amantadine has been researched along with Orthomyxoviridae Infections in 85 studies
amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source
Orthomyxoviridae Infections: Virus diseases caused by the ORTHOMYXOVIRIDAE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Influenza A and influenza B viruses are continuing causes of morbidity and mortality on an annual basis." | 2.44 | Influenza viruses: basic biology and potential drug targets. ( Basler, CF, 2007) |
| "Highly pathogenic H5N1 avian influenza viruses have spread in poultry and wild birds in Asia, Europe, and Africa since 2003." | 1.40 | Characterization of the amantadine-resistant H5N1 highly pathogenic avian influenza variants isolated from quails in Southern China. ( Dong, G; He, H; Ji, G; Luo, J; Peng, C; Wu, B; Zhou, K, 2014) |
| "By attaching multiple copies of the influenza M2 ion channel inhibitors amantadine (1) and rimantadine (2) to polymeric chains, we endeavored to recover their potency in inhibiting drug-resistant influenza viruses." | 1.39 | Conjugation to polymeric chains of influenza drugs targeting M2 ion channels partially restores inhibition of drug-resistant mutants. ( Chen, J; Klibanov, AM; Larson, AM, 2013) |
| "Amantadine was effective at 10, 30, and 100mg/kg/day, rimantadine was protective at 10 and 30mg/kg/day (highest dose tested), and ribavirin was active at 30 and 75mg/kg/day, with survival ranging from 60-100% for oral treatments initiated at -2h." | 1.38 | Treatment of oseltamivir-resistant influenza A (H1N1) virus infections in mice with antiviral agents. ( Gross, M; Julander, JG; Nguyen, J; Smee, DF; Tarbet, EB, 2012) |
| "Amantadine is an antiviral agent effective against influenza A viruses." | 1.30 | Amantadine and equine influenza: pharmacology, pharmacokinetics and neurological effects in the horse. ( Blouin, RA; Chambers, TM; Fenger, C; Harkins, JD; Holland, RE; Lu, M; Rees, WA; Tobin, T; Woods, WE, 1997) |
| " While readily bioavailable by systemic routes, it was poorly bioavailable by the oral route." | 1.29 | Inhibition of influenza virus replication in mice by GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is consistent with extracellular activity of viral neuraminidase (sialidase). ( Dempsey, MH; Penn, CR; Ryan, DM; Ticehurst, J, 1994) |
| "5 h after oral administration, and the elimination half-life was 1." | 1.27 | Pharmacokinetics and metabolism of rimantadine hydrochloride in mice and dogs. ( Blasecki, JW; Gaylord, JC; Hoffman, HE; Shalaby, LM; Whitney, CC, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 44 (51.76) | 18.7374 |
| 1990's | 8 (9.41) | 18.2507 |
| 2000's | 19 (22.35) | 29.6817 |
| 2010's | 14 (16.47) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tilley, JW | 1 |
| Levitan, P | 1 |
| Kramer, MJ | 1 |
| Conti, G | 1 |
| Magliani, W | 1 |
| Conti, S | 1 |
| Nencioni, L | 1 |
| Sgarbanti, R | 1 |
| Palamara, AT | 2 |
| Polonelli, L | 1 |
| Rey-Carrizo, M | 1 |
| Barniol-Xicota, M | 1 |
| Ma, C | 2 |
