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ambroxol and Chronic Disease

ambroxol has been researched along with Chronic Disease in 23 studies

Ambroxol: A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.

Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).

Research Excerpts

ExcerptRelevanceReference
"This study was designed to examine the efficacy and tolerability of ambroxol (Ambrosol) on the symptomatology of chronic bronchitis among in- and out-patients."9.08[Clinical evaluation of efficacy and tolerance of oral treatment with ambroxol in patients with chronic bronchitis]. ( Michnar, M; Milanowski, J, 1996)
"In a double-blind, randomized, controlled trial using parallel groups, we evaluated the effects of two dose levels of ambroxol (60 and 120 mg daily) versus placebo by means of pulmonary function tests, patients' diary cards, interviews on current airway symptoms and subjective drug effects in 92 subjects with simple hypersecretory chronic bronchitis."9.06Ambroxol and simple chronic bronchitis. Effects on subjective symptoms and ventilatory function. ( Ericsson, CH; Jönsson, E; Juhasz, J; Mossberg, B, 1987)
"In a 6-month, double-blind multicenter trial conducted over the winter, the effects of daily administration of ambroxol retard (75 mg) were compared with those of placebo in preventing exacerbations and improving symptoms and clinical signs in chronic bronchitis patients."9.06Ambroxol for the prevention of chronic bronchitis exacerbations: long-term multicenter trial. Protective effect of ambroxol against winter semester exacerbations: a double-blind study versus placebo. ( Bonsignore, G; Carnimeo, N; Catena, E; Chianese, R; Daniotti, S; Ferrara, G; Marcatili, S; Olivieri, D; Tomasini, G; Zavattini, G, 1987)
"Twenty-three patients with exacerbations of chronic bronchitis were divided in two groups in a randomized fashion receiving either amoxicillin 1500 mg/d (n = 13) or amoxicillin 1500 mg/d associated with the mucolytic drug ambroxol 90 mg/d (n = 10)."9.06Ambroxol plus amoxicillin in the treatment of exacerbations of chronic bronchitis. ( Corazza, C; Fernández, M; Guerreiro, RB; Peralta, J; Poderoso, JJ; Wiemeyer, JC, 1987)
"Ambroxol is a mucus-modifying drug with a known ability to stimulate surfactant secretion and inhibit, in vitro, the production of proinflammatory cytokines, neutrophil chemotaxis, and Na+ absorption by the airway epithelium."6.68Intraluminal inflammation in the airways of patients with chronic bronchitis after treatment with Ambroxol. ( Capelli, A; Cerutti, CG; Donner, CF; Lusuardi, M; Salmona, M; Tacconi, MT, 1995)
"Ambroxol was associated with a 25% reduction of the average bronchial flow resistance."6.64[Clinical results in the treatment of chronic obstructive bronchitis with ambroxol in comparison with bromhexine (author's transl)]. ( Niemeyer, K; Wiessmann, KJ, 1978)
"Ninety-seven cases with chronic rhinosinusitis were randomly divided into three groups, with 31 cases in B group treated by ambroxol, 33 cases in C group treated by eucalyptol-limonene-pinene enteric soft capsule and 33 cases in control group (A group)."5.15[Clinical observation of mucoregulatory agents' application after chronic rhinosinusitis surgery]. ( Liu, L; Qian, J; Sun, J; Zhao, J, 2011)
"This study was designed to examine the efficacy and tolerability of ambroxol (Ambrosol) on the symptomatology of chronic bronchitis among in- and out-patients."5.08[Clinical evaluation of efficacy and tolerance of oral treatment with ambroxol in patients with chronic bronchitis]. ( Michnar, M; Milanowski, J, 1996)
