amantadine has been researched along with Neuroblastoma in 6 studies
amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Potential neuroprotective activity of the novel antiparkinsonian drug hemantane (hydrochloride N-2-(adamantyl)-hexamethylenimine) in comparison to amantadine has been studied in various regimes of administration on human neuroblastoma SH-SY5Y cell line injury induced by 6-hydroxydopamine (6-OHDA), which is used as in vitro model of dopaminergic neurons for Parkinson's disease." | 7.83 | [COMPARISON OF CYTOPROTECTIVE EFFECTS OF HEMANTANE AND AMANTADINE UNDER CONDITIONS OF 6-HYDROXYDOPAMINE NEUROTOXIN ACTION ON CULTURED HUMAN NEUROBLASTOMA CELLS]. ( Antipova, TA; Logvinov, IO; Nepoklonov, AV; Valdman, EA, 2016) |
| "Potential neuroprotective activity of the novel antiparkinsonian drug hemantane (hydrochloride N-2-(adamantyl)-hexamethylenimine) in comparison to amantadine has been studied in various regimes of administration on human neuroblastoma SH-SY5Y cell line injury induced by 6-hydroxydopamine (6-OHDA), which is used as in vitro model of dopaminergic neurons for Parkinson's disease." | 3.83 | [COMPARISON OF CYTOPROTECTIVE EFFECTS OF HEMANTANE AND AMANTADINE UNDER CONDITIONS OF 6-HYDROXYDOPAMINE NEUROTOXIN ACTION ON CULTURED HUMAN NEUROBLASTOMA CELLS]. ( Antipova, TA; Logvinov, IO; Nepoklonov, AV; Valdman, EA, 2016) |
| "Serotonin (5-HT) evoked a rise of cytosolic Ca2+ activity in neuroblastoma X glioma hybrid cells, most probably due to the entry of extracellular Ca2+; cyclic GMP synthesis was also stimulated." | 3.67 | Memantine inhibits serotonin-induced rise of cytosolic Ca2+ activity and of cyclic GMP level in a neuronal cell line. ( Koch, R; Reiser, G, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Egunlusi, AO | 1 |
| Malan, SF | 1 |
| Omoruyi, SI | 1 |
| Ekpo, OE | 1 |
| Palchykov, VA | 1 |
| Joubert, J | 1 |
| Beran, M | 1 |
| Okyere, B | 1 |
| Vova, J | 1 |
| Logvinov, IO | 1 |
| Antipova, TA | 1 |
| Nepoklonov, AV | 1 |
| Valdman, EA | 1 |
| Li, YP | 1 |
| Li, ZR | 1 |
| Cao, J | 1 |
| Tao, YJ | 1 |
| Reiser, G | 2 |
| Koch, R | 2 |
| Binmöller, FJ | 1 |
6 other studies available for amantadine and Neuroblastoma
| Article | Year |
|---|---|
Open and rearranged norbornane derived polycyclic cage molecules as potential neuroprotective agents through attenuation of MPP
Topics: 1-Methyl-4-phenylpyridinium; Calcium; Cell Line, Tumor; Humans; Ion Transport; Molecular Docking Sim | 2020 |
Amantadine-Induced Corneal Edema in a Pediatric Neuro-Oncology Patient: A Case Report.
Topics: Adolescent; Amantadine; Brain Neoplasms; Corneal Edema; Follow-Up Studies; Humans; Male; Neuroblasto | 2018 |
[COMPARISON OF CYTOPROTECTIVE EFFECTS OF HEMANTANE AND AMANTADINE UNDER CONDITIONS OF 6-HYDROXYDOPAMINE NEUROTOXIN ACTION ON CULTURED HUMAN NEUROBLASTOMA CELLS].
Topics: Adamantane; Amantadine; Cell Line, Tumor; Cytoprotection; Dose-Response Relationship, Drug; Humans; | 2016 |
[Synthesis and neuroprotective activity in cell culture of aminoadamantane analogues].
Topics: Amantadine; Cell Death; Cell Line, Tumor; Glutamic Acid; Humans; L-Lactate Dehydrogenase; Memantine; | 2007 |
Memantine inhibits serotonin-induced rise of cytosolic Ca2+ activity and of cyclic GMP level in a neuronal cell line.
Topics: Amantadine; Animals; Calcium; Cyclic GMP; Cytosol; Glioma; Memantine; Nervous System Neoplasms; Neur | 1989 |
Memantine (1-amino-3,5-dimethyladamantane) blocks the serotonin-induced depolarization response in a neuronal cell line.
Topics: Amantadine; Animals; Calcium; Cell Line; Glioma; Hybrid Cells; Memantine; Membrane Potentials; Neuro | 1988 |