| Frigolé-Vivas, M | 1 |
| Torres, E | 1 |
| Naesens, L | 2 |
| Llabrés, S | 1 |
| Juárez-Jiménez, J | 1 |
| Luque, FJ | 1 |
| DeGrado, WF | 2 |
| Lamb, RA | 1 |
| Pinto, LH | 1 |
| Vázquez, S | 1 |
| Clark, MP | 1 |
| Ledeboer, MW | 1 |
| Davies, I | 1 |
| Byrn, RA | 1 |
| Jones, SM | 1 |
| Perola, E | 1 |
| Tsai, A | 1 |
| Jacobs, M | 1 |
| Nti-Addae, K | 1 |
| Bandarage, UK | 1 |
| Boyd, MJ | 1 |
| Bethiel, RS | 1 |
| Court, JJ | 1 |
| Deng, H | 1 |
| Duffy, JP | 1 |
| Dorsch, WA | 1 |
| Farmer, LJ | 1 |
| Gao, H | 1 |
| Gu, W | 1 |
| Jackson, K | 1 |
| Jacobs, DH | 1 |
| Kennedy, JM | 1 |
| Ledford, B | 1 |
| Liang, J | 1 |
| Maltais, F | 1 |
| Murcko, M | 1 |
| Wang, T | 1 |
| Wannamaker, MW | 1 |
| Bennett, HB | 1 |
| Leeman, JR | 1 |
| McNeil, C | 1 |
| Taylor, WP | 1 |
| Memmott, C | 1 |
| Jiang, M | 1 |
| Rijnbrand, R | 1 |
| Bral, C | 1 |
| Germann, U | 1 |
| Nezami, A | 1 |
| Zhang, Y | 1 |
| Salituro, FG | 1 |
| Bennani, YL | 1 |
| Charifson, PS | 1 |
| Li, Y | 1 |
| Lin, Z | 1 |
| Guo, M | 1 |
| Zhao, M | 1 |
| Xia, Y | 1 |
| Wang, C | 1 |
| Xu, T | 1 |
| Zhu, B | 1 |
| Jiang, J | 1 |
| Zhao, X | 1 |
| Niu, T | 1 |
| Yan, H | 1 |
| Yinghong, LI | 1 |
| Yuhuan, LI | 1 |
| Song, D | 1 |
| Tang, S | 1 |
| Xing, J | 1 |
| Larson, AM | 1 |
| Chen, J | 1 |
| Klibanov, AM | 1 |
| Wan, XF | 1 |
| Carrel, M | 1 |
| Long, LP | 1 |
| Alker, AP | 1 |
| Emch, M | 1 |
| Deryabin, PG | 1 |
| Galegov, GA | 1 |
| Konstantinova, ID | 1 |
| Muzyka, IS | 1 |
| Miroshnikov, AI | 1 |
| L'vov, DK | 1 |
| Sutton, TC | 1 |
| Obadan, A | 1 |
| Lavigne, J | 1 |
| Chen, H | 1 |
| Li, W | 1 |
| Perez, DR | 1 |
| Dong, G | 1 |
| Luo, J | 1 |
| Zhou, K | 1 |
| Wu, B | 1 |
| Peng, C | 1 |
| Ji, G | 1 |
| He, H | 1 |
| Durrant, MG | 1 |
| Eggett, DL | 1 |
| Busath, DD | 1 |
| Hu, Y | 1 |
| Musharrafieh, R | 1 |
| Zhang, J | 1 |
| Smee, DF | 4 |
| Wang, J | 1 |
| Beauchemin, CA | 1 |
| McSharry, JJ | 1 |
| Drusano, GL | 1 |
| Nguyen, JT | 2 |
| Went, GT | 2 |
| Ribeiro, RM | 1 |
| Perelson, AS | 1 |
| Zoidis, G | 1 |
| Tsotinis, A | 1 |
| Kolocouris, N | 1 |
| Kelly, JM | 1 |
| Prathalingam, SR | 1 |
| De Clercq, E | 2 |
| Krumbholz, A | 2 |
| Schmidtke, M | 2 |
| Bergmann, S | 1 |
| Motzke, S | 1 |
| Bauer, K | 2 |
| Stech, J | 1 |
| Dürrwald, R | 1 |
| Wutzler, P | 3 |
| Zell, R | 2 |
| Hurst, BL | 1 |
| Wong, MH | 1 |
| Bailey, KW | 1 |
| Morrey, JD | 1 |
| Kim, Y | 1 |
| Narayanan, S | 1 |
| Chang, KO | 1 |
| Bryans, JT | 1 |
| Zent, WW | 1 |
| Grunert, RR | 2 |
| Boughton, DC | 1 |
| Barnard, DL | 1 |
| Julander, JG | 2 |
| Gross, M | 2 |
| de Jong, MD | 1 |
| Tarbet, EB | 1 |
| Nguyen, J | 1 |
| Mori, I | 1 |
| Liu, B | 1 |
| Hossain, MJ | 1 |
| Takakuwa, H | 1 |
| Daikoku, T | 1 |
| Nishiyama, Y | 1 |
| Naiki, H | 1 |
| Matsumoto, K | 1 |
| Yokochi, T | 1 |
| Kimura, Y | 1 |
| Herlocher, ML | 1 |
| Truscon, R | 1 |
| Fenton, R | 1 |
| Klimov, A | 1 |
| Elias, S | 1 |
| Ohmit, SE | 1 |
| Monto, AS | 1 |
| Härtl, A | 1 |
| Sauerbrei, A | 1 |
| Stelzner, A | 1 |
