amantadine and Herpes Simplex studies

amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source

Herpes Simplex: A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)

Research Excerpts

Excerpt	Relevance	Reference
"In a randomised, double-blind trial on 20 patients with herpes simplex, tromantadine hydrochloride (TH) ointment had a significant therapeutic effect."	9.05	Tromantadine hydrochloride in the treatment of herpes simplex. Results of a double-blind therapeutic trial and an open prophylactic investigation. ( Hellgren, L; Hermann, LS, 1983)
" Trifluridine, idoxuridine, and vidarabine are effective topically in herpes simplex virus keratoconjunctivitis infection."	6.15	Antiviral drugs 1983. ( Douglas, RG, 1983)
"In a randomised, double-blind trial on 20 patients with herpes simplex, tromantadine hydrochloride (TH) ointment had a significant therapeutic effect."	5.05	Tromantadine hydrochloride in the treatment of herpes simplex. Results of a double-blind therapeutic trial and an open prophylactic investigation. ( Hellgren, L; Hermann, LS, 1983)
" In some children, treatment with acyclovir is an alternative to vaccination for the treatment and prevention of chickenpox."	4.80	Antiviral drugs in healthy children. ( Margo, KL; Shaughnessy, AF, 1998)
" Idoxuridine and adenine arabinoside have found application as topical agents in the treatment of herpes simplex keratitis."	4.76	Antiviral agents. ( Cockerill, FR; Hermans, PE, 1983)
" Currently, acyclovir is the most effective agent for the treatment of herpes simplex and varicella-zoster virus infections."	3.67	Antiviral agents. ( Cockerill, FR; Hermans, PE, 1987)
" These questions concern appropriate routes of administration for antiviral compounds, optimal dosage regimens, risks of long-term prophylaxis, and the emergence of resistant organisms."	2.66	Antiviral chemotherapy and chemoprophylaxis. ( Dolin, R, 1985)
"The mechanism of recurrence is yet not fully elucidated and therapy still remains a problem."	2.36	[Herpes simplex]. ( Fanta, D, 1981)
"Panhypopituitarism was diagnosed after measuring the basal hormone levels (ACTH, TSH, FT3, FT4, Cortisol, Prolactin, LH, FSH, ADH) and conducting the pituitary stimulation test."	1.30	[Virus encephalitis with symptomatic Parkinson syndrome, diabetes insipidus and panhypopituitarism]. ( Ickenstein, GW; Klotz, JM; Langohr, HD, 1999)

Timeframe	Studies, this research(%)	All Research%
pre-1990	40 (88.89)	18.7374
1990's	4 (8.89)	18.2507
2000's	1 (2.22)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Moriuchi, M	1
Moriuchi, H	1
Galasso, GJ	1
Douglas, RG	1
White, DO	1
Agathos, M	1
Remien, C	1
Mutzeck, E	1
Fanta, D	4
Lefrock, JL	1
Smith, BR	1
Hermans, PE	2
Cockerill, FR	2
Hellgren, L	1
Hermann, LS	1
Goldwater, PN	1
Przybilla, B	1
Balda, BR	1
Hirsch, MS	1
Swartz, MN	1
Fisher, DA	1
van der Walle, HB	1
Malten, KE	1
Waegemakers, TH	1
Eggers, HJ	1
Margo, KL	1
Shaughnessy, AF	1
Ickenstein, GW	1
Klotz, JM	1
Langohr, HD	1
Luby, JP	1
St Geme, JW	1
Mischer, P	1
Dostal, V	1
Reiss-Gutfreund, RJ	1
Whitley, RJ	1
Alford, CA	1
Ahumada, M	1
ter Meulen, V	1
Grupper, C	1
Feuerman, EJ	1
Berger-Roscher, J	1
Meyer-Rohn, J	1
Gosling, PH	1
Fattal-German, M	2
Bizzini, B	2
Bean, B	1
Rosenthal, KS	1
Roess, D	1
Barisas, BG	1
van Joost, T	1
Stolz, E	1
Piket-van Ulsen, J	1
Dolin, R	1
van Ketel, WG	1
Rytel, MW	1
Coonrod, JD	1
Jung, EG	1
Grafe, A	1
Weinstein, L	1
Chang, TW	1
Bauer, DJ	1
Nasemann, T	1

