amantadine has been researched along with Seizures in 20 studies
amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pilocarpine-induced status epilepticus (SE), which results in the development of spontaneous recurrent seizures (SRSs) activates glutamatergic receptors that contribute to seizure sustenance and neuronal cell death." | 7.91 | Perampanel but Not Amantadine Prevents Behavioral Alterations and Epileptogenesis in Pilocarpine Rat Model of Status Epilepticus. ( Mohammad, H; Moien-Afshari, F; Sekar, S; Taghibiglou, C; Wei, Z, 2019) |
| "5 g of amantadine developed status epilepticus." | 7.75 | Status epilepticus in a pediatric patient with amantadine overdose. ( Claudet, I; Maréchal, C, 2009) |
| "We report here the efficacy of amantadine hydrochloride for two patients with alternating hemiplegia of childhood (AHC) that did not respond to flunarizine." | 7.70 | Successful trial of amantadine hydrochloride for two patients with alternating hemiplegia of childhood. ( Funatsuka, M; Katsumori, H; Oguni, H; Osawa, M; Sone, K; Tanaka, T, 2000) |
| "Memantine (1-amino-3,5-dimethyladamantane) has previously been shown to attenuate or block chemically or electrically induced seizures in rodents at doses of 5-20 mg/kg i." | 7.68 | High doses of memantine (1-amino-3,5-dimethyladamantane) induce seizures in kindled but not in non-kindled rats. ( Hönack, D; Löscher, W, 1990) |
| "We pooled individual patient data of five single-centre observational studies to determine the effect of amantadine treatment among patients with ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, community-acquired bacterial meningitis and status epilepticus, admitted between January 2012 and December 2015 and ventilated ≥7 days." | 4.12 | Amantadine treatment is associated with improved consciousness in patients with non-traumatic brain injury. ( Balk, S; Gerner, ST; Giede-Jeppe, A; Huttner, HB; Jäger, J; Kallmünzer, B; Kuramatsu, JB; Madzar, D; Mueller, T; Rühl, L; Schwab, S; Sembill, JA; Sprügel, MI, 2022) |
| "Pilocarpine-induced status epilepticus (SE), which results in the development of spontaneous recurrent seizures (SRSs) activates glutamatergic receptors that contribute to seizure sustenance and neuronal cell death." | 3.91 | Perampanel but Not Amantadine Prevents Behavioral Alterations and Epileptogenesis in Pilocarpine Rat Model of Status Epilepticus. ( Mohammad, H; Moien-Afshari, F; Sekar, S; Taghibiglou, C; Wei, Z, 2019) |
| " Following rapid intravenous infusion of equianalgesic bupivacaine, memantine, amantadine and saline (vehicle) in rats, we observed the onset time of seizure, apnea and impending death, and monitored mean arterial blood pressure and heart rate." | 3.78 | Cutaneous analgesia after subcutaneous injection of memantine and amantadine and their systemic toxicity in rats. ( Chen, YC; Chen, YW; Hung, CH; Leung, YM; Shieh, JP; Wang, JJ, 2012) |
| "5 g of amantadine developed status epilepticus." | 3.75 | Status epilepticus in a pediatric patient with amantadine overdose. ( Claudet, I; Maréchal, C, 2009) |
| "We report here the efficacy of amantadine hydrochloride for two patients with alternating hemiplegia of childhood (AHC) that did not respond to flunarizine." | 3.70 | Successful trial of amantadine hydrochloride for two patients with alternating hemiplegia of childhood. ( Funatsuka, M; Katsumori, H; Oguni, H; Osawa, M; Sone, K; Tanaka, T, 2000) |
| "Memantine (1-amino-3,5-dimethyladamantane) has previously been shown to attenuate or block chemically or electrically induced seizures in rodents at doses of 5-20 mg/kg i." | 3.68 | High doses of memantine (1-amino-3,5-dimethyladamantane) induce seizures in kindled but not in non-kindled rats. ( Hönack, D; Löscher, W, 1990) |