| Schrader, C | 1 |
| Suess, J | 1 |
| Ilyushina, NA | 2 |
| Govorkova, EA | 2 |
| Russell, CJ | 1 |
| Hoffmann, E | 2 |
| Webster, RG | 4 |
| Salomon, R | 1 |
| Masihi, KN | 3 |
| Schweiger, B | 1 |
| Finsterbusch, T | 1 |
| Hengel, H | 1 |
| Evseenko, VA | 1 |
| Bukin, EK | 1 |
| Zaykovskaya, AV | 1 |
| Sharshov, KA | 1 |
| Ternovoi, VA | 1 |
| Ignatyev, GM | 1 |
| Shestopalov, AM | 1 |
| Basler, CF | 1 |
| Muldoon, RL | 1 |
| Jackson, GG | 1 |
| Potter, CW | 3 |
| Teh, CZ | 1 |
| Harvey, L | 1 |
| Jennings, R | 1 |
| Wilson, SZ | 1 |
| Knight, V | 1 |
| Wyde, PR | 1 |
| Drake, S | 1 |
| Couch, RB | 1 |
| Ryan, DM | 1 |
| Ticehurst, J | 1 |
| Dempsey, MH | 1 |
| Penn, CR | 1 |
| Robinson, HL | 1 |
| Hunt, LA | 1 |
| D'Agostini, C | 1 |
| Favalli, C | 1 |
| Sivilia, M | 1 |
| Febbraro, G | 1 |
| Bue, C | 1 |
| Garaci, E | 1 |
| Lee, MG | 1 |
| Kim, KH | 1 |
| Park, KY | 1 |
| Kim, JS | 1 |
| Rees, WA | 1 |
| Harkins, JD | 1 |
| Woods, WE | 1 |
| Blouin, RA | 1 |
| Lu, M | 1 |
| Fenger, C | 1 |
| Holland, RE | 1 |
| Chambers, TM | 1 |
| Tobin, T | 1 |
| Takeda, N | 1 |
| Kurosaki, T | 1 |
| Nakamura, A | 1 |
| Munakata, M | 1 |
| Kato, R | 1 |
| Yokoyama, H | 1 |
| Haginoya, K | 1 |
| Tanaka, Y | 1 |
| Kayaba, J | 1 |
| Kato, T | 1 |
| Takayanagi, R | 1 |
| Endo, H | 1 |
| Hasegawa, R | 1 |
| Ejima, Y | 1 |
| Hoshi, K | 1 |
| Iinuma, K | 1 |
| Ito, S | 1 |
| Iijima, N | 1 |
| Kanemaki, K | 1 |
| Hayashi, S | 1 |
| Hujii, S | 1 |
| Watanabe, T | 1 |
| Hosokawa, T | 1 |
| Kakehi, K | 1 |
| Kandel, R | 1 |
| Hartshorn, KL | 1 |
| Tisdale, M | 2 |
| Bauer, DJ | 2 |
| Scott, GH | 1 |
| Stephen, EL | 2 |
| Berendt, RF | 1 |
| Nugent, KM | 1 |
| Pesanti, EL | 1 |
| Schmidt-Ruppin, KH | 2 |
| Poncioni, B | 1 |
| Fenton, RJ | 1 |
| Bessell, C | 1 |
| Spilling, CR | 1 |
| Walker, JS | 1 |
| Spertzel, RO | 1 |
| Obrosova-Serova, NP | 1 |
| Kupriashina, IM | 1 |
| Isachenko, VA | 1 |
| Vorontsova, RM | 1 |
| Utkin, VG | 1 |
| Kanao, S | 1 |
| Toyoda, T | 1 |
| Suyama, T | 1 |
| Toyoshima, S | 1 |
| Rohde-Schulz, B | 1 |
| Masek, K | 2 |
| Palache, B | 1 |
| Fattal-German, M | 2 |
| Bizzini, B | 2 |
| Lange, W | 1 |
| Schwenke, S | 1 |
| Gast, G | 1 |
| Huchshorn, P | 1 |
| Palache, A | 1 |
| Ikeda, S | 1 |
| Mori, K | 1 |
| Nishimura, C | 1 |
| Hoffman, HE | 1 |
| Gaylord, JC | 1 |
| Blasecki, JW | 1 |
| Shalaby, LM | 1 |
| Whitney, CC | 1 |
| Kawaoka, Y | 1 |
| Bean, WJ | 1 |
| Hayden, FG | 1 |
| Benda, R | 2 |
| Hála, S | 1 |
| Dostálová, J | 2 |
| Vojtísková-Tucková, E | 1 |
| Weidenhoffer, Z | 1 |
| Rehn, F | 2 |
| Cochran, KW | 2 |
| Maassab, HF | 2 |
| Tsunoda, A | 1 |
| Berlin, BS | 1 |
| Smith, GB | 1 |
| Purcell, RH | 1 |
| Chanock, RM | 1 |
| Goetz, O | 1 |
| Schirmböck, J | 1 |
| Stott, EJ | 1 |
| Taylor-Robinson, D | 1 |
| Lundahl, K | 1 |
| Schut, J | 1 |
| Schlatmann, JL | 1 |
| Paerels, GB | 1 |
| Peters, A | 2 |
| Solovyov, VN | 1 |
| Tolmacheva, NS | 1 |
| Kashiwagi, S | 1 |
| Nakamura, S | 1 |
| Nii, F | 1 |
| Inoue, S | 1 |