Article	Year
[Adverse effects of antiviral agents]. Nihon rinsho. Japanese journal of clinical medicine, 2007, Oct-28, Volume: 65 Suppl 8 Topics: Acyclovir; Amantadine; Anti-HIV Agents; Antiviral Agents; Cytomegalovirus Infections; Herpes Simplex	2007
An assessment of antiviral drugs for the management of infectious diseases in humans. Antiviral research, 1981, Volume: 1, Issue:2 Topics: Amantadine; Antiviral Agents; Ascorbic Acid; Dosage Forms; Drug Evaluation; Encephalitis; Hepatitis;	1981
Antiviral drugs 1983. The Medical clinics of North America, 1983, Volume: 67, Issue:5 Topics: Acyclovir; Amantadine; Antiviral Agents; Clinical Trials as Topic; Female; Herpes Genitalis; Herpes	1983
Antiviral chemotherapy. The Medical journal of Australia, 1984, Jun-09, Volume: 140, Issue:12 Topics: Acyclovir; Amantadine; Animals; Antiviral Agents; Bromodeoxyuridine; Female; Hepatitis B; Herpes Gen	1984
[Herpes simplex]. Wiener klinische Wochenschrift, 1981, Dec-25, Volume: 93, Issue:24 Topics: Adolescent; Adult; Amantadine; Antigens, Viral; Cell Transformation, Viral; Female; Foscarnet; Herpe	1981
Antiviral agents. Mayo Clinic proceedings, 1983, Volume: 58, Issue:4 Topics: Acyclovir; Amantadine; Animals; Antiviral Agents; Herpes Simplex; Herpes Zoster; Humans; Idoxuridine	1983
Antiviral drugs today. The New Zealand medical journal, 1984, Dec-12, Volume: 97, Issue:769 Topics: Acyclovir; Administration, Topical; Adolescent; Amantadine; Antiviral Agents; Chickenpox; Child; Cli	1984
Drug therapy: antiviral agents (first of two parts). The New England journal of medicine, 1980, Apr-17, Volume: 302, Issue:16 Topics: Adult; Amantadine; Animals; Antiviral Agents; Encephalitis; Herpes Simplex; Herpes Zoster; Humans; I	1980
Antiviral drugs in healthy children. American family physician, 1998, Mar-01, Volume: 57, Issue:5 Topics: Acyclovir; Amantadine; Antiviral Agents; Chickenpox; Child; Child, Preschool; Drug Administration Sc	1998
Antivirals with clinical potential. Advances in internal medicine, 1979, Volume: 24 Topics: Amantadine; Animals; Antiviral Agents; Cytarabine; Herpes Labialis; Herpes Simplex; Humans; Idoxurid	1979
Therapeutic control of viral infections: chemotherapy, interferon and gamma globulin. Current problems in pediatrics, 1979, Volume: 10, Issue:1 Topics: Amantadine; Animals; Benzimidazoles; Chickenpox; Cytarabine; gamma-Globulins; Hepatitis, Viral, Huma	1979
[Herpes simplex virus (hsv-1 and hsv-2) infection: its clinical and oncogenic properties (author's transl)]. Wiener klinische Wochenschrift, 1977, Nov-25, Volume: 89, Issue:22 Topics: Amantadine; Animals; Antibody Formation; Antigen-Antibody Complex; BCG Vaccine; Cell Transformation,	1977
Current status of antiviral chemotherapy. Southern medical journal, 1978, Volume: 71, Issue:9 Topics: Amantadine; Antiviral Agents; Cytarabine; Encephalitis; Herpes Simplex; Herpes Zoster; Herpesviridae	1978
[Present state of antiviral therapy (author's transl)]. Monatsschrift fur Kinderheilkunde, 1979, Volume: 127, Issue:6 Topics: Amantadine; Antiviral Agents; Child; Cytarabine; Encephalitis; Herpes Simplex; Humans; Idoxuridine;	1979
Therapy of viral, mycoplasmal and rickettsial infections. Wisconsin medical journal, 1971, Volume: 70, Issue:4 Topics: Amantadine; Antiviral Agents; Chloramphenicol; Cytarabine; Cytomegalovirus Infections; Erythromycin;	1971
Antiviral chemotherapy: the first decade. British medical journal, 1973, Aug-04, Volume: 3, Issue:5874 Topics: Acute Disease; Amantadine; Antiviral Agents; Chickenpox; Chronic Disease; Cytarabine; Herpes Simplex	1973

