amantadine has been researched along with Minimally Conscious State in 14 studies
amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "We observed the changes of seven patients with UWS of intracerebral hemorrhage after taking amantadine." | 7.96 | The use of amantadine in patients with unresponsive wakefulness syndrome after severe cerebral hemorrhage. ( Gao, Y; Liang, F; Liu, X; Ma, L; Yang, J; Yang, L; Zhang, Y, 2020) |
| "We observed the changes of seven patients with UWS of intracerebral hemorrhage after taking amantadine." | 3.96 | The use of amantadine in patients with unresponsive wakefulness syndrome after severe cerebral hemorrhage. ( Gao, Y; Liang, F; Liu, X; Ma, L; Yang, J; Yang, L; Zhang, Y, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 5 (35.71) | 24.3611 |
| 2020's | 4 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, Y | 2 |
| Ma, L | 2 |
| Liang, F | 1 |
| Zhang, Y | 2 |
| Yang, L | 1 |
| Liu, X | 1 |
| Yang, J | 2 |
| Li, Z | 2 |
| Zão, A | 1 |
| Almeida, AF | 1 |
| Beça, G | 1 |
| Nunes, R | 1 |
| Kondratieva, EA | 1 |
| Kondratev, SA | 1 |
| Denisova, AA | 1 |
| Ivanova, NE | 1 |
| Kondratiev, AN | 1 |
| Lehnerer, SM | 1 |
| Scheibe, F | 1 |
| Buchert, R | 1 |
| Kliesch, S | 1 |
| Meisel, A | 1 |
| Chen, X | 1 |
| Tang, C | 1 |
| Zhou, H | 1 |
| Avecillas-Chasín, JM | 1 |
| Barcia, JA | 1 |
| Oliveira, L | 1 |
| Fregni, F | 1 |
| Giacino, JT | 1 |
| Whyte, J | 3 |
| Bagiella, E | 1 |
| Kalmar, K | 2 |
| Childs, N | 2 |
| Khademi, A | 1 |
| Eifert, B | 2 |
| Long, D | 2 |
| Katz, DI | 1 |
| Cho, S | 1 |
| Yablon, SA | 1 |
| Luther, M | 1 |
| Hammond, FM | 1 |
| Nordenbo, A | 1 |
| Novak, P | 2 |
| Mercer, W | 2 |
| Maurer-Karattup, P | 1 |
| Sherer, M | 1 |
| Katz, D | 1 |
| DiPasquale, MC | 1 |
| Polansky, M | 1 |
| Giacino, J | 1 |
| Maurer, P | 1 |
| Barrett, AM | 1 |
| Levy, CE | 1 |
| Gonzalez Rothi, LJ | 1 |
| Schnakers, C | 1 |
| Hustinx, R | 1 |
| Vandewalle, G | 1 |
| Majerus, S | 1 |
| Moonen, G | 1 |
| Boly, M | 1 |
| Vanhaudenhuyse, A | 1 |
| Laureys, S | 1 |
| Zafonte, RD | 1 |
| Watanabe, T | 1 |
| Mann, NR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effectiveness of Sensory Stimulation for Person in a Coma or Persistent Vegetative State After Traumatic Brain Injury[NCT02629588] | 9 participants (Actual) | Observational | 2015-01-31 | Completed | |||
| Efficacy and Safety of Cerebrolysin on Prolonged Disorders of Consciousness in Patients With Hemorrhagic Stroke: A Pilot Study[NCT04427241] | Phase 4 | 12 participants (Anticipated) | Interventional | 2023-06-01 | Not yet recruiting | ||
| Safety and Efficacy of Transcranial Direct Current Stimulation in Pediatric Disorders of Consciousness[NCT05929274] | 10 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | |||
| The Impact and Outcomes of Combined Cerebrolysin and Amantadine Sulfate Administration on Management of Patients With Traumatic Brain Injury in the ICU[NCT06052787] | Phase 3 | 150 participants (Anticipated) | Interventional | 2023-09-01 | Recruiting | ||
| A Multicenter Prospective Randomized Controlled Trial of the Effectiveness of Amantadine Hydrochloride in Promoting Recovery of Function Following Severe Traumatic Brain Injury[NCT00970944] | Phase 2/Phase 3 | 184 participants (Actual) | Interventional | 2003-02-28 | Completed | ||
| Utility of Amantadine Hydrochloride in the Treatment of Post-traumatic Irritability: A Randomized, Double-Blind, Placebo-Controlled Trial[NCT00627250] | 76 participants (Actual) | Interventional | 2003-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Measure of function after traumatic brain injury (TBI) intended to measure function from coma to community. Minimum score= 0; Maximum score= 29 (High scores are indicative of greater degree of disability)." (NCT00970944)
Timeframe: Randomization and weekly for 6 weeks. The primary study endpoint was week 4 and drug washout was week 6.