| Nakanishi, I | 1 |
| Shimizu, M | 1 |
| Fujita, H | 1 |
| Denk, H | 1 |
| Kovac, W | 1 |
| Müller, R | 1 |
| Auterhoff, H | 1 |
| David-West, TS | 1 |
| Smit, A | 1 |
| Kralt, T | 1 |
| van Hes, R | 1 |
| Altucci, P | 1 |
| Degen, L | 1 |
| Del Vecchio-Blanco, C | 1 |
| Varone, GL | 1 |
| Magrassi, F | 1 |
| Oxford, JS | 1 |
| Logan, IS | 1 |
| Goedemans, WT | 1 |
| De Bock, CA | 1 |
| Grossgebauer, K | 1 |
| Langmaack, H | 1 |
| Lang, G | 1 |
| Narayan, O | 1 |
| Rouse, BT | 1 |
| Maciag, WJ | 1 |
| Hoffmann, CE | 3 |
| McGahen, JW | 1 |
| Davies, WL | 1 |
7 reviews available for amantadine and Orthomyxoviridae Infections
| Article | Year |
|---|---|
Influenza viruses: basic biology and potential drug targets.
Topics: Amantadine; Antiviral Agents; Drug Design; Enzyme Inhibitors; Humans; Influenza A virus; Influenza, | 2007 |
[Therapeutic efficacy of amantadine hydrochloride in patients with epidemic influenza A virus infection].
Topics: Adult; Amantadine; Antiviral Agents; Drug Therapy, Combination; Female; Fever; Humans; Influenza A v | 2000 |
Prophylaxis and treatment of influenza virus infection.
Topics: Amantadine; Antiviral Agents; Humans; Influenza Vaccines; Neuraminidase; Orthomyxoviridae Infections | 2001 |
Antiviral and adjuvant activity of immunomodulator adamantylamide dipeptide.
Topics: Adjuvants, Immunologic; Amantadine; Animals; Antibodies, Viral; Antiviral Agents; Dipeptides; Hypers | 1992 |
The common cold.
Topics: Adenoviridae; Adult; Amantadine; Animals; Ascorbic Acid; Cephalosporins; Common Cold; Cricetinae; En | 1970 |
[Adamantane and its significance for pharmaceutical chemistry].
Topics: Amantadine; Animals; Chemistry, Pharmaceutical; Cholagogues and Choleretics; Culture Techniques; Est | 1969 |
Antiviral chemotherapy.
Topics: Adsorption; Amantadine; Animals; Antimetabolites; Antiviral Agents; Benzimidazoles; Chick Embryo; Cr | 1970 |
3 trials available for amantadine and Orthomyxoviridae Infections
| Article | Year |
|---|---|
[A trial of amantadine for the treatment of influenza A infection in children].
Topics: Adolescent; Adult; Amantadine; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Influenza A | 2000 |
[Therapeutic efficacy of amantadine hydrochloride in patients with epidemic influenza A virus infection].
Topics: Adult; Amantadine; Antiviral Agents; Drug Therapy, Combination; Female; Fever; Humans; Influenza A v | 2000 |
[Epidemiological studies of common cold diseases. Diagnosis and therapy].
Topics: Adenoviridae; Amantadine; Complement Fixation Tests; Germany, West; Humans; Male; Military Medicine; | 1967 |
76 other studies available for amantadine and Orthomyxoviridae Infections
| Article | Year |
|---|---|
Adamantylthiourea derivatives as antiviral agents.
Topics: Adamantane; Amantadine; Animals; Antiviral Agents; Lethal Dose 50; Mice; Orthomyxoviridae Infections | 1979 |
Therapeutic activity of an anti-idiotypic antibody-derived killer peptide against influenza A virus experimental infection.
