amantadine has been researched along with Respiratory Insufficiency in 5 studies
amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source
Respiratory Insufficiency: Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amantadine has complex activity including antiviral, antiinflammatory and dopaminergic effects." | 1.72 | The use of amantadine in the prevention of progression and treatment of COVID-19 symptoms in patients infected with the SARS-CoV-2 virus (COV-PREVENT): Study rationale and design. ( Bonek, R; Chełstowski, W; Dąbrowski, P; Dec, M; Fiedor, P; Gala-Błądzińska, A; Goch, A; Grieb, P; Kiciak, S; Król, ZJ; Papuć, E; Rejdak, K; Segiet, A; Zasybska, A; Łukasiak, J, 2022) |
| "In patients treated in ICU with severe respiratory failure, administration of amantadine is associated with lower mortality, which may be associated with the potential anti-inflammatory and immunomodulatory effects of this agent." | 1.72 | Improved survival in intensive care unit in severe COVID-19 associated with amantadine use - retrospective study. ( Aksak-Wąs, B; Chober, D; Czajkowski, Z; Dalewska-Kucharczyk, K; Hołubczak, K; Jaremko, M; Karasińska-Cieślak, M; Karasińska-Milchert, S; Parczewski, M; Skowron, M, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (60.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rejdak, K | 1 |
| Fiedor, P | 1 |
| Bonek, R | 1 |
| Goch, A | 1 |
| Gala-Błądzińska, A | 1 |
| Chełstowski, W | 1 |
| Łukasiak, J | 1 |
| Kiciak, S | 1 |
| Dąbrowski, P | 1 |
| Dec, M | 1 |
| Król, ZJ | 1 |
| Papuć, E | 1 |
| Zasybska, A | 1 |
| Segiet, A | 1 |
| Grieb, P | 1 |
| Chober, D | 1 |
| Czajkowski, Z | 1 |
| Aksak-Wąs, B | 1 |
| Dalewska-Kucharczyk, K | 1 |
| Hołubczak, K | 1 |
| Karasińska-Milchert, S | 1 |
| Jaremko, M | 1 |
| Skowron, M | 1 |
| Karasińska-Cieślak, M | 1 |
| Parczewski, M | 1 |
| Brenner, SR | 1 |
| Botez, MI | 1 |
| Mayer, P | 1 |
| Bellemare, F | 1 |
| Couture, J | 1 |
| Kamianov, IM | 1 |
| Kupisk, AG | 1 |
| Katsen, IZ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Use of Amantadine in the Prevention of Progression and Treatment of COVID-19 Symptoms in Patients Infected With the SARS-CoV-2 Virus[NCT04854759] | Phase 3 | 200 participants (Anticipated) | Interventional | 2021-03-15 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for amantadine and Respiratory Insufficiency
| Article | Year |
|---|---|
The use of amantadine in the prevention of progression and treatment of COVID-19 symptoms in patients infected with the SARS-CoV-2 virus (COV-PREVENT): Study rationale and design.
Topics: Amantadine; COVID-19; COVID-19 Drug Treatment; Humans; Post-Acute COVID-19 Syndrome; Respiratory Ins | 2022 |
Improved survival in intensive care unit in severe COVID-19 associated with amantadine use - retrospective study.
Topics: Amantadine; COVID-19 Drug Treatment; Humans; Intensive Care Units; Respiration, Artificial; Respirat | 2022 |
The potential of memantine and related adamantanes such as amantadine, to reduce the neurotoxic effects of COVID-19, including ARDS and to reduce viral replication through lysosomal effects.
Topics: Adamantane; Amantadine; COVID-19; Humans; Lysosomes; Memantine; Respiratory Distress Syndrome; Respi | 2020 |
Can we treat respiratory failure in Friedreich ataxia?
Topics: 5-Hydroxytryptophan; Adult; Amantadine; Dopamine Agents; Friedreich Ataxia; Humans; Male; Respirator | 1997 |
[Experience with the use of midantan for treatment and prevention of the neuroleptic syndrome].
Topics: Adult; Amantadine; Antiparkinson Agents; Antipsychotic Agents; Catatonia; Chlorpromazine; Facial Mus | 1973 |