| " Amantadine in a dose of 25 mg/kg and particularly markedly in a dose of 100 mg/kg potentaites convulsive seizures." | 3.66 | On certain effects of dopaminergic agents in pentylenetetrazol convulsions. ( Lazarova, MB; Roussinov, KS, 1978) |
| "Influenza encephalopathy typically is associated with a sudden onset of high fever, severe convulsions, rapidly progressive coma, and death within 2 or 3 days." | 2.41 | Influenza-associated encephalopathy in Japan. ( Sugaya, N, 2002) |
| "Amantadine is an antiviral agent effective against influenza A viruses." | 1.30 | Amantadine and equine influenza: pharmacology, pharmacokinetics and neurological effects in the horse. ( Blouin, RA; Chambers, TM; Fenger, C; Harkins, JD; Holland, RE; Lu, M; Rees, WA; Tobin, T; Woods, WE, 1997) |
| "In January 1984, an outbreak of influenza caused by A/Victoria/7/83-like virus, a new H1N1 variant, occurred in an institution for mentally handicapped children and adults." | 1.27 | Amantadine prophylaxis during an institutional outbreak of type A (H1N1) influenza. ( Arden, NH; Atkinson, WL; Gohd, R; Leslie, N; Lui, KJ; Patriarca, PA, 1986) |
| "Experiments with pentylenetetrazol convulsion model in albino mice--80 mg/kg subcutaneously--have revealed the following." | 1.26 | On some relationships between dopaminergic and serotoninergic mechanisms in pentylenetetrazol convulsions in albino mice. ( Lazarova, M; Roussinov, K, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (40.00) | 18.7374 |
| 1990's | 5 (25.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 2 (10.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rühl, L | 1 |
| Kuramatsu, JB | 1 |
| Sembill, JA | 1 |
| Kallmünzer, B | 1 |
| Madzar, D | 1 |
| Gerner, ST | 1 |
| Giede-Jeppe, A | 1 |
| Balk, S | 1 |
| Mueller, T | 1 |
| Jäger, J | 1 |
| Schwab, S | 1 |
| Huttner, HB | 1 |
| Sprügel, MI | 1 |
| Mohammad, H | 1 |
| Sekar, S | 1 |
| Wei, Z | 1 |
| Moien-Afshari, F | 1 |
| Taghibiglou, C | 1 |
| Claudet, I | 1 |
| Maréchal, C | 1 |
| Chen, YW | 1 |
| Shieh, JP | 1 |
| Chen, YC | 1 |
| Leung, YM | 1 |
| Hung, CH | 1 |
| Wang, JJ | 1 |
| Sugaya, N | 1 |
| Lazarova, M | 2 |
| Roussinov, K | 2 |
| Kleinrok, Z | 1 |
| Czuczwar, SJ | 1 |
| Kozicka, M | 1 |
| Oxford, JS | 1 |
| Rees, WA | 1 |
| Harkins, JD | 1 |
| Woods, WE | 1 |
| Blouin, RA | 1 |
| Lu, M | 1 |
| Fenger, C | 1 |
| Holland, RE | 1 |
| Chambers, TM | 1 |
| Tobin, T | 1 |
| Micheli, F | 1 |
| Di Fabio, R | 1 |
| Capelli, AM | 1 |
| Cugola, A | 1 |
| Curcuruto, O | 1 |
| Feriani, A | 1 |
| Gastaldi, P | 1 |
| Gaviraghi, G | 1 |
| Marchioro, C | 1 |
| Orlandi, A | 1 |
| Pozzan, A | 1 |
| Quaglia, AM | 1 |
| Reggiani, A | 1 |
| van Amsterdam, F | 1 |
| Sone, K | 1 |
| Oguni, H | 1 |
| Katsumori, H | 1 |
| Funatsuka, M | 1 |
| Tanaka, T | 1 |
| Osawa, M | 1 |
| Chatterjie, N | 1 |
| Alexander, G | 1 |
| Wang, H | 1 |
| Roussinov, KS | 2 |
| Lazarova, MB | 2 |
| Vamvakides, A | 1 |
| Löscher, W | 1 |
| Hönack, D | 1 |
| Atkinson, WL | 1 |
| Arden, NH | 1 |
| Patriarca, PA | 1 |
| Leslie, N | 1 |
| Lui, KJ | 1 |
| Gohd, R | 1 |
| Spilker, BA | 1 |
| Dhasmana, KM | 1 |
| Davies, JE | 1 |
| Claassen, V | 1 |
| De Carolis, AS | 1 |
| Ziegler, H | 1 |
| Del Basso, P | 1 |
| Longo, VG | 1 |
2 reviews available for amantadine and Seizures
| Article | Year |
|---|---|
Influenza-associated encephalopathy in Japan.
Topics: Amantadine; Antiviral Agents; Brain Diseases; Child; Coma; Fever; Humans; Incidence; Influenza A vir | 2002 |
[Are there glutamatergic, anti-GABAergic or antiglycinergic components in the action mechanism of adamantamines? Study of convulsions induced by amantadine or 1-adamantylcyclopentanamine in mice].
