Page last updated: 2024-10-22

ambroxol and Alveolitis, Fibrosing

ambroxol has been researched along with Alveolitis, Fibrosing in 8 studies

Ambroxol: A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the possible therapeutic effect of ambroxol on pulmonary fibrosis induced by paraquat."7.77Protective effect of ambroxol against paraquat-induced pulmonary fibrosis in rats. ( Sun, HC; Yang, LT; Zhi, QM, 2011)
"To evaluate the possible therapeutic effect of ambroxol on pulmonary fibrosis induced by paraquat."3.77Protective effect of ambroxol against paraquat-induced pulmonary fibrosis in rats. ( Sun, HC; Yang, LT; Zhi, QM, 2011)
" The present study found that: (1) in healthy rats, the ambroxol-induced increase of alveolar antielastase activity did not appear due to reactivation of alpha 1-antitrypsin normally oxidized in the alveolar milieu; (2) in bleomycin-induced pulmonary fibrosis, ambroxol protection reduced total long collagen content at day 28, and (3) in paraquat-induced pulmonary fibrosis, alveolar phospholipids were markedly reduced throughout the 21 days of the experiment."3.67Relationship between changes in alveolar surfactant levels and lung defence mechanisms. ( Cetta, G; Coccia, P; Donnini, M; Luisetti, M; Pozzi, E; Rossi, A; Salmona, M; Spialtini, L, 1989)
" Patients in the treatment group took ambroxol orally at a dosage of 90 mg, three times per day for 3 months from the beginning of radiotherapy."2.75The protective effects of ambroxol on radiation lung injury and influence on production of transforming growth factor beta1 and tumor necrosis factor alpha. ( Dai, M; Mao, WD; Shen, WS; Shu, ZQ; Xi, L; Xia, DH; Xv, C; Yang, HZ, 2010)
"Pulmonary fibrosis is the end point of progressive functional disorder of respiratory mechanism and alveolo-capillary gas exchanges."2.66Nitrosourea derivatives-induced pulmonary toxicity in patients treated for malignant brain tumors. Early subclinical detection and its prevention. ( Butti, G; Gaetani, P; Knerich, R; Rossi, A; Silvani, V; Spanu, G, 1987)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19906 (75.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Xia, DH1
Xi, L1
Xv, C1
Mao, WD1
Shen, WS1
Shu, ZQ1
Yang, HZ1
Dai, M1
Zhi, QM1
Yang, LT1
Sun, HC1
VANWORMER, DE1
RANKIN, J1
KOBAYASHI, M1
BARBEE, RA1
DICKIE, HA1
Luisetti, M3
Peona, V1
Salmona, M3
Pagnoni, AM1
Villani, F1
Knerich, R2
Genghini, M2
AbbĂ , L1
Pozzi, E3
Masturzo, P1
Scelsi, M1
Spialtini, L2
Coccia, P1
Rossi, A2
Donnini, M1
Cetta, G1
Gaetani, P1
Silvani, V1
Butti, G1
Spanu, G1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Ambroxol on the Inflammatory Markers and Clinical Outcome of Patients With Diabetic Peripheral Neuropathy[NCT05558878]80 participants (Anticipated)Interventional2022-10-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for ambroxol and Alveolitis, Fibrosing

ArticleYear
The protective effects of ambroxol on radiation lung injury and influence on production of transforming growth factor beta1 and tumor necrosis factor alpha.
    Medical oncology (Northwood, London, England), 2010, Volume: 27, Issue:3

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ambroxol; Carbon Monoxide; Female; Free Radical Scavengers; Hu

2010
Nitrosourea derivatives-induced pulmonary toxicity in patients treated for malignant brain tumors. Early subclinical detection and its prevention.
    European journal of cancer & clinical oncology, 1987, Volume: 23, Issue:3

    Topics: Adult; Aged; Ambroxol; Brain Neoplasms; Bromhexine; Carmustine; Clinical Trials as Topic; Double-Bli

1987

Other Studies

6 other studies available for ambroxol and Alveolitis, Fibrosing

ArticleYear
Protective effect of ambroxol against paraquat-induced pulmonary fibrosis in rats.
    Internal medicine (Tokyo, Japan), 2011, Volume: 50, Issue:18

    Topics: Ambroxol; Animals; Collagen; Cytokines; Disease Models, Animal; Expectorants; Lung; Male; Oxidative

2011
FARMER'S LUNG.
    Archives of environmental health, 1965, Volume: 10

    Topics: Ambroxol; Biopsy; Farmer's Lung; Granuloma; Humans; Leukocyte Count; Pathology; Precipitin Tests; Pu

1965
AGRICULTURAL DUSTS AND DIFFUSE PULMONARY FIBROSIS.
    Archives of environmental health, 1965, Volume: 10

    Topics: Agricultural Workers' Diseases; Allergy and Immunology; Ambroxol; Dust; Farmer's Lung; Fungi; Humans

1965
Ambroxol and pulmonary toxicity induced by antineoplastic drugs.
    International journal of clinical pharmacology research, 1986, Volume: 6, Issue:2

    Topics: Ambroxol; Animals; Antineoplastic Agents; Bleomycin; Bromhexine; Busulfan; Cyclophosphamide; Humans;

1986
Role of alveolar phospholipids in bleomycin-induced pulmonary fibrosis in the rat.
    Respiration; international review of thoracic diseases, 1987, Volume: 51 Suppl 1

    Topics: Ambroxol; Animals; Bleomycin; Macrophages; Male; Membrane Fluidity; Phosphatidylcholines; Pulmonary

1987
Relationship between changes in alveolar surfactant levels and lung defence mechanisms.
    Respiration; international review of thoracic diseases, 1989, Volume: 55 Suppl 1

    Topics: Ambroxol; Animals; Bleomycin; Bronchoalveolar Lavage Fluid; Collagen; Glutathione; Lung; Macrophage

1989