Topics: Animals; Antibodies, Anti-Idiotypic; Antiviral Agents; Cell Line; Humans; Influenza A Virus, H1N1 Su | 2008 |
Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus.
Topics: Amantadine; Amines; Animals; Dogs; Drug Resistance, Viral; Influenza A virus; Ion Channels; Madin Da | 2014 |
Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2.
Topics: Administration, Oral; Animals; Antiviral Agents; Aza Compounds; Biological Availability; Dogs; Drug | 2014 |
Inhibition of H1N1 influenza virus-induced apoptosis by functionalized selenium nanoparticles with amantadine through ROS-mediated AKT signaling pathways.
Topics: Amantadine; Animals; Antiviral Agents; Apoptosis; Dogs; Drug Delivery Systems; Drug Resistance, Vira | 2018 |
Construction and synthesis of tricyclic matrinic derivatives against influenza A virus by privileged structure strategy.
Topics: Alkaloids; Amantadine; Animals; Antiviral Agents; Humans; Influenza A Virus, H3N2 Subtype; Influenza | 2019 |
Conjugation to polymeric chains of influenza drugs targeting M2 ion channels partially restores inhibition of drug-resistant mutants.
Topics: Amantadine; Animals; Antiviral Agents; Cell Line; Dogs; Drug Carriers; Drug Resistance, Viral; Human | 2013 |
Perspective on emergence and re-emergence of amantadine resistant influenza A viruses in domestic animals in China.
Topics: Amantadine; Animals; Animals, Domestic; Antiviral Agents; China; Drug Resistance, Viral; Influenza A | 2013 |
The combination of ribavirin and ozeltamivir effectively inhibits reproduction of influenza A virus resistant to rimantadine (amantadine) in vitro and in vivo.
Topics: Amantadine; Animals; Antiviral Agents; Dogs; Drug Combinations; Drug Resistance, Viral; Influenza A | 2014 |
Genome rearrangement of influenza virus for anti-viral drug screening.
Topics: Amantadine; Animals; Antiviral Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Female; | 2014 |
Characterization of the amantadine-resistant H5N1 highly pathogenic avian influenza variants isolated from quails in Southern China.
Topics: Amantadine; Animals; Antiviral Agents; China; Cluster Analysis; Drug Resistance, Viral; Evolution, M | 2014 |
Investigation of a recent rise of dual amantadine-resistance mutations in the influenza A M2 sequence.
Topics: Amantadine; Animals; Drug Resistance, Viral; Influenza A virus; Midwestern United States; Orthomyxov | 2015 |
An M2-V27A channel blocker demonstrates potent in vitro and in vivo antiviral activities against amantadine-sensitive and -resistant influenza A viruses.
Topics: Adamantane; Amantadine; Animals; Antiviral Agents; Dogs; Drug Resistance, Viral; Humans; Influenza A | 2017 |
Modeling amantadine treatment of influenza A virus in vitro.
Topics: Amantadine; Animals; Cell Death; Cell Line; Dogs; Drug Resistance, Viral; Influenza A virus; Influen | 2008 |
Design and synthesis of bioactive 1,2-annulated adamantane derivatives.
Topics: Amantadine; Animals; Antiviral Agents; Drug Design; Influenza A Virus, H3N2 Subtype; Orthomyxovirida | 2008 |
High prevalence of amantadine resistance among circulating European porcine influenza A viruses.
Topics: Amantadine; Animals; Antiviral Agents; Cell Line; Drug Resistance, Viral; Europe; Influenza A virus; | 2009 |
Effects of double combinations of amantadine, oseltamivir, and ribavirin on influenza A (H5N1) virus infections in cell culture and in mice.
Topics: Amantadine; Animals; Antiviral Agents; Cell Line; Disease Models, Animal; Drug Interactions; Drug Re | 2009 |
Inhibition of influenza virus replication by plant-derived isoquercetin.
Topics: Amantadine; Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Drug Evaluation, Preclinical | 2010 |
I-adamantanamine hydrochloride prophylaxis for experimentally induced A/equine 2 influenza virus infection.
Topics: Amantadine; Animals; Antiviral Agents; Horse Diseases; Horses; Influenza A virus; Orthomyxoviridae I | 1966 |
Efficacy of combined therapy with amantadine, oseltamivir, and ribavirin in vivo against susceptible and amantadine-resistant influenza A viruses.
Topics: Amantadine; Animals; Antiviral Agents; Cells, Cultured; Disease Models, Animal; Dogs; Drug Combinati | 2012 |
Treatment of oseltamivir-resistant influenza A (H1N1) virus infections in mice with antiviral agents.
