amantadine has been researched along with Status Epilepticus in 4 studies
amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source
Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pilocarpine-induced status epilepticus (SE), which results in the development of spontaneous recurrent seizures (SRSs) activates glutamatergic receptors that contribute to seizure sustenance and neuronal cell death." | 7.91 | Perampanel but Not Amantadine Prevents Behavioral Alterations and Epileptogenesis in Pilocarpine Rat Model of Status Epilepticus. ( Mohammad, H; Moien-Afshari, F; Sekar, S; Taghibiglou, C; Wei, Z, 2019) |
| "5 g of amantadine developed status epilepticus." | 7.75 | Status epilepticus in a pediatric patient with amantadine overdose. ( Claudet, I; Maréchal, C, 2009) |
| "Amantadine was generally well-tolerated despite substantial dosage and duration of therapy." | 5.48 | Amantadine: A new treatment for refractory electrical status epilepticus in sleep. ( Eliyan, Y; Hussain, SA; Sankar, R; Wilson, RB, 2018) |
| "Pilocarpine-induced status epilepticus (SE), which results in the development of spontaneous recurrent seizures (SRSs) activates glutamatergic receptors that contribute to seizure sustenance and neuronal cell death." | 3.91 | Perampanel but Not Amantadine Prevents Behavioral Alterations and Epileptogenesis in Pilocarpine Rat Model of Status Epilepticus. ( Mohammad, H; Moien-Afshari, F; Sekar, S; Taghibiglou, C; Wei, Z, 2019) |
| "5 g of amantadine developed status epilepticus." | 3.75 | Status epilepticus in a pediatric patient with amantadine overdose. ( Claudet, I; Maréchal, C, 2009) |
| "Generalized convulsive status epilepticus is associated with high mortality." | 1.56 | α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor Plasticity Sustains Severe, Fatal Status Epilepticus. ( Adotevi, N; Dabrowska, N; Joshi, S; Kapur, J; Lewczuk, E; Shan, S; Sun, H; Williamson, J, 2020) |
| "Amantadine was generally well-tolerated despite substantial dosage and duration of therapy." | 1.48 | Amantadine: A new treatment for refractory electrical status epilepticus in sleep. ( Eliyan, Y; Hussain, SA; Sankar, R; Wilson, RB, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adotevi, N | 1 |
| Lewczuk, E | 1 |
| Sun, H | 1 |
| Joshi, S | 1 |
| Dabrowska, N | 1 |
| Shan, S | 1 |
| Williamson, J | 1 |
| Kapur, J | 1 |
| Wilson, RB | 1 |
| Eliyan, Y | 1 |
| Sankar, R | 1 |
| Hussain, SA | 1 |
| Mohammad, H | 1 |
| Sekar, S | 1 |
| Wei, Z | 1 |
| Moien-Afshari, F | 1 |
| Taghibiglou, C | 1 |
| Claudet, I | 1 |
| Maréchal, C | 1 |
4 other studies available for amantadine and Status Epilepticus
| Article | Year |
|---|---|
α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor Plasticity Sustains Severe, Fatal Status Epilepticus.
Topics: Adamantane; Amantadine; Animals; Atropine; CA1 Region, Hippocampal; Dose-Response Relationship, Drug | 2020 |
Amantadine: A new treatment for refractory electrical status epilepticus in sleep.
Topics: Adolescent; Amantadine; Autistic Disorder; Child; Child, Preschool; Cognition; Cognitive Dysfunction | 2018 |
Perampanel but Not Amantadine Prevents Behavioral Alterations and Epileptogenesis in Pilocarpine Rat Model of Status Epilepticus.
Topics: Amantadine; Animals; Astrocytes; Behavior, Animal; Caspase 3; Cell Survival; Cognition Disorders; Di | 2019 |
Status epilepticus in a pediatric patient with amantadine overdose.
Topics: Amantadine; Child, Preschool; Dopamine Agents; Drug Overdose; Humans; Male; Mydriasis; Receptors, N- | 2009 |