Article	Year
Antiviral drugs 1983. The Medical clinics of North America, 1983, Volume: 67, Issue:5 Topics: Acyclovir; Amantadine; Antiviral Agents; Clinical Trials as Topic; Female; Herpes Genitalis; Herpes	1983
Tromantadine hydrochloride in the treatment of herpes simplex. Results of a double-blind therapeutic trial and an open prophylactic investigation. Dermatologica, 1983, Volume: 167, Issue:5 Topics: Administration, Oral; Amantadine; Antiviral Agents; Clinical Trials as Topic; Double-Blind Method; E	1983
Antiviral drugs today. The New Zealand medical journal, 1984, Dec-12, Volume: 97, Issue:769 Topics: Acyclovir; Administration, Topical; Adolescent; Amantadine; Antiviral Agents; Chickenpox; Child; Cli	1984
[The effectiveness of tromantadine in herpes simplex: double-blind study]. Therapie der Gegenwart, 1977, Volume: 116, Issue:1 Topics: Amantadine; Antiviral Agents; Clinical Trials as Topic; Drug Evaluation; Female; Herpes Simplex; Hum	1977
[Treatment of herpes simplex using tromantadine hydrochloride]. Wiener medizinische Wochenschrift (1946), 1976, May-21, Volume: 126, Issue:20-22 Topics: Adamantane; Amantadine; Clinical Trials as Topic; Drug Evaluation; Drug Tolerance; Herpes Simplex; H	1976
[Outpatient testing of Viru-Merz in herpes simples infections of the skin]. Die Medizinische Welt, 1975, May-02, Volume: 26, Issue:18 Topics: Adolescent; Adult; Aged; Amantadine; Antiviral Agents; Clinical Trials as Topic; Dimethylamines; Fem	1975
Antiviral chemotherapy and chemoprophylaxis. Science (New York, N.Y.), 1985, Mar-15, Volume: 227, Issue:4692 Topics: Acyclovir; Adult; Aged; Amantadine; Antiviral Agents; Chickenpox; Clinical Trials as Topic; Cytomega	1985
[Virostatic treatment of eruptive warts. Preliminary report]. Deutsche medizinische Wochenschrift (1946), 1971, Nov-26, Volume: 96, Issue:48 Topics: Adolescent; Adult; Aged; Amantadine; Cautery; Child; Condylomata Acuminata; Female; Herpes Simplex;	1971