"In a double-blind, randomized, controlled trial using parallel groups, we evaluated the effects of two dose levels of ambroxol (60 and 120 mg daily) versus placebo by means of pulmonary function tests, patients' diary cards, interviews on current airway symptoms and subjective drug effects in 92 subjects with simple hypersecretory chronic bronchitis."5.06Ambroxol and simple chronic bronchitis. Effects on subjective symptoms and ventilatory function. ( Ericsson, CH; Jönsson, E; Juhasz, J; Mossberg, B, 1987)
"In a 6-month, double-blind multicenter trial conducted over the winter, the effects of daily administration of ambroxol retard (75 mg) were compared with those of placebo in preventing exacerbations and improving symptoms and clinical signs in chronic bronchitis patients."5.06Ambroxol for the prevention of chronic bronchitis exacerbations: long-term multicenter trial. Protective effect of ambroxol against winter semester exacerbations: a double-blind study versus placebo. ( Bonsignore, G; Carnimeo, N; Catena, E; Chianese, R; Daniotti, S; Ferrara, G; Marcatili, S; Olivieri, D; Tomasini, G; Zavattini, G, 1987)
"Twenty-three patients with exacerbations of chronic bronchitis were divided in two groups in a randomized fashion receiving either amoxicillin 1500 mg/d (n = 13) or amoxicillin 1500 mg/d associated with the mucolytic drug ambroxol 90 mg/d (n = 10)."5.06Ambroxol plus amoxicillin in the treatment of exacerbations of chronic bronchitis. ( Corazza, C; Fernández, M; Guerreiro, RB; Peralta, J; Poderoso, JJ; Wiemeyer, JC, 1987)
"The clinical activity of trans-4-[(2-amino-3,5-dibromo-benzyl)-amino]-cyclohexanol-hydrochloride (ambroxol, NA 872) as well as its influence on lung function was examined in a total of 63 patients (34 suffering from silicosis, 28 from chronic obstructive bronchitis and 1 from cryptococcosis)."3.66[Therapeutic study on ambroxol in chronic bronchopulmonary diseases (author's transl)]. ( Curti, PC; Renovanz, HD, 1978)
"Ambroxol is a mucus-modifying drug with a known ability to stimulate surfactant secretion and inhibit, in vitro, the production of proinflammatory cytokines, neutrophil chemotaxis, and Na+ absorption by the airway epithelium."2.68Intraluminal inflammation in the airways of patients with chronic bronchitis after treatment with Ambroxol. ( Capelli, A; Cerutti, CG; Donner, CF; Lusuardi, M; Salmona, M; Tacconi, MT, 1995)
"Ambroxol was associated with a 25% reduction of the average bronchial flow resistance."2.64[Clinical results in the treatment of chronic obstructive bronchitis with ambroxol in comparison with bromhexine (author's transl)]. ( Niemeyer, K; Wiessmann, KJ, 1978)
"Ambroxol is able to inhibit mediator release involved in the pathogenesis of allergic inflammation."2.41[Mucolytics in acute and chronic respiratory tract disorders. II. Uses for treatment and antioxidant properties]. ( Kuna, P; Kupczyk, M, 2002)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-199015 (65.22)18.7374
1990's2 (8.70)18.2507
2000's5 (21.74)29.6817
2010's1 (4.35)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sun, J1
Qian, J1
Zhao, J1
Liu, L1
Ueda, T1
Schöpp, W1
Lusuardi, M1
Capelli, A1
Salmona, M1
Tacconi, MT1
Cerutti, CG1
Donner, CF1
Michnar, M1
Milanowski, J1
Ekberg-Jansson, A1
Larsson, S1
Löfdahl, CG1
Aleksa, VI1
Prozorova, VK1
Mal'tseva, NA1
Shatikhina, LN1
Kupczyk, M2
Kuna, P2
Wiessmann, KJ1
Niemeyer, K1
Curti, PC1
Renovanz, HD1
Aliperta, A1
Bellissimo, U1
Turco, D1
Antinolfi, G1
Solopov, VN2
Kolganova, NA2
Cegla, UH1
Ericsson, CH2
Juhasz, J2
Jönsson, E2
Mossberg, B2
Olivieri, D1
Zavattini, G1
Tomasini, G1
Daniotti, S1
Bonsignore, G1
Ferrara, G1
Carnimeo, N1
Chianese, R1
Catena, E1
Marcatili, S1
Dirksen, H1
Hermansen, F1
Groth, S1
Mølgaard, F1
Disse, BG1
Calero del Castillo, JB1
Pérez Martínez, F1
Piqueras Pérez, F1
Redondo Luciáñez, ER1
Peralta, J1
Poderoso, JJ1
Corazza, C1
Fernández, M1
Guerreiro, RB1
Wiemeyer, JC1

