Page last updated: 2024-10-22

amantadine and Corneal Edema

amantadine has been researched along with Corneal Edema in 24 studies

amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source

Corneal Edema: An excessive amount of fluid in the cornea due to damage of the epithelium or endothelium causing decreased visual acuity.

Research Excerpts

ExcerptRelevanceReference
"Amantadine increases the risk of corneal edema in a dose-dependent manner."7.83Amantadine Use as a Risk Factor for Corneal Edema: A Nationwide Cohort Study in Taiwan. ( Chang, CH; Cheng, KC; Hsu, SL; Lee, PY; Lin, CC; Lin, CP; Tu, HP, 2016)
"The authors report the successful use of Descemet's stripping automated endothelial keratoplasty (DSAEK) to treat a 45-year-old woman with amantadine-associated corneal edema."7.76Amantadine-associated corneal edema treated with descemet's stripping automated endothelial keratoplasty. ( Dupps, WJ; Hood, CT; Langston, RH; Schoenfield, LR, 2010)
"With one exception, a case report of amantadine-induced corneal toxicity has described reversible corneal edema."7.75Nonimmunologic graft failure after Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) for presumed amantadine-induced corneal edema. ( Koenig, SB; McDermott, ML; Simons, KB, 2009)
"In this article, we report a case of bilateral severe reversible corneal edema caused by amantadine therapy."7.75Bilateral reversible corneal edema associated with amantadine use. ( Esquenazi, S, 2009)
"To determine the proportion of patients who were dispensed amantadine and diagnosed with corneal edema or Fuchs dystrophy within specified time frames."7.74Postmarketing surveillance of corneal edema, Fuchs dystrophy, and amantadine use in the Veterans Health Administration. ( French, DD; Margo, CE, 2007)
"To describe the clinical features of 3 patients with amantadine-associated corneal edema, including the histopathologic findings from 1 patient who underwent corneal transplantation for irreversible corneal edema."7.74Amantadine-associated corneal edema potentially irreversible even after cessation of the medication. ( Galor, A; Hollyfield, JG; Jeng, BH; Langston, RH; Lee, MS; McMahon, JT; Meisler, DM; Schoenfield, L, 2008)
"To document reversible corneal edema caused by amantadine in a pediatric patient."7.72Reversible amantadine-induced corneal edema in an adolescent. ( Brodsky, MC; Feiz, V; Flynn, SB; Hughes, B, 2004)
"Amantadine was originally developed as an antiviral agent for influenza A."5.72Amantadine-induced bilateral corneal edema in a pediatric patient. ( Bohra, L; Chao, J; Dunn, S, 2022)
"Corneal edema is a known but unusual side effect of amantadine therapy, rarely reported in the neurological literature."5.37Amantadine induced reversible corneal edema. ( Deogaonkar, M; Vitek, J; Wilson, K, 2011)
"To report a case of a patient showing bilateral corneal opacities after amantadine chronic treatment for Parkinson's Disease (PD) and corneal edema associated with intra-epithelial and -endothelial depositions."4.12Amantadine therapy for Parkinson's Disease: In Vivo Confocal Microscopy corneal findings, case report and revision of literature. ( Cennamo, M; Dragotto, F; Favuzza, E; Mencucci, R; Morelli, A, 2022)
"An adverse effect of amantadine, a drug used for Parkinson's disease, is corneal edema."3.91Effects of amantadine on corneal endothelium. ( Dudley, CE; Duffey, ME; Morell, AJ; Patel, SP, 2019)
"Amantadine increases the risk of corneal edema in a dose-dependent manner."3.83Amantadine Use as a Risk Factor for Corneal Edema: A Nationwide Cohort Study in Taiwan. ( Chang, CH; Cheng, KC; Hsu, SL; Lee, PY; Lin, CC; Lin, CP; Tu, HP, 2016)
"A 64 year-old female with Parkinson disease treated with amantadine for two years who suddenly suffered bilateral corneal oedema."3.78[Corneal toxicity due to amantadine]. ( Avendaño-Cantos, EM; Celis-Sánchez, J; Gálvez-Martínez, J; González Del Valle, F; López-Arroquia, E; Mesa-Varona, D, 2012)
"Six eyes of 4 consecutive patients with clear crystalline lenses and corneal edema because of either Fuchs dystrophy (4 eyes) or amantadine-induced corneal endothelial toxicity (2 eyes) were included in this study."3.76Descemet stripping automated endothelial keratoplasty in the phakic eye. ( Koenig, SB, 2010)
"The authors report the successful use of Descemet's stripping automated endothelial keratoplasty (DSAEK) to treat a 45-year-old woman with amantadine-associated corneal edema."3.76Amantadine-associated corneal edema treated with descemet's stripping automated endothelial keratoplasty. ( Dupps, WJ; Hood, CT; Langston, RH; Schoenfield, LR, 2010)
"To describe bilateral corneal endothelial dysfunction in a patient with Parkinson disease who was treated with long-term amantadine."3.74Corneal endothelial dysfunction associated with amantadine toxicity. ( Chang, KC; Kim, MK; Lee, JH; Wee, WR, 2008)
"To determine the proportion of patients who were dispensed amantadine and diagnosed with corneal edema or Fuchs dystrophy within specified time frames."3.74Postmarketing surveillance of corneal edema, Fuchs dystrophy, and amantadine use in the Veterans Health Administration. ( French, DD; Margo, CE, 2007)
"To describe the clinical features of 3 patients with amantadine-associated corneal edema, including the histopathologic findings from 1 patient who underwent corneal transplantation for irreversible corneal edema."3.74Amantadine-associated corneal edema potentially irreversible even after cessation of the medication. ( Galor, A; Hollyfield, JG; Jeng, BH; Langston, RH; Lee, MS; McMahon, JT; Meisler, DM; Schoenfield, L, 2008)
"Corneal edema is a known but unusual side effect of amantadine therapy, rarely reported in the neurological literature."1.37Amantadine induced reversible corneal edema. ( Deogaonkar, M; Vitek, J; Wilson, K, 2011)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (4.17)18.2507
2000's9 (37.50)29.6817
2010's12 (50.00)24.3611
2020's2 (8.33)2.80

