amantadine has been researched along with Friedreich Ataxia in 7 studies
amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source
Friedreich Ataxia: An autosomal recessive disease, usually of childhood onset, characterized pathologically by degeneration of the spinocerebellar tracts, posterior columns, and to a lesser extent the corticospinal tracts. Clinical manifestations include GAIT ATAXIA, pes cavus, speech impairment, lateral curvature of spine, rhythmic head tremor, kyphoscoliosis, congestive heart failure (secondary to a cardiomyopathy), and lower extremity weakness. Most forms of this condition are associated with a mutation in a gene on chromosome 9, at band q13, which codes for the mitochondrial protein frataxin. (From Adams et al., Principles of Neurology, 6th ed, p1081; N Engl J Med 1996 Oct 17;335(16):1169-75) The severity of Friedreich ataxia associated with expansion of GAA repeats in the first intron of the frataxin gene correlates with the number of trinucleotide repeats. (From Durr et al, N Engl J Med 1996 Oct 17;335(16):1169-75)
Excerpt | Relevance | Reference |
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"A group of 27 patients with Friedreich's ataxia and another group of 30 patients with olivopontocerebellar atrophies were each randomly divided into two subgroups, one receiving placebo and the other amantadine hydrochloride (AH; 200 mg daily) for three to four months." | 2.68 | Amantadine hydrochloride treatment in heredodegenerative ataxias: a double blind study. ( Botez, MI; Botez-Marquard, T; Elie, R; Goyette, K; Lalonde, R; Pedraza, OL, 1996) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (28.57) | 18.7374 |
1990's | 5 (71.43) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Filla, A | 1 |
De Michele, G | 1 |
Orefice, G | 1 |
Santorelli, F | 1 |
Trombetta, L | 1 |
Banfi, S | 1 |
Squitieri, F | 1 |
Napolitano, G | 1 |
Puma, D | 1 |
Campanella, G | 1 |
Botez, MI | 4 |
Botez-Marquard, T | 1 |
Elie, R | 1 |
Pedraza, OL | 2 |
Goyette, K | 1 |
Lalonde, R | 1 |
Mayer, P | 1 |
Bellemare, F | 1 |
Couture, J | 1 |
Young, SN | 2 |
Botez, T | 1 |
Mariani, C | 1 |
Canesi, M | 1 |
Barbieri, S | 1 |
Pezzoli, G | 1 |
Rotez, T | 1 |
Courchesne, Y | 1 |
Peterson, PL | 1 |
Saad, J | 1 |
Nigro, MA | 1 |
3 trials available for amantadine and Friedreich Ataxia
Article | Year |
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A double-blind cross-over trial of amantadine hydrochloride in Friedreich's ataxia.
Topics: Adolescent; Adult; Amantadine; Double-Blind Method; Female; Friedreich Ataxia; Humans; Male; Psychom | 1993 |
Amantadine hydrochloride treatment in heredodegenerative ataxias: a double blind study.
Topics: Adult; Amantadine; Analysis of Variance; Antiparkinson Agents; Dopamine; Double-Blind Method; Female | 1996 |
Treatment of heredo-degenerative ataxias with amantadine hydrochloride.
Topics: Adult; Amantadine; Female; Friedreich Ataxia; Homovanillic Acid; Humans; Male; Middle Aged; Muscles; | 1991 |
4 other studies available for amantadine and Friedreich Ataxia
Article | Year |
---|---|
Can we treat respiratory failure in Friedreich ataxia?
Topics: 5-Hydroxytryptophan; Adult; Amantadine; Dopamine Agents; Friedreich Ataxia; Humans; Male; Respirator | 1997 |
Amantadine for Friedreich's ataxia.
Topics: Adult; Amantadine; Friedreich Ataxia; Humans; Male | 1990 |
Treatment of Friedreich's ataxia with amantadine.
Topics: Adolescent; Adult; Amantadine; Female; Friedreich Ataxia; Humans; Male; Middle Aged; Movement; React | 1989 |
The treatment of Friedreich's ataxia with amantadine hydrochloride.
Topics: Adolescent; Adult; Amantadine; Child; Female; Friedreich Ataxia; Humans; Male | 1988 |