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amantadine and Friedreich Ataxia

amantadine has been researched along with Friedreich Ataxia in 7 studies

amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source

Friedreich Ataxia: An autosomal recessive disease, usually of childhood onset, characterized pathologically by degeneration of the spinocerebellar tracts, posterior columns, and to a lesser extent the corticospinal tracts. Clinical manifestations include GAIT ATAXIA, pes cavus, speech impairment, lateral curvature of spine, rhythmic head tremor, kyphoscoliosis, congestive heart failure (secondary to a cardiomyopathy), and lower extremity weakness. Most forms of this condition are associated with a mutation in a gene on chromosome 9, at band q13, which codes for the mitochondrial protein frataxin. (From Adams et al., Principles of Neurology, 6th ed, p1081; N Engl J Med 1996 Oct 17;335(16):1169-75) The severity of Friedreich ataxia associated with expansion of GAA repeats in the first intron of the frataxin gene correlates with the number of trinucleotide repeats. (From Durr et al, N Engl J Med 1996 Oct 17;335(16):1169-75)

Research Excerpts

ExcerptRelevanceReference
"A group of 27 patients with Friedreich's ataxia and another group of 30 patients with olivopontocerebellar atrophies were each randomly divided into two subgroups, one receiving placebo and the other amantadine hydrochloride (AH; 200 mg daily) for three to four months."2.68Amantadine hydrochloride treatment in heredodegenerative ataxias: a double blind study. ( Botez, MI; Botez-Marquard, T; Elie, R; Goyette, K; Lalonde, R; Pedraza, OL, 1996)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19902 (28.57)18.7374
1990's5 (71.43)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Filla, A1
De Michele, G1
Orefice, G1
Santorelli, F1
Trombetta, L1
Banfi, S1
Squitieri, F1
Napolitano, G1
Puma, D1
Campanella, G1
Botez, MI4
Botez-Marquard, T1
Elie, R1
Pedraza, OL2
Goyette, K1
Lalonde, R1
Mayer, P1
Bellemare, F1
Couture, J1
Young, SN2
Botez, T1
Mariani, C1
Canesi, M1
Barbieri, S1
Pezzoli, G1
Rotez, T1
Courchesne, Y1
Peterson, PL1
Saad, J1
Nigro, MA1

Trials

3 trials available for amantadine and Friedreich Ataxia

ArticleYear
A double-blind cross-over trial of amantadine hydrochloride in Friedreich's ataxia.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1993, Volume: 20, Issue:1

    Topics: Adolescent; Adult; Amantadine; Double-Blind Method; Female; Friedreich Ataxia; Humans; Male; Psychom

1993
Amantadine hydrochloride treatment in heredodegenerative ataxias: a double blind study.
    Journal of neurology, neurosurgery, and psychiatry, 1996, Volume: 61, Issue:3

    Topics: Adult; Amantadine; Analysis of Variance; Antiparkinson Agents; Dopamine; Double-Blind Method; Female

1996
Treatment of heredo-degenerative ataxias with amantadine hydrochloride.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1991, Volume: 18, Issue:3

    Topics: Adult; Amantadine; Female; Friedreich Ataxia; Homovanillic Acid; Humans; Male; Middle Aged; Muscles;

1991

Other Studies

4 other studies available for amantadine and Friedreich Ataxia

ArticleYear
Can we treat respiratory failure in Friedreich ataxia?
    Archives of neurology, 1997, Volume: 54, Issue:8

    Topics: 5-Hydroxytryptophan; Adult; Amantadine; Dopamine Agents; Friedreich Ataxia; Humans; Male; Respirator

1997
Amantadine for Friedreich's ataxia.
    Neurology, 1990, Volume: 40, Issue:1

    Topics: Adult; Amantadine; Friedreich Ataxia; Humans; Male

1990
Treatment of Friedreich's ataxia with amantadine.
    Neurology, 1989, Volume: 39, Issue:5

    Topics: Adolescent; Adult; Amantadine; Female; Friedreich Ataxia; Humans; Male; Middle Aged; Movement; React

1989
The treatment of Friedreich's ataxia with amantadine hydrochloride.
    Neurology, 1988, Volume: 38, Issue:9

    Topics: Adolescent; Adult; Amantadine; Child; Female; Friedreich Ataxia; Humans; Male

1988