amantadine has been researched along with Postpoliomyelitis Syndrome in 3 studies
amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source
Postpoliomyelitis Syndrome: A syndrome characterized by new neuromuscular symptoms that occur at least 15 years after clinical stability has been attained in patients with a prior history of symptomatic poliomyelitis. Clinical features include new muscular weakness and atrophy of the limbs, bulbar innervated musculature, and muscles of respiration, combined with excessive fatigue, joint pain, and reduced stamina. The process is marked by slow progression and periods of stabilization. (From Ann NY Acad Sci 1995 May 25;753:68-80)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Because amantadine has been shown to reduce fatigue in patients with multiple sclerosis, we performed a double-blind, placebo-controlled study to assess its efficacy in the disabling symptom of post-polio fatigue." | 9.08 | A double-blind, placebo-controlled trial of amantadine for the treatment of fatigue in patients with the post-polio syndrome. ( Dalakas, MC; Dambrosia, JM; Stein, DP, 1995) |
| "Because amantadine has been shown to reduce fatigue in patients with multiple sclerosis, we performed a double-blind, placebo-controlled study to assess its efficacy in the disabling symptom of post-polio fatigue." | 5.08 | A double-blind, placebo-controlled trial of amantadine for the treatment of fatigue in patients with the post-polio syndrome. ( Dalakas, MC; Dambrosia, JM; Stein, DP, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Farbu, E | 1 |
| Gilhus, NE | 1 |
| Barnes, MP | 1 |
| Borg, K | 1 |
| de Visser, M | 1 |
| Driessen, A | 1 |
| Howard, R | 1 |
| Nollet, F | 1 |
| Opara, J | 1 |
| Stalberg, E | 1 |
| Stein, DP | 1 |
| Dambrosia, JM | 1 |
| Dalakas, MC | 1 |
| Dunn, MG | 1 |
1 trial available for amantadine and Postpoliomyelitis Syndrome
| Article | Year |
|---|---|
A double-blind, placebo-controlled trial of amantadine for the treatment of fatigue in patients with the post-polio syndrome.
Topics: Amantadine; Double-Blind Method; Fatigue; Humans; Postpoliomyelitis Syndrome; Surveys and Questionna | 1995 |
2 other studies available for amantadine and Postpoliomyelitis Syndrome
| Article | Year |
|---|---|
EFNS guideline on diagnosis and management of post-polio syndrome. Report of an EFNS task force.
Topics: Advisory Committees; Amantadine; Antiviral Agents; Cholinesterase Inhibitors; Europe; Exercise Thera | 2006 |
Post-polio fatigue treated with amantadine.
Topics: Amantadine; Fatigue; Humans; Postpoliomyelitis Syndrome | 1991 |