amantadine has been researched along with Kidney Failure, Chronic in 20 studies
amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source
Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amantadine toxicity is a particular problem in patients with renal insufficiency because 90% of an oral dose is excreted unchanged in the urine." | 5.29 | Amantadine-induced coma. ( Ito, V; Macchio, GJ; Sahgal, V, 1993) |
| " We included studies investigating pemoline and modafinil in participants with multiple sclerosis (MS)-associated fatigue and methylphenidate in patients suffering from advanced cancer and fatigue in meta-analysis." | 4.91 | Pharmacological treatments for fatigue associated with palliative care. ( Cuhls, H; Minton, O; Mücke, M; Peuckmann-Post, V; Radbruch, L; Stone, P, 2015) |
| " Studies investigating amantadine, pemoline, and modafinil in participants with Multiple Sclerosis (MS)-associated fatigue and methylphenidate in patients suffering from advanced cancer and fatigue could be used for meta-analysis." | 4.86 | Pharmacological treatments for fatigue associated with palliative care. ( Elsner, F; Krumm, N; Peuckmann, V; Radbruch, L; Trottenberg, P, 2010) |
| " Plasma half-life averaged 68." | 2.65 | Amantadine hydrochloride pharmacokinetics in patients with impaired renal function. ( Daugirdas, JT; Gandhi, VC; Hano, JE; Ing, TS; Soung, LS; Wu, MJ, 1982) |
| "To provide a review of rimantadine, including its antiviral activity, pharmacokinetics, efficacy, adverse effects, drug interactions, and dosage and administration." | 2.39 | Rimantadine: a clinical perspective. ( Nahata, MC; Wintermeyer, SM, 1995) |
| " Therefore, their interchangeable use cannot be advocated in the dosing of medications until further prospective validations are performed." | 1.34 | Use of GFR equations to adjust drug doses in an elderly multi-ethnic group--a cautionary tale. ( Djurdjev, O; Gill, J; Levin, A; Malyuk, R, 2007) |
| "Amantadine toxicity is a particular problem in patients with renal insufficiency because 90% of an oral dose is excreted unchanged in the urine." | 1.29 | Amantadine-induced coma. ( Ito, V; Macchio, GJ; Sahgal, V, 1993) |
| " The half-life of elimination in subjects with normal renal function was 11." | 1.26 | Pharmacokinetics of amantadine hydrochloride in subjects with normal and impaired renal function. ( Brater, DC; Garriott, JC; Horadam, VW; McAnalley, BH; Prati, RC; Sharp, JG; Smilack, JD; Stephens, MK, 1981) |
| " The average half-life of amantadine in eight patients studied while receiving maintenance hemodialysis was 24." | 1.26 | Amantadine hydrochloride pharmacokinetics in hemodialysis patients. ( Daugirdas, JT; Gandhi, VC; Hano, JE; Ing, TS; Ivanovich, PT; Soung, LS; Viol, GW; Wu, MJ, 1980) |
| "Two patients with Parkinson's disease and renal insufficiency had excessively high concentrations of amantadine hydrochloride in the blood." | 1.26 | Removal of amantadine hydrochloride by dialysis in patients with renal insufficiency. ( Dunea, G; Hayashi, JA; Ing, TS; Klawans, HL; Mahurkar, SD; Markey, WS, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (50.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 2 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mücke, M | 1 |
| Cuhls, H | 1 |
| Peuckmann-Post, V | 1 |
| Minton, O | 1 |
| Stone, P | 1 |
| Radbruch, L | 2 |
| Michalski, LS | 1 |
| Hantsch Bardsley, C | 1 |
| Holt, DR | 1 |
| Milner, JE | 1 |
| Hou, SH | 1 |
| Peuckmann, V | 1 |
| Elsner, F | 1 |
| Krumm, N | 1 |
| Trottenberg, P | 1 |
| Myers, JW | 1 |
| Gill, J | 1 |
| Malyuk, R | 1 |
| Djurdjev, O | 1 |
| Levin, A | 1 |
| Goforth, H | 1 |
| Cheng, PL | 1 |
| Hung, SW | 1 |
| Lin, LW | 1 |
| Chong, CF | 1 |
| Lau, CI | 1 |
| Ing, TS | 7 |
| Cheng, PJ | 2 |
| Wu, MJ | 4 |
| Daugirdas, JT | 5 |
| Soung, LS | 5 |
| Ing, IL | 1 |
| Klawans, HL | 5 |
| Hano, JE | 3 |
| Gandhi, VC | 2 |
| Horadam, VW | 1 |
| Sharp, JG | 1 |
| Smilack, JD | 1 |
| McAnalley, BH | 1 |
| Garriott, JC | 1 |
| Stephens, MK | 1 |
| Prati, RC | 1 |
| Brater, DC | 1 |
| Ivanovich, PT | 1 |
| Viol, GW | 1 |
| Wintermeyer, SM | 1 |
| Nahata, MC | 1 |
| Miller, KS | 1 |
| Miller, JM | 1 |
| Macchio, GJ | 1 |
| Ito, V | 1 |
| Sahgal, V | 1 |
| Mahurkar, SD | 2 |
| Hayashi, JA | 2 |
| Geis, WP | 1 |
| Borison, RL | 1 |
| Dunea, G | 1 |
| Markey, WS | 1 |
| Rahn, AC | 2 |
| Armbruster, KF | 2 |
| Oyama, JH | 2 |
| Halper, IS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Feasibility Study of Adjunctive Bright Light Therapy (BLT) for Amelioration of Fatigue in Chinese Cancer Patients Admitted to a Palliative Care Unit[NCT04525924] | 42 participants (Anticipated) | Interventional | 2020-08-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for amantadine and Kidney Failure, Chronic
| Article | Year |
|---|---|
Pharmacological treatments for fatigue associated with palliative care.