Reviews

3 reviews available for ambroxol and Chronic Disease

ArticleYear
[Mucolytics in acute and chronic respiratory tract disorders. I. Pathophysiology and mechanisms of action].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2002, Volume: 12, Issue:69

    Topics: Acetylcysteine; Acute Disease; Ambroxol; Chronic Disease; Expectorants; Humans; Respiratory Tract Di

2002
[Mucolytics in acute and chronic respiratory tract disorders. II. Uses for treatment and antioxidant properties].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2002, Volume: 12, Issue:69

    Topics: Acetylcysteine; Acute Disease; Ambroxol; Antioxidants; Asthma; Chronic Disease; Expectorants; Humans

2002
The pharmacology of ambroxol--review and new results.
    European journal of respiratory diseases. Supplement, 1987, Volume: 153

    Topics: Airway Resistance; Ambroxol; Animals; Bromhexine; Bronchitis; Chronic Disease; Humans; Infant, Newbo

1987

Trials

13 trials available for ambroxol and Chronic Disease

ArticleYear
[Clinical observation of mucoregulatory agents' application after chronic rhinosinusitis surgery].
    Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, 2011, Volume: 25, Issue:20

    Topics: Adolescent; Adult; Aged; Ambroxol; Chronic Disease; Cyclohexanols; Cyclohexenes; Eucalyptol; Expecto

2011
[Efficacy of combined drug therapy using a macrolide antibiotic and an antihistamine for adult patients with chronic paranasal sinusitis].
    The Japanese journal of antibiotics, 2003, Volume: 56 Suppl A

    Topics: Adult; Ambroxol; Anti-Bacterial Agents; Chronic Disease; Dibenzazepines; Drug Therapy, Combination;

2003
Intraluminal inflammation in the airways of patients with chronic bronchitis after treatment with Ambroxol.
    Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace, 1995, Volume: 50, Issue:5

    Topics: Ambroxol; Bronchi; Bronchitis; Bronchoalveolar Lavage Fluid; Chronic Disease; Double-Blind Method; E

1995
[Clinical evaluation of efficacy and tolerance of oral treatment with ambroxol in patients with chronic bronchitis].
    Pneumonologia i alergologia polska, 1996, Volume: 64 Suppl 1

    Topics: Administration, Oral; Adult; Aged; Ambroxol; Anti-Bacterial Agents; Bronchitis; Chronic Disease; Cou

1996
[Clinical results in the treatment of chronic obstructive bronchitis with ambroxol in comparison with bromhexine (author's transl)].
    Arzneimittel-Forschung, 1978, Volume: 28, Issue:5a

    Topics: Adult; Aged; Airway Resistance; Ambroxol; Bromhexine; Bronchitis; Chronic Disease; Clinical Trials a

1978
Prevention of chronic bronchitis exacerbations with ambroxol (mucosolvan retard). An open, long-term, multicenter study in 5,635 patients.
    Respiration; international review of thoracic diseases, 1989, Volume: 55 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambroxol; Bromhexine; Bronchitis; Chronic Disease; Doubl

1989
[Comparative evaluation of the effectiveness of lasolvan and mucodine in chronic nonspecific lung diseases].
    Sovetskaia meditsina, 1988, Issue:5

    Topics: Ambroxol; Asthma; Bromhexine; Bronchitis; Carbocysteine; Chronic Disease; Clinical Trials as Topic;

1988
[Long-term therapy over 2 years with ambroxol (Mucosolvan) retard capsules in patients with chronic bronchitis. Results of a double-blind study of 180 patients].
    Praxis und Klinik der Pneumologie, 1988, Volume: 42, Issue:9

    Topics: Administration, Oral; Adult; Ambroxol; Bromhexine; Bronchitis; Chronic Disease; Clinical Trials as T