Authors

AuthorsStudies
Chao, J1
Dunn, S1
Bohra, L1
Cennamo, M1
Dragotto, F1
Favuzza, E1
Morelli, A1
Mencucci, R1
Beran, M1
Okyere, B1
Vova, J1
Dudley, CE1
Morell, AJ1
Duffey, ME1
Patel, SP1
Yang, Y1
Teja, S1
Baig, K1
Lee, PY1
Tu, HP1
Lin, CP1
Chang, CH1
Cheng, KC1
Lin, CC1
Hsu, SL1
Soin, K1
Feinstein, EG1
Guo, J1
Dubow, JS1
Rezak, M1
Berman, AA1
Chang, KC1
Kim, MK1
Wee, WR1
Lee, JH1
Pond, A1
Lee, MS2
Hardten, DR1
Harrison, AR1
Krachmer, JH1
Naumann, GO1
Schlötzer-Schrehardt, U1
Koenig, SB2
McDermott, ML1
Simons, KB1
Park, CY1
Chuck, RS1
Esquenazi, S1
Ghaffariyeh, A1
Honarpisheh, N1
Hood, CT1
Langston, RH2
Schoenfield, LR1
Dupps, WJ1
Deogaonkar, M1
Wilson, K1
Vitek, J1
Hotehama, A1
Mimura, T1
Usui, T1
Kawashima, H1
Amano, S1
Avendaño-Cantos, EM1
Celis-Sánchez, J1
Mesa-Varona, D1
Gálvez-Martínez, J1
López-Arroquia, E1
González Del Valle, F1
Hughes, B1
Feiz, V1
Flynn, SB1
Brodsky, MC1
French, DD1
Margo, CE1
Jeng, BH1
Galor, A1
Meisler, DM1
Hollyfield, JG1
Schoenfield, L1
McMahon, JT1
Blanchard, DL1

Other Studies

24 other studies available for amantadine and Corneal Edema

ArticleYear
Amantadine-induced bilateral corneal edema in a pediatric patient.
    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2022, Volume: 26, Issue:3

    Topics: Amantadine; Child; Corneal Edema; Humans

2022
Amantadine therapy for Parkinson's Disease: In Vivo Confocal Microscopy corneal findings, case report and revision of literature.
    BMC ophthalmology, 2022, May-10, Volume: 22, Issue:1

    Topics: Aged; Amantadine; Corneal Edema; Endothelial Cells; Humans; Male; Microscopy, Confocal; Parkinson Di

2022
Amantadine-Induced Corneal Edema in a Pediatric Neuro-Oncology Patient: A Case Report.
    PM & R : the journal of injury, function, and rehabilitation, 2018, Volume: 10, Issue:10

    Topics: Adolescent; Amantadine; Brain Neoplasms; Corneal Edema; Follow-Up Studies; Humans; Male; Neuroblasto

2018
Effects of amantadine on corneal endothelium.
    Experimental eye research, 2019, Volume: 181

    Topics: Amantadine; Animals; Apoptosis; Cattle; Corneal Edema; Dopamine Agents; Endothelium, Corneal; Ion Tr

2019
Bilateral corneal edema associated with amantadine.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2015, Oct-20, Volume: 187, Issue:15

    Topics: Amantadine; Corneal Edema; Corneal Pachymetry; Dopamine Agents; Humans; Male; Middle Aged; Slit Lamp

2015
Amantadine Use as a Risk Factor for Corneal Edema: A Nationwide Cohort Study in Taiwan.
    American journal of ophthalmology, 2016, Volume: 171

    Topics: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Amantadine; Antiparkinson Agents; Corn