Topics: Amantadine; Animals; Antiviral Agents; Disease Models, Animal; Drug Resistance, Viral; Female; Influ | 2012 |
Successful protection by amantadine hydrochloride against lethal encephalitis caused by a highly neurovirulent recombinant influenza A virus in mice.
Topics: Amantadine; Animals; Antiviral Agents; Encephalitis, Viral; Female; Influenza A virus; Mice; Mice, I | 2002 |
Assessment of development of resistance to antivirals in the ferret model of influenza virus infection.
Topics: Amantadine; Animals; Antiviral Agents; Disease Models, Animal; Drug Resistance, Viral; Ferrets; Guan | 2003 |
Influenza infection of the embryonated hen's egg/an alternative model for in vivo evaluation of antiviral compounds.
Topics: Amantadine; Animals; Antiviral Agents; Chick Embryo; Drug Evaluation, Preclinical; Guanidines; Influ | 2004 |
Influenza virus inhibitors available for the chemotherapy and/or chemoprophylaxis of influenza virus infections.
Topics: Amantadine; Animals; Antibiotic Prophylaxis; Antiviral Agents; Humans; Neuraminidase; Orthomyxovirid | 2006 |
Amantadine resistance among porcine H1N1, H1N2, and H3N2 influenza A viruses isolated in Germany between 1981 and 2001.
Topics: Alphainfluenzavirus; Amantadine; Amino Acid Sequence; Amino Acid Substitution; Animals; Antiviral Ag | 2006 |
Contribution of H7 haemagglutinin to amantadine resistance and infectivity of influenza virus.
Topics: Amantadine; Amino Acid Substitution; Animals; Antiviral Agents; Blood; Brain; Cell Line; Chick Embry | 2007 |
Amantadine-oseltamivir combination therapy for H5N1 influenza virus infection in mice.
Topics: Administration, Oral; Amantadine; Animals; Antiviral Agents; Dose-Response Relationship, Drug; Drug | 2007 |
Low dose oral combination chemoprophylaxis with oseltamivir and amantadine for influenza A virus infections in mice.
Topics: Amantadine; Animals; Antiviral Agents; Cell Line; Dogs; Dose-Response Relationship, Drug; Drug Combi | 2007 |
Experimental infection of H5N1 HPAI in BALB/c mice.
Topics: Amantadine; Animals; Antibodies, Viral; Antiviral Agents; Biomarkers; Chick Embryo; Cross Reactions; | 2007 |
Antibody response in rabbits to antigenic stimulation during amantadine treatment.
Topics: Amantadine; Animals; Antibody Formation; Female; Glucose; Hemagglutination Inhibition Tests; Hemaggl | 1967 |
The antiviral activity of amantadine and poly (C,S4U) on influenza virus infection of infant rats.
Topics: Amantadine; Animals; Antiviral Agents; Haemophilus influenzae; Influenza A virus; Meningitis; Orthom | 1981 |
Amantadine and ribavirin aerosol treatment of influenza A and B infection in mice.
Topics: Aerosols; Amantadine; Animals; Cell Survival; Drug Therapy, Combination; Immunity, Cellular; Influen | 1980 |
Inhibition of influenza virus replication in mice by GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is consistent with extracellular activity of viral neuraminidase (sialidase).
Topics: Amantadine; Animals; Antiviral Agents; Guanidines; Influenza A virus; Influenza B virus; Mice; Neura | 1994 |
Protection against a lethal influenza virus challenge by immunization with a haemagglutinin-expressing plasmid DNA.
Topics: Amantadine; Animals; Avian Leukosis Virus; Chickens; Defective Viruses; DNA, Viral; Genetic Vectors; | 1993 |
Efficacy of combination therapy with amantadine, thymosin alpha 1 and alpha/beta interferon in mice infected with influenza A virus.
Topics: Amantadine; Animals; Antiviral Agents; Cell Count; Drug Therapy, Combination; Influenza A virus; Int | 1996 |
Evaluation of anti-influenza effects of camostat in mice infected with non-adapted human influenza viruses.
Topics: Adaptation, Physiological; Amantadine; Animals; Antiviral Agents; Cell Line; Disease Models, Animal; | 1996 |
Amantadine and equine influenza: pharmacology, pharmacokinetics and neurological effects in the horse.
Topics: Administration, Oral; Amantadine; Animals; Antiviral Agents; Biological Availability; Central Nervou | 1997 |
Combined therapy with hypothermia and anticytokine agents in influenza A encephalopathy.