Article	Year
[Contact allergy to tromantadine]. Dermatosen in Beruf und Umwelt. Occupation and environment, 1984, Volume: 32, Issue:5 Topics: Adult; Amantadine; Antiviral Agents; Dermatitis, Contact; Drug Eruptions; Female; Herpes Labialis; H	1984
Antiviral agents. American family physician, 1983, Volume: 27, Issue:1 Topics: Acyclovir; Amantadine; Antiviral Agents; Cytomegalovirus Infections; Drug Resistance, Microbial; Her	1983
[Allergic contact dermatitis due to tromantadin (author's transl)]. MMW, Munchener medizinische Wochenschrift, 1980, Aug-29, Volume: 122, Issue:35 Topics: Adolescent; Adult; Amantadine; Cheilitis; Child; Drug Eruptions; Female; Herpes Simplex; Humans; In	1980
Recurrent herpes simplex sciatica and its treatment with amantadine hydrochloride. Cutis, 1982, Volume: 29, Issue:5 Topics: Adult; Amantadine; Female; Herpes Simplex; Humans; Menstruation; Middle Aged; Neuralgia; Recurrence;	1982
[Contact allergy to tromantadine (Viru-Merz) in the treatment of herpes simplex infections]. Nederlands tijdschrift voor geneeskunde, 1982, Jun-05, Volume: 126, Issue:23 Topics: Adult; Amantadine; Antiviral Agents; Dermatitis, Contact; Female; Herpes Labialis; Herpes Simplex; H	1982
[Trends in the chemotherapy of viral infections]. Medizinische Klinik, 1980, Feb-15, Volume: 75, Issue:4 Topics: Acyclovir; Amantadine; Antiviral Agents; Guanine; Herpes Simplex; Herpes Zoster; Humans; Influenza,	1980
[Virus encephalitis with symptomatic Parkinson syndrome, diabetes insipidus and panhypopituitarism]. Fortschritte der Neurologie-Psychiatrie, 1999, Volume: 67, Issue:10 Topics: Aged; Amantadine; Anti-Inflammatory Agents; Antiparkinson Agents; Brain; Diabetes Insipidus; Encepha	1999
Drugs for non-HIV viral infections. The Medical letter on drugs and therapeutics, 1999, Dec-03, Volume: 41, Issue:1067 Topics: 2-Aminopurine; Acetamides; Acyclovir; Aged; Amantadine; Animals; Anti-HIV Agents; Antiviral Agents;	1999
Contact dermatitis from tromantadine hydrochloride. Contact dermatitis, 1976, Volume: 2, Issue:5 Topics: Amantadine; Antiviral Agents; Dermatitis, Contact; Drug Eruptions; Female; Herpes Simplex; Humans; M	1976
[Treatment of herpes simplex]. Fortschritte der Medizin, 1978, Jun-15, Volume: 96, Issue:23 Topics: Amantadine; Antiviral Agents; Herpes Simplex; Herpes Zoster; Humans	1978
[Current status of herpes simplex therapy in France]. Zeitschrift fur Hautkrankheiten, 1977, Apr-15, Volume: 52, Issue:8 Topics: Amantadine; France; Herpes Simplex; Humans; Idoxuridine; Immunotherapy	1977
[Treatment of herpes simplex with Viru-Merz Serol]. Harefuah, 1977, Volume: 93, Issue:3-4 Topics: Amantadine; Herpes Simplex; Humans; Time Factors	1977
Letter: Treatment of herpes simplex with co-trimoxazole. British medical journal, 1975, Jan-04, Volume: 1, Issue:5948 Topics: Amantadine; Drug Antagonism; Drug Combinations; Herpes Simplex; Humans; Penicillins; Sulfamethoxazol	1975
Assessment of the anti-viral effect of a short-term oral treatment of mice with live Saccharomyces cerevisiae cells. Developments in biological standardization, 1992, Volume: 77 Topics: Adjuvants, Immunologic; Administration, Oral; Amantadine; Animals; Antiviral Agents; Combined Modali	1992
Antiviral therapy. New drugs and their uses. Postgraduate medicine, 1986, Volume: 80, Issue:1 Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Amantadine; Antiviral Agents; Chickenpox; Common Cold	1986
Herpes simplex virus type 1 penetration initiates mobilization of cell surface proteins. Biochimica et biophysica acta, 1988, Jul-07, Volume: 942, Issue:1 Topics: Actin Cytoskeleton; Amantadine; Animals; Colchicine; Cytochalasin B; Endocytosis; Herpes Simplex; Hy	1988
[Sensitization to tromantadine (Viru-Merz) in herpes simplex infections]. Nederlands tijdschrift voor geneeskunde, 1987, Jan-03, Volume: 131, Issue:1 Topics: Adult; Amantadine; Antiviral Agents; Drug Eruptions; Female; Herpes Simplex; Humans; Male; Ointments	1987
The Corynebacterium granulosum-derived P40 immunomodulator exerts a synergistic effect on the activity of antiviral drugs in the treatment of experimental viral infections. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1988, Volume: 42, Issue:3 Topics: Adjuvants, Immunologic; Amantadine; Animals; Antiviral Agents; Corynebacterium; Female; Herpes Simpl	1988
Antiviral agents. Mayo Clinic proceedings, 1987, Volume: 62, Issue:12 Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Amantadine; Antiviral Agents; Ganciclovir; Herpes Sim	1987
[Sensitization for tromantadine (Viru-Merz) in herpes simplex infections]. Nederlands tijdschrift voor geneeskunde, 1987, Mar-14, Volume: 131, Issue:11 Topics: Amantadine; Antiviral Agents; Dermatitis, Contact; Herpes Simplex; Humans	1987
Antiviral chemotherapy. The Medical letter on drugs and therapeutics, 1971, Sep-17, Volume: 13, Issue:19 Topics: Amantadine; Animals; Antiviral Agents; Cytarabine; Encephalitis; Herpes Labialis; Herpes Simplex; He	1971
The chemotherapy of viral infections. The New England journal of medicine, 1973, Oct-04, Volume: 289, Issue:14 Topics: Acridines; Adenine; Amantadine; Amino Alcohols; Antiviral Agents; Arabinose; Benzoates; Coloring Age	1973
[Letter: Adamantan derivatives and vacination in herpes simplex]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1973, Volume: 24, Issue:9 Topics: Amantadine; Herpes Simplex; Humans; Immunotherapy; Vaccination	1973

amantadine and Herpes Simplex

Research Excerpts

Research

Studies (45)

Authors

Reviews

Trials

Other Studies