Topics: Amantadine; Animals; Convulsants; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glycine; Ma | 1990 |
18 other studies available for amantadine and Seizures
| Article | Year |
|---|---|
Amantadine treatment is associated with improved consciousness in patients with non-traumatic brain injury.
Topics: Amantadine; Brain Injuries; Brain Ischemia; Consciousness; Delirium; Glasgow Coma Scale; Humans; Sei | 2022 |
Perampanel but Not Amantadine Prevents Behavioral Alterations and Epileptogenesis in Pilocarpine Rat Model of Status Epilepticus.
Topics: Amantadine; Animals; Astrocytes; Behavior, Animal; Caspase 3; Cell Survival; Cognition Disorders; Di | 2019 |
Status epilepticus in a pediatric patient with amantadine overdose.
Topics: Amantadine; Child, Preschool; Dopamine Agents; Drug Overdose; Humans; Male; Mydriasis; Receptors, N- | 2009 |
Cutaneous analgesia after subcutaneous injection of memantine and amantadine and their systemic toxicity in rats.
Topics: Amantadine; Analgesia; Analgesics, Non-Narcotic; Anesthetics, Local; Animals; Apnea; Behavior, Anima | 2012 |
Role of the relationships between the neurotransmitter systems in the convulsive-seizure reactions.
Topics: 5-Hydroxytryptophan; Amantadine; Amphetamine; Animals; Dopamine; Electroshock; gamma-Aminobutyric Ac | 1982 |
Effect of dopaminergic and GABA-ergic drugs given alone or in combination on the anticonvulsant action of phenobarbital and diphenylhydantoin in the electroshock test in mice.
Topics: Amantadine; Aminooxyacetic Acid; Amphetamine; Animals; Apomorphine; Baclofen; Dopamine; Electroshock | 1980 |
Amantadine in man and horse--can we learn from each other?
Topics: Amantadine; Animals; Antiviral Agents; Dose-Response Relationship, Drug; Europe; Horse Diseases; Hor | 1997 |
Amantadine and equine influenza: pharmacology, pharmacokinetics and neurological effects in the horse.
Topics: Administration, Oral; Amantadine; Animals; Antiviral Agents; Biological Availability; Central Nervou | 1997 |
Cycloalkyl indole-2-carboxylates as useful tools for mapping the "north-eastern" region of the glycine binding site associated with the NMDA receptor.
Topics: Amantadine; Animals; Anticonvulsants; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagoni | 1999 |
Successful trial of amantadine hydrochloride for two patients with alternating hemiplegia of childhood.
Topics: Adult; Amantadine; Dopamine Agents; Female; Glutamic Acid; Hemiplegia; Humans; Infant; Male; Recepto | 2000 |
Synthesis of valproic acid amides of a melatonin derivative, a piracetam and amantadine for biological tests.
Topics: Amantadine; Animals; Melatonin; Pentylenetetrazole; Piracetam; Rodentia; Seizures; Valproic Acid | 2001 |
On certain relationships between gamma-aminobutyric acid (GABA) and dopaminergic agents in pentylenetetrazol convulsions.
Topics: Amantadine; Animals; Apomorphine; Dextroamphetamine; Ditiocarb; Dopamine; Drug Interactions; gamma-A | 1978 |
On some relationships between dopaminergic and serotoninergic mechanisms in pentylenetetrazol convulsions in albino mice.
Topics: 5-Hydroxytryptophan; Amantadine; Amphetamine; Animals; Apomorphine; Dopamine; Levodopa; Male; Mice; | 1979 |
On certain effects of dopaminergic agents in pentylenetetrazol convulsions.
Topics: Amantadine; Animals; Benserazide; Dextroamphetamine; Dopamine; Drug Interactions; Haloperidol; Levod | 1978 |
High doses of memantine (1-amino-3,5-dimethyladamantane) induce seizures in kindled but not in non-kindled rats.
Topics: Amantadine; Amygdala; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Female; Kindl | 1990 |
Amantadine prophylaxis during an institutional outbreak of type A (H1N1) influenza.
Topics: Adolescent; Adult; Amantadine; Anorexia; Child; Cross Infection; Disease Outbreaks; Female; Humans; | 1986 |
Differentiation between effects of nicotine and DMPP by amantadine.
Topics: Acetylcholine; Amantadine; Animals; Blood Pressure; Cats; Drug Antagonism; Drug Interactions; Drug S | 1973 |
Central effects of 6-hydroxydopamine.
Topics: Amantadine; Amitriptyline; Amphetamine; Animals; Behavior, Animal; Brain; Brain Chemistry; Desiprami | 1971 |