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Week 4 (Primary endpoint) | Week 6 (Drug washout) | |
| Amantadine | 17.3 | 17.1 |
| Placebo | 18.7 | 17.8 |
"Measure of neurobehavioral function and clinical change for individuals with severe alterations of consciousness.~Minimum score= 0; Maximum score= 23 (Higher scores are indicative of a higher-level of neurobehavioral function)." (NCT00970944)
Timeframe: Week 4 (primary endpoint); Week 6 (post-washout)
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Week 4 (Primary endpoint) | Week 6 (Post-washout) | |
| Amantadine | 15.8 | 15.7 |
| Placebo | 14.2 | 15.1 |
1 review available for amantadine and Minimally Conscious State
| Article | Year |
|---|---|
Pharmacological and electrical stimulation in chronic disorders of consciousness: new insights and future directions.
Topics: Amantadine; Chronic Disease; Combined Modality Therapy; Deep Brain Stimulation; Dopamine Agents; Hum | 2011 |
1 trial available for amantadine and Minimally Conscious State
| Article | Year |
|---|---|
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Topics: Adult; Amantadine; Brain Injuries; Coma, Post-Head Injury; Disability Evaluation; Dopamine Agents; F | 2012 |
12 other studies available for amantadine and Minimally Conscious State
| Article | Year |
|---|---|
The use of amantadine in patients with unresponsive wakefulness syndrome after severe cerebral hemorrhage.
Topics: Amantadine; Cerebral Hemorrhage; Consciousness Disorders; Humans; Persistent Vegetative State; Wakef | 2020 |
Persistent vegetative state after severe cerebral hemorrhage treated with amantadine: A retrospective controlled study.
Topics: Adult; Aged; Amantadine; Cerebral Hemorrhage; Dopamine Agents; Female; Humans; Male; Middle Aged; Pe | 2020 |
[From Vegetative State to Participation: Amantadine As a Trigger of the Rehabilitation Program].
Topics: Adolescent; Amantadine; Brain Injuries, Traumatic; Hospitalization; Humans; Male; Persistent Vegetat | 2020 |
[Results of treatment with intravenous amantadine sulfate (PK-Merz) patients with chronic disorders of consciousness].
Topics: Amantadine; Consciousness; Consciousness Disorders; Humans; Persistent Vegetative State; Wakefulness | 2020 |
Awakening with amantadine from a persistent vegetative state after subarachnoid haemorrhage.
Topics: Adult; Amantadine; Brain; Dopamine Agents; Female; Humans; Intracranial Aneurysm; Persistent Vegetat | 2017 |
Effect of amantadine on vegetative state after traumatic brain injury: a functional magnetic resonance imaging study.
Topics: Amantadine; Antiparkinson Agents; Brain Injuries, Traumatic; Brain Mapping; Cerebral Cortex; Humans; | 2019 |
Effect of amantadine in minimally conscious state of non-traumatic etiology.
Topics: Amantadine; Carotid Artery Diseases; Dopamine Agonists; Embolization, Therapeutic; Encephalocele; Fe | 2014 |
Predictors of outcome in prolonged posttraumatic disorders of consciousness and assessment of medication effects: A multicenter study.
Topics: Adult; Aged; Amantadine; Brain Injuries; Dantrolene; Data Collection; Disability Evaluation; Dopamin | 2005 |
Treatments to enhance recovery from the vegetative and minimally conscious states: ethical issues surrounding efficacy studies.
Topics: Amantadine; Brain Injuries; Caregivers; Decision Making; Ethics, Research; Humans; Multicenter Studi | 2007 |
Pharmaceuticals for poststroke and brain injury rehabilitation.
Topics: Amantadine; Aphasia, Broca; Brain Injuries; Dopamine Agents; Humans; Methylphenidate; Persistent Veg | 2007 |
Measuring the effect of amantadine in chronic anoxic minimally conscious state.
Topics: Adult; Amantadine; Arousal; Blood Glucose; Cerebral Cortex; Drug Administration Schedule; Energy Met | 2008 |
Amantadine: a potential treatment for the minimally conscious state.
Topics: Adult; Amantadine; Brain Injuries; Coma; Consciousness; Dopamine Agents; Dose-Response Relationship, | 1998 |