amantadine has been researched along with Psychomotor Agitation in 11 studies
amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source
Psychomotor Agitation: A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug toxicity or other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To test the hypothesis that amantadine hydrochloride is a safe and effective treatment for behavioral disturbances--for example, hyperactivity and irritability--in children with autism." | 9.09 | Double-blind, placebo-controlled study of amantadine hydrochloride in the treatment of children with autistic disorder. ( Cantwell, E; Cook, EH; Davanzo, PA; Dourish, CT; Dykens, EM; Handen, BL; Hooper, SR; Jaselskis, CA; King, BH; Leventhal, BL; Levitt, J; Lord, C; Lubetsky, MJ; McMahon, W; Myers, SM; Ozonoff, S; Shah, BG; Shernoff, EW; Sikich, L; Snape, M; Williamson, K; Wright, DM; Zimmerman, AW, 2001) |
| "To test the hypothesis that amantadine hydrochloride is a safe and effective treatment for behavioral disturbances--for example, hyperactivity and irritability--in children with autism." | 5.09 | Double-blind, placebo-controlled study of amantadine hydrochloride in the treatment of children with autistic disorder. ( Cantwell, E; Cook, EH; Davanzo, PA; Dourish, CT; Dykens, EM; Handen, BL; Hooper, SR; Jaselskis, CA; King, BH; Leventhal, BL; Levitt, J; Lord, C; Lubetsky, MJ; McMahon, W; Myers, SM; Ozonoff, S; Shah, BG; Shernoff, EW; Sikich, L; Snape, M; Williamson, K; Wright, DM; Zimmerman, AW, 2001) |
| "The use of the atypical neuroleptic medication, risperidone, may be considered as part of the armamentarium available to physicians treating restlessness in severe brain injuries." | 3.72 | Risperidone treatment of motor restlessness following anoxic brain injury. ( Collins, L; Silver, BV; Zidek, KA, 2003) |
| " A retrospective review of electronic medical records was conducted by researchers and data were collected on the following measures: ordered psycho-pharmacological agents, frequency, dosing and duration of orders, whether each administered psycho-pharmacological agent was started before or after psychiatric consultation, and psycho-pharmacological agents prescribed upon discharge." | 2.82 | A descriptive analysis of pharmacological management of aggression and/or agitation in patients with traumatic brain injury in a Southwest Virginia inpatient population. ( Kablinger, A; Lemelle, T; Rahmani, E; Sharp, H; Smarbafzadeh, E, 2022) |
| "Neurobehavioural sequelae of traumatic brain injuries require an appropriate/effective pharmacological response in that they represent an important cause of disability." | 1.35 | Pharmacological treatment of neurobehavioural sequelae of traumatic brain injury. ( Lombardi, F, 2008) |
| "Amantadine is a reasonable option for improving cognition and reducing agitation following a TBI but confirmatory evidence of the efficacy the drug is necessary." | 1.33 | Amantadine for traumatic brain injury: does it improve cognition and reduce agitation? ( Leone, H; Polsonetti, BW, 2005) |
| " An increase in dosage also had only a transient effect." | 1.27 | Development of tolerance to the therapeutic effect of amantadine on akathisia. ( Barreira, P; Lipinski, JF; Zubenko, GS, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (63.64) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Rahmani, E | 1 |
| Lemelle, T | 1 |
| Sharp, H | 1 |
| Smarbafzadeh, E | 1 |
| Kablinger, A | 1 |
| Luauté, J | 1 |
| Plantier, D | 1 |
| Wiart, L | 1 |
| Tell, L | 1 |
| Silver, BV | 1 |
| Collins, L | 1 |
| Zidek, KA | 1 |
| Leone, H | 1 |
| Polsonetti, BW | 1 |
| Visanji, NP | 1 |
| Gomez-Ramirez, J | 1 |
| Johnston, TH | 1 |
