fibrosis airway epithelial cells. ( Hussain, R; Johannesson, M; Oliynyk, I; Roomans, GM; Strid, H; Varelogianni, G, 2013) |
| "Cystic fibrosis is an inherited condition resulting in thickened, sticky respiratory secretions." | 2.49 | Nebulized and oral thiol derivatives for pulmonary disease in cystic fibrosis. ( Nash, EF; Ratjen, F; Stephenson, A; Tam, J; Tullis, E, 2013) |
| "Cystic fibrosis is an inherited condition resulting in thickened, sticky respiratory secretions." | 2.45 | Nebulized and oral thiol derivatives for pulmonary disease in cystic fibrosis. ( Nash, EF; Ratjen, F; Stephenson, A; Tullis, E, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Varelogianni, G | 1 |
| Hussain, R | 1 |
| Strid, H | 1 |
| Oliynyk, I | 1 |
| Roomans, GM | 1 |
| Johannesson, M | 1 |
| Tam, J | 1 |
| Nash, EF | 2 |
| Ratjen, F | 3 |
| Tullis, E | 2 |
| Stephenson, A | 2 |
| Dhar, R | 1 |
| Sharafkhaneh, A | 1 |
| Velamuri, S | 1 |
| Badmaev, V | 1 |
| Lan, C | 1 |
| Hanania, N | 1 |
| Akkoca Yildiz, O | 1 |
| Romano, C | 1 |
| Gargani, GF | 1 |
| Minicucci, L | 1 |
| Nantron, M | 1 |
| Zapletal, A | 1 |
| Vávrová, V | 1 |
| Stefanová, J | 1 |
| Horák, J | 1 |
| Samánek, M | 1 |
| Serrano, J | 1 |
| Sanchis, J | 1 |
| Derelle, J | 1 |
| Bertolo-Houriez, E | 1 |
| Marchal, F | 1 |
| Weber, M | 1 |
| Virion, JM | 1 |
| Vidailhet, M | 1 |
| Wönne, R | 1 |
| Posselt, HG | 1 |
| Stöver, B | 1 |
| Hofmann, D | 1 |
| Bender, SW | 1 |
6 reviews available for ambroxol and Cystic Fibrosis
| Article | Year |
|---|---|
Nebulized and oral thiol derivatives for pulmonary disease in cystic fibrosis.
Topics: Acetylcysteine; Administration, Inhalation; Administration, Oral; Ambroxol; Carbocysteine; Cystic Fi | 2013 |
Role of mucolytics in wet cough.
Topics: Ambroxol; Asthma; Bronchodilator Agents; Cholinergic Antagonists; Cough; Cystic Fibrosis; Expectoran | 2013 |
The potential role of natural agents in treatment of airway inflammation.
Topics: Ambroxol; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Cystic Fibrosis; Diet; Expectorants; Hu | 2007 |
Nebulized and oral thiol derivatives for pulmonary disease in cystic fibrosis.
Topics: Acetylcysteine; Administration, Inhalation; Administration, Oral; Ambroxol; Carbocysteine; Cystic Fi | 2009 |
[Ambroxol].
Topics: Ambroxol; Anti-Inflammatory Agents; Antioxidants; Asthma; Bronchial Hyperreactivity; Cystic Fibrosis | 2006 |
[Usefulness of mucoactive drugs in respiratory diseases].
Topics: Acetylcysteine; Ambroxol; Bromhexine; Bronchiectasis; Bronchitis; Cystic Fibrosis; Deoxyribonuclease | 1998 |
2 trials available for ambroxol and Cystic Fibrosis
| Article | Year |
|---|---|
[Controlled clinical study on the activity of a new mucoregulating drug in obstructive bronchial pathology with a marked hypersecretory feature. The pediatric experience].
Topics: Acetylcysteine; Adolescent; Ambroxol; Bromhexine; Bronchial Diseases; Child; Child, Preschool; Clini | 1984 |
A double-blind placebo controlled trial with oral ambroxol and N-acetylcysteine for mucolytic treatment in cystic fibrosis.
Topics: Acetylcysteine; Adolescent; Adult; Ambroxol; Bromhexine; Child; Clinical Trials as Topic; Cystic Fib | 1985 |
3 other studies available for ambroxol and Cystic Fibrosis
| Article | Year |
|---|---|
The effect of ambroxol on chloride transport, CFTR and ENaC in cystic fibrosis airway epithelial cells.
Topics: Ambroxol; Biological Transport; Blotting, Western; Bronchi; Calcium; Chlorides; Cystic Fibrosis; Cys | 2013 |
[Functional examination of the lungs in evaluating the effect of respiratory rehabilitation and mucolytics in cystic fibrosis].
Topics: Adolescent; Adult; Ambroxol; Bromhexine; Child; Cystic Fibrosis; Female; Humans; Male; Respiratory F | 1983 |
[Respiratory evolution of patient with mucoviscidosis treated with mucolytic agents plus dornase alfa].
Topics: Adolescent; Adult; Ambroxol; Anti-Bacterial Agents; Child; Child, Preschool; Cystic Fibrosis; Deoxyr | 1998 |