amantadine has been researched along with Muscle Spasticity in 4 studies
amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source
Muscle Spasticity: A form of muscle hypertonia associated with upper MOTOR NEURON DISEASE. Resistance to passive stretch of a spastic muscle results in minimal initial resistance (a free interval) followed by an incremental increase in muscle tone. Tone increases in proportion to the velocity of stretch. Spasticity is usually accompanied by HYPERREFLEXIA and variable degrees of MUSCLE WEAKNESS. (From Adams et al., Principles of Neurology, 6th ed, p54)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Multiple sclerosis is a demyelinating disorder of the central nervous system characterized by exacerbations and remissions of symptoms." | 2.38 | Update on multiple sclerosis therapy. ( Mitchell, G, 1993) |
| "Amantadine was introduced for the pharmacological management of NMS because of its beneficial effects in Parkinson's disease which were attributed to direct or indirect dopaminomimetic properties of amantadine." | 1.28 | A rationale for NMDA receptor antagonist therapy of the neuroleptic malignant syndrome. ( Kornhuber, J; Weller, M, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grossmann, W | 1 |
| Schütz, W | 1 |
| Mitchell, G | 1 |
| Weller, M | 1 |
| Kornhuber, J | 1 |
| Mundinger, F | 1 |
| Milios, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Utility of Amantadine Hydrochloride in the Treatment of Post-traumatic Irritability: A Randomized, Double-Blind, Placebo-Controlled Trial[NCT00627250] | 76 participants (Actual) | Interventional | 2003-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for amantadine and Muscle Spasticity
| Article | Year |
|---|---|
Update on multiple sclerosis therapy.
Topics: Amantadine; Baclofen; Fatigue; Humans; Immunosuppression Therapy; Interferons; Multiple Sclerosis; M | 1993 |
3 other studies available for amantadine and Muscle Spasticity
| Article | Year |
|---|---|
[Memantine and neurogenic bladder disorders within the bounds of spastic conditions].
Topics: Adult; Aged; Amantadine; Electromyography; Female; Humans; Male; Memantine; Middle Aged; Muscle Spas | 1982 |
A rationale for NMDA receptor antagonist therapy of the neuroleptic malignant syndrome.
Topics: Amantadine; Humans; Models, Biological; Muscle Spasticity; Neuroleptic Malignant Syndrome; Receptors | 1992 |
[Experiences with memantine in the treatment of severe spastic and extrapyramidal movement disorders in combination with stereotaxic surgery].
Topics: Adolescent; Adult; Aged; Amantadine; Athetosis; Basal Ganglia Diseases; Cerebral Palsy; Child; Chore | 1985 |