| Pires, D | 1 |
| Voon, V | 1 |
| Brotchie, JM | 1 |
| Fox, SH | 1 |
| Fleminger, S | 1 |
| Greenwood, RJ | 1 |
| Oliver, DL | 1 |
| Lombardi, F | 1 |
| Zubenko, GS | 1 |
| Barreira, P | 1 |
| Lipinski, JF | 1 |
| King, BH | 1 |
| Wright, DM | 1 |
| Handen, BL | 1 |
| Sikich, L | 1 |
| Zimmerman, AW | 1 |
| McMahon, W | 1 |
| Cantwell, E | 1 |
| Davanzo, PA | 1 |
| Dourish, CT | 1 |
| Dykens, EM | 1 |
| Hooper, SR | 1 |
| Jaselskis, CA | 1 |
| Leventhal, BL | 1 |
| Levitt, J | 1 |
| Lord, C | 1 |
| Lubetsky, MJ | 1 |
| Myers, SM | 1 |
| Ozonoff, S | 1 |
| Shah, BG | 1 |
| Snape, M | 1 |
| Shernoff, EW | 1 |
| Williamson, K | 1 |
| Cook, EH | 1 |
| Rosati, DL | 1 |
| Keepers, GA | 1 |
| Casey, DE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Utility of Amantadine Hydrochloride in the Treatment of Post-traumatic Irritability: A Randomized, Double-Blind, Placebo-Controlled Trial[NCT00627250] | 76 participants (Actual) | Interventional | 2003-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for amantadine and Psychomotor Agitation
| Article | Year |
|---|---|
A descriptive analysis of pharmacological management of aggression and/or agitation in patients with traumatic brain injury in a Southwest Virginia inpatient population.
Topics: Adrenergic beta-Antagonists; Adult; Aggression; Amantadine; Anticonvulsants; Antipsychotic Agents; B | 2022 |
Care management of the agitation or aggressiveness crisis in patients with TBI. Systematic review of the literature and practice recommendations.
Topics: Adrenergic beta-Antagonists; Aggression; Amantadine; Anti-Anxiety Agents; Anticonvulsants; Antipsych | 2016 |
Pharmacological management for agitation and aggression in people with acquired brain injury.
Topics: Adrenergic beta-Antagonists; Aggression; Amantadine; Anxiety; Brain Injuries; Humans; Methylphenidat | 2006 |
Clinical management of acute neuroleptic-induced extrapyramidal syndromes.
Topics: Acute Disease; Adolescent; Adult; Age Factors; Akathisia, Drug-Induced; Amantadine; Antipsychotic Ag | 1986 |
1 trial available for amantadine and Psychomotor Agitation
| Article | Year |
|---|---|
Double-blind, placebo-controlled study of amantadine hydrochloride in the treatment of children with autistic disorder.
Topics: Adolescent; Adult; Amantadine; Autistic Disorder; Child; Child, Preschool; Dopamine Agents; Double-B | 2001 |
6 other studies available for amantadine and Psychomotor Agitation
| Article | Year |
|---|---|
Risperidone treatment of motor restlessness following anoxic brain injury.
Topics: Adolescent; Amantadine; Brain Injuries; Dopamine Agents; Drug Therapy, Combination; Humans; Hypoxia, | 2003 |
Amantadine for traumatic brain injury: does it improve cognition and reduce agitation?
Topics: Administration, Oral; Adolescent; Adult; Aged; Amantadine; Brain Injuries; Cognition Disorders; Huma | 2005 |
Pharmacological characterization of psychosis-like behavior in the MPTP-lesioned nonhuman primate model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amantadine; Animals; Antiparkinson Agents; Apomorphine | 2006 |
Pharmacological treatment of neurobehavioural sequelae of traumatic brain injury.
Topics: Amantadine; Animals; Antidepressive Agents; Antipsychotic Agents; Brain Injuries; Cognition; Cogniti | 2008 |
Development of tolerance to the therapeutic effect of amantadine on akathisia.
Topics: Adult; Akathisia, Drug-Induced; Amantadine; Bipolar Disorder; Drug Tolerance; Female; Haloperidol; H | 1984 |
Early polyneuropharmacologic intervention in brain injury agitation.
Topics: Adolescent; Adult; Amantadine; Antipsychotic Agents; Brain Injuries; Dextroamphetamine; Drug Adminis | 2002 |