1988
Ambroxol and simple chronic bronchitis. Effects on subjective symptoms and ventilatory function.
    Respiration; international review of thoracic diseases, 1987, Volume: 51 Suppl 1

    Topics: Adult; Ambroxol; Bromhexine; Bronchitis; Chronic Disease; Clinical Trials as Topic; Double-Blind Met

1987
Ambroxol for the prevention of chronic bronchitis exacerbations: long-term multicenter trial. Protective effect of ambroxol against winter semester exacerbations: a double-blind study versus placebo.
    Respiration; international review of thoracic diseases, 1987, Volume: 51 Suppl 1

    Topics: Adult; Ambroxol; Bacterial Infections; Bromhexine; Bronchitis; Chronic Disease; Clinical Trials as T

1987
Mucociliary clearance in early simple chronic bronchitis.
    European journal of respiratory diseases. Supplement, 1987, Volume: 153

    Topics: Adult; Ambroxol; Bronchi; Bronchitis; Chronic Disease; Clinical Trials as Topic; Humans; Mucociliary

1987
Ambroxol therapy in simple chronic bronchitis: effects on subjective symptoms and ventilatory function.
    European journal of respiratory diseases, 1986, Volume: 69, Issue:4

    Topics: Adult; Ambroxol; Bromhexine; Bronchitis; Chronic Disease; Clinical Trials as Topic; Double-Blind Met

1986
Ambroxol plus amoxicillin in the treatment of exacerbations of chronic bronchitis.
    Arzneimittel-Forschung, 1987, Volume: 37, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Ambroxol; Amoxicillin; Blood Gas Analysis; Bromhexine; Bronchitis; C

1987

Other Studies

7 other studies available for ambroxol and Chronic Disease

ArticleYear
[Long-term treatment of chronic bronchitis with ambroxol].
    ZFA. Zeitschrift fur Allgemeinmedizin, 1981, Sep-20, Volume: 57, Issue:26

    Topics: Adult; Aged; Ambroxol; Bromhexine; Bronchitis; Chronic Disease; Drug Administration Schedule; Drug E

1981
Preventing exacerbations of chronic bronchitis and COPD.
    BMJ (Clinical research ed.), 2001, May-26, Volume: 322, Issue:7297

    Topics: Acetylcysteine; Adjuvants, Immunologic; Ambroxol; Antioxidants; Bacteria; Bronchitis; Cell Extracts;

2001
[Effectiveness of lasolvan in patients with chronic obstructive bronchitis and non-atopic bronchial asthma].
    Terapevticheskii arkhiv, 2001, Volume: 73, Issue:3

    Topics: Adult; Ambroxol; Asthma; Bronchitis; Chronic Disease; Expectorants; Humans; Injections, Intramuscula

2001
[Therapeutic study on ambroxol in chronic bronchopulmonary diseases (author's transl)].
    Arzneimittel-Forschung, 1978, Volume: 28, Issue:5a

    Topics: Ambroxol; Bromhexine; Bronchitis; Chronic Disease; Cryptococcosis; Humans; Lung Diseases; Lung Disea

1978
Normalization of bronchial exocrine pathology after endobronchial treatment with ambroxol.
    International journal of tissue reactions, 1986, Volume: 8, Issue:2

    Topics: Adult; Aged; Ambroxol; Biopsy; Bromhexine; Bronchi; Bronchitis; Bronchoscopy; Chronic Disease; Exocr

1986
[Incorporation of a stimulant of the synthesis and secretion of pulmonary surfactant (ambroxol) in the medical treatment of serous otitis].
    Anales otorrinolaringologicos ibero-americanos, 1988, Volume: 15, Issue:2

    Topics: Acoustic Impedance Tests; Acute Disease; Adolescent; Adult; Ambroxol; Bromhexine; Child; Child, Pres

1988
[Effect of lasolvan on mucociliary transport in patients with chronic nonspecific lung diseases].
    Klinicheskaia meditsina, 1988, Volume: 66, Issue:3

    Topics: Adhesiveness; Ambroxol; Bromhexine; Chronic Disease; Drug Evaluation; Humans; Lung Diseases; Mucocil

1988