Topics: Amantadine; Brain; Child, Preschool; Cytokines; Disease Progression; Encephalitis, Viral; Female; Gl | 2000 |
The relative potencies of anti-influenza compounds.
Topics: Adamantane; Amantadine; Amines; Animals; Antiviral Agents; Cells, Cultured; Cycloparaffins; Influenz | 1977 |
Activity of amantadine, rimantadine, and ribavirin against swine influenza in mice and squirrel monkeys.
Topics: Amantadine; Animals; Female; Haplorhini; Influenza A virus; Male; Mice; Orthomyxoviridae Infections; | 1978 |
Effect of influenza infection on the phagocytic and bactericidal activities of pulmonary macrophages.
Topics: Amantadine; Animals; Cycloheximide; Deoxyglucose; Female; Hemagglutinins; Immune Sera; In Vitro Tech | 1979 |
Effects of individual inhalation of aerosolized amantadine hydrochloride in mice infected with influenza virus A/Bethesda 10/63 (H2N2) and A/Hong Kong 1/68 (H3N2).
Topics: Administration, Intranasal; Administration, Oral; Aerosols; Amantadine; Animals; Drug Administration | 1979 |
The effects of peroral or local aerosol administration of 1-aminoadamantane hydrochloride (amantadine hydrochloride) on influenza infections of the ferret.
Topics: Administration, Oral; Aerosols; Amantadine; Animals; Carnivora; Disease Models, Animal; Ferrets; Hem | 1977 |
Small-particle aerosols of antiviral compounds in treatment of type A influenza pneumonia in mice.
Topics: Administration, Intranasal; Aerosols; Amantadine; Animals; Antiviral Agents; Female; Injections, Int | 1976 |
[Experience with prevention of chicken influenza with amantadine].
Topics: Amantadine; Animals; Chickens; Orthomyxoviridae Infections; Poultry Diseases | 1976 |
[Syntheses of aminoacid derivatives and their biological activities. I. Anti-influenza activity (author's transl)].
Topics: 2-Naphthylamine; Alanine; Amantadine; Amino Acids; Animals; Antiviral Agents; Drug Evaluation, Precl | 1975 |
A comparison of test methods in influenza chemotherapy.
Topics: Allantois; Amantadine; Animals; Cells, Cultured; Chick Embryo; Mice; Orthomyxoviridae; Orthomyxoviri | 1975 |
Assessment of the anti-viral effect of a short-term oral treatment of mice with live Saccharomyces cerevisiae cells.
Topics: Adjuvants, Immunologic; Administration, Oral; Amantadine; Animals; Antiviral Agents; Combined Modali | 1992 |
Effect of immunomodulator adamantylamide dipeptide on antibody response to influenza subunit vaccines and protection against aerosol influenza infection.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Aerosols; Aluminum Hydroxide; Amantadine; | 1990 |
[A new inhalation apparatus and its application to screening of anti-influenza agents].
Topics: Aerosols; Amantadine; Animals; Antiviral Agents; Drug Evaluation, Preclinical; Female; Mice; Orthomy | 1986 |
The Corynebacterium granulosum-derived P40 immunomodulator exerts a synergistic effect on the activity of antiviral drugs in the treatment of experimental viral infections.
Topics: Adjuvants, Immunologic; Amantadine; Animals; Antiviral Agents; Corynebacterium; Female; Herpes Simpl | 1988 |
Pharmacokinetics and metabolism of rimantadine hydrochloride in mice and dogs.
Topics: Adamantane; Administration, Oral; Amantadine; Animals; Biological Availability; Dogs; Dose-Response | 1988 |
Vaccination as a strategy to reduce the emergence of amantadine- and rimantadine-resistant strains of A/Chick/Pennsylvania/83 (H5N2) influenza virus.
Topics: Adamantane; Amantadine; Animals; Drug Resistance, Microbial; Influenza A virus; Influenza A Virus, H | 1986 |
Combinations of antiviral agents for treatment of influenza virus infections.
Topics: Amantadine; Animals; Antiviral Agents; Drug Synergism; Drug Therapy, Combination; In Vitro Technique | 1986 |
[Preventive effect of 1-aminoadamantane of domestic origin on experimental asiatic influenza].
Topics: Amantadine; Animals; Czechoslovakia; Mice; Orthomyxoviridae; Orthomyxoviridae Infections | 1970 |
Studies on the antiviral activity of amantadine hydrochloride.
Topics: Amantadine; Animals; Antiviral Agents; Carnivora; Culture Techniques; Mice; Orthomyxoviridae; Orthom | 1965 |
Effect of amantadine hydrochloride on parainfluenza type 1 virus infections in adult volunteers.