2016
Recent-Onset Bilateral Blurred Vision.
    JAMA ophthalmology, 2017, 01-01, Volume: 135, Issue:1

    Topics: Amantadine; Antiviral Agents; Corneal Edema; Corneal Pachymetry; Endothelium, Corneal; Female; Human

2017
Reversible corneal edema associated with amantadine use: an unrecognized problem.
    Movement disorders : official journal of the Movement Disorder Society, 2008, Oct-30, Volume: 23, Issue:14

    Topics: Aged; Amantadine; Antiparkinson Agents; Corneal Edema; Female; Humans; Movement Disorders

2008
Corneal endothelial dysfunction associated with amantadine toxicity.
    Cornea, 2008, Volume: 27, Issue:10

    Topics: Administration, Oral; Amantadine; Antiparkinson Agents; Cell Count; Corneal Edema; Endothelium, Corn

2008
Toxic corneal oedema associated with amantadine use.
    The British journal of ophthalmology, 2009, Volume: 93, Issue:3

    Topics: Amantadine; Antiparkinson Agents; Child; Cornea; Corneal Edema; Female; Humans; Middle Aged; Parkins

2009
Amantadine-associated corneal edema.
    Ophthalmology, 2009, Volume: 116, Issue:6

    Topics: Amantadine; Analgesics, Non-Narcotic; Bipolar Disorder; Corneal Edema; Dopamine Agents; Humans; Kera

2009
Nonimmunologic graft failure after Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) for presumed amantadine-induced corneal edema.
    Eye & contact lens, 2009, Volume: 35, Issue:4

    Topics: Adult; Amantadine; Automation; Corneal Edema; Corneal Transplantation; Descemet Membrane; Drug Admin

2009
Sudden bilateral corneal oedema in a patient with Parkinson's disease.
    Acta ophthalmologica, 2011, Volume: 89, Issue:2

    Topics: Adult; Amantadine; Antiparkinson Agents; Blindness; Corneal Edema; Functional Laterality; Humans; Ma

2011
Bilateral reversible corneal edema associated with amantadine use.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2009, Volume: 25, Issue:6

    Topics: Adult; Amantadine; Cornea; Corneal Edema; Diagnosis, Differential; Dopamine Agents; Female; Humans;

2009
Descemet stripping automated endothelial keratoplasty in the phakic eye.
    Cornea, 2010, Volume: 29, Issue:5

    Topics: Adult; Amantadine; Cornea; Corneal Edema; Descemet Stripping Endothelial Keratoplasty; Female; Fuchs

2010
Amantadine-associated corneal edema.
    Parkinsonism & related disorders, 2010, Volume: 16, Issue:6

    Topics: Aged; Amantadine; Anti-Inflammatory Agents; Antiparkinson Agents; Corneal Edema; Female; Humans; Oph

2010
Amantadine-associated corneal edema treated with descemet's stripping automated endothelial keratoplasty.
    Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye, 2010, Jul-29, Volume: 41 Online

    Topics: Amantadine; Automation; Corneal Edema; Descemet Stripping Endothelial Keratoplasty; Diagnosis, Diffe

2010
Amantadine induced reversible corneal edema.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2011, Volume: 18, Issue:2

    Topics: Amantadine; Antiparkinson Agents; Corneal Edema; Female; Humans; Iatrogenic Disease; Middle Aged; Pa

2011
Sudden onset of amantadine-induced reversible bilateral corneal edema in an elderly patient: case report and literature review.
    Japanese journal of ophthalmology, 2011, Volume: 55, Issue:1

    Topics: Aged; Amantadine; Corneal Edema; Dopamine Agents; Endothelium, Corneal; Female; Functional Lateralit

2011
[Corneal toxicity due to amantadine].
    Archivos de la Sociedad Espanola de Oftalmologia, 2012, Volume: 87, Issue:9

    Topics: Acyclovir; Amantadine; Antiparkinson Agents; Aqueous Humor; Cataract Extraction; Ceftazidime; Cornea

2012
Reversible amantadine-induced corneal edema in an adolescent.
    Cornea, 2004, Volume: 23, Issue:8

    Topics: Adolescent; Amantadine; Cornea; Corneal Edema; Dopamine Agents; Humans; Male; Visual Acuity

2004
Postmarketing surveillance of corneal edema, Fuchs dystrophy, and amantadine use in the Veterans Health Administration.
    Cornea, 2007, Volume: 26, Issue:9

    Topics: Aged; Amantadine; Antiparkinson Agents; Antiviral Agents; Corneal Edema; Databases, Factual; Drug Pr

2007
Amantadine-associated corneal edema potentially irreversible even after cessation of the medication.
    Ophthalmology, 2008, Volume: 115, Issue:9

    Topics: Adult; Amantadine; Analgesics, Non-Narcotic; Bipolar Disorder; Corneal Edema; Dopamine Agents; Femal

2008
Amantadine caused corneal edema.
    Cornea, 1990, Volume: 9, Issue:2

    Topics: Amantadine; Corneal Edema; Female; Humans; Middle Aged

1990