Topics: Adult; Amantadine; Benzhydryl Compounds; Carnitine; Central Nervous System Stimulants; Chronic Disea | 2015 |
Pharmacological treatments for fatigue associated with palliative care.
Topics: Adult; Amantadine; Benzhydryl Compounds; Central Nervous System Stimulants; Fatigue; Humans; Kidney | 2010 |
Influenza therapy.
Topics: Acetamides; Adult; Age Factors; Amantadine; Antiviral Agents; Child; Cost-Benefit Analysis; Creatine | 2003 |
Rimantadine: a clinical perspective.
Topics: Absorption; Amantadine; Controlled Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Comb | 1995 |
1 trial available for amantadine and Kidney Failure, Chronic
| Article | Year |
|---|---|
Amantadine hydrochloride pharmacokinetics in patients with impaired renal function.
Topics: Adult; Amantadine; Antiviral Agents; Clinical Trials as Topic; Creatinine; Drug Evaluation; Humans; | 1982 |
15 other studies available for amantadine and Kidney Failure, Chronic
| Article | Year |
|---|---|
Altered mental status in a transplant patient. Amantadine toxicity.
Topics: Adult; Amantadine; Confusion; Diabetes Complications; Diabetes Mellitus, Type 1; Female; Hallucinati | 2009 |
Use of GFR equations to adjust drug doses in an elderly multi-ethnic group--a cautionary tale.
Topics: Aged; Aged, 80 and over; Algorithms; Amantadine; Asian People; Creatinine; Digoxin; Drug Administrat | 2007 |
Amantadine in catatonia due to major depressive disorder in a medically ill patient.
Topics: Adult; Amantadine; Antiparkinson Agents; Catatonia; Depressive Disorder, Major; Electroconvulsive Th | 2007 |
Amantadine-induced serotonin syndrome in a patient with renal failure.
Topics: Aged; Amantadine; Antiparkinson Agents; Comorbidity; Electroencephalography; Humans; Kidney Failure, | 2008 |
Plasma protein-binding of amantadine in maintenance hemodialysis patients.
Topics: Amantadine; Blood Proteins; Humans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Ultr | 1984 |
Binding of amantadine to red blood cells.
Topics: Adult; Aged; Amantadine; Binding Sites; Dose-Response Relationship, Drug; Erythrocytes; Female; Huma | 1984 |
Pharmacokinetics of amantadine hydrochloride in subjects with normal and impaired renal function.
Topics: Adult; Aged; Amantadine; Creatinine; Female; Half-Life; Humans; Kidney; Kidney Failure, Chronic; Kin | 1981 |
Amantadine hydrochloride pharmacokinetics in hemodialysis patients.
Topics: Amantadine; Half-Life; Humans; Influenza, Human; Kidney Failure, Chronic; Kinetics; Renal Dialysis | 1980 |
Toxic effects of amantadine in patients with renal failure.
Topics: Amantadine; Female; Humans; Kidney Failure, Chronic; Middle Aged; Muscular Diseases; Poisoning | 1994 |
Amantadine-induced coma.
Topics: Adult; Amantadine; Coma; Humans; Kidney Failure, Chronic; Male; Multiple Sclerosis | 1993 |
Toxic effects of amantadine in patients with renal failure.
Topics: Acute Kidney Injury; Adult; Aged; Amantadine; Female; Humans; Kidney Failure, Chronic; Male; Middle | 1979 |
Amantadine-induced psychosis in a geriatric patient with renal disease.
Topics: Aged; Amantadine; Female; Humans; Kidney Failure, Chronic; Parkinson Disease; Psychoses, Substance-I | 1979 |
Removal of amantadine hydrochloride by dialysis in patients with renal insufficiency.
Topics: Aged; Amantadine; Humans; Kidney Failure, Chronic; Male; Parkinson Disease; Peritoneal Dialysis; Ren | 1976 |
Letter: Accumulation of amantadine hydrochloride in renal insufficiency.
Topics: Adult; Amantadine; Humans; Kidney Failure, Chronic | 1974 |
Amantadine toxicity in a patient with renal insufficiency.
Topics: Amantadine; Dose-Response Relationship, Drug; Female; Humans; Influenza, Human; Kidney Failure, Chro | 1974 |