Topics: Amantadine; Antiviral Agents; Humans; Orthomyxoviridae Infections; Paramyxoviridae Infections; Respi | 1967 |
Synthesis and antiviral activities of adamantane spiro compounds. 1. Adamantane and analogous spiro-3'-pyrrolidines.
Topics: Amantadine; Animals; Antiviral Agents; Bridged-Ring Compounds; Enterovirus; Mice; Mice, Inbred Strai | 1972 |
Therapeutic effect of adamantanamine aerosol in experimental influenza infection of white mice.
Topics: Aerosols; Amantadine; Animals; Mice; Orthomyxoviridae Infections | 1967 |
[Studies on the anti-influenzal agents by methods of mouse rale recording and lung lesion score (author's transl)].
Topics: Amantadine; Animals; Antiviral Agents; Auscultation; Biguanides; Drug Evaluation, Preclinical; Lung; | 1974 |
Antiinfluenzal effect of rugulosin.
Topics: Administration, Oral; Aerosols; Amantadine; Animals; Anti-Bacterial Agents; Hemagglutination Tests; | 1974 |
Dual effect in the mechanism of action of anti-influenza virus amino acid analogues.
Topics: Amantadine; Amino Acids; Animals; Antiviral Agents; Chick Embryo; Male; Mice; Orthomyxoviridae; Orth | 1973 |
[Fluorescence-microphotometry studies on the action of adamantine on influenza infections in mice].
Topics: Amantadine; Animals; Fluorescent Antibody Technique; Fluorometry; Mice; Microscopy, Fluorescence; Or | 1967 |
Synthesis and antiviral activities of adamantane spiro compounds. 2.
Topics: Amantadine; Animals; Antiviral Agents; Azepines; Bridged-Ring Compounds; Infrared Rays; Magnetic Res | 1972 |
Search for a synergism with different drugs in the field of antiviral chemotherapy.
Topics: Aldehydes; Amantadine; Aniline Compounds; Animals; Body Weight; Chick Embryo; Drug Synergism; Mice; | 1971 |
[The dynamics of multiplication of influenza-virus A-2 in mouse lungs under the influence of 1-aminoadamantan preparations].
Topics: Amantadine; Animals; Antiviral Agents; Lung; Mice; Orthomyxoviridae; Orthomyxoviridae Infections | 1969 |
In vivo selection of an influenza A2 strain resistant to amantadine.
Topics: Amantadine; Animals; Body Fluids; Drug Resistance, Microbial; Hemagglutination Inhibition Tests; Lun | 1970 |
Inhibition of influenza A viruses by adamantanamines: rate of resistance development in embryonated eggs and in mice.
Topics: Amantadine; Animals; Chick Embryo; Culture Techniques; Drug Resistance, Microbial; Mice; Orthomyxovi | 1970 |
Failure of 1-adamantanamine (Symmetrel) to modify influenza virus-induced pyrogenicity. Brief report.
Topics: Amantadine; Analgesics; Animals; Fever; Orthomyxoviridae; Orthomyxoviridae Infections; Phagocytosis; | 1970 |
Prevention of malignant avian influenza by 1-adamantanamine hydrochloride.
Topics: Administration, Oral; Amantadine; Animal Feed; Animals; Antibodies; Body Fluids; Chick Embryo; Chlor | 1970 |
Inhibition of a cold variant of influenza virus by selected chemicals.
Topics: Amantadine; Ammonium Chloride; Animals; Antiviral Agents; Culture Techniques; Cysteine; Glycosides; | 1970 |
Production of antibody in amantadine hydrochloride-treated mice.
Topics: Amantadine; Animals; Antibodies; Antibody Formation; Coliphages; Female; Mice; Neutralization Tests; | 1968 |
Influenza infections of mice. I. Curative activity of amantadine HCl.
Topics: Amantadine; Animals; Female; Methods; Mice; Orthomyxoviridae Infections; Water | 1968 |
Intraperitoneal infection of Ehrlich ascites tumor mice with viruses of low virulence in vivo, a new chemotherapeutic test system.
Topics: Adenoviridae; Amantadine; Animals; Antiviral Agents; Carcinoma, Ehrlich Tumor; Methods; Mice; Orthom | 1968 |
Influenza virus growth and antibody response in amantadine-treated mice.
Topics: Amantadine; Amines; Animals; Antibody Formation; Antiviral Agents; Mice; Orthomyxoviridae; Orthomyxo | 1965 |