Page last updated: 2024-10-22

amantadine and Delirium

amantadine has been researched along with Delirium in 12 studies

amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source

Delirium: A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instances autonomic nervous system overactivity. It may result from toxic/metabolic conditions or structural brain lesions. (From Adams et al., Principles of Neurology, 6th ed, pp411-2)

Research Excerpts

ExcerptRelevanceReference
"Amantadine hydrochloride is a risky drug for triggering delirium in dialysis patients; however, it is often administered casually."8.31Amantadine-associated delirium in patients with maintenance dialysis: Insomnia-associated recovery and uneven seasonal distribution. ( Chao, J; He, J; Li, J; Si, B, 2023)
"We present three patients who, after long-term therapy with amantadine (4 to 18 years), experienced an acute delirium with confusion, disorientation, agitation, and paranoia on withdrawal."7.70Acute delirium after withdrawal of amantadine in Parkinson's disease. ( Brown, DL; Factor, SA; Molho, ES, 1998)
"In 13 elderly patients, 12 of whom had Parkinson's disease, visual hallucinations and delirium developed as a side effect of amantadine hydrochloride (Symmetrel) therapy."7.65Visual hallucinations and delirium during treatment with amantadine (Symmetrel). ( Postma, JU; Van Tilburg, W, 1975)
" Drugs used to treat PD, such as levodopa, offer symptomatic relief but often have neuropsychiatric adverse effects, most prominently psychosis and delirium."4.79Neuropsychiatric adverse effects of antiparkinsonian drugs. Characteristics, evaluation and treatment. ( Camicioli, R; Ganzini, L; Young, BK, 1997)
"Amantadine hydrochloride is a risky drug for triggering delirium in dialysis patients; however, it is often administered casually."4.31Amantadine-associated delirium in patients with maintenance dialysis: Insomnia-associated recovery and uneven seasonal distribution. ( Chao, J; He, J; Li, J; Si, B, 2023)
"We pooled individual patient data of five single-centre observational studies to determine the effect of amantadine treatment among patients with ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, community-acquired bacterial meningitis and status epilepticus, admitted between January 2012 and December 2015 and ventilated ≥7 days."4.12Amantadine treatment is associated with improved consciousness in patients with non-traumatic brain injury. ( Balk, S; Gerner, ST; Giede-Jeppe, A; Huttner, HB; Jäger, J; Kallmünzer, B; Kuramatsu, JB; Madzar, D; Mueller, T; Rühl, L; Schwab, S; Sembill, JA; Sprügel, MI, 2022)
"Amantadine, which was originally developed as an antiviral medication, functions as a dopamine agonist in the central nervous system and consequently is utilized in the treatment of Parkinson disease, drug-induced extrapyramidal reactions, and neuroleptic malignant syndrome."3.85The Role of Amantadine Withdrawal in 3 Cases of Treatment-Refractory Altered Mental Status. ( Fox, J; Fryml, LD; Pelic, CG; Revuelta, GJ; Robert, S; Sahlem, G; Short, EB; Williams, KR, 2017)
"We present three patients who, after long-term therapy with amantadine (4 to 18 years), experienced an acute delirium with confusion, disorientation, agitation, and paranoia on withdrawal."3.70Acute delirium after withdrawal of amantadine in Parkinson's disease. ( Brown, DL; Factor, SA; Molho, ES, 1998)
"In 13 elderly patients, 12 of whom had Parkinson's disease, visual hallucinations and delirium developed as a side effect of amantadine hydrochloride (Symmetrel) therapy."3.65Visual hallucinations and delirium during treatment with amantadine (Symmetrel). ( Postma, JU; Van Tilburg, W, 1975)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19903 (25.00)18.7374
1990's5 (41.67)18.2507
2000's1 (8.33)29.6817
2010's1 (8.33)24.3611
2020's2 (16.67)2.80

Authors

AuthorsStudies
Rühl, L1
Kuramatsu, JB1
Sembill, JA1
Kallmünzer, B1
Madzar, D1
Gerner, ST1
Giede-Jeppe, A1
Balk, S1
Mueller, T1
Jäger, J1
Schwab, S1
Huttner, HB1
Sprügel, MI1
Li, J1
Si, B1
Chao, J1
He, J1
Fryml, LD1
Williams, KR1
Pelic, CG1
Fox, J1
Sahlem, G1
Robert, S1
Revuelta, GJ1
Short, EB1
Nishikawa, N1
Nagai, M1
Moritoyo, T1
Yabe, H1
Nomoto, M1
Young, BK1
Camicioli, R1
Ganzini, L1
Factor, SA1
Molho, ES1
Brown, DL1
Miyasaki, JM1
Grimes, D1
Lang, AE1
Postma, JU1
Van Tilburg, W1
Rudorfer, MV1
Manji, HK1
Potter, WZ1
Liberzon, I1
Dequardo, JR1
Silk, KR1
Speeg, KV1
Leighton, JA1
Maldonado, AL1
Herishanu, Y1
Noah, Z1

Reviews

1 review available for amantadine and Delirium

ArticleYear
Neuropsychiatric adverse effects of antiparkinsonian drugs. Characteristics, evaluation and treatment.
    Drugs & aging, 1997, Volume: 10, Issue:5

    Topics: Aging; Akathisia, Drug-Induced; Amantadine; Antiparkinson Agents; Antipsychotic Agents; Cholinergic

1997

Other Studies

11 other studies available for amantadine and Delirium

ArticleYear
Amantadine treatment is associated with improved consciousness in patients with non-traumatic brain injury.
    Journal of neurology, neurosurgery, and psychiatry, 2022, Volume: 93, Issue:6

    Topics: Amantadine; Brain Injuries; Brain Ischemia; Consciousness; Delirium; Glasgow Coma Scale; Humans; Sei

2022
Amantadine-associated delirium in patients with maintenance dialysis: Insomnia-associated recovery and uneven seasonal distribution.
    Medicine, 2023, Jun-30, Volume: 102, Issue:26

    Topics: Amantadine; Delirium; Humans; Renal Dialysis; Retrospective Studies; Seasons; Sleep Initiation and M

2023
The Role of Amantadine Withdrawal in 3 Cases of Treatment-Refractory Altered Mental Status.
    Journal of psychiatric practice, 2017, Volume: 23, Issue:3

    Topics: Aged; Amantadine; Catatonia; Delirium; Dopamine Agents; Electroconvulsive Therapy; Humans; Male; Mid

2017
Plasma amantadine concentrations in patients with Parkinson's disease.
    Parkinsonism & related disorders, 2009, Volume: 15, Issue:5

    Topics: Adult; Aged; Amantadine; Antiparkinson Agents; Creatinine; Delirium; Female; Hallucinations; Humans;

2009
Acute delirium after withdrawal of amantadine in Parkinson's disease.
    Neurology, 1998, Volume: 50, Issue:5

    Topics: Acute Disease; Age of Onset; Aged; Amantadine; Delirium; Female; Humans; Male; Parkinson Disease; Su

1998
Acute delirium after withdrawal of amantadine in Parkinson's disease.
    Neurology, 1999, May-12, Volume: 52, Issue:8

    Topics: Amantadine; Delirium; Humans; Parkinson Disease; Substance Withdrawal Syndrome

1999
Visual hallucinations and delirium during treatment with amantadine (Symmetrel).
    Journal of the American Geriatrics Society, 1975, Volume: 23, Issue:5

    Topics: Aged; Amantadine; Benztropine; Biperiden; Delirium; Drug Eruptions; Female; Hallucinations; Humans;

1975
Bupropion, ECT, and dopaminergic overdrive.
    The American journal of psychiatry, 1991, Volume: 148, Issue:8

    Topics: Aged; Amantadine; Antidepressive Agents; Bupropion; Combined Modality Therapy; Delirium; Drug Therap

1991
Bupropion and delirium.
    The American journal of psychiatry, 1990, Volume: 147, Issue:12

    Topics: Aged; Amantadine; Antidepressive Agents; Bupropion; Delirium; Depressive Disorder; Drug Therapy, Com

1990
Toxic delirium in a patient taking amantadine and trimethoprim-sulfamethoxazole.
    The American journal of the medical sciences, 1989, Volume: 298, Issue:6

    Topics: Aged; Amantadine; Biological Transport; Delirium; Drug Interactions; Humans; Kidney; Male; Procainam

1989
On acute encephalitic parkinsonian syndrome. Case report and review of the recent literature.
    European neurology, 1973, Volume: 10, Issue:2

    Topics: Amantadine; Child, Preschool; Delirium; Electroencephalography; Encephalitis, Arbovirus